SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4n9n'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BDW_B_DVAB8_0
(GRAMICIDIN A)		 4n9n STEROL UPTAKE
CONTROL PROTEIN 2,
LYSOZYME
(Saccharomyces
cerevisiae;
Escherichia
virus
T4) 		3 / 3 VAL A 866
VAL A 875
TRP A 867
 None
 0.96A 1bdwA-4n9nA:
undetectable
1bdwB-4n9nA:
undetectable		 1bdwA-4n9nA:
3.16
1bdwB-4n9nA:
3.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L7H_A_BCZA801_1
(NEURAMINIDASE)		 4n9n STEROL UPTAKE
CONTROL PROTEIN 2,
LYSOZYME
(Saccharomyces
cerevisiae;
Escherichia
virus
T4) 		3 / 3 ARG A 856
ARG A1154
ARG A 849
 None
 0.97A 1l7hA-4n9nA:
undetectable		 1l7hA-4n9nA:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_C_FUAC701_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4n9n STEROL UPTAKE
CONTROL PROTEIN 2,
LYSOZYME
(Escherichia
virus
T4;
Saccharomyces
cerevisiae) 		5 / 12 PHE A 818
PHE A 868
LEU A 710
VAL A 736
VAL A 872
 None
 1.31A 1q23C-4n9nA:
undetectable		 1q23C-4n9nA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_L_FUAL710_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4n9n STEROL UPTAKE
CONTROL PROTEIN 2,
LYSOZYME
(Escherichia
virus
T4;
Saccharomyces
cerevisiae) 		5 / 11 PHE A 818
PHE A 868
LEU A 710
VAL A 736
VAL A 872
 None
 1.33A 1q23L-4n9nA:
undetectable		 1q23L-4n9nA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E1Q_A_SALA2006_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 4n9n STEROL UPTAKE
CONTROL PROTEIN 2,
LYSOZYME
(Escherichia
virus
T4;
Saccharomyces
cerevisiae) 		4 / 6 PHE A1153
VAL A1087
LEU A1118
ALA A1129
 None
 1.08A 2e1qA-4n9nA:
undetectable		 2e1qA-4n9nA:
16.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IZQ_B_DVAB6_0
(GRAMICIDIN D)		 4n9n STEROL UPTAKE
CONTROL PROTEIN 2,
LYSOZYME
(Saccharomyces
cerevisiae;
Escherichia
virus
T4) 		3 / 3 TRP A 732
ALA A 711
VAL A 872
 None
 0.74A 2izqA-4n9nA:
undetectable
2izqB-4n9nA:
undetectable		 2izqA-4n9nA:
3.16
2izqB-4n9nA:
3.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XYT_D_TC9D1206_2
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 4n9n STEROL UPTAKE
CONTROL PROTEIN 2,
LYSOZYME
(Escherichia
virus
T4;
Saccharomyces
cerevisiae) 		4 / 8 THR A1034
TYR A1025
ILE A1017
SER A1036
 None
 0.99A 2xytE-4n9nA:
undetectable		 2xytE-4n9nA:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XYT_G_TC9G1206_2
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 4n9n STEROL UPTAKE
CONTROL PROTEIN 2,
LYSOZYME
(Escherichia
virus
T4;
Saccharomyces
cerevisiae) 		4 / 8 THR A1034
TYR A1025
ILE A1017
SER A1036
 None
 0.95A 2xytH-4n9nA:
undetectable		 2xytH-4n9nA:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XYT_H_TC9H1206_2
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 4n9n STEROL UPTAKE
CONTROL PROTEIN 2,
LYSOZYME
(Escherichia
virus
T4;
Saccharomyces
cerevisiae) 		4 / 7 THR A1034
TYR A1025
ILE A1017
SER A1036
 None
 0.97A 2xytI-4n9nA:
undetectable		 2xytI-4n9nA:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7W_A_SALA1300_1
(LYSR-TYPE REGULATORY
PROTEIN)		 4n9n STEROL UPTAKE
CONTROL PROTEIN 2,
LYSOZYME
(Escherichia
virus
T4;
Saccharomyces
cerevisiae) 		5 / 9 THR A 625
ILE A 624
GLY A 631
PHE A 755
