SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4n9w'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EI6_D_PPFD412_1
(PHOSPHONOACETATE
HYDROLASE)		 4n9w GDP-MANNOSE-DEPENDEN
T
ALPHA-(1-2)-PHOSPHAT
IDYLINOSITOL
MANNOSYLTRANSFERASE
(Mycolicibacteriu
m
smegmatis) 		4 / 8 HIS A  94
ILE A 356
HIS A  92
HIS A  20
 None
 0.96A 1ei6D-4n9wA:
undetectable		 1ei6D-4n9wA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MAG_A_DVAA6_0
(GRAMICIDIN A)		 4n9w GDP-MANNOSE-DEPENDEN
T
ALPHA-(1-2)-PHOSPHAT
IDYLINOSITOL
MANNOSYLTRANSFERASE
(Mycolicibacteriu
m
smegmatis) 		3 / 3 ALA A  25
VAL A  27
TRP A 349
 None
 0.90A 1magA-4n9wA:
undetectable		 1magA-4n9wA:
6.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MAG_B_DVAB6_0
(GRAMICIDIN A)		 4n9w GDP-MANNOSE-DEPENDEN
T
ALPHA-(1-2)-PHOSPHAT
IDYLINOSITOL
MANNOSYLTRANSFERASE
(Mycolicibacteriu
m
smegmatis) 		3 / 3 ALA A  25
VAL A  27
TRP A 349
 None
 0.89A 1magB-4n9wA:
undetectable		 1magB-4n9wA:
6.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T6Z_B_RBFB596_1
(RIBOFLAVIN
KINASE/FMN
ADENYLYLTRANSFERASE)		 4n9w GDP-MANNOSE-DEPENDEN
T
ALPHA-(1-2)-PHOSPHAT
IDYLINOSITOL
MANNOSYLTRANSFERASE
(Mycolicibacteriu
m
smegmatis) 		5 / 11 VAL A 363
ARG A 144
GLU A 139
LEU A 106
ILE A 113
 None
 1.31A 1t6zB-4n9wA:
undetectable		 1t6zB-4n9wA:
23.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y0X_X_T44X500_2
(THYROID HORMONE
RECEPTOR BETA-1)		 4n9w GDP-MANNOSE-DEPENDEN
T
ALPHA-(1-2)-PHOSPHAT
IDYLINOSITOL
MANNOSYLTRANSFERASE
(Mycolicibacteriu
m
smegmatis) 		4 / 5 ILE A 225
SER A 262
ARG A 186
LEU A 192
 None
 1.17A 1y0xX-4n9wA:
undetectable		 1y0xX-4n9wA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_F_SC2F1291_1
(FICOLIN-2)		 4n9w GDP-MANNOSE-DEPENDEN
T
ALPHA-(1-2)-PHOSPHAT
IDYLINOSITOL
MANNOSYLTRANSFERASE
(Mycolicibacteriu
m
smegmatis) 		4 / 6 SER A 262
LEU A 181
ASP A 264
GLU A 222
 None
 1.20A 2j2pE-4n9wA:
undetectable
2j2pF-4n9wA:
undetectable		 2j2pE-4n9wA:
20.51
2j2pF-4n9wA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y05_A_RALA801_1
(PROSTAGLANDIN
REDUCTASE 1)		 4n9w GDP-MANNOSE-DEPENDEN
T
ALPHA-(1-2)-PHOSPHAT
IDYLINOSITOL
MANNOSYLTRANSFERASE
(Mycolicibacteriu
m
smegmatis) 		4 / 8 VAL A 344
SER A 275
VAL A 290
VAL A 301
 None
GDP  A 401 (-3.5A)
None
None
 1.14A 2y05A-4n9wA:
6.0
2y05B-4n9wA:
6.2		 2y05A-4n9wA:
22.54
2y05B-4n9wA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VW1_D_CVID301_0
(PUTATIVE REGULATORY
PROTEIN)		 4n9w GDP-MANNOSE-DEPENDEN
T
ALPHA-(1-2)-PHOSPHAT
IDYLINOSITOL
MANNOSYLTRANSFERASE
(Mycolicibacteriu
m
smegmatis) 		5 / 12 LEU A 194
ILE A 278
ALA A 263
VAL A 344
PHE A 175
 GDP  A 401 (-4.8A)
GDP  A 401 (-4.9A)
None
None
None
 1.14A 3vw1D-4n9wA:
undetectable		 3vw1D-4n9wA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B17_A_SAMA1358_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE M)		 4n9w GDP-MANNOSE-DEPENDEN
T
ALPHA-(1-2)-PHOSPHAT
IDYLINOSITOL
MANNOSYLTRANSFERASE
(Mycolicibacteriu
m
smegmatis) 		5 / 12 SER A  19
GLY A  15
GLY A  16
ASP A 198
VAL A 226
 GDP  A 401 ( 4.0A)
GDP  A 401 (-3.6A)
GDP  A 401 (-3.7A)
