SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4n83'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

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	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	11GS_A_EAAA211_1 (GLUTATHIONE S-TRANSFERASE)	4n83	RIBONUCLEOSIDE-DIPHO SPHATE REDUCTASE SUBUNIT BETA (Streptococcus sanguinis)	4 / 7	TYR A 104 PHE A 59 ILE A 188 GLY A 164	None	0.89A	11gsA-4n83A: undetectable	11gsA-4n83A: 22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1IE4_A_T44A128_1 (TRANSTHYRETIN)	4n83	RIBONUCLEOSIDE-DIPHO SPHATE REDUCTASE SUBUNIT BETA (Streptococcus sanguinis)	5 / 10	LEU A 156 LEU A 160 LEU A 64 ALA A 134 LEU A 130	None	1.37A	1ie4A-4n83A: undetectable 1ie4C-4n83A: undetectable	1ie4A-4n83A: 16.93 1ie4C-4n83A: 16.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1RNR_A_DAHA208_1 (RIBONUCLEOTIDE REDUCTASE R1 PROTEIN)	4n83	RIBONUCLEOSIDE-DIPHO SPHATE REDUCTASE SUBUNIT BETA (Streptococcus sanguinis)	8 / 11	ASP A 66 GLU A 97 HIS A 100 LEU A 156 TYR A 162 PHE A 165 ILE A 187 GLU A 191	MN A 402 (-2.8A) MN A 402 ( 2.8A) MN A 402 (-4.0A) None None None None MN A 401 ( 2.7A)	0.94A	1rnrA-4n83A: 29.9	1rnrA-4n83A: 26.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1RNR_A_DAHA208_1 (RIBONUCLEOTIDE REDUCTASE R1 PROTEIN)	4n83	RIBONUCLEOSIDE-DIPHO SPHATE REDUCTASE SUBUNIT BETA (Streptococcus sanguinis)	8 / 11	GLU A 97 HIS A 100 LEU A 156 GLU A 157 TYR A 162 PHE A 165 ILE A 187 GLU A 191	MN A 402 ( 2.8A) MN A 402 (-4.0A) None MN A 401 ( 2.5A) None None None MN A 401 ( 2.7A)	1.09A	1rnrA-4n83A: 29.9	1rnrA-4n83A: 26.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1RNR_A_DAHA208_1 (RIBONUCLEOTIDE REDUCTASE R1 PROTEIN)	4n83	RIBONUCLEOSIDE-DIPHO SPHATE REDUCTASE SUBUNIT BETA (Streptococcus sanguinis)	5 / 11	GLU A 157 TYR A 162 SER A 163 PHE A 165 ILE A 184	MN A 401 ( 2.5A) None None None None	1.49A	1rnrA-4n83A: 29.9	1rnrA-4n83A: 26.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1RNR_A_DAHA208_1 (RIBONUCLEOTIDE REDUCTASE R1 PROTEIN)	4n83	RIBONUCLEOSIDE-DIPHO SPHATE REDUCTASE SUBUNIT BETA (Streptococcus sanguinis)	5 / 11	LEU A 156 GLU A 157 TYR A 162 SER A 163 PHE A 165	None MN A 401 ( 2.5A) None None None	1.02A	1rnrA-4n83A: 29.9	1rnrA-4n83A: 26.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1RNR_B_DAHB208_1 (RIBONUCLEOTIDE REDUCTASE R1 PROTEIN)	4n83	RIBONUCLEOSIDE-DIPHO SPHATE REDUCTASE SUBUNIT BETA (Streptococcus sanguinis)	9 / 12	ASP A 66 GLU A 97 HIS A 100 TYR A 104 LEU A 156 TYR A 162 PHE A 165 ILE A 187 GLU A 191	MN A 402 (-2.8A) MN A 402 ( 2.8A) MN A 402 (-4.0A) None None None None None MN A 401 ( 2.7A)	0.85A	1rnrB-4n83A: 30.2	1rnrB-4n83A: 26.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1RNR_B_DAHB208_1 (RIBONUCLEOTIDE REDUCTASE R1 PROTEIN)	4n83	RIBONUCLEOSIDE-DIPHO SPHATE REDUCTASE SUBUNIT BETA (Streptococcus sanguinis)	8 / 12	GLU A 97 HIS A 100 LEU A 156 GLU A 157 TYR A 162 PHE A 165 ILE A 187 GLU A 191	MN A 402 ( 2.8A) MN A 402 (-4.0A) None MN A 401 ( 2.5A) None None None MN A 401 ( 2.7A)	0.95A	1rnrB-4n83A: 30.2	1rnrB-4n83A: 26.