ILE A 634
 None
 1.27A 2y7wA-4n9nA:
undetectable		 2y7wA-4n9nA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L8L_A_DVAA6_0
(GRAMICIDIN D)		 4n9n STEROL UPTAKE
CONTROL PROTEIN 2,
LYSOZYME
(Saccharomyces
cerevisiae;
Escherichia
virus
T4) 		3 / 3 ALA A 711
VAL A 872
TRP A 732
 None
 0.74A 3l8lA-4n9nA:
undetectable
3l8lB-4n9nA:
undetectable		 3l8lA-4n9nA:
3.16
3l8lB-4n9nA:
3.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L8L_C_DVAC6_0
(GRAMICIDIN D)		 4n9n STEROL UPTAKE
CONTROL PROTEIN 2,
LYSOZYME
(Saccharomyces
cerevisiae;
Escherichia
virus
T4) 		3 / 3 ALA A 711
VAL A 872
TRP A 732
 None
 0.79A 3l8lC-4n9nA:
undetectable
3l8lD-4n9nA:
undetectable		 3l8lC-4n9nA:
3.16
3l8lD-4n9nA:
3.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IIZ_A_LURA201_1
(TRANSTHYRETIN)		 4n9n STEROL UPTAKE
CONTROL PROTEIN 2,
LYSOZYME
(Escherichia
virus
T4;
Saccharomyces
cerevisiae) 		3 / 3 LYS A1060
LEU A1015
ALA A1063
 None
 0.84A 4iizA-4n9nA:
undetectable		 4iizA-4n9nA:
16.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O7G_A_ASCA303_0
(PROBABLE
TRANSMEMBRANE
ASCORBATE
FERRIREDUCTASE 2)		 4n9n STEROL UPTAKE
CONTROL PROTEIN 2,
LYSOZYME
(Saccharomyces
cerevisiae;
Escherichia
virus
T4) 		4 / 7 PHE A1104
ILE A1100
TYR A1088
ASN A1068
 None
 1.27A 4o7gA-4n9nA:
undetectable
4o7gB-4n9nA:
undetectable		 4o7gA-4n9nA:
19.86
4o7gB-4n9nA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O8F_A_BRLA501_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 4n9n STEROL UPTAKE
CONTROL PROTEIN 2,
LYSOZYME
(Escherichia
virus
T4;
Saccharomyces
cerevisiae) 		4 / 5 GLY A 816
LEU A 703
LEU A 763
LEU A 855
 None
 0.86A 4o8fA-4n9nA:
undetectable		 4o8fA-4n9nA:
24.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R29_D_SAMD301_1
(UNCHARACTERIZED
PROTEIN)		 4n9n STEROL UPTAKE
CONTROL PROTEIN 2,
LYSOZYME
(Saccharomyces
cerevisiae;
Escherichia
virus
T4) 		3 / 3 ARG A1148
GLU A1011
TYR A1161
 None
 0.98A 4r29D-4n9nA:
undetectable		 4r29D-4n9nA:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1Y_B_LOCB502_1
(TUBULIN BETA CHAIN)		 4n9n STEROL UPTAKE
CONTROL PROTEIN 2,
LYSOZYME
(Escherichia
virus
T4;
Saccharomyces
cerevisiae) 		5 / 12 LEU A 683
LEU A 649
LEU A 705
THR A 659
ALA A 655
 None
 1.08A 4x1yB-4n9nA:
undetectable		 4x1yB-4n9nA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_B_SORB1341_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 4n9n STEROL UPTAKE
CONTROL PROTEIN 2,
LYSOZYME
(Saccharomyces
cerevisiae;
Escherichia
virus
T4) 		4 / 7 ARG A1145
PHE A1004
ARG A1008
ILE A1029
 None
 1.24A 5a06B-4n9nA:
undetectable		 5a06B-4n9nA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MKE_C_FK5C201_0
(PEPTIDYLPROLYL
ISOMERASE)		 4n9n STEROL UPTAKE
CONTROL PROTEIN 2,
LYSOZYME
(Saccharomyces
cerevisiae;
Escherichia
virus
T4) 		4 / 4 ASP A 696
ILE A 639
PRO A 640
LEU A 642
 None
 0.75A 6mkeB-4n9nA:
undetectable		 6mkeB-4n9nA:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MKE_D_FK5D201_0
(PEPTIDYLPROLYL
ISOMERASE)		 4n9n STEROL UPTAKE
CONTROL PROTEIN 2,
LYSOZYME
(Saccharomyces
cerevisiae;
Escherichia
virus
T4) 		4 / 4 ASP A 696
ILE A 639
PRO A 640
LEU A 642
 None
 0.77A 6mkeA-4n9nA:
undetectable		 6mkeA-4n9nA:
12.50