SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4n78'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CMC_A_SAMA105_0
(MET REPRESSOR)		 4n78 CYTOPLASMIC
FMR1-INTERACTING
PROTEIN 1
WISKOTT-ALDRICH
SYNDROME PROTEIN
FAMILY MEMBER 1
(Homo
sapiens;
Homo
sapiens) 		5 / 10 ALA A1003
ARG D 498
LEU A 940
GLU A 999
LEU A 852
 None
 1.29A 1cmcA-4n78A:
undetectable
1cmcB-4n78A:
undetectable		 1cmcA-4n78A:
7.13
1cmcB-4n78A:
7.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CMC_B_SAMB105_0
(MET REPRESSOR)		 4n78 CYTOPLASMIC
FMR1-INTERACTING
PROTEIN 1
WISKOTT-ALDRICH
SYNDROME PROTEIN
FAMILY MEMBER 1
(Homo
sapiens;
Homo
sapiens) 		5 / 10 ARG D 498
LEU A 940
GLU A 999
LEU A 852
ALA A1003
 None
 1.30A 1cmcA-4n78D:
undetectable
1cmcB-4n78D:
undetectable		 1cmcA-4n78D:
12.33
1cmcB-4n78D:
12.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERR_B_RALB600_2
(ESTROGEN RECEPTOR)		 4n78 CYTOPLASMIC
FMR1-INTERACTING
PROTEIN 1
(Homo
sapiens) 		4 / 6 LEU A 798
ASP A 791
LEU A 782
HIS A 889
 None
 1.22A 1errB-4n78A:
undetectable		 1errB-4n78A:
12.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HRK_A_CHDA1501_0
(FERROCHELATASE)		 4n78 CYTOPLASMIC
FMR1-INTERACTING
PROTEIN 1
(Homo
sapiens) 		5 / 12 LEU A1167
ILE A1096
LEU A 946
VAL A 949
VAL A1000
 None
 1.21A 1hrkA-4n78A:
undetectable		 1hrkA-4n78A:
15.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ISM_B_NCAB305_0
(BONE MARROW STROMAL
CELL ANTIGEN 1)		 4n78 CYTOPLASMIC
FMR1-INTERACTING
PROTEIN 1
(Homo
sapiens) 		4 / 7 TRP A 332
SER A 322
ASP A 275
PHE A 299
 None
 1.17A 1ismB-4n78A:
undetectable		 1ismB-4n78A:
12.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KT6_A_RTLA184_0
(PLASMA
RETINOL-BINDING
PROTEIN)		 4n78 CYTOPLASMIC
FMR1-INTERACTING
PROTEIN 1
(Homo
sapiens) 		5 / 11 LEU A 158
VAL A 153
MET A 274
LEU A 143
ARG A 289
 None
 1.28A 1kt6A-4n78A:
undetectable		 1kt6A-4n78A:
10.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KT7_A_RTLA184_0
(PLASMA
RETINOL-BINDING
PROTEIN)		 4n78 CYTOPLASMIC
FMR1-INTERACTING
PROTEIN 1
(Homo
sapiens) 		5 / 11 LEU A 158
VAL A 153
MET A 274
LEU A 143
ARG A 289
 None
 1.27A 1kt7A-4n78A:
undetectable		 1kt7A-4n78A:
10.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L2I_B_CCSB417_0
(ESTROGEN RECEPTOR)		 4n78 CYTOPLASMIC
FMR1-INTERACTING
PROTEIN 1
(Homo
sapiens) 		4 / 6 PRO A  94
GLU A 109
GLN A 101
VAL A 105
 None
 1.25A 1l2iB-4n78A:
undetectable		 1l2iB-4n78A:
11.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SBR_A_VIBA501_1
(YKOF)		 4n78 CYTOPLASMIC
FMR1-INTERACTING
PROTEIN 1
(Homo
sapiens) 		4 / 8 SER A 402
LEU A 401
ILE A 455
ILE A 458
 None
 0.87A 1sbrA-4n78A:
undetectable		 1sbrA-4n78A:
9.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_A_BEZA11_0
(CES1 PROTEIN)		 4n78 CYTOPLASMIC
FMR1-INTERACTING
PROTEIN 1
(Homo
sapiens) 		4 / 4 LEU A 782
SER A 789
LEU A 801
LEU A 888
 None
 1.17A 1yajA-4n78A:
undetectable		 1yajA-4n78A:
17.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z95_A_198A501_1
(ANDROGEN RECEPTOR)		 4n78 CYTOPLASMIC
FMR1-INTERACTING
PROTEIN 1
(Homo