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1RNR_B_DAHB208_1 (RIBONUCLEOTIDE REDUCTASE R1 PROTEIN)	4n83	RIBONUCLEOSIDE-DIPHO SPHATE REDUCTASE SUBUNIT BETA (Streptococcus sanguinis)	5 / 12	GLU A 191 HIS A 194 LEU A 156 ILE A 93 GLU A 97	MN A 401 ( 2.7A) MN A 401 (-3.7A) None None MN A 402 ( 2.8A)	1.10A	1rnrB-4n83A: 30.2	1rnrB-4n83A: 26.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2GSS_A_EAAA0_1 (GLUTATHIONE S-TRANSFERASE P1-1)	4n83	RIBONUCLEOSIDE-DIPHO SPHATE REDUCTASE SUBUNIT BETA (Streptococcus sanguinis)	4 / 8	TYR A 104 PHE A 59 ILE A 188 GLY A 164	None	0.86A	2gssA-4n83A: undetectable	2gssA-4n83A: 21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2GSS_B_EAAB0_1 (GLUTATHIONE S-TRANSFERASE P1-1)	4n83	RIBONUCLEOSIDE-DIPHO SPHATE REDUCTASE SUBUNIT BETA (Streptococcus sanguinis)	4 / 8	TYR A 104 PHE A 59 ILE A 188 GLY A 164	None	0.86A	2gssB-4n83A: undetectable	2gssB-4n83A: 21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3B6H_B_MXDB551_1 (PROSTACYCLIN SYNTHASE)	4n83	RIBONUCLEOSIDE-DIPHO SPHATE REDUCTASE SUBUNIT BETA (Streptococcus sanguinis)	4 / 6	ALA A 181 LEU A 177 THR A 110 ASN A 112	None	0.90A	3b6hB-4n83A: 1.9	3b6hB-4n83A: 21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3KM6_A_EAAA222_1 (GLUTATHIONE S-TRANSFERASE P)	4n83	RIBONUCLEOSIDE-DIPHO SPHATE REDUCTASE SUBUNIT BETA (Streptococcus sanguinis)	5 / 10	TYR A 104 PHE A 59 VAL A 55 ILE A 188 GLY A 164	None	1.24A	3km6A-4n83A: undetectable	3km6A-4n83A: 21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3N9J_A_EAAA210_1 (GLUTATHIONE S-TRANSFERASE P)	4n83	RIBONUCLEOSIDE-DIPHO SPHATE REDUCTASE SUBUNIT BETA (Streptococcus sanguinis)	4 / 8	TYR A 104 PHE A 59 ILE A 188 GLY A 164	None	0.86A	3n9jA-4n83A: undetectable	3n9jA-4n83A: 22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4QZU_C_ACTC202_0 (RETINOL-BINDING PROTEIN 2)	4n83	RIBONUCLEOSIDE-DIPHO SPHATE REDUCTASE SUBUNIT BETA (Streptococcus sanguinis)	4 / 6	GLU A 116 THR A 113 TRP A 44 LEU A 41	None	1.18A	4qzuC-4n83A: undetectable	4qzuC-4n83A: 16.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4RTP_A_SAMA301_0 (DNA ADENINE METHYLASE)	4n83	RIBONUCLEOSIDE-DIPHO SPHATE REDUCTASE SUBUNIT BETA (Streptococcus sanguinis)	5 / 12	ILE A 183 ASN A 179 SER A 103 TYR A 104 PRO A 168	None	1.00A	4rtpA-4n83A: undetectable	4rtpA-4n83A: 21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4TVT_A_ASCA303_0 (THAUMATIN-1)	4n83	RIBONUCLEOSIDE-DIPHO SPHATE REDUCTASE SUBUNIT BETA (Streptococcus sanguinis)	4 / 7	LEU A 156 GLU A 157 SER A 153 VAL A 74	None MN A 401 ( 2.5A) MN A 401 ( 4.6A) None	1.18A	4tvtA-4n83A: undetectable	4tvtA-4n83A: 16.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4ZN7_B_DESB600_1 (ESTROGEN RECEPTOR)	4n83	RIBONUCLEOSIDE-DIPHO SPHATE REDUCTASE SUBUNIT BETA (Streptococcus sanguinis)	5 / 11	LEU A 130 GLU A 232 LEU A 156 LEU A 160 LEU A 68	None	1.34A	4zn7B-4n83A: 3.4	4zn7B-4n83A: 20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5DLV_A_5D5A930_0 (ECTONUCLEOTIDE PYROPHOSPHATASE/PHOS PHODIESTERASE FAMILY MEMBER 2)	4n83	RIBONUCLEOSIDE-DIPHO SPHATE REDUCTASE SUBUNIT BETA (Streptococcus sanguinis)	5 / 12	LEU A 130 ASP A 241 THR A 246 PRO A 168 ILE A 184	None	1.14A	5dlvA-4n83A: undetectable	5dlvA-4n83A: 18.