SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4n9x'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DDR_B_MTXB200_1
(DIHYDROFOLATE
REDUCTASE)		 4n9x PUTATIVE
MONOOXYGENASE
(Pectobacterium
atrosepticum) 		5 / 12 ILE A   8
ALA A  30
ILE A 326
ARG A 318
LEU A 316
 None
 1.09A 1ddrB-4n9xA:
undetectable		 1ddrB-4n9xA:
16.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DDS_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 4n9x PUTATIVE
MONOOXYGENASE
(Pectobacterium
atrosepticum) 		5 / 12 ILE A   8
ALA A  30
ILE A 326
ARG A 318
LEU A 316
 None
 1.02A 1ddsA-4n9xA:
undetectable		 1ddsA-4n9xA:
16.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JOL_A_FFOA161_0
(DIHYDROFOLATE
REDUCTASE)		 4n9x PUTATIVE
MONOOXYGENASE
(Pectobacterium
atrosepticum) 		5 / 12 ILE A   8
ALA A  30
ILE A 326
ARG A 318
LEU A 316
 None
 1.20A 1jolA-4n9xA:
undetectable		 1jolA-4n9xA:
17.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RX8_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 4n9x PUTATIVE
MONOOXYGENASE
(Pectobacterium
atrosepticum) 		5 / 12 ILE A   8
ALA A  30
ILE A 326
ARG A 318
LEU A 316
 None
 1.04A 1rx8A-4n9xA:
undetectable		 1rx8A-4n9xA:
17.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWJ_A_BAXA1723_2
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 4n9x PUTATIVE
MONOOXYGENASE
(Pectobacterium
atrosepticum) 		4 / 7 LEU A  22
ILE A   8
ILE A 127
ASP A   5
 None
 0.84A 1uwjA-4n9xA:
undetectable		 1uwjA-4n9xA:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WSV_A_THHA3001_0
(AMINOMETHYLTRANSFERA
SE)		 4n9x PUTATIVE
MONOOXYGENASE
(Pectobacterium
atrosepticum) 		5 / 12 THR A 156
LEU A 155
ILE A 147
VAL A 138
LEU A 130
 None
 1.27A 1wsvA-4n9xA:
undetectable		 1wsvA-4n9xA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WSV_B_THHB4001_0
(AMINOMETHYLTRANSFERA
SE)		 4n9x PUTATIVE
MONOOXYGENASE
(Pectobacterium
atrosepticum) 		5 / 12 THR A 156
LEU A 155
ILE A 147
VAL A 138
LEU A 130
 None
 1.29A 1wsvB-4n9xA:
undetectable		 1wsvB-4n9xA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDK_F_9CRF1600_2
(RETINOIC ACID
RECEPTOR, BETA)		 4n9x PUTATIVE
MONOOXYGENASE
(Pectobacterium
atrosepticum) 		3 / 3 LEU A 257
PHE A 214
ARG A 247
 None
 0.83A 1xdkF-4n9xA:
undetectable		 1xdkF-4n9xA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OIP_B_MTXB609_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 4n9x PUTATIVE
MONOOXYGENASE
(Pectobacterium
atrosepticum) 		5 / 12 LEU A  32
LEU A 155
LYS A   1
SER A   3
THR A 128
 None
 1.23A 2oipB-4n9xA:
undetectable		 2oipB-4n9xA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AOD_C_RFPC2002_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 4n9x PUTATIVE
MONOOXYGENASE
(Pectobacterium
atrosepticum) 		5 / 12 PHE A   4
ALA A 157
ARG A 318
GLY A 327
ARG A 283
 None
 1.25A 3aodC-4n9xA:
undetectable		 3aodC-4n9xA:
17.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLD_B_GW6B2_2
(GLUCOCORTICOID
RECEPTOR)		 4n9x PUTATIVE
MONOOXYGENASE
(Pectobacterium
atrosepticum) 		4 / 8 LEU A 104
ALA A 298
LEU A 297
GLN A  82
 None
 0.77A 3cldB-4n9xA:
undetectable		 3cldB-4n9xA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DDY_A_RBFA187_1
(LUMAZINE PROTEIN)		 4n9x PUTATIVE
MONOOXYGENASE
(Pectobacterium
atrosepticum) 		5 / 12 ASN A 110
ASP A 164
ALA A 291
THR A 293
ASN A 303
 None
 1.18A 3ddyA-4n9xA:
undetectable		 3ddyA-4n9xA:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JWQ_D_VIAD901_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
CATALYTIC DOMAIN,
CONE CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
SUBUNIT ALPHA
CHIMERA)		 4n9x PUTATIVE
