SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4n9j'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J9D_J_ACTJ1116_0
(HYPOTHETICAL
NITROGEN REGULATORY
PII-LIKE PROTEIN
MJ0059)		 4n9j SERINE/THREONINE-PRO
TEIN KINASE PLK4
(Homo
sapiens) 		4 / 8 LYS A 762
GLU A 764
ILE A 765
LYS A 748
 None
 0.62A 2j9dJ-4n9jA:
undetectable
2j9dK-4n9jA:
undetectable
2j9dL-4n9jA:
undetectable		 2j9dJ-4n9jA:
19.66
2j9dK-4n9jA:
19.66
2j9dL-4n9jA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J9D_J_ACTJ1116_0
(HYPOTHETICAL
NITROGEN REGULATORY
PII-LIKE PROTEIN
MJ0059)		 4n9j SERINE/THREONINE-PRO
TEIN KINASE PLK4
(Homo
sapiens) 		4 / 8 LYS A 762
GLU A 764
ILE A 765
LYS A 748
 None
 0.65A 2j9dJ-4n9jA:
undetectable
2j9dK-4n9jA:
undetectable
2j9dL-4n9jA:
undetectable		 2j9dJ-4n9jA:
19.66
2j9dK-4n9jA:
19.66
2j9dL-4n9jA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W8Y_A_486A1000_2
(PROGESTERONE
RECEPTOR)		 4n9j SERINE/THREONINE-PRO
TEIN KINASE PLK4
(Homo
sapiens) 		4 / 7 LEU A 637
GLU A 618
LEU A 614
TYR A 650
 None
 1.15A 2w8yA-4n9jA:
undetectable		 2w8yA-4n9jA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWD_D_GLYD713_0
(DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1)		 4n9j SERINE/THREONINE-PRO
TEIN KINASE PLK4
(Homo
sapiens) 		3 / 3 ARG A 697
HIS A 597
ARG A 598
 None
 0.93A 6dwdD-4n9jA:
undetectable		 6dwdD-4n9jA:
19.58