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5DLV_B_5D5B927_0 (ECTONUCLEOTIDE PYROPHOSPHATASE/PHOS PHODIESTERASE FAMILY MEMBER 2)	4n83	RIBONUCLEOSIDE-DIPHO SPHATE REDUCTASE SUBUNIT BETA (Streptococcus sanguinis)	5 / 12	LEU A 130 ASP A 241 THR A 246 PRO A 168 ILE A 184	None	1.13A	5dlvB-4n83A: undetectable	5dlvB-4n83A: 18.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5SXQ_A_NIZA808_1 (CATALASE-PEROXIDASE)	4n83	RIBONUCLEOSIDE-DIPHO SPHATE REDUCTASE SUBUNIT BETA (Streptococcus sanguinis)	4 / 8	GLU A 97 VAL A 74 GLY A 195 THR A 158	MN A 402 ( 2.8A) None None None	0.93A	5sxqA-4n83A: undetectable	5sxqA-4n83A: 17.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5SXQ_B_NIZB808_1 (CATALASE-PEROXIDASE)	4n83	RIBONUCLEOSIDE-DIPHO SPHATE REDUCTASE SUBUNIT BETA (Streptococcus sanguinis)	4 / 8	GLU A 97 VAL A 74 GLY A 195 THR A 158	MN A 402 ( 2.8A) None None None	0.91A	5sxqB-4n83A: undetectable	5sxqB-4n83A: 17.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5SYJ_A_NIZA809_1 (CATALASE-PEROXIDASE)	4n83	RIBONUCLEOSIDE-DIPHO SPHATE REDUCTASE SUBUNIT BETA (Streptococcus sanguinis)	4 / 8	GLU A 97 VAL A 74 GLY A 195 THR A 158	MN A 402 ( 2.8A) None None None	0.90A	5syjA-4n83A: undetectable	5syjA-4n83A: 17.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5UC1_A_486A801_1 (GLUCOCORTICOID RECEPTOR)	4n83	RIBONUCLEOSIDE-DIPHO SPHATE REDUCTASE SUBUNIT BETA (Streptococcus sanguinis)	5 / 12	LEU A 65 LEU A 62 GLY A 61 GLY A 60 TRP A 123	None	1.15A	5uc1A-4n83A: 2.4	5uc1A-4n83A: 10.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6EBP_A_DAHA123_0 (RIBONUCLEOSIDE-DIPHO SPHATE REDUCTASE, BETA SUBUNIT)	4n83	RIBONUCLEOSIDE-DIPHO SPHATE REDUCTASE SUBUNIT BETA (Streptococcus sanguinis)	8 / 9	LEU A 62 THR A 63 ASP A 66 SER A 103 ILE A 107 PHE A 108 PHE A 165 ILE A 187	None None MN A 402 (-2.8A) None None None None None	0.47A	6ebpA-4n83A: 38.9	6ebpA-4n83A: 13.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6EBP_B_DAHB123_0 (RIBONUCLEOSIDE-DIPHO SPHATE REDUCTASE, BETA SUBUNIT)	4n83	RIBONUCLEOSIDE-DIPHO SPHATE REDUCTASE SUBUNIT BETA (Streptococcus sanguinis)	9 / 10	PHE A 59 LEU A 62 THR A 63 ASP A 66 SER A 103 ILE A 107 PHE A 108 PHE A 165 ILE A 187	None None None MN A 402 (-2.8A) None None None None None	0.43A	6ebpB-4n83A: 38.6	6ebpB-4n83A: 13.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6EBP_C_DAHC123_0 (RIBONUCLEOSIDE-DIPHO SPHATE REDUCTASE, BETA SUBUNIT)	4n83	RIBONUCLEOSIDE-DIPHO SPHATE REDUCTASE SUBUNIT BETA (Streptococcus sanguinis)	9 / 10	PHE A 59 LEU A 62 THR A 63 ASP A 66 SER A 103 ILE A 107 PHE A 108 PHE A 165 ILE A 187	None None None MN A 402 (-2.8A) None None None None None	0.46A	6ebpC-4n83A: 38.8	6ebpC-4n83A: 13.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6EBP_D_DAHD123_0 (RIBONUCLEOSIDE-DIPHO SPHATE REDUCTASE, BETA SUBUNIT)	4n83	RIBONUCLEOSIDE-DIPHO SPHATE REDUCTASE SUBUNIT BETA (Streptococcus sanguinis)	9 / 10	PHE A 59 LEU A 62 THR A 63 ASP A 66 SER A 103 ILE A 107 PHE A 108 ILE A 184 ILE A 187	None None None MN A 402 (-2.8A) None None None None None	0.52A	6ebpD-4n83A: 38.5	6ebpD-4n83A: 13.