sapiens) 		5 / 12 LEU A 398
GLY A 397
MET A 465
VAL A 463
HIS A 356
 None
 1.29A 1z95A-4n78A:
undetectable		 1z95A-4n78A:
11.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXG_A_IBPA2002_1
(SERUM ALBUMIN)		 4n78 CYTOPLASMIC
FMR1-INTERACTING
PROTEIN 1
WISKOTT-ALDRICH
SYNDROME PROTEIN
FAMILY MEMBER 1
(Homo
sapiens) 		4 / 8 ARG A 838
ALA D 100
GLU A 781
LEU D 511
 None
 0.75A 2bxgA-4n78A:
2.4		 2bxgA-4n78A:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8D_A_BEZA1002_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 4n78 CYTOPLASMIC
FMR1-INTERACTING
PROTEIN 1
(Homo
sapiens) 		5 / 10 LEU A 721
GLY A 719
LEU A 723
LEU A 722
ARG A 728
 None
 1.11A 2f8dA-4n78A:
undetectable		 2f8dA-4n78A:
11.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HRC_A_CHDA701_0
(FERROCHELATASE)		 4n78 CYTOPLASMIC
FMR1-INTERACTING
PROTEIN 1
(Homo
sapiens) 		5 / 12 LEU A1167
ILE A1096
LEU A 946
VAL A 949
VAL A1000
 None
 1.22A 2hrcA-4n78A:
undetectable		 2hrcA-4n78A:
15.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HRC_B_CHDB1605_0
(FERROCHELATASE)		 4n78 CYTOPLASMIC
FMR1-INTERACTING
PROTEIN 1
(Homo
sapiens) 		5 / 12 LEU A1167
ILE A1096
LEU A 946
VAL A 949
VAL A1000
 None
 1.20A 2hrcB-4n78A:
undetectable		 2hrcB-4n78A:
15.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JFA_A_RALA600_2
(ESTROGEN RECEPTOR)		 4n78 CYTOPLASMIC
FMR1-INTERACTING
PROTEIN 1
(Homo
sapiens) 		4 / 5 LEU A 798
ASP A 791
LEU A 782
HIS A 889
 None
 1.24A 2jfaA-4n78A:
undetectable		 2jfaA-4n78A:
11.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO7_A_CHDA501_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4n78 CYTOPLASMIC
FMR1-INTERACTING
PROTEIN 1
(Homo
sapiens) 		5 / 12 LEU A1167
ILE A1096
LEU A 946
VAL A 949
VAL A1000
 None
 1.17A 2po7A-4n78A:
undetectable		 2po7A-4n78A:
15.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQD_A_AG2A671_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 4n78 ABL INTERACTOR 2
CYTOPLASMIC
FMR1-INTERACTING
PROTEIN 1
(Homo
sapiens) 		4 / 7 LEU F 112
ILE A1100
MET A 930
GLU A 931
 None
 0.98A 2qqdA-4n78F:
undetectable
2qqdE-4n78F:
undetectable		 2qqdA-4n78F:
7.60
2qqdE-4n78F:
11.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QXS_A_RALA600_2
(ESTROGEN RECEPTOR)		 4n78 CYTOPLASMIC
FMR1-INTERACTING
PROTEIN 1
(Homo
sapiens) 		4 / 5 LEU A 798
ASP A 791
LEU A 782
HIS A 889
 None
 1.25A 2qxsA-4n78A:
undetectable		 2qxsA-4n78A:
11.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QXS_B_RALB600_2
(ESTROGEN RECEPTOR)		 4n78 CYTOPLASMIC
FMR1-INTERACTING
PROTEIN 1
(Homo
sapiens) 		4 / 5 LEU A 798
ASP A 791
LEU A 782
HIS A 889
 None
 1.27A 2qxsB-4n78A:
undetectable		 2qxsB-4n78A:
11.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_D_ASDD1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 4n78 CYTOPLASMIC
FMR1-INTERACTING
PROTEIN 1
(Homo
sapiens) 		5 / 9 PHE A 359
LEU A 612
LEU A 255
ALA A 394
LEU A 395
 None
 1.17A 2vcvD-4n78A:
4.5		 2vcvD-4n78A:
11.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_H_ASDH1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 4n78 CYTOPLASMIC
