SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4n8y'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FDS_A_ESTA350_1
(17-BETA-HYDROXYSTERO
ID-DEHYDROGENASE)		 4n8y PUTATIVE TRAP-TYPE
C4-DICARBOXYLATE
TRANSPORT SYSTEM,
BINDING PERIPLASMIC
PROTEIN (DCTP
SUBUNIT)
(Bradyrhizobium
sp.
BTAi1) 		5 / 12 VAL A 302
LEU A 103
GLY A 175
SER A  89
PHE A 306
 None
 1.34A 1fdsA-4n8yA:
undetectable		 1fdsA-4n8yA:
24.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KT3_A_RTLA184_0
(PLASMA
RETINOL-BINDING
PROTEIN)		 4n8y PUTATIVE TRAP-TYPE
C4-DICARBOXYLATE
TRANSPORT SYSTEM,
BINDING PERIPLASMIC
PROTEIN (DCTP
SUBUNIT)
(Bradyrhizobium
sp.
BTAi1) 		4 / 7 LEU A 101
LEU A 172
TYR A 303
LEU A 312
 None
 1.03A 1kt3A-4n8yA:
undetectable		 1kt3A-4n8yA:
16.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEU_A_ACTA141_0
(PUTATIVE
CARBOXYMUCONOLACTONE
DECARBOXYLASE)		 4n8y PUTATIVE TRAP-TYPE
C4-DICARBOXYLATE
TRANSPORT SYSTEM,
BINDING PERIPLASMIC
PROTEIN (DCTP
SUBUNIT)
(Bradyrhizobium
sp.
BTAi1) 		3 / 3 VAL A  30
ASP A  29
GLU A  69
 None
None
GTR  A 402 (-2.9A)
 0.76A 2qeuA-4n8yA:
undetectable		 2qeuA-4n8yA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEU_C_ACTC141_0
(PUTATIVE
CARBOXYMUCONOLACTONE
DECARBOXYLASE)		 4n8y PUTATIVE TRAP-TYPE
C4-DICARBOXYLATE
TRANSPORT SYSTEM,
BINDING PERIPLASMIC
PROTEIN (DCTP
SUBUNIT)
(Bradyrhizobium
sp.
BTAi1) 		3 / 3 VAL A  30
ASP A  29
GLU A  69
 None
None
GTR  A 402 (-2.9A)
 0.74A 2qeuC-4n8yA:
undetectable		 2qeuC-4n8yA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEK_B_DIFB1376_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 4n8y PUTATIVE TRAP-TYPE
C4-DICARBOXYLATE
TRANSPORT SYSTEM,
BINDING PERIPLASMIC
PROTEIN (DCTP
SUBUNIT)
(Bradyrhizobium
sp.
BTAi1) 		4 / 7 VAL A 241
GLY A  79
ALA A  80
SER A 238
 None
 0.84A 2wekB-4n8yA:
undetectable		 2wekB-4n8yA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7W_C_SALC1300_1
(LYSR-TYPE REGULATORY
PROTEIN)		 4n8y PUTATIVE TRAP-TYPE
C4-DICARBOXYLATE
TRANSPORT SYSTEM,
BINDING PERIPLASMIC
PROTEIN (DCTP
SUBUNIT)
(Bradyrhizobium
sp.
BTAi1) 		4 / 7 ILE A 125
GLY A 122
PHE A 107
ILE A 319
 None
 0.78A 2y7wC-4n8yA:
4.9		 2y7wC-4n8yA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UQ6_A_ADNA401_1
(ADENOSINE KINASE,
PUTATIVE)		 4n8y PUTATIVE TRAP-TYPE
C4-DICARBOXYLATE
TRANSPORT SYSTEM,
BINDING PERIPLASMIC
PROTEIN (DCTP
SUBUNIT)
(Bradyrhizobium
sp.
BTAi1) 		5 / 12 ILE A  86
LEU A  76
GLY A  64
THR A  72
LEU A  81
 None
 1.04A 3uq6A-4n8yA:
undetectable		 3uq6A-4n8yA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DO3_B_0LAB602_1
(FATTY-ACID AMIDE
HYDROLASE 1)		 4n8y PUTATIVE TRAP-TYPE
C4-DICARBOXYLATE
TRANSPORT SYSTEM,
BINDING PERIPLASMIC
PROTEIN (DCTP
SUBUNIT)
(Bradyrhizobium
sp.