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6EBZ_A_DAHA123_0 (RIBONUCLEOSIDE-DIPHO SPHATE REDUCTASE, BETA SUBUNIT)	4n83	RIBONUCLEOSIDE-DIPHO SPHATE REDUCTASE SUBUNIT BETA (Streptococcus sanguinis)	10 / 11	PHE A 59 LEU A 62 THR A 63 ASP A 66 SER A 103 ILE A 107 PHE A 108 PHE A 165 ILE A 184 ILE A 187	None None None MN A 402 (-2.8A) None None None None None None	0.49A	6ebzA-4n83A: 38.8	6ebzA-4n83A: 13.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6EBZ_B_DAHB123_0 (RIBONUCLEOSIDE-DIPHO SPHATE REDUCTASE, BETA SUBUNIT)	4n83	RIBONUCLEOSIDE-DIPHO SPHATE REDUCTASE SUBUNIT BETA (Streptococcus sanguinis)	10 / 11	PHE A 59 LEU A 62 THR A 63 ASP A 66 SER A 103 ILE A 107 PHE A 108 PHE A 165 ILE A 184 ILE A 187	None None None MN A 402 (-2.8A) None None None None None None	0.51A	6ebzB-4n83A: 38.9	6ebzB-4n83A: 13.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6EBZ_C_DAHC123_0 (RIBONUCLEOSIDE-DIPHO SPHATE REDUCTASE, BETA SUBUNIT)	4n83	RIBONUCLEOSIDE-DIPHO SPHATE REDUCTASE SUBUNIT BETA (Streptococcus sanguinis)	9 / 11	PHE A 59 LEU A 62 THR A 63 ASP A 66 ILE A 107 PHE A 108 PHE A 165 ILE A 184 ILE A 187	None None None MN A 402 (-2.8A) None None None None None	0.53A	6ebzC-4n83A: 39.1	6ebzC-4n83A: 13.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6EBZ_C_DAHC123_0 (RIBONUCLEOSIDE-DIPHO SPHATE REDUCTASE, BETA SUBUNIT)	4n83	RIBONUCLEOSIDE-DIPHO SPHATE REDUCTASE SUBUNIT BETA (Streptococcus sanguinis)	7 / 11	PHE A 59 THR A 63 SER A 103 ILE A 107 PHE A 108 PHE A 165 ILE A 187	None	0.69A	6ebzC-4n83A: 39.1	6ebzC-4n83A: 13.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6EBZ_D_DAHD123_0 (RIBONUCLEOSIDE-DIPHO SPHATE REDUCTASE, BETA SUBUNIT)	4n83	RIBONUCLEOSIDE-DIPHO SPHATE REDUCTASE SUBUNIT BETA (Streptococcus sanguinis)	10 / 11	PHE A 59 LEU A 62 THR A 63 ASP A 66 SER A 103 ILE A 107 PHE A 108 PHE A 165 ILE A 184 ILE A 187	None None None MN A 402 (-2.8A) None None None None None None	0.52A	6ebzD-4n83A: 38.7	6ebzD-4n83A: 13.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6GP2_A_DAHA126_0 (RIBONUCLEOSIDE-DIPHO SPHATE REDUCTASE BETA CHAIN)	4n83	RIBONUCLEOSIDE-DIPHO SPHATE REDUCTASE SUBUNIT BETA (Streptococcus sanguinis)	9 / 11	PHE A 59 LEU A 62 ASP A 66 SER A 103 ILE A 107 PHE A 108 PHE A 165 ILE A 184 ILE A 187	None None MN A 402 (-2.8A) None None None None None None	0.66A	6gp2A-4n83A: 37.8	6gp2A-4n83A: 13.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6GP2_A_DAHA126_0 (RIBONUCLEOSIDE-DIPHO SPHATE REDUCTASE BETA CHAIN)	4n83	RIBONUCLEOSIDE-DIPHO SPHATE REDUCTASE SUBUNIT BETA (Streptococcus sanguinis)	9 / 11	PHE A 59 LEU A 62 THR A 63 SER A 103 ILE A 107 PHE A 108 PHE A 165 ILE A 184 ILE A 187	None	0.54A	6gp2A-4n83A: 37.8	6gp2A-4n83A: 13.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6GP2_B_DAHB126_0 (RIBONUCLEOSIDE-DIPHO SPHATE REDUCTASE BETA CHAIN)	4n83	RIBONUCLEOSIDE-DIPHO SPHATE REDUCTASE SUBUNIT BETA (Streptococcus sanguinis)	10 / 11	PHE A 59 LEU A 62 THR A 63 ASP A 66 SER A 103 ILE A 107 PHE A 108 PHE A 165 ILE A 184 ILE A 187	None None None MN A 402 (-2.8A) None None None None None None	0.71A	6gp2B-4n83A: 37.5	6gp2B-4n83A: 13.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6MXT_A_K5YA1401_1 (ENDOLYSIN, BETA-2 ADRENERGIC RECEPTOR CHIMERA)	4n83	RIBONUCLEOSIDE-DIPHO SPHATE REDUCTASE SUBUNIT BETA (Streptococcus sanguinis)	3 / 3	ASP A 118 SER A 105 SER A 109	None	0.81A	6mxtA-4n83A: undetectable	6mxtA-4n83A: 20.75