FMR1-INTERACTING
PROTEIN 1
(Homo
sapiens) 		5 / 9 PHE A 359
LEU A 612
LEU A 255
ALA A 394
LEU A 395
 None
 1.20A 2vcvH-4n78A:
4.5		 2vcvH-4n78A:
11.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WM3_A_NFLA1301_1
(NMRA-LIKE FAMILY
DOMAIN CONTAINING
PROTEIN 1)		 4n78 CYTOPLASMIC
FMR1-INTERACTING
PROTEIN 1
WISKOTT-ALDRICH
SYNDROME PROTEIN
FAMILY MEMBER 1
(Homo
sapiens) 		4 / 6 LEU D 111
PHE A 699
LEU A 757
ASP A 763
 None
 1.14A 2wm3A-4n78D:
undetectable		 2wm3A-4n78D:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_C_ACHC1211_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 4n78 CYTOPLASMIC
FMR1-INTERACTING
PROTEIN 1
(Homo
sapiens) 		4 / 8 THR A 420
ASP A 421
SER A 424
TRP A 414
 None
 1.25A 2xz5A-4n78A:
undetectable
2xz5C-4n78A:
undetectable		 2xz5A-4n78A:
10.20
2xz5C-4n78A:
10.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ADS_A_IMNA1_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 4n78 WISKOTT-ALDRICH
SYNDROME PROTEIN
FAMILY MEMBER 1
(Homo
sapiens) 		5 / 10 GLU D 503
ARG D 506
ILE D 505
GLY D 508
ILE D  95
 None
 1.36A 3adsA-4n78D:
undetectable		 3adsA-4n78D:
17.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3APW_A_DP0A190_2
(ALPHA-1-ACID
GLYCOPROTEIN 2)		 4n78 CYTOPLASMIC
FMR1-INTERACTING
PROTEIN 1
(Homo
sapiens) 		4 / 4 VAL A 480
ARG A 477
HIS A 474
PHE A 391
 None
 1.30A 3apwA-4n78A:
0.0		 3apwA-4n78A:
9.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B6R_B_CRNB603_1
(CREATINE KINASE
B-TYPE)		 4n78 ABL INTERACTOR 2
WISKOTT-ALDRICH
SYNDROME PROTEIN
FAMILY MEMBER 1
(Homo
sapiens) 		4 / 6 THR F  96
VAL F  97
LEU D  83
GLU D  88
 None
 1.23A 3b6rB-4n78F:
undetectable		 3b6rB-4n78F:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DZY_D_BRLD478_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 4n78 CYTOPLASMIC
FMR1-INTERACTING
PROTEIN 1
(Homo
sapiens) 		4 / 4 ILE A 507
GLN A 512
ILE A 592
LEU A 533
 None
 1.17A 3dzyD-4n78A:
2.2		 3dzyD-4n78A:
16.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWU_A_SREA801_1
(TRANSPORTER)		 4n78 CYTOPLASMIC
FMR1-INTERACTING
PROTEIN 1
(Homo
sapiens) 		5 / 12 LEU A 393
PHE A 608
PHE A 359
LEU A 461
THR A 611
 None
 1.29A 3gwuA-4n78A:
0.5		 3gwuA-4n78A:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWX_A_EPAA1_1
(PROTEIN (PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
(PPAR-DELTA)))		 4n78 CYTOPLASMIC
FMR1-INTERACTING
PROTEIN 1
(Homo
sapiens) 		5 / 10 GLN A1012
ILE A1004
LEU A 847
VAL A 929
VAL A 843
 None
 1.05A 3gwxA-4n78A:
undetectable		 3gwxA-4n78A:
12.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWX_A_EPAA1_1
(PROTEIN (PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
(PPAR-DELTA)))		 4n78 CYTOPLASMIC
FMR1-INTERACTING
PROTEIN 1
(Homo
sapiens) 		5 / 10 ILE A1004
LEU A 847
VAL A 929
VAL A 843
LEU A 792
 None
 1.04A 3gwxA-4n78A:
undetectable		 3gwxA-4n78A:
12.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IX9_A_MTXA200_1
(DIHYDROFOLATE
REDUCTASE)		 4n78 CYTOPLASMIC
FMR1-INTERACTING
PROTEIN 1
(Homo
sapiens) 		5 / 12 ILE A 458
LEU A 648
