SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4n9f'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E73_M_ASCM995_0
(MYROSINASE MA1)		 4n9f CORE-BINDING FACTOR
SUBUNIT BETA
VIRION INFECTIVITY
FACTOR
(Homo
sapiens;
Human
immunodeficiency
virus
1) 		4 / 6 GLN b  97
ILE b   9
PHE a  17
PHE a 143
 None
 1.40A 1e73M-4n9fb:
undetectable		 1e73M-4n9fb:
15.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTB_A_PZQA901_0
(GLUTATHIONE
S-TRANSFERASE)		 4n9f CORE-BINDING FACTOR
SUBUNIT BETA
VIRION INFECTIVITY
FACTOR
(Homo
sapiens;
Human
immunodeficiency
virus
1) 		3 / 3 GLN a   8
TYR b  94
ARG b  93
 None
 0.93A 1gtbA-4n9fa:
undetectable		 1gtbA-4n9fa:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_F_BEZF511_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 4n9f CULLIN-5
(Homo
sapiens) 		4 / 5 GLU U  67
PHE U  15
ARG U  23
ALA U  64
 None
 1.31A 1oniE-4n9fU:
undetectable
1oniF-4n9fU:
undetectable		 1oniE-4n9fU:
15.82
1oniF-4n9fU:
15.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OIP_B_MTXB609_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 4n9f TRANSCRIPTION
ELONGATION FACTOR B
POLYPEPTIDE 2
(Homo
sapiens) 		5 / 12 ALA X  67
LEU X   5
LEU X  57
SER X  21
THR X  66
 None
 1.28A 2oipB-4n9fX:
undetectable		 2oipB-4n9fX:
12.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCT_A_ASDA1223_1
(GLUTATHIONE
S-TRANSFERASE A2)		 4n9f CULLIN-5
(Homo
sapiens) 		4 / 8 ILE U  69
ARG U 136
LEU U 140
PHE U 100
 None
 0.85A 2vctA-4n9fU:
undetectable		 2vctA-4n9fU:
23.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XRH_A_NIOA200_1
(PROTEIN HP0721)		 4n9f TRANSCRIPTION
ELONGATION FACTOR B
POLYPEPTIDE 2
(Homo
sapiens) 		4 / 7 GLY X  33
ILE X  14
THR X  16
GLN X  42
 None
 0.79A 2xrhA-4n9fX:
0.4		 2xrhA-4n9fX:
24.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BPX_B_SALB258_1
(TRANSCRIPTIONAL
REGULATOR)		 4n9f CULLIN-5
(Homo
sapiens) 		5 / 11 LEU U 176
PHE U 202
ILE U 178
GLY U 179
SER U 183
 None
 1.21A 3bpxA-4n9fU:
undetectable
3bpxB-4n9fU:
undetectable		 3bpxA-4n9fU:
19.00
3bpxB-4n9fU:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_H_TRPH1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 4n9f CORE-BINDING FACTOR
SUBUNIT BETA
(Homo
sapiens) 		5 / 9 GLY a  93
ASP a 115
ILE a 114
VAL a  95
GLN a  45
 None
 1.39A 3fi0H-4n9fa:
undetectable		 3fi0H-4n9fa:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S8P_B_SAMB500_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H1)		 4n9f VIRION INFECTIVITY
FACTOR
(Human
immunodeficiency
virus
1) 		3 / 3 HIS b  80
SER b  52
ASN b  19
 None
 0.82A 3s8pB-4n9fb:
undetectable		 3s8pB-4n9fb:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9L_A_CAMA1419_0
(CYTOCHROME P450)		 4n9f TRANSCRIPTION
ELONGATION FACTOR B
POLYPEPTIDE 2
(Homo
sapiens) 		5 / 12 ILE X  30
LEU X  44
LEU X  77
GLY X  76
ILE X  34
 None
 0.99A 4c9lA-4n9fX:
undetectable		 4c9lA-4n9fX:
12.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9L_B_CAMB1419_0
(CYTOCHROME P450)		 4n9f TRANSCRIPTION
ELONGATION FACTOR B
POLYPEPTIDE 2
(Homo
sapiens) 		5 / 12 ILE X  30
LEU X  44
LEU X  77
GLY X  76
ILE X  34
 None
 0.97A 4c9lB-4n9fX:
undetectable		 4c9lB-4n9fX:
12.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9O_A_CAMA423_0
(CYTOCHROME P450)		 4n9f TRANSCRIPTION
ELONGATION FACTOR B
POLYPEPTIDE 2
(Homo
sapiens) 		5 / 12 ILE X  30
LEU X  44
LEU X  77
GLY X  76
ILE X  34
 None
 1.01A 4c9oA-4n9fX:
undetectable		 4c9oA-4n9fX:
12.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9O_B_CAMB423_0
(CYTOCHROME P450)		 4n9f TRANSCRIPTION
ELONGATION FACTOR B
POLYPEPTIDE 2
(Homo
sapiens) 		5 / 12 ILE X  30
LEU X  44
LEU X  77
GLY X  76
ILE X  34
 None
 1.02A 4c9oB-4n9fX:
undetectable		 4c9oB-4n9fX:
12.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MDB_A_RLTA401_1
(MARINER MOS1
TRANSPOSASE)		 4n9f CULLIN-5
(Homo
sapiens) 		4 / 6 ASP U 200
ASN U 201
TYR U 198
ASP U 193
 None
 1.21A 4mdbA-4n9fU:
undetectable		 4mdbA-4n9fU:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q0D_C_MTXC604_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4n9f TRANSCRIPTION
ELONGATION FACTOR B
POLYPEPTIDE 2
(Homo
sapiens) 		5 / 12 ALA X  67
LEU X   5
LEU X  57
SER X  21
THR X  66
 None
 1.30A 4q0dC-4n9fX:
undetectable		 4q0dC-4n9fX:
10.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q0D_D_MTXD604_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4n9f TRANSCRIPTION
ELONGATION FACTOR B
POLYPEPTIDE 2
(Homo
sapiens) 		5 / 12 ALA X  67
LEU X   5
LEU X  57
SER X  21
THR X  66
 None
 1.30A 4q0dD-4n9fX:
undetectable		 4q0dD-4n9fX:
10.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y0P_A_TE4A201_1
(BETA-LACTOGLOBULIN)		 4n9f TRANSCRIPTION
ELONGATION FACTOR B
POLYPEPTIDE 2
(Homo
sapiens) 		5 / 12 LEU X   5
ILE X   7
ILE X  14
VAL X  24
LEU X  51
 None
 1.15A 4y0pA-4n9fX:
undetectable		 4y0pA-4n9fX:
24.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CPR_B_SAMB402_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H1)		 4n9f VIRION INFECTIVITY
FACTOR
(Human
immunodeficiency
virus
1) 		3 / 3 HIS b  80
SER b  52
ASN b  19
 None
 0.71A 5cprB-4n9fb:
undetectable		 5cprB-4n9fb:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D0Y_A_FOLA201_1
(CONSERVED
HYPOTHETICAL
MEMBRANE PROTEIN)		 4n9f CULLIN-5
(Homo
sapiens) 		3 / 3 ARG U 244
LYS U 237
GLU U 240
 None
 0.78A 5d0yA-4n9fU:
undetectable		 5d0yA-4n9fU:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JH7_B_6K9B503_0
(TUBULIN BETA-2B
CHAIN)		 4n9f CULLIN-5
(Homo
sapiens) 		5 / 11 GLN U  63
VAL U 135
ASP U 141
THR U 142
LEU U 114
 None
 1.30A 5jh7B-4n9fU:
undetectable		 5jh7B-4n9fU:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JH7_D_6K9D502_0
(TUBULIN BETA-2B
CHAIN)		 4n9f CULLIN-5
(Homo
sapiens) 		5 / 11 GLN U  63
VAL U 135
ASP U 141
THR U 142
LEU U 114
 None
 1.35A 5jh7D-4n9fU:
undetectable		 5jh7D-4n9fU:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NWV_A_ACAA18_2
(SCRFP-TAG,GP41)		 4n9f CULLIN-5
(Homo
sapiens) 		4 / 7 LEU U  43
ALA U  49
LEU U  52
TRP U  53
 None
 0.98A 5nwvA-4n9fU:
undetectable		 5nwvA-4n9fU:
8.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NWV_A_ACAA18_2
(SCRFP-TAG,GP41)		 4n9f CULLIN-5
(Homo
sapiens) 		4 / 7 LEU U  43
ASP U  46
ALA U  49
TRP U  53
 None
 1.02A 5nwvA-4n9fU:
undetectable		 5nwvA-4n9fU:
8.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TWJ_A_SAMA201_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE H)		 4n9f CORE-BINDING FACTOR
SUBUNIT BETA
(Homo
sapiens) 		5 / 12 LEU a 103
GLY a 105
LEU a 125
SER a  22
VAL a 108
 None
 0.90A 5twjA-4n9fa:
undetectable		 5twjA-4n9fa:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TWJ_B_SAMB201_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE H)		 4n9f CORE-BINDING FACTOR
SUBUNIT BETA
(Homo
sapiens) 		5 / 10 LEU a 103
GLY a 105
LEU a 125
SER a  22
VAL a 108
 None
 0.93A 5twjB-4n9fa:
undetectable		 5twjB-4n9fa:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TWJ_C_SAMC201_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE H)		 4n9f CORE-BINDING FACTOR
SUBUNIT BETA
(Homo
sapiens) 		5 / 12 LEU a 103
GLY a 105
LEU a 125
SER a  22
VAL a 108
 None
 0.88A 5twjC-4n9fa:
undetectable		 5twjC-4n9fa:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V0I_B_TRPB402_0
(TRYPTOPHAN--TRNA
LIGASE)		 4n9f CORE-BINDING FACTOR
SUBUNIT BETA
(Homo
sapiens) 		5 / 9 GLY a  93
ASP a 115
ILE a 114
VAL a  95
GLN a  45
 None
 1.49A 5v0iB-4n9fa:
undetectable		 5v0iB-4n9fa:
16.82