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["11GS_A_EAAA211_1","GLUTATHIONE S-TRANSFERASE","4n83","RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE SUBUNIT BETA","Streptococcus sanguinis",4,"TYR A 104;PHE A  59;ILE A 188;GLY A 164","None","0.89A","11gsA-4n83A:undetectable","11gsA-4n83A:22.12"],["1IE4_A_T44A128_1","TRANSTHYRETIN;TRANSTHYRETIN","4n83","RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE SUBUNIT BETA","Streptococcus sanguinis",5,"LEU A 156;LEU A 160;LEU A  64;ALA A 134;LEU A 130","None","1.37A","1ie4A-4n83A:undetectable;1ie4C-4n83A:undetectable","1ie4A-4n83A:16.93;1ie4C-4n83A:16.93"],["1RNR_A_DAHA208_1","RIBONUCLEOTIDE REDUCTASE R1 PROTEIN","4n83","RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE SUBUNIT BETA","Streptococcus sanguinis",8,"ASP A  66;GLU A  97;HIS A 100;LEU A 156;TYR A 162;PHE A 165;ILE A 187;GLU A 191"," MN A 402 (-2.8A); MN A 402 ( 2.8A); MN A 402 (-4.0A);None;None;None;None; MN A 401 ( 2.7A)","0.94A","1rnrA-4n83A:29.9","1rnrA-4n83A:26.56"],["1RNR_A_DAHA208_1","RIBONUCLEOTIDE REDUCTASE R1 PROTEIN","4n83","RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE SUBUNIT BETA","Streptococcus sanguinis",8,"GLU A  97;HIS A 100;LEU A 156;GLU A 157;TYR A 162;PHE A 165;ILE A 187;GLU A 191"," MN A 402 ( 2.8A); MN A 402 (-4.0A);None; MN A 401 ( 2.5A);None;None;None; MN A 401 ( 2.7A)","1.09A","1rnrA-4n83A:29.9","1rnrA-4n83A:26.56"],["1RNR_A_DAHA208_1","RIBONUCLEOTIDE REDUCTASE R1 PROTEIN","4n83","RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE SUBUNIT BETA","Streptococcus sanguinis",5,"GLU A 157;TYR A 162;SER A 163;PHE A 165;ILE A 184"," MN A 401 ( 2.5A);None;None;None;None","1.49A","1rnrA-4n83A:29.9","1rnrA-4n83A:26.56"],["1RNR_A_DAHA208_1","RIBONUCLEOTIDE REDUCTASE R1 PROTEIN","4n83","RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE SUBUNIT BETA","Streptococcus sanguinis",5,"LEU A 156;GLU A 157;TYR A 162;SER A 163;PHE A 165","None; MN A 401 ( 2.5A);None;None;None","1.02A","1rnrA-4n83A:29.9","1rnrA-4n83A:26.56"],["1RNR_B_DAHB208_1","RIBONUCLEOTIDE REDUCTASE R1 PROTEIN","4n83","RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE SUBUNIT BETA","Streptococcus sanguinis",9,"ASP A  66;GLU A  97;HIS A 100;TYR A 104;LEU A 156;TYR A 162;PHE A 165;ILE A 187;GLU A 191"," MN A 402 (-2.8A); MN A 402 ( 2.8A); MN A 402 (-4.0A);None;None;None;None;None; MN A 401 ( 2.7A)","0.85A","1rnrB-4n83A:30.2","1rnrB-4n83A:26.56"],["1RNR_B_DAHB208_1","RIBONUCLEOTIDE REDUCTASE R1 PROTEIN","4n83","RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE SUBUNIT BETA","Streptococcus sanguinis",8,"GLU A  97;HIS A 100;LEU A 156;GLU A 157;TYR A 162;PHE A 165;ILE A 187;GLU A 191"," MN A 402 ( 2.8A); MN A 402 (-4.0A);None; MN A 401 ( 2.5A);None;None;None; MN A 401 ( 2.7A)","0.95A","1rnrB-4n83A:30.2","1rnrB-4n83A:26.56"],["1RNR_B_DAHB208_1","RIBONUCLEOTIDE