BTAi1) 		4 / 6 LEU A 157
LEU A 160
ILE A 165
THR A 226
 None
 0.98A 4do3B-4n8yA:
2.5		 4do3B-4n8yA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEV_E_KANE301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 4n8y PUTATIVE TRAP-TYPE
C4-DICARBOXYLATE
TRANSPORT SYSTEM,
BINDING PERIPLASMIC
PROTEIN (DCTP
SUBUNIT)
(Bradyrhizobium
sp.
BTAi1) 		5 / 11 SER A 229
HIS A 228
ASN A 206
GLU A 205
GLU A 233
 None
None
ADA  A 401 (-2.9A)
None
GTR  A 402 (-2.8A)
 1.28A 4fevE-4n8yA:
undetectable		 4fevE-4n8yA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEW_C_KANC301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 4n8y PUTATIVE TRAP-TYPE
C4-DICARBOXYLATE
TRANSPORT SYSTEM,
BINDING PERIPLASMIC
PROTEIN (DCTP
SUBUNIT)
(Bradyrhizobium
sp.
BTAi1) 		5 / 12 ASN A 206
GLU A 233
SER A 229
HIS A 228
ARG A 166
 ADA  A 401 (-2.9A)
GTR  A 402 (-2.8A)
None
None
ADA  A 401 (-3.0A)
 1.35A 4fewC-4n8yA:
0.0
4fewD-4n8yA:
0.1
4fewF-4n8yA:
0.8		 4fewC-4n8yA:
22.06
4fewD-4n8yA:
22.06
4fewF-4n8yA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEW_E_KANE301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 4n8y PUTATIVE TRAP-TYPE
C4-DICARBOXYLATE
TRANSPORT SYSTEM,
BINDING PERIPLASMIC
PROTEIN (DCTP
SUBUNIT)
(Bradyrhizobium
sp.
BTAi1) 		5 / 11 ASN A 206
GLU A 205
GLU A 233
SER A 229
HIS A 228
 ADA  A 401 (-2.9A)
None
GTR  A 402 (-2.8A)
None
None
 1.27A 4fewE-4n8yA:
0.0
4fewF-4n8yA:
0.8		 4fewE-4n8yA:
22.06
4fewF-4n8yA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKH_H_KANH301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 4n8y PUTATIVE TRAP-TYPE
C4-DICARBOXYLATE
TRANSPORT SYSTEM,
BINDING PERIPLASMIC
PROTEIN (DCTP
SUBUNIT)
(Bradyrhizobium
sp.
BTAi1) 		5 / 10 SER A 229
HIS A 228
ASN A 206
GLU A 205
GLU A 233
 None
None
ADA  A 401 (-2.9A)
None
GTR  A 402 (-2.8A)
 1.27A 4gkhG-4n8yA:
0.1
4gkhH-4n8yA:
0.3		 4gkhG-4n8yA:
22.06
4gkhH-4n8yA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKI_D_KAND301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 4n8y PUTATIVE TRAP-TYPE
C4-DICARBOXYLATE
TRANSPORT SYSTEM,
BINDING PERIPLASMIC
PROTEIN (DCTP
SUBUNIT)
(Bradyrhizobium
sp.
BTAi1) 		5 / 11 SER A 229
HIS A 228
ASN A 206
GLU A 205
GLU A 233
 None
None
ADA  A 401 (-2.9A)
None
GTR  A 402 (-2.8A)
 1.30A 4gkiC-4n8yA:
undetectable
4gkiD-4n8yA:
undetectable		 4gkiC-4n8yA:
22.06
4gkiD-4n8yA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKI_H_KANH301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 4n8y PUTATIVE TRAP-TYPE
C4-DICARBOXYLATE
TRANSPORT SYSTEM,
BINDING PERIPLASMIC
PROTEIN (DCTP
SUBUNIT)
(Bradyrhizobium
sp.