LEU A 621
GLN A 620
VAL A 454
 None
None
None
GOL  A1304 (-2.9A)
None
 1.04A 3ix9A-4n78A:
undetectable		 3ix9A-4n78A:
9.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RUK_B_AERB601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 4n78 CYTOPLASMIC
FMR1-INTERACTING
PROTEIN 1
(Homo
sapiens) 		5 / 12 ASN A1215
ILE A1218
ILE A1219
LEU A1222
VAL A1166
 None
 0.62A 3rukB-4n78A:
undetectable		 3rukB-4n78A:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3Z_A_9PLA501_1
(CYTOCHROME P450 2E1)		 4n78 CYTOPLASMIC
FMR1-INTERACTING
PROTEIN 1
(Homo
sapiens) 		4 / 6 PHE A 600
LEU A 263
ALA A 156
THR A 160
 None
 0.96A 3t3zA-4n78A:
undetectable		 3t3zA-4n78A:
16.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3Z_B_9PLB501_1
(CYTOCHROME P450 2E1)		 4n78 CYTOPLASMIC
FMR1-INTERACTING
PROTEIN 1
(Homo
sapiens) 		4 / 6 PHE A 600
LEU A 263
ALA A 156
THR A 160
 None
 0.92A 3t3zB-4n78A:
undetectable		 3t3zB-4n78A:
16.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3Z_D_9PLD501_1
(CYTOCHROME P450 2E1)		 4n78 CYTOPLASMIC
FMR1-INTERACTING
PROTEIN 1
(Homo
sapiens) 		4 / 6 PHE A 600
LEU A 263
ALA A 156
THR A 160
 None
 0.94A 3t3zD-4n78A:
undetectable		 3t3zD-4n78A:
16.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZMD_A_SALA201_1
(PUTATIVE
TRANSCRIPTIONAL
REGULATOR)		 4n78 CYTOPLASMIC
FMR1-INTERACTING
PROTEIN 1
WISKOTT-ALDRICH
SYNDROME PROTEIN
FAMILY MEMBER 1
(Homo
sapiens) 		4 / 8 ARG A 624
LEU A 628
ARG A  87
TYR D 156
 None
 1.24A 3zmdA-4n78A:
1.4
3zmdB-4n78A:
1.2		 3zmdA-4n78A:
9.39
3zmdB-4n78A:
9.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZMD_A_SALA201_1
(PUTATIVE
TRANSCRIPTIONAL
REGULATOR)		 4n78 CYTOPLASMIC
FMR1-INTERACTING
PROTEIN 1
WISKOTT-ALDRICH
SYNDROME PROTEIN
FAMILY MEMBER 1
(Homo
sapiens) 		4 / 8 LEU A 628
ARG A  87
TYR D 156
GLU A 690
 None
 1.42A 3zmdA-4n78A:
1.4
3zmdB-4n78A:
1.2		 3zmdA-4n78A:
9.39
3zmdB-4n78A:
9.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AGA_A_ACTA1131_0
(LYSOZYME C)		 4n78 CYTOPLASMIC
FMR1-INTERACTING
PROTEIN 1
(Homo
sapiens) 		3 / 3 ASN A 176
ASP A 172
ASN A 218
 None
 0.80A 4agaA-4n78A:
undetectable		 4agaA-4n78A:
7.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KLR_A_CHDA505_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4n78 CYTOPLASMIC
FMR1-INTERACTING
PROTEIN 1
(Homo
sapiens) 		4 / 5 LEU A 492
PRO A 495
LEU A 511
ILE A 514
 None
 1.02A 4klrA-4n78A:
undetectable		 4klrA-4n78A:
15.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L9Q_B_9TPB601_1
(SERUM ALBUMIN)		 4n78 CYTOPLASMIC
FMR1-INTERACTING
PROTEIN 1
(Homo
sapiens) 		5 / 12 LEU A 398
ALA A 475
LEU A 363
LEU A 464
GLY A 460
 None
 1.21A 4l9qB-4n78A:
2.6		 4l9qB-4n78A:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_B_AERB601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 4n78 CYTOPLASMIC
FMR1-INTERACTING
PROTEIN 1
(Homo
sapiens) 		5 / 12 ASN A1215
ILE A1218
ILE A1219
LEU A1222
VAL A1166
 None
 0.76A 4nkvB-4n78A:
undetectable		 4nkvB-4n78A:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OJB_A_198A1001_1
(ANDROGEN RECEPTOR)		 4n78 CYTOPLASMIC