REDUCTASE R1 PROTEIN","4n83","RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE SUBUNIT BETA","Streptococcus sanguinis",5,"GLU A 191;HIS A 194;LEU A 156;ILE A  93;GLU A  97"," MN A 401 ( 2.7A); MN A 401 (-3.7A);None;None; MN A 402 ( 2.8A)","1.10A","1rnrB-4n83A:30.2","1rnrB-4n83A:26.56"],["2GSS_A_EAAA0_1","GLUTATHIONE S-TRANSFERASE P1-1","4n83","RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE SUBUNIT BETA","Streptococcus sanguinis",4,"TYR A 104;PHE A  59;ILE A 188;GLY A 164","None","0.86A","2gssA-4n83A:undetectable","2gssA-4n83A:21.77"],["2GSS_B_EAAB0_1","GLUTATHIONE S-TRANSFERASE P1-1","4n83","RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE SUBUNIT BETA","Streptococcus sanguinis",4,"TYR A 104;PHE A  59;ILE A 188;GLY A 164","None","0.86A","2gssB-4n83A:undetectable","2gssB-4n83A:21.77"],["3B6H_B_MXDB551_1","PROSTACYCLIN SYNTHASE","4n83","RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE SUBUNIT BETA","Streptococcus sanguinis",4,"ALA A 181;LEU A 177;THR A 110;ASN A 112","None","0.90A","3b6hB-4n83A:1.9","3b6hB-4n83A:21.06"],["3KM6_A_EAAA222_1","GLUTATHIONE S-TRANSFERASE P","4n83","RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE SUBUNIT BETA","Streptococcus sanguinis",5,"TYR A 104;PHE A  59;VAL A  55;ILE A 188;GLY A 164","None","1.24A","3km6A-4n83A:undetectable","3km6A-4n83A:21.45"],["3N9J_A_EAAA210_1","GLUTATHIONE S-TRANSFERASE P","4n83","RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE SUBUNIT BETA","Streptococcus sanguinis",4,"TYR A 104;PHE A  59;ILE A 188;GLY A 164","None","0.86A","3n9jA-4n83A:undetectable","3n9jA-4n83A:22.12"],["4QZU_C_ACTC202_0","RETINOL-BINDING PROTEIN 2","4n83","RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE SUBUNIT BETA","Streptococcus sanguinis",4,"GLU A 116;THR A 113;TRP A  44;LEU A  41","None","1.18A","4qzuC-4n83A:undetectable","4qzuC-4n83A:16.61"],["4RTP_A_SAMA301_0","DNA ADENINE METHYLASE","4n83","RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE SUBUNIT BETA","Streptococcus sanguinis",5,"ILE A 183;ASN A 179;SER A 103;TYR A 104;PRO A 168","None","1.00A","4rtpA-4n83A:undetectable","4rtpA-4n83A:21.01"],["4TVT_A_ASCA303_0","THAUMATIN-1","4n83","RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE SUBUNIT BETA","Streptococcus sanguinis",4,"LEU A 156;GLU A 157;SER A 153;VAL A  74","None; MN A 401 ( 2.5A); MN A 401 ( 4.6A);None","1.18A","4tvtA-4n83A:undetectable","4tvtA-4n83A:16.46"],["4ZN7_B_DESB600_1","ESTROGEN RECEPTOR","4n83","RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE SUBUNIT BETA","Streptococcus sanguinis",5,"LEU A 130;GLU A 232;LEU A 156;LEU A 160;LEU A  68","None","1.34A","4zn7B-4n83A:3.4","4zn7B-4n83A:20.93"],["5DLV_A_5D5A930_0","ECTONUCLEOTIDE PYROPHOSPHATASE\/PHOSPHODIESTERASE FAMILY MEMBER 2","4n83","RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE SUBUNIT BETA","Streptococcus sanguinis",5,"LEU A 130;ASP A 241;THR A 246;PRO A 168;ILE A 184","None","1.14A","5dlvA-4n83A:undetectable","5dlvA-4n83A:18.04"],["5DLV_B_5D5B927_0","ECTONUCLEOTIDE PYROPHOSPHATASE\/PHOSPHODIESTERASE FAMILY MEMBER 2","4n83","RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE SUBUNIT BETA","Streptococcus sanguinis",5,"LEU A 130;ASP A 241;THR A 246;PRO A 168;ILE A 184","None","1.13A","5dlvB-4n83A:undetectable","5dlvB-4n83A:18.04"],["5SXQ_A_NIZA808_1","CATALASE-PEROXIDASE","4n83","RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE SUBUNIT BETA","Streptococcus sanguinis",4,"GLU A  97;VAL A  74;GLY A 195;THR A 158"," MN A 402 ( 2.8A);None;None;None","0.93A","5sxqA-4n83A:undetectable","5sxqA-4n83A:17.03"],["5SXQ_B_NIZB808_1","CATALASE-PEROXIDASE","4n83","RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE SUBUNIT BETA","Streptococcus sanguinis",4,"GLU A  97;VAL A  74;GLY A 195;THR A 158"," MN A 402 ( 2.8A);None;None;None","0.91A","5sxqB-4n83A:undetectable","5sxqB-4n83A:17.03"],["5SYJ_A_NIZA809_1","CATALASE-PEROXIDASE","4n83","RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE SUBUNIT BETA","Streptococcus sanguinis",4,"GLU A  97;VAL A  74;GLY A 195;THR A 158"," MN A 402 ( 2.8A);None;None;None","0.90A","5syjA-4n83A:undetectable","5syjA-4n83A:17.03"],["5UC1_A_486A801_1","GLUCOCORTICOID RECEPTOR","4n83","RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE SUBUNIT BETA","Streptococcus sanguinis",5,"LEU A  65;LEU A  62;GLY A  61;GLY A  60;TRP A 123","None","1.15A","5uc1A-4n83A:2.4","5uc1A-4n83A:10.97"],["6EBP_A_DAHA123_0","RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE, BETA SUBUNIT","4n83","RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE SUBUNIT BETA","Streptococcus sanguinis",8,"LEU A  62;THR A  63;ASP A  66;SER A 103;ILE A 107;PHE A 108;PHE A 165;ILE A 187","None;None; MN A 402 (-2.8A);None;None;None;None;None","0.47A","6ebpA-4n83A:38.9","6ebpA-4n83A:13.18"],["6EBP_B_DAHB123_0","RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE, BETA SUBUNIT","4n83","RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE SUBUNIT BETA","Streptococcus sanguinis",9,"PHE A  59;LEU A  62;THR A  63;ASP A  66;SER A 103;ILE A 107;PHE A 108;PHE A 165;ILE A 187","None;None;None; MN A 402 (-2.8A);None;None;None;None;None","0.43A","6ebpB-4n83A:38.6","6ebpB-4n83A:13.18"],["6EBP_C_DAHC123_0","RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE, BETA SUBUNIT","4n83","RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE SUBUNIT BETA","Streptococcus sanguinis",9,"PHE A  59;LEU A  62;THR A  63;ASP A  66;SER A 103;ILE A 107;PHE A 108;PHE A 165;ILE A 187","None;None;None; MN A 402 (-2.8A);None;None;None;None;None","0.46A","6ebpC-4n83A:38.8","6ebpC-4n83A:13.18"],["6EBP_D_DAHD123_0","RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE, BETA SUBUNIT","4n83","RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE SUBUNIT BETA","Streptococcus sanguinis",9,"PHE A  59;LEU A  62;THR A  63;ASP A  66;SER A 103;ILE A 107;PHE A 108;ILE A 184;ILE A 187","None;None;None; MN A 402 (-2.8A);None;None;None;None;None","0.52A","6ebpD-4n83A:38.5","6ebpD-4n83A:13.18"],["6EBZ_A_DAHA123_0","RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE, BETA SUBUNIT","4n83","RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE SUBUNIT BETA","Streptococcus sanguinis",10,"PHE A  59;LEU A  62;THR A  63;ASP A  66;SER A 103;ILE A 107;PHE A 108;PHE