MONOOXYGENASE
(Pectobacterium
atrosepticum) 		5 / 11 ARG A  28
GLN A  23
LEU A  22
ALA A 163
LEU A 130
 None
 1.49A 3jwqA-4n9xA:
undetectable
3jwqD-4n9xA:
undetectable		 3jwqA-4n9xA:
21.50
3jwqD-4n9xA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JX1_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4n9x PUTATIVE
MONOOXYGENASE
(Pectobacterium
atrosepticum) 		4 / 8 PHE A 101
GLU A  97
SER A  95
VAL A 386
 None
 1.31A 3jx1A-4n9xA:
undetectable
3jx1B-4n9xA:
undetectable		 3jx1A-4n9xA:
22.15
3jx1B-4n9xA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N3I_A_ROCA201_2
(PROTEASE)		 4n9x PUTATIVE
MONOOXYGENASE
(Pectobacterium
atrosepticum) 		4 / 6 ILE A  29
ASP A 289
GLY A  10
VAL A 285
 None
 0.92A 3n3iA-4n9xA:
undetectable		 3n3iA-4n9xA:
17.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N61_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE)		 4n9x PUTATIVE
MONOOXYGENASE
(Pectobacterium
atrosepticum) 		4 / 7 PHE A 101
GLU A  97
SER A  95
VAL A 386
 None
 1.31A 3n61A-4n9xA:
undetectable
3n61B-4n9xA:
undetectable		 3n61A-4n9xA:
22.15
3n61B-4n9xA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLY_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4n9x PUTATIVE
MONOOXYGENASE
(Pectobacterium
atrosepticum) 		4 / 8 PHE A 101
GLU A  97
SER A  95
VAL A 386
 None
 1.28A 3nlyA-4n9xA:
undetectable
3nlyB-4n9xA:
undetectable		 3nlyA-4n9xA:
22.15
3nlyB-4n9xA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NVK_I_SAMI228_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 4n9x PUTATIVE
MONOOXYGENASE
(Pectobacterium
atrosepticum) 		5 / 12 GLY A 288
ALA A 163
PHE A 279
ALA A 276
ASP A 289
 None
 1.08A 3nvkI-4n9xA:
4.1		 3nvkI-4n9xA:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NVK_J_SAMJ228_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE
NOP5/NOP56 RELATED
PROTEIN)		 4n9x PUTATIVE
MONOOXYGENASE
(Pectobacterium
atrosepticum) 		5 / 12 GLY A 288
ALA A 163
PHE A 279
ALA A 276
ASP A 289
 None
 1.16A 3nvkF-4n9xA:
undetectable
3nvkJ-4n9xA:
4.0		 3nvkF-4n9xA:
23.22
3nvkJ-4n9xA:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXV_C_478C200_1
(HIV-1 PROTEASE)		 4n9x PUTATIVE
MONOOXYGENASE
(Pectobacterium
atrosepticum) 		5 / 9 LEU A 155
ALA A 145
VAL A 138
VAL A 161
ILE A 147
 None
 0.89A 3oxvC-4n9xA:
undetectable		 3oxvC-4n9xA:
12.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXW_D_017D200_2
(HIV-1 PROTEASE)		 4n9x PUTATIVE
MONOOXYGENASE
(Pectobacterium
atrosepticum) 		5 / 10 LEU A 155
ALA A 145
VAL A 138
VAL A 161
ILE A 147
 None
 0.88A 3oxwD-4n9xA:
undetectable		 3oxwD-4n9xA:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QXV_D_MTXD2000_2
(ANTI-METHOTREXATE
CDR1-4 GRAFT VHH)		 4n9x PUTATIVE
MONOOXYGENASE
(Pectobacterium
atrosepticum) 		3 / 3 LEU A 117
ARG A  62
ASN A 303
 None
 0.70A 3qxvD-4n9xA:
undetectable		 3qxvD-4n9xA:
13.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RQL_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4n9x PUTATIVE
MONOOXYGENASE
(Pectobacterium
atrosepticum) 		4 / 8 PHE A 101
GLU A  97
SER A  95
VAL A 386
 None
 1.28A 3rqlA-4n9xA:
undetectable
3rqlB-4n9xA:
undetectable		 3rqlA-4n9xA:
22.15
3rqlB-4n9xA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T7S_B_SAMB300_0
(PUTATIVE
METHYLTRANSFERASE)		 4n9x PUTATIVE
MONOOXYGENASE
(Pectobacterium
atrosepticum) 		5 / 12 GLN A 114
GLY A  15
GLY A  12
ASP A 164
ALA A  17
 None
 1.26A 3t7sB-4n9xA:
2.5		 3t7sB-4n9xA:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T7S_D_SAMD300_0
(PUTATIVE
METHYLTRANSFERASE)		 4n9x PUTATIVE
MONOOXYGENASE
(Pectobacterium
atrosepticum) 		5 / 12 GLN A 114
GLY A  15
