SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4n7w'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZZ_A_SAMA635_0
(ACLACINOMYCIN-10-HYD
ROXYLASE)		 4n7w TRANSPORTER,
SODIUM/BILE ACID
SYMPORTER FAMILY
(Yersinia
frederiksenii) 		5 / 12 GLY A 238
GLY A 237
GLY A 234
ASP A 244
PHE A 243
 None
 1.09A 1qzzA-4n7wA:
undetectable		 1qzzA-4n7wA:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDS_B_SAMB9635_0
(PROTEIN RDMB)		 4n7w TRANSPORTER,
SODIUM/BILE ACID
SYMPORTER FAMILY
(Yersinia
frederiksenii) 		5 / 12 GLY A 238
GLY A 237
GLY A 234
ASP A 244
PHE A 243
 None
 1.15A 1xdsB-4n7wA:
undetectable		 1xdsB-4n7wA:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UVN_B_ECNB1406_1
(CYTOCHROME P450 130)		 4n7w TRANSPORTER,
SODIUM/BILE ACID
SYMPORTER FAMILY
(Yersinia
frederiksenii) 		5 / 11 PRO A 138
THR A 137
GLY A 133
THR A 130
VAL A 165
 None
 1.47A 2uvnB-4n7wA:
0.4		 2uvnB-4n7wA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL4_A_ROCA100_1
(PROTEASE)		 4n7w TRANSPORTER,
SODIUM/BILE ACID
SYMPORTER FAMILY
(Yersinia
frederiksenii) 		5 / 12 GLY A 261
GLY A 267
ILE A 269
PRO A 138
VAL A 102
 CIT  A 401 (-3.5A)
None
None
None
None
 0.90A 3el4A-4n7wA:
undetectable		 3el4A-4n7wA:
15.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FZG_A_SAMA300_0
(16S RRNA METHYLASE)		 4n7w TRANSPORTER,
SODIUM/BILE ACID
SYMPORTER FAMILY
(Yersinia
frederiksenii) 		5 / 12 GLY A 261
GLY A 279
ILE A 197
LEU A 266
VAL A  34
 CIT  A 401 (-3.5A)
None
CIT  A 401 (-3.8A)
None
None
 1.15A 3fzgA-4n7wA:
undetectable		 3fzgA-4n7wA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BLV_B_SAMB1281_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE J)		 4n7w TRANSPORTER,
SODIUM/BILE ACID
SYMPORTER FAMILY
(Yersinia
frederiksenii) 		5 / 12 HIS A 226
GLY A 256
SER A 233
HIS A 286
GLY A 100
 None
None
None
CIT  A 401 (-4.0A)
None
 1.12A 4blvB-4n7wA:
undetectable		 4blvB-4n7wA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E0F_A_RBFA301_1
(RIBOFLAVIN SYNTHASE
SUBUNIT ALPHA)		 4n7w TRANSPORTER,
SODIUM/BILE ACID
SYMPORTER FAMILY
(Yersinia
frederiksenii) 		5 / 11 SER A  59
GLU A 254
ALA A  67
THR A  68
VAL A 128
 None
 1.19A 4e0fA-4n7wA:
undetectable		 4e0fA-4n7wA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EAH_F_ACTF402_0
(ACTIN, ALPHA
SKELETAL MUSCLE)		 4n7w TRANSPORTER,
SODIUM/BILE ACID
SYMPORTER FAMILY
(Yersinia
frederiksenii) 		3 / 3 PHE A 243
ASP A 118
ARG A  60
 None
 0.87A 4eahF-4n7wA:
undetectable		 4eahF-4n7wA:
24.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EAH_G_ACTG401_0
(ACTIN, ALPHA
SKELETAL MUSCLE)		 4n7w TRANSPORTER,
SODIUM/BILE ACID
SYMPORTER FAMILY
(Yersinia
frederiksenii) 		3 / 3 PHE A 243
ASP A 118
ARG A  60
 None
 0.87A 4eahG-4n7wA:
undetectable		 4eahG-4n7wA:
24.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJG_A_NCTA501_1
(CYTOCHROME P450 2A13)		 4n7w TRANSPORTER,
SODIUM/BILE ACID
SYMPORTER FAMILY
(Yersinia
frederiksenii) 		4 / 7 PHE A 241
PHE A 243
ALA A  65
LEU A 251
 None
 1.03A 4ejgA-4n7wA:
undetectable		 4ejgA-4n7wA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LTW_A_486A303_1
(ANCESTRAL STEROID
RECEPTOR 2)		 4n7w TRANSPORTER,
SODIUM/BILE ACID
SYMPORTER FAMILY
(Yersinia
frederiksenii) 		5 / 9 LEU A 251
ALA A  66
PHE A 243
THR A 247
LEU A 121
 None
 1.35A 4ltwA-4n7wA:
undetectable		 4ltwA-4n7wA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5K9D_A_CE9A402_0
(DIHYDROOROTATE
DEHYDROGENASE
(QUINONE),
MITOCHONDRIAL)		 4n7w TRANSPORTER,
SODIUM/BILE ACID
SYMPORTER FAMILY
(Yersinia
frederiksenii) 		5 / 12 ALA A  79
LEU A  82
ALA A  83
PHE A  86
PRO A  89
 None
 1.15A 5k9dA-4n7wA:
undetectable		 5k9dA-4n7wA:
26.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M8R_B_MMSB514_1
(5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE)		 4n7w TRANSPORTER,
SODIUM/BILE ACID
SYMPORTER FAMILY
(Yersinia
frederiksenii) 		4 / 8 SER A 208
LEU A 277
VAL A 284
SER A 283
 None
None
None
CIT  A 401 (-3.0A)
 0.98A 5m8rB-4n7wA:
undetectable		 5m8rB-4n7wA:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M8R_D_MMSD509_1
(5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE)		 4n7w TRANSPORTER,
SODIUM/BILE ACID
SYMPORTER FAMILY
(Yersinia
frederiksenii) 		4 / 8 SER A 208
LEU A 277
VAL A 284
SER A 283
 None
None
None
CIT  A 401 (-3.0A)
 0.94A 5m8rD-4n7wA:
undetectable		 5m8rD-4n7wA:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TT3_H_EZLH303_1
(ALPHA-CARBONIC
ANHYDRASE)		 4n7w TRANSPORTER,
SODIUM/BILE ACID
SYMPORTER FAMILY
(Yersinia
frederiksenii) 		4 / 8 HIS A  71
LEU A 140
THR A 137
ALA A 136
 None
 0.90A 5tt3H-4n7wA:
undetectable		 5tt3H-4n7wA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X2S_I_PEMI202_1
(HEMOGLOBIN SUBUNIT
ALPHA
HEMOGLOBIN SUBUNIT
BETA)		 4n7w TRANSPORTER,
SODIUM/BILE ACID
SYMPORTER FAMILY
(Yersinia
frederiksenii) 		4 / 8 THR A 141
THR A 137
TYR A  72
PRO A 278
 None
 1.33A 5x2sI-4n7wA:
undetectable
5x2sJ-4n7wA:
undetectable
5x2sK-4n7wA:
undetectable		 5x2sI-4n7wA:
22.62
5x2sJ-4n7wA:
20.28
5x2sK-4n7wA:
22.62