A 165;ILE A 184;ILE A 187","None;None;None; MN A 402 (-2.8A);None;None;None;None;None;None","0.49A","6ebzA-4n83A:38.8","6ebzA-4n83A:13.18"],["6EBZ_B_DAHB123_0","RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE, BETA SUBUNIT","4n83","RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE SUBUNIT BETA","Streptococcus sanguinis",10,"PHE A  59;LEU A  62;THR A  63;ASP A  66;SER A 103;ILE A 107;PHE A 108;PHE A 165;ILE A 184;ILE A 187","None;None;None; MN A 402 (-2.8A);None;None;None;None;None;None","0.51A","6ebzB-4n83A:38.9","6ebzB-4n83A:13.18"],["6EBZ_C_DAHC123_0","RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE, BETA SUBUNIT","4n83","RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE SUBUNIT BETA","Streptococcus sanguinis",9,"PHE A  59;LEU A  62;THR A  63;ASP A  66;ILE A 107;PHE A 108;PHE A 165;ILE A 184;ILE A 187","None;None;None; MN A 402 (-2.8A);None;None;None;None;None","0.53A","6ebzC-4n83A:39.1","6ebzC-4n83A:13.18"],["6EBZ_C_DAHC123_0","RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE, BETA SUBUNIT","4n83","RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE SUBUNIT BETA","Streptococcus sanguinis",7,"PHE A  59;THR A  63;SER A 103;ILE A 107;PHE A 108;PHE A 165;ILE A 187","None","0.69A","6ebzC-4n83A:39.1","6ebzC-4n83A:13.18"],["6EBZ_D_DAHD123_0","RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE, BETA SUBUNIT","4n83","RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE SUBUNIT BETA","Streptococcus sanguinis",10,"PHE A  59;LEU A  62;THR A  63;ASP A  66;SER A 103;ILE A 107;PHE A 108;PHE A 165;ILE A 184;ILE A 187","None;None;None; MN A 402 (-2.8A);None;None;None;None;None;None","0.52A","6ebzD-4n83A:38.7","6ebzD-4n83A:13.18"],["6GP2_A_DAHA126_0","RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE BETA CHAIN","4n83","RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE SUBUNIT BETA","Streptococcus sanguinis",9,"PHE A  59;LEU A  62;ASP A  66;SER A 103;ILE A 107;PHE A 108;PHE A 165;ILE A 184;ILE A 187","None;None; MN A 402 (-2.8A);None;None;None;None;None;None","0.66A","6gp2A-4n83A:37.8","6gp2A-4n83A:13.77"],["6GP2_A_DAHA126_0","RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE BETA CHAIN","4n83","RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE SUBUNIT BETA","Streptococcus sanguinis",9,"PHE A  59;LEU A  62;THR A  63;SER A 103;ILE A 107;PHE A 108;PHE A 165;ILE A 184;ILE A 187","None","0.54A","6gp2A-4n83A:37.8","6gp2A-4n83A:13.77"],["6GP2_B_DAHB126_0","RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE BETA CHAIN","4n83","RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE SUBUNIT BETA","Streptococcus sanguinis",10,"PHE A  59;LEU A  62;THR A  63;ASP A  66;SER A 103;ILE A 107;PHE A 108;PHE A 165;ILE A 184;ILE A 187","None;None;None; MN A 402 (-2.8A);None;None;None;None;None;None","0.71A","6gp2B-4n83A:37.5","6gp2B-4n83A:13.77"],["6MXT_A_K5YA1401_1","ENDOLYSIN, BETA-2 ADRENERGIC RECEPTOR CHIMERA","4n83","RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE SUBUNIT BETA","Streptococcus sanguinis",3,"ASP A 118;SER A 105;SER A 109","None","0.81A","6mxtA-4n83A:undetectable","6mxtA-4n83A:20.75"]]