FMR1-INTERACTING
PROTEIN 1
(Homo
sapiens) 		5 / 12 LEU A 398
GLY A 397
LEU A 363
MET A 465
VAL A 463
 None
 0.98A 4ojbA-4n78A:
undetectable		 4ojbA-4n78A:
11.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OJB_A_198A1001_1
(ANDROGEN RECEPTOR)		 4n78 CYTOPLASMIC
FMR1-INTERACTING
PROTEIN 1
(Homo
sapiens) 		5 / 12 LEU A 398
GLY A 397
MET A 465
VAL A 463
HIS A 356
 None
 1.25A 4ojbA-4n78A:
undetectable		 4ojbA-4n78A:
11.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OKB_A_198A1002_1
(ANDROGEN RECEPTOR)		 4n78 CYTOPLASMIC
FMR1-INTERACTING
PROTEIN 1
(Homo
sapiens) 		5 / 12 LEU A 398
GLY A 397
LEU A 363
MET A 465
VAL A 463
 None
 1.00A 4okbA-4n78A:
undetectable		 4okbA-4n78A:
11.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OKB_A_198A1002_1
(ANDROGEN RECEPTOR)		 4n78 CYTOPLASMIC
FMR1-INTERACTING
PROTEIN 1
(Homo
sapiens) 		5 / 12 LEU A 398
GLY A 397
MET A 465
VAL A 463
HIS A 356
 None
 1.27A 4okbA-4n78A:
undetectable		 4okbA-4n78A:
11.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OKW_A_198A1001_1
(ANDROGEN RECEPTOR)		 4n78 CYTOPLASMIC
FMR1-INTERACTING
PROTEIN 1
(Homo
sapiens) 		5 / 12 LEU A 398
GLY A 397
MET A 465
VAL A 463
HIS A 356
 None
 1.26A 4okwA-4n78A:
undetectable		 4okwA-4n78A:
11.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OKX_A_198A1002_1
(ANDROGEN RECEPTOR)		 4n78 CYTOPLASMIC
FMR1-INTERACTING
PROTEIN 1
(Homo
sapiens) 		5 / 12 LEU A 398
GLY A 397
LEU A 363
MET A 465
VAL A 463
 None
 0.99A 4okxA-4n78A:
undetectable		 4okxA-4n78A:
11.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OKX_A_198A1002_1
(ANDROGEN RECEPTOR)		 4n78 CYTOPLASMIC
FMR1-INTERACTING
PROTEIN 1
(Homo
sapiens) 		5 / 12 LEU A 398
GLY A 397
MET A 465
VAL A 463
HIS A 356
 None
 1.30A 4okxA-4n78A:
undetectable		 4okxA-4n78A:
11.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLM_A_198A1001_1
(ANDROGEN RECEPTOR)		 4n78 CYTOPLASMIC
FMR1-INTERACTING
PROTEIN 1
(Homo
sapiens) 		5 / 12 LEU A 398
GLY A 397
LEU A 363
MET A 465
VAL A 463
 None
 1.11A 4olmA-4n78A:
undetectable		 4olmA-4n78A:
11.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P3Q_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 4n78 CYTOPLASMIC
FMR1-INTERACTING
PROTEIN 1
(Homo
sapiens) 		4 / 5 ASP A 591
LEU A 590
ARG A 581
THR A 491
 None
 1.25A 4p3qA-4n78A:
undetectable		 4p3qA-4n78A:
8.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YIA_B_IMNB401_2
(THYROXINE-BINDING
GLOBULIN)		 4n78 ABL INTERACTOR 2
(Homo
sapiens) 		3 / 3 LEU F  83
ARG F  85
ARG F  84
 None
 0.95A 4yiaB-4n78F:
undetectable		 4yiaB-4n78F:
5.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4D_A_IPHA903_0
(PROTEIN ARGONAUTE-2)		 4n78 CYTOPLASMIC
FMR1-INTERACTING
PROTEIN 1
(Homo
sapiens) 		4 / 5 LYS A 389
LEU A 363
GLU A 362
TYR A 366
 None
 1.44A 4z4dA-4n78A:
undetectable		 4z4dA-4n78A:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4F_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 4n78 CYTOPLASMIC
FMR1-INTERACTING
PROTEIN 1
(Homo
sapiens) 		5 / 7 LEU A 852
TYR A 855
PRO A 853
LEU A 847
GLU A 846
 None