GLY A  12
ASP A 164
ALA A  17
 None
 1.24A 3t7sD-4n9xA:
3.2		 3t7sD-4n9xA:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACB_C_DXCC1475_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 4n9x PUTATIVE
MONOOXYGENASE
(Pectobacterium
atrosepticum) 		4 / 8 ASP A 126
ILE A  29
VAL A 161
GLY A  15
 None
 0.82A 4acbC-4n9xA:
undetectable		 4acbC-4n9xA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CAP_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4n9x PUTATIVE
MONOOXYGENASE
(Pectobacterium
atrosepticum) 		4 / 8 PHE A 101
GLU A  97
SER A  95
VAL A 386
 None
 1.29A 4capA-4n9xA:
undetectable
4capB-4n9xA:
undetectable		 4capA-4n9xA:
22.15
4capB-4n9xA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D32_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4n9x PUTATIVE
MONOOXYGENASE
(Pectobacterium
atrosepticum) 		4 / 8 PHE A 101
GLU A  97
SER A  95
VAL A 386
 None
 1.28A 4d32A-4n9xA:
undetectable
4d32B-4n9xA:
undetectable		 4d32A-4n9xA:
22.15
4d32B-4n9xA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E3H_A_HQEA303_1
(CARBONIC ANHYDRASE 2)		 4n9x PUTATIVE
MONOOXYGENASE
(Pectobacterium
atrosepticum) 		5 / 10 VAL A 285
LEU A 159
VAL A 161
LEU A 316
VAL A   6
 None
 0.94A 4e3hA-4n9xA:
undetectable		 4e3hA-4n9xA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KY8_A_MTXA603_1
(BIFUNCTIONAL
THYMIDYLATE
SYNTHASE-DIHYDROFOLA
TE REDUCTASE)		 4n9x PUTATIVE
MONOOXYGENASE
(Pectobacterium
atrosepticum) 		5 / 12 LEU A  32
LEU A 155
LYS A   1
SER A   3
THR A 128
 None
 1.12A 4ky8A-4n9xA:
undetectable		 4ky8A-4n9xA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LG1_A_SAMA301_0
(PROTEIN-LYSINE
METHYLTRANSFERASE
METTL21D)		 4n9x PUTATIVE
MONOOXYGENASE
(Pectobacterium
atrosepticum) 		5 / 12 ALA A 121
GLY A  15
GLY A  12
ASP A 164
ALA A  19
 None
 1.09A 4lg1A-4n9xA:
3.4		 4lg1A-4n9xA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LG1_C_SAMC301_0
(PROTEIN-LYSINE
METHYLTRANSFERASE
METTL21D)		 4n9x PUTATIVE
MONOOXYGENASE
(Pectobacterium
atrosepticum) 		5 / 12 ALA A 121
GLY A  15
GLY A  12
ASP A 164
ALA A  19
 None
 1.07A 4lg1C-4n9xA:
3.4		 4lg1C-4n9xA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QI9_C_MTXC201_1
(DIHYDROFOLATE
REDUCTASE)		 4n9x PUTATIVE
MONOOXYGENASE
(Pectobacterium
atrosepticum) 		5 / 11 ILE A   8
ALA A  30
ILE A 326
ARG A 318
LEU A 316
 None
 1.13A 4qi9C-4n9xA:
undetectable		 4qi9C-4n9xA:
16.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V3Y_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4n9x PUTATIVE
MONOOXYGENASE
(Pectobacterium
atrosepticum) 		4 / 8 PHE A 101
GLU A  97
SER A  95
VAL A 386
 None
 1.31A 4v3yA-4n9xA:
undetectable
4v3yB-4n9xA:
undetectable		 4v3yA-4n9xA:
22.15
4v3yB-4n9xA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HI6_B_MTXB201_1
(DIHYDROFOLATE
REDUCTASE)		 4n9x PUTATIVE
MONOOXYGENASE
(Pectobacterium
atrosepticum) 		5 / 12 ILE A   8
ALA A  30
ILE A 326
ARG A 318
LEU A 316
 None
 1.14A 5hi6B-4n9xA:
undetectable		 5hi6B-4n9xA:
18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UO7_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4n9x PUTATIVE
MONOOXYGENASE
(Pectobacterium
atrosepticum) 		4 / 8 SER A  95
VAL A 386
PHE A 101
GLU A  97
 None
 1.32A 5uo7A-4n9xA:
undetectable
5uo7B-4n9xA:
undetectable		 5uo7A-4n9xA:
21.24
5uo7B-4n9xA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6IEY_A_CLMA401_0
(ESTERASE)		 4n9x PUTATIVE
MONOOXYGENASE
(Pectobacterium
atrosepticum) 		5 / 11 ILE A 211
LEU A 297
HIS A 295
GLY A 301
ALA A 187
 None
 1.24A 6ieyA-4n9xA:
undetectable
6ieyB-4n9xA:
undetectable		 6ieyA-4n9xA:
23.44
6ieyB-4n9xA:
23.44