SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4n80'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YKI_A_NFZA1219_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 4n80 UNCHARACTERIZED
PROTEIN
(Pseudomonas
aeruginosa) 		4 / 8 PHE A 318
ASN A 319
GLY A 277
THR A 274
 None
 1.03A 1ykiA-4n80A:
undetectable
1ykiB-4n80A:
undetectable		 1ykiA-4n80A:
20.84
1ykiB-4n80A:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YKI_B_NFZB2219_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 4n80 UNCHARACTERIZED
PROTEIN
(Pseudomonas
aeruginosa) 		4 / 8 THR A 274
PHE A 318
ASN A 319
GLY A 277
 None
 1.01A 1ykiA-4n80A:
undetectable
1ykiB-4n80A:
undetectable		 1ykiA-4n80A:
20.84
1ykiB-4n80A:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YKI_C_NFZC3219_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 4n80 UNCHARACTERIZED
PROTEIN
(Pseudomonas
aeruginosa) 		4 / 8 PHE A 318
ASN A 319
GLY A 277
THR A 274
 None
 1.03A 1ykiC-4n80A:
undetectable
1ykiD-4n80A:
undetectable		 1ykiC-4n80A:
20.84
1ykiD-4n80A:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YKI_D_NFZD4219_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 4n80 UNCHARACTERIZED
PROTEIN
(Pseudomonas
aeruginosa) 		4 / 8 THR A 274
PHE A 318
ASN A 319
GLY A 277
 None
 1.09A 1ykiC-4n80A:
undetectable
1ykiD-4n80A:
undetectable		 1ykiC-4n80A:
20.84
1ykiD-4n80A:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
209D_C_DVAC2_0
(N8-ACTINOMYCIN D)		 4n80 UNCHARACTERIZED
PROTEIN
(Pseudomonas
aeruginosa) 		3 / 3 THR A 175
PRO A 173
THR A 177
 None
 0.76A 209dC-4n80A:
undetectable		 209dC-4n80A:
3.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K9F_F_LFXF0_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B)		 4n80 UNCHARACTERIZED
PROTEIN
(Pseudomonas
aeruginosa) 		4 / 5 SER A 230
ARG A 234
ARG A 124
GLY A 123
 None
 1.33A 3k9fA-4n80A:
undetectable
3k9fB-4n80A:
undetectable
3k9fC-4n80A:
undetectable		 3k9fA-4n80A:
22.07
3k9fB-4n80A:
22.07
3k9fC-4n80A:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B7Q_A_ZMRA601_2
(NEURAMINIDASE)		 4n80 UNCHARACTERIZED
PROTEIN
(Pseudomonas
aeruginosa) 		3 / 3 ARG A  84
ARG A  80
ILE A 109
 None
 0.84A 4b7qA-4n80A:
undetectable		 4b7qA-4n80A:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EAT_A_BEZA1000_0
(BENZOATE-COENZYME A
LIGASE)		 4n80 UNCHARACTERIZED
PROTEIN
(Pseudomonas
aeruginosa) 		4 / 7 ALA A 396
TYR A 397
ILE A 243
GLY A 244
 None
 0.50A 4eatA-4n80A:
undetectable		 4eatA-4n80A:
25.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZVM_A_DM2A303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 4n80 UNCHARACTERIZED
PROTEIN
(Pseudomonas
aeruginosa) 		5 / 12 GLY A  74
THR A  76
ILE A  33
PHE A 111
ILE A  69
 None
 1.10A 4zvmA-4n80A:
undetectable
4zvmB-4n80A:
undetectable		 4zvmA-4n80A:
19.70
4zvmB-4n80A:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E4D_B_BEZB203_0
(HYDROXYNITRILE LYASE)		 4n80 UNCHARACTERIZED
PROTEIN
(Pseudomonas
aeruginosa) 		4 / 4 VAL A 267
ALA A 272
ILE A 276
THR A 274
 None
 1.12A 5e4dB-4n80A:
undetectable		 5e4dB-4n80A:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCE_A_RITA602_2
(CYTOCHROME P450 3A4)		 4n80 UNCHARACTERIZED
PROTEIN
(Pseudomonas
aeruginosa) 		4 / 6 ARG A 306
PHE A 292
ILE A 114
THR A 110
 None
 1.16A 5vceA-4n80A:
undetectable		 5vceA-4n80A:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z6F_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4n80 UNCHARACTERIZED
PROTEIN
(Pseudomonas
aeruginosa) 		5 / 12 ILE A  69
LEU A  55
PHE A  56
THR A  76
ILE A  43
 None
 1.23A 5z6fA-4n80A:
undetectable		 5z6fA-4n80A:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6I0Y_A_TRPA3001_0
(23S RIBOSOMAL RNA
TRYPTOPHANASE OPERON
LEADER PEPTIDE)		 4n80 UNCHARACTERIZED
PROTEIN
(Pseudomonas
aeruginosa) 		3 / 3 TRP A 103
ILE A 104
ASP A 101
 None
 0.81A 6i0y7-4n80A:
undetectable		 6i0y7-4n80A:
5.28