SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4n7r'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QHY_A_CLMA999_0
(CHLORAMPHENICOL
PHOSPHOTRANSFERASE)		 4n7r GLUTAMYL-TRNA
REDUCTASE 1,
CHLOROPLASTIC
(Arabidopsis
thaliana) 		5 / 12 ILE A 318
ILE A 327
ILE A 325
VAL A 293
LEU A 297
 None
 1.06A 1qhyA-4n7rA:
undetectable		 1qhyA-4n7rA:
17.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD4_B_CHDB927_0
(FERROCHELATASE)		 4n7r GLUTAMYL-TRNA
REDUCTASE 1,
CHLOROPLASTIC
(Arabidopsis
thaliana) 		3 / 3 LEU A 271
PRO A 272
ARG A 280
 None
 0.44A 2qd4B-4n7rA:
4.3		 2qd4B-4n7rA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD5_A_CHDA702_0
(FERROCHELATASE)		 4n7r GLUTAMYL-TRNA
REDUCTASE 1,
CHLOROPLASTIC
(Arabidopsis
thaliana) 		3 / 3 LEU A 271
PRO A 272
ARG A 280
 None
 0.45A 2qd5A-4n7rA:
3.3		 2qd5A-4n7rA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W98_B_P1ZB1358_1
(PROSTAGLANDIN
REDUCTASE 2)		 4n7r GLUTAMYL-TRNA
REDUCTASE 1,
CHLOROPLASTIC
(Arabidopsis
thaliana) 		4 / 6 ASP A 189
TYR A 186
PHE A 195
LEU A 235
 None
 1.14A 2w98A-4n7rA:
5.7
2w98B-4n7rA:
8.9		 2w98A-4n7rA:
22.09
2w98B-4n7rA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A25_A_SAMA279_1
(UNCHARACTERIZED
PROTEIN PH0793)		 4n7r GLUTAMYL-TRNA
REDUCTASE 1,
CHLOROPLASTIC
(Arabidopsis
thaliana) 		3 / 3 MET A 420
GLU A 196
ASP A 189
 None
 0.86A 3a25A-4n7rA:
6.5		 3a25A-4n7rA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EBZ_B_017B201_1
(PROTEASE)		 4n7r GLUTAMYL-TRNA
REDUCTASE 1,
CHLOROPLASTIC
(Arabidopsis
thaliana) 		5 / 11 LEU A 235
ALA A 139
ILE A 100
ILE A  97
ILE A 232
 None
 0.98A 3ebzA-4n7rA:
undetectable		 3ebzA-4n7rA:
12.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GYQ_B_SAMB270_0
(RRNA
(ADENOSINE-2'-O-)-ME
THYLTRANSFERASE)		 4n7r GLUTAMYL-TRNA
REDUCTASE 1,
CHLOROPLASTIC
(Arabidopsis
thaliana) 		5 / 11 LEU A 152
ALA A 138
GLY A 159
ILE A 232
VAL A  98
 None
 1.18A 3gyqB-4n7rA:
3.5		 3gyqB-4n7rA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P2K_A_SAMA6735_1
(16S RRNA METHYLASE)		 4n7r GLUTAMYL-TRNA
REDUCTASE 1,
CHLOROPLASTIC
(Arabidopsis
thaliana) 		3 / 3 ASP A 438
GLU A 514
SER A  96
 None
 0.82A 3p2kA-4n7rA:
4.7		 3p2kA-4n7rA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PGL_A_RZXA257_1
(CARBOXY-TERMINAL
DOMAIN RNA
POLYMERASE II
POLYPEPTIDE A SMALL
PHOSPHATASE 1)		 4n7r GLUTAMYL-TRNA
REDUCTASE 1,
CHLOROPLASTIC
(Arabidopsis
thaliana) 		4 / 7 PHE A 356
VAL A 345
ILE A 284
ARG A 330
 None
 1.00A 3pglA-4n7rA:
2.5		 3pglA-4n7rA:
17.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R24_A_SAMA302_0
