SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4n81'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXD_A_ACRA733_1
(ALPHA AMYLASE)		 4n81 INOSITOL
MONOPHOSPHATASE
(Zymomonas
mobilis) 		4 / 6 SER A 194
THR A 144
LEU A 200
ASP A 199
 None
 1.25A 1mxdA-4n81A:
undetectable		 1mxdA-4n81A:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N13_B_AG2B7011_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN)		 4n81 INOSITOL
MONOPHOSPHATASE
(Zymomonas
mobilis) 		4 / 5 ARG A  81
LEU A  12
ASP A   9
LEU A 115
 None
 1.12A 1n13B-4n81A:
undetectable
1n13C-4n81A:
undetectable		 1n13B-4n81A:
19.32
1n13C-4n81A:
13.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_F_SNLF6001_1
(MINERALOCORTICOID
RECEPTOR)		 4n81 INOSITOL
MONOPHOSPHATASE
(Zymomonas
mobilis) 		5 / 12 LEU A 254
ALA A 253
LEU A 193
THR A 157
PHE A 171
 None
 1.44A 2oaxF-4n81A:
undetectable		 2oaxF-4n81A:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQC_I_AG2I672_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 4n81 INOSITOL
MONOPHOSPHATASE
(Zymomonas
mobilis) 		4 / 7 LEU A  12
ASP A   9
LEU A 115
ARG A  81
 None
 1.05A 2qqcI-4n81A:
undetectable
2qqcL-4n81A:
undetectable		 2qqcI-4n81A:
12.24
2qqcL-4n81A:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL4_A_ROCA100_2
(PROTEASE)		 4n81 INOSITOL
MONOPHOSPHATASE
(Zymomonas
mobilis) 		5 / 9 ASP A 210
ILE A 118
GLY A 102
ILE A  88
THR A 158
 SO4  A 301 (-3.7A)
None
None
None
None
 1.14A 3el4B-4n81A:
undetectable		 3el4B-4n81A:
16.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MNE_A_DEXA784_1
(GLUCOCORTICOID
RECEPTOR)		 4n81 INOSITOL
MONOPHOSPHATASE
(Zymomonas
mobilis) 		5 / 12 GLY A 245
MET A 225
LEU A 214
THR A 135
ILE A 142
 None
 1.21A 3mneA-4n81A:
undetectable		 3mneA-4n81A:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MNO_A_DEXA784_1
(GLUCOCORTICOID
RECEPTOR)		 4n81 INOSITOL
MONOPHOSPHATASE
(Zymomonas
mobilis) 		5 / 12 GLY A 245
MET A 225
LEU A 214
THR A 135
ILE A 142
 None
 1.11A 3mnoA-4n81A:
undetectable		 3mnoA-4n81A:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MNP_A_DEXA784_1
(GLUCOCORTICOID
RECEPTOR)		 4n81 INOSITOL
MONOPHOSPHATASE
(Zymomonas
mobilis) 		5 / 12 GLY A 245
MET A 225
LEU A 214
THR A 135
ILE A 142
 None
 1.12A 3mnpA-4n81A:
undetectable		 3mnpA-4n81A:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDW_A_RITA100_2
(PROTEASE)		 4n81 INOSITOL
MONOPHOSPHATASE
(Zymomonas
mobilis) 		5 / 9 ALA A  17
ILE A 118
GLY A 102
ILE A  88
ILE A 105
 None
 1.06A 3ndwB-4n81A:
undetectable		 3ndwB-4n81A:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BWL_C_MN9C1297_0
(N-ACETYLNEURAMINATE
LYASE)		 4n81 INOSITOL
MONOPHOSPHATASE
(Zymomonas
mobilis) 		5 / 10 ILE A 142
LEU A 195
THR A 135
GLY A 220
GLY A 223
 None
 1.28A 4bwlC-4n81A:
undetectable		 4bwlC-4n81A:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLM_A_198A1001_1
(ANDROGEN RECEPTOR)		 4n81 INOSITOL
MONOPHOSPHATASE
(Zymomonas
mobilis) 		5 / 12 LEU A 195
LEU A 192
GLY A 191
LEU A 214
THR A 135
 None
 1.39A 4olmA-4n81A:
undetectable		 4olmA-4n81A:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XJE_A_TOYA202_1
(AADB)		 4n81 INOSITOL
MONOPHOSPHATASE
(Zymomonas
mobilis) 		4 / 8 ASP A 210
ASP A  89
ASP A  86
ILE A  24
 SO4  A 301 (-3.7A)
SO4  A 301 (-4.1A)
SO4  A 301 (-3.3A)
None
 1.02A 4xjeA-4n81A:
undetectable		 4xjeA-4n81A:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C0O_E_SAME301_0
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI)		 4n81 INOSITOL
MONOPHOSPHATASE
(Zymomonas
mobilis) 		5 / 12 GLY A 245
LEU A 249
ALA A 221
ASP A 199
LEU A 193
 None
 1.09A 5c0oE-4n81A:
2.7		 5c0oE-4n81A:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KR2_A_ROCA101_2
(PROTEASE PR5-SQV)		 4n81 INOSITOL
MONOPHOSPHATASE
(Zymomonas
mobilis) 		5 / 11 ALA A  13
GLY A 129
ILE A 217
PRO A 113
VAL A 108
 None
 1.12A 5kr2B-4n81A:
undetectable		 5kr2B-4n81A:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7P_B_ACRB1421_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)		 4n81 INOSITOL
MONOPHOSPHATASE
(Zymomonas
mobilis) 		4 / 6 GLU A 125
TYR A 188
GLY A 185
GLY A 184
 None
 0.85A 5x7pB-4n81A:
undetectable		 5x7pB-4n81A:
11.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CB4_A_BEZA501_0
(CANAVALIN)		 4n81 INOSITOL
MONOPHOSPHATASE
(Zymomonas
mobilis) 		4 / 8 LEU A 150
VAL A 202
LEU A 200
ILE A 242
 None
 0.78A 6cb4A-4n81A:
undetectable		 6cb4A-4n81A:
21.05