None
GDP  A 401 (-4.9A)
 1.12A 4b17A-4n9wA:
3.6		 4b17A-4n9wA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_G_HCYG900_2
(GLUCOCORTICOID
RECEPTOR)		 4n9w GDP-MANNOSE-DEPENDEN
T
ALPHA-(1-2)-PHOSPHAT
IDYLINOSITOL
MANNOSYLTRANSFERASE
(Mycolicibacteriu
m
smegmatis) 		3 / 3 LEU A 280
MET A 260
TYR A 336
 None
 0.95A 4p6xG-4n9wA:
undetectable		 4p6xG-4n9wA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WCX_C_SAMC503_0
(BIOTIN AND THIAMIN
SYNTHESIS ASSOCIATED)		 4n9w GDP-MANNOSE-DEPENDEN
T
ALPHA-(1-2)-PHOSPHAT
IDYLINOSITOL
MANNOSYLTRANSFERASE
(Mycolicibacteriu
m
smegmatis) 		5 / 12 GLY A 249
GLU A 231
LEU A 207
PRO A 269
ALA A 263
 None
 1.25A 4wcxC-4n9wA:
2.4		 4wcxC-4n9wA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XP6_A_B40A601_1
(TRANSPORTER)		 4n9w GDP-MANNOSE-DEPENDEN
T
ALPHA-(1-2)-PHOSPHAT
IDYLINOSITOL
MANNOSYLTRANSFERASE
(Mycolicibacteriu
m
smegmatis) 		4 / 5 ASP A 232
ASP A 198
PHE A 247
GLY A 229
 None
 1.24A 4xp6A-4n9wA:
undetectable		 4xp6A-4n9wA:
23.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUM_A_IMNA502_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 4n9w GDP-MANNOSE-DEPENDEN
T
ALPHA-(1-2)-PHOSPHAT
IDYLINOSITOL
MANNOSYLTRANSFERASE
(Mycolicibacteriu
m
smegmatis) 		4 / 7 GLU A 361
ILE A 356
ARG A  29
ILE A   3
 None
 0.97A 4xumA-4n9wA:
undetectable		 4xumA-4n9wA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESK_A_1YNA701_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 4n9w GDP-MANNOSE-DEPENDEN
T
ALPHA-(1-2)-PHOSPHAT
IDYLINOSITOL
MANNOSYLTRANSFERASE
(Mycolicibacteriu
m
smegmatis) 		4 / 4 ALA A 146
PRO A  96
LEU A  91
HIS A  92
 None
 1.24A 5eskA-4n9wA:
undetectable		 5eskA-4n9wA:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_H_CVIH301_1
(REGULATORY PROTEIN
TETR)		 4n9w GDP-MANNOSE-DEPENDEN
T
ALPHA-(1-2)-PHOSPHAT
IDYLINOSITOL
MANNOSYLTRANSFERASE
(Mycolicibacteriu
m
smegmatis) 		4 / 8 GLN A 250
GLY A 195
ILE A 225
GLN A 237
 None
GDP  A 401 ( 4.7A)
None
None
 1.02A 5vlmH-4n9wA:
undetectable		 5vlmH-4n9wA:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VNC_C_GCSC801_1
(GLYCOGEN [STARCH]
SYNTHASE ISOFORM 2)		 4n9w GDP-MANNOSE-DEPENDEN
T
ALPHA-(1-2)-PHOSPHAT
IDYLINOSITOL
MANNOSYLTRANSFERASE
(Mycolicibacteriu
m
smegmatis) 		5 / 10 GLY A  16
HIS A 118
VAL A 147
ASN A 168
GLY A 277
 GDP  A 401 (-3.7A)
None
None
None
None
 0.63A 5vncC-4n9wA:
20.8		 5vncC-4n9wA:
13.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNE_A_ACRA602_1
(-)		 4n9w GDP-MANNOSE-DEPENDEN
T
ALPHA-(1-2)-PHOSPHAT
IDYLINOSITOL
MANNOSYLTRANSFERASE
(Mycolicibacteriu
m
smegmatis) 		5 / 12 GLY A  15
GLY A  16
VAL A 147
ASN A 168
GLY A 277
 GDP  A 401 (-3.6A)
GDP  A 401 (-3.7A)
None
None
None
 0.94A 6gneA-4n9wA:
24.5		 6gneA-4n9wA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNE_B_ACRB602_1
(-)		 4n9w GDP-MANNOSE-DEPENDEN
T
ALPHA-(1-2)-PHOSPHAT
IDYLINOSITOL
MANNOSYLTRANSFERASE
(Mycolicibacteriu
m
smegmatis) 		5 / 12 GLY A  15
GLY A  16
VAL A 147
ASN A 168
GLY A 277
 GDP  A 401 (-3.6A)
GDP  A 401 (-3.7A)
None
None
None
 0.94A 6gneB-4n9wA:
24.5		 6gneB-4n9wA:
21.25