BTAi1) 		5 / 10 SER A 229
HIS A 228
ASN A 206
GLU A 205
GLU A 233
 None
None
ADA  A 401 (-2.9A)
None
GTR  A 402 (-2.8A)
 1.29A 4gkiG-4n8yA:
0.8
4gkiH-4n8yA:
0.2		 4gkiG-4n8yA:
22.06
4gkiH-4n8yA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K5J_B_H4BB502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4n8y PUTATIVE TRAP-TYPE
C4-DICARBOXYLATE
TRANSPORT SYSTEM,
BINDING PERIPLASMIC
PROTEIN (DCTP
SUBUNIT)
(Bradyrhizobium
sp.
BTAi1) 		4 / 7 PHE A  25
SER A 238
VAL A 135
TRP A 242
 None
 1.45A 4k5jA-4n8yA:
undetectable
4k5jB-4n8yA:
undetectable		 4k5jA-4n8yA:
22.65
4k5jB-4n8yA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OK1_A_198A1001_2
(ANDROGEN RECEPTOR)		 4n8y PUTATIVE TRAP-TYPE
C4-DICARBOXYLATE
TRANSPORT SYSTEM,
BINDING PERIPLASMIC
PROTEIN (DCTP
SUBUNIT)
(Bradyrhizobium
sp.
BTAi1) 		4 / 8 LEU A  76
MET A  44
LEU A 235
ILE A 125
 None
 1.01A 4ok1A-4n8yA:
undetectable		 4ok1A-4n8yA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UAC_A_ACRA501_2
(CARBOHYDRATE ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN, CUT1 FAMILY
(TC 3.A.1.1.-))		 4n8y PUTATIVE TRAP-TYPE
C4-DICARBOXYLATE
TRANSPORT SYSTEM,
BINDING PERIPLASMIC
PROTEIN (DCTP
SUBUNIT)
(Bradyrhizobium
sp.
BTAi1) 		4 / 7 PRO A 104
GLU A 227
TRP A 268
ASP A 269
 None
 1.17A 4uacA-4n8yA:
5.7		 4uacA-4n8yA:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1K_D_LOCD502_2
(TUBULIN BETA CHAIN)		 4n8y PUTATIVE TRAP-TYPE
C4-DICARBOXYLATE
TRANSPORT SYSTEM,
BINDING PERIPLASMIC
PROTEIN (DCTP
SUBUNIT)
(Bradyrhizobium
sp.
BTAi1) 		5 / 12 LEU A 126
MET A  84
THR A  72
VAL A  95
ALA A 132
 None
 1.09A 4x1kD-4n8yA:
undetectable		 4x1kD-4n8yA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X5I_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 4n8y PUTATIVE TRAP-TYPE
C4-DICARBOXYLATE
TRANSPORT SYSTEM,
BINDING PERIPLASMIC
PROTEIN (DCTP
SUBUNIT)
(Bradyrhizobium
sp.
BTAi1) 		3 / 3 ASP A  29
ARG A 166
ARG A 145
 None
ADA  A 401 (-3.0A)
GTR  A 402 (-3.0A)
 0.98A 4x5iA-4n8yA:
undetectable		 4x5iA-4n8yA:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YBN_A_ACTA303_0
(FLAVIN-NUCLEOTIDE-BI
NDING PROTEIN)		 4n8y PUTATIVE TRAP-TYPE
C4-DICARBOXYLATE
TRANSPORT SYSTEM,
BINDING PERIPLASMIC
PROTEIN (DCTP
SUBUNIT)
(Bradyrhizobium
sp.
BTAi1) 		3 / 3 VAL A 316
TYR A 303
ALA A 307
 None
 0.50A 4ybnA-4n8yA:
undetectable		 4ybnA-4n8yA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_A_ACTA307_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 4n8y PUTATIVE TRAP-TYPE
C4-DICARBOXYLATE
TRANSPORT SYSTEM,
BINDING PERIPLASMIC
PROTEIN (DCTP
SUBUNIT)
(Bradyrhizobium
sp.
BTAi1) 		4 / 4 LEU A 157
LEU A 160
SER A 179
ALA A 182
 None
 1.01A 5uunA-4n8yA:
undetectable		 5uunA-4n8yA:
25.07