 1.47A 4z4fA-4n78A:
undetectable		 4z4fA-4n78A:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4H_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 4n78 CYTOPLASMIC
FMR1-INTERACTING
PROTEIN 1
(Homo
sapiens) 		4 / 5 LYS A 389
LEU A 363
GLU A 362
TYR A 366
 None
 1.38A 4z4hA-4n78A:
undetectable		 4z4hA-4n78A:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DPD_A_SAMA601_0
(PROTEIN LYSINE
METHYLTRANSFERASE 1)		 4n78 CYTOPLASMIC
FMR1-INTERACTING
PROTEIN 1
(Homo
sapiens) 		5 / 12 GLY A 268
LEU A 264
ILE A 295
VAL A 242
VAL A 246
 None
 1.04A 5dpdA-4n78A:
3.3		 5dpdA-4n78A:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E72_A_SAMA400_0
(N2,
N2-DIMETHYLGUANOSINE
TRNA
METHYLTRANSFERASE)		 4n78 CYTOPLASMIC
FMR1-INTERACTING
PROTEIN 1
(Homo
sapiens) 		5 / 12 ILE A 295
PHE A 269
ILE A 241
ILE A 313
ALA A 169
 None
 0.97A 5e72A-4n78A:
undetectable		 5e72A-4n78A:
14.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G5G_B_ACTB1321_0
(PUTATIVE XANTHINE
DEHYDROGENASE YAGR
MOLYBDENUM-BINDING
SU SUBUNIT)		 4n78 CYTOPLASMIC
FMR1-INTERACTING
PROTEIN 1
(Homo
sapiens) 		3 / 3 THR A 383
ASP A 384
ALA A 385
 None
 0.00A 5g5gB-4n78A:
undetectable		 5g5gB-4n78A:
12.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_B_TLFB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4n78 CYTOPLASMIC
FMR1-INTERACTING
PROTEIN 1
(Homo
sapiens) 		3 / 3 TYR A 443
TYR A 671
SER A 667
 None
 0.96A 5iktB-4n78A:
undetectable		 5iktB-4n78A:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KXI_A_NCTA402_1
(NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
ALPHA-4
NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
BETA-2)		 4n78 CYTOPLASMIC
FMR1-INTERACTING
PROTEIN 1
(Homo
sapiens) 		4 / 8 TYR A 282
THR A 321
CYH A 334
TYR A 325
 None
 1.36A 5kxiA-4n78A:
6.7
5kxiB-4n78A:
6.7		 5kxiA-4n78A:
16.04
5kxiB-4n78A:
16.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KXI_A_NCTA402_1
(NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
ALPHA-4
NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
BETA-2)		 4n78 CYTOPLASMIC
FMR1-INTERACTING
PROTEIN 1
(Homo
sapiens) 		4 / 8 TYR A 923
THR A1082
CYH A1088
LEU A1022
 None
 1.06A 5kxiA-4n78A:
6.7
5kxiB-4n78A:
6.7		 5kxiA-4n78A:
16.04
5kxiB-4n78A:
16.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KXI_A_NCTA402_1
(NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
ALPHA-4
NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
BETA-2)		 4n78 CYTOPLASMIC
FMR1-INTERACTING
PROTEIN 1
(Homo
sapiens) 		4 / 8 TYR A 923
THR A1082
CYH A1088
LEU A1022
 None
 1.17A 5kxiA-4n78A:
6.7
5kxiB-4n78A:
6.7		 5kxiA-4n78A:
16.04
5kxiB-4n78A:
16.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KXI_D_NCTD402_1
(NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
ALPHA-4
NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
BETA-2)		 4n78 CYTOPLASMIC
FMR1-INTERACTING
PROTEIN 1
(Homo
sapiens) 		4 / 8 TYR A 282
THR A 321
CYH A 334
TYR A 325
 None
 1.35A 5kxiD-4n78A:
6.8
5kxiE-4n78A:
6.6		 5kxiD-4n78A:
16.04
5kxiE-4n78A:
16.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KXI_D_NCTD402_1
(NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
ALPHA-4
NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
BETA-2)		 4n78 CYTOPLASMIC
FMR1-INTERACTING
PROTEIN 1
(Homo
sapiens) 		4 / 8 TYR A 923
THR A1082
CYH A1088
LEU A1022
 None
 1.07A 5kxiD-4n78A:
6.8
5kxiE-4n78A:
6.6		 5kxiD-4n78A:
16.04
5kxiE-4n78A:
16.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KXI_D_NCTD402_1
(NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
ALPHA-4
NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
BETA-2)		 4n78 CYTOPLASMIC
FMR1-INTERACTING
PROTEIN 1
(Homo
sapiens) 		4 / 8 TYR A 923
THR A1082
CYH A1088
LEU A1022
 None
 1.23A 5kxiD-4n78A:
6.8
5kxiE-4n78A:
6.6		 5kxiD-4n78A:
16.04
5kxiE-4n78A:
16.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ODI_A_ACTA701_0
(HETERODISULFIDE
REDUCTASE, SUBUNIT A)		 4n78 CYTOPLASMIC
FMR1-INTERACTING
PROTEIN 1
(Homo
sapiens) 		3 / 3 LYS A 715
LYS A 778
SER A 779
 None
 1.48A 5odiA-4n78A:
undetectable		 5odiA-4n78A:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TE8_A_08JA602_1
(CYTOCHROME P450 3A4)		 4n78 CYTOPLASMIC
FMR1-INTERACTING
PROTEIN 1
(Homo
sapiens) 		4 / 7 ARG A 289
LEU A 284
ILE A 295
LEU A 292
 None
 1.00A 5te8A-4n78A:
undetectable		 5te8A-4n78A:
16.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUD_A_ERMA2001_1
(5-HYDROXYTRYPTAMINE
RECEPTOR 2B,SOLUBLE
CYTOCHROME B562
CHIMERA)		 4n78 CYTOPLASMIC
FMR1-INTERACTING
PROTEIN 1
(Homo
sapiens) 		5 / 12 ASP A 172
ALA A 132
PHE A 213
LEU A 122
LEU A 214
 None
 1.14A 5tudA-4n78A:
2.5		 5tudA-4n78A:
16.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_B_ACTB308_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 4n78 CYTOPLASMIC
FMR1-INTERACTING
PROTEIN 1
(Homo
sapiens) 		3 / 3 LEU A 618
ILE A 455
TYR A 443
 None
 0.65A 5uunB-4n78A:
undetectable		 5uunB-4n78A:
12.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CBD_A_TRPA901_0
(PROTEIN ARGONAUTE-2)		 4n78 CYTOPLASMIC
FMR1-INTERACTING
PROTEIN 1
(Homo
sapiens) 		4 / 5 LYS A 389
LEU A 363
GLU A 362
TYR A 366
 None
 1.48A 6cbdA-4n78A:
undetectable		 6cbdA-4n78A:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CNJ_D_NCTD402_1
(NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
ALPHA-4
NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
BETA-2)		 4n78 CYTOPLASMIC
FMR1-INTERACTING
PROTEIN 1
(Homo
sapiens) 		4 / 8 TYR A 923
THR A1082
CYH A1088
LEU A1022
 None
 1.45A 6cnjD-4n78A:
3.3
6cnjE-4n78A:
7.2		 6cnjD-4n78A:
5.57
6cnjE-4n78A:
5.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6D8F_A_ACTA803_0
(UNCHARACTERIZED
PROTEIN)		 4n78 CYTOPLASMIC
FMR1-INTERACTING
PROTEIN 1
(Homo
sapiens) 		3 / 3 GLU A1094
LEU A1097
ARG A1101
 None
 0.56A 6d8fA-4n78A:
undetectable		 6d8fA-4n78A:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FBV_D_FI8D1904_1
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA')		 4n78 CYTOPLASMIC
FMR1-INTERACTING
PROTEIN 1
(Homo
sapiens) 		4 / 8 ARG A 597
ARG A 563
VAL A 518
GLN A  62
 None
 1.14A 6fbvD-4n78A:
undetectable		 6fbvD-4n78A:
22.90