(2'-O-METHYL
TRANSFERASE)		 4n7r GLUTAMYL-TRNA
REDUCTASE 1,
CHLOROPLASTIC
(Arabidopsis
thaliana) 		5 / 12 GLY A 227
SER A 233
GLY A 224
LEU A 152
ASN A 231
 None
 1.24A 3r24A-4n7rA:
4.7		 3r24A-4n7rA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R6W_A_NFZA213_1
(FMN-DEPENDENT
NADH-AZOREDUCTASE 1)		 4n7r GLUTAMYL-TRNA
REDUCTASE 1,
CHLOROPLASTIC
(Arabidopsis
thaliana) 		5 / 10 GLY A 101
GLU A 148
VAL A 218
PHE A 236
TYR A 150
 None
 1.39A 3r6wA-4n7rA:
undetectable
3r6wB-4n7rA:
3.3		 3r6wA-4n7rA:
18.72
3r6wB-4n7rA:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AC9_C_DXCC1476_0
(MJ0495-LIKE PROTEIN)		 4n7r GLUTAMYL-TRNA
REDUCTASE 1,
CHLOROPLASTIC
(Arabidopsis
thaliana) 		4 / 5 ILE A 194
ALA A 190
HIS A 238
ARG A 437
 None
 1.15A 4ac9B-4n7rA:
4.2
4ac9C-4n7rA:
3.4		 4ac9B-4n7rA:
22.30
4ac9C-4n7rA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACA_C_DXCC1476_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 4n7r GLUTAMYL-TRNA
REDUCTASE 1,
CHLOROPLASTIC
(Arabidopsis
thaliana) 		4 / 5 ILE A 194
ALA A 190
HIS A 238
ARG A 437
 None
 1.14A 4acaB-4n7rA:
4.2
4acaC-4n7rA:
3.5		 4acaB-4n7rA:
22.30
4acaC-4n7rA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MA8_C_Z80C301_1
(MAJOR PRION PROTEIN)		 4n7r GLUTAMYL-TRNA
REDUCTASE 1,
CHLOROPLASTIC
(Arabidopsis
thaliana) 		4 / 5 LEU A 201
GLY A 200
ILE A 425
GLN A 423
 None
 1.09A 4ma8C-4n7rA:
0.7		 4ma8C-4n7rA:
12.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E4D_B_BEZB201_0
(HYDROXYNITRILE LYASE)		 4n7r GLUTAMYL-TRNA
REDUCTASE 1,
CHLOROPLASTIC
(Arabidopsis
thaliana) 		5 / 11 VAL A 215
VAL A 218
VAL A 219
ILE A  97
ILE A 232
 None
 1.05A 5e4dB-4n7rA:
undetectable		 5e4dB-4n7rA:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_A_ACTA309_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 4n7r GLUTAMYL-TRNA
REDUCTASE 1,
CHLOROPLASTIC
(Arabidopsis
thaliana) 		4 / 4 LEU A 206
GLY A 207
SER A 258
SER A 260
 None
 1.24A 5uunA-4n7rA:
undetectable		 5uunA-4n7rA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_B_ACTB306_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 4n7r GLUTAMYL-TRNA
REDUCTASE 1,
CHLOROPLASTIC
(Arabidopsis
thaliana) 		4 / 4 LEU A 206
GLY A 207
SER A 258
SER A 260
 None
 1.31A 5uunB-4n7rA:
undetectable		 5uunB-4n7rA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X23_A_LSNA502_2
(CYTOCHROME P450 2C9)		 4n7r GLUTAMYL-TRNA
REDUCTASE 1,
CHLOROPLASTIC
(Arabidopsis
thaliana) 		3 / 3 LEU A 204
VAL A 401
ASP A 402
 None
 0.65A 5x23A-4n7rA:
undetectable		 5x23A-4n7rA:
20.30