SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4n9q'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1O76_B_CAMB1420_0
(CYTOCHROME P450-CAM)		 4n9q FMN-DEPENDENT
NADH-AZOREDUCTASE 1
(Pseudomonas
aeruginosa) 		4 / 8 LEU A  91
VAL A   7
THR A  95
VAL A 102
 None
 1.15A 1o76B-4n9qA:
undetectable		 1o76B-4n9qA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QHF_A_ACTA508_0
(CHORISMATE SYNTHASE)		 4n9q FMN-DEPENDENT
NADH-AZOREDUCTASE 1
(Pseudomonas
aeruginosa) 		4 / 5 LEU A 171
ARG A 168
ALA A 170
ILE A 142
 None
 1.08A 2qhfA-4n9qA:
undetectable		 2qhfA-4n9qA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8I_A_RO7A1_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA)		 4n9q FMN-DEPENDENT
NADH-AZOREDUCTASE 1
(Pseudomonas
aeruginosa) 		4 / 7 GLN A 112
LEU A   5
LEU A 171
LEU A  77
 None
 0.92A 3g8iA-4n9qA:
undetectable		 3g8iA-4n9qA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXW_B_017B200_2
(HIV-1 PROTEASE)		 4n9q FMN-DEPENDENT
NADH-AZOREDUCTASE 1
(Pseudomonas
aeruginosa) 		5 / 10 LEU A  90
ALA A   6
VAL A  38
VAL A  24
ILE A   4
 None
None
SO4  A 304 ( 4.4A)
None
None
 1.05A 3oxwB-4n9qA:
undetectable		 3oxwB-4n9qA:
20.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3R6W_A_NFZA213_1
(FMN-DEPENDENT
NADH-AZOREDUCTASE 1)		 4n9q FMN-DEPENDENT
NADH-AZOREDUCTASE 1
(Pseudomonas
aeruginosa) 		5 / 10 PHE A  60
VAL A 114
PHE A 120
TYR A 131
PHE A 173
 UQ1  A 302 (-4.4A)
None
UQ1  A 302 (-3.9A)
UQ1  A 302 (-3.7A)
UQ1  A 302 (-3.0A)
 0.44A 3r6wA-4n9qA:
35.7
3r6wB-4n9qA:
34.2		 3r6wA-4n9qA:
100.00
3r6wB-4n9qA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3R6W_A_NFZA214_1
(FMN-DEPENDENT
NADH-AZOREDUCTASE 1)		 4n9q FMN-DEPENDENT
NADH-AZOREDUCTASE 1
(Pseudomonas
aeruginosa) 		5 / 10 ASN A  99
PHE A 100
GLY A 148
PHE A 151
ASN A 157
 FMN  A 301 (-2.9A)
FMN  A 301 (-3.9A)
FMN  A 301 (-3.6A)
FMN  A 301 (-3.8A)
None
 0.19A 3r6wA-4n9qA:
35.7
3r6wB-4n9qA:
34.2		 3r6wA-4n9qA:
100.00
3r6wB-4n9qA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3R6W_A_NFZA214_1
(FMN-DEPENDENT
NADH-AZOREDUCTASE 1)		 4n9q FMN-DEPENDENT
NADH-AZOREDUCTASE 1
(Pseudomonas
aeruginosa) 		5 / 10 PHE A  60
VAL A 114
PHE A 120
TYR A 131
PHE A 173
 UQ1  A 302 (-4.4A)
None
UQ1  A 302 (-3.9A)
UQ1  A 302 (-3.7A)
UQ1  A 302 (-3.0A)
 0.13A 3r6wA-4n9qA:
35.7
3r6wB-4n9qA:
34.2		 3r6wA-4n9qA:
100.00
3r6wB-4n9qA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LTW_A_486A303_1
(ANCESTRAL STEROID
RECEPTOR 2)		 4n9q FMN-DEPENDENT
NADH-AZOREDUCTASE 1
(Pseudomonas
aeruginosa) 		5 / 9 THR A 180
LEU A 141
LEU A 206
TYR A  29
LEU A  90
 None
 1.39A 4ltwA-4n9qA:
undetectable		 4ltwA-4n9qA:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FPD_A_PZAA1385_0
(HEAT SHOCK-RELATED
70KDA PROTEIN 2)		 4n9q FMN-DEPENDENT
NADH-AZOREDUCTASE 1
(Pseudomonas
aeruginosa) 		4 / 7 VAL A 181
ALA A 183
GLY A 152
ARG A 168
 None
 0.86A 5fpdA-4n9qA:
undetectable		 5fpdA-4n9qA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BQ4_B_ADNB401_1
(THERMOSPERMINE
SYNTHASE ACAULIS
PROTEIN)		 4n9q FMN-DEPENDENT
NADH-AZOREDUCTASE 1
(Pseudomonas
aeruginosa) 		5 / 12 ILE A 142
ASP A 164
ALA A 140
LEU A 171
ALA A 170
 None
 1.08A 6bq4B-4n9qA:
undetectable		 6bq4B-4n9qA:
13.74