SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4nae'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NW3_A_SAMA500_0
(HISTONE
METHYLTRANSFERASE
DOT1L)		 4nae HEPTAPRENYLGLYCERYL
PHOSPHATE SYNTHASE
(Geobacillus
kaustophilus) 		5 / 12 TYR A 118
GLU A 161
ALA A 115
LEU A 152
ASN A  86
 None
1GP  A 301 (-2.7A)
None
None
None
 1.34A 1nw3A-4naeA:
undetectable		 1nw3A-4naeA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AZQ_A_PCFA954_0
(CATECHOL
1,2-DIOXYGENASE)		 4nae HEPTAPRENYLGLYCERYL
PHOSPHATE SYNTHASE
(Geobacillus
kaustophilus) 		5 / 9 LEU A 160
HIS A 151
ALA A 149
TYR A 153
LEU A 155
 None
 1.43A 2azqA-4naeA:
undetectable		 2azqA-4naeA:
23.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QHF_A_NCAA493_0
(CHORISMATE SYNTHASE)		 4nae HEPTAPRENYLGLYCERYL
PHOSPHATE SYNTHASE
(Geobacillus
kaustophilus) 		5 / 11 THR A 222
ILE A 190
ALA A 215
ALA A 211
VAL A 208
 None
None
None
None
1GP  A 301 ( 4.6A)
 1.10A 2qhfA-4naeA:
undetectable		 2qhfA-4naeA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KSZ_A_CYSA620_0
(LACTOPEROXIDASE)		 4nae HEPTAPRENYLGLYCERYL
PHOSPHATE SYNTHASE
(Geobacillus
kaustophilus) 		3 / 3 ARG A  26
GLU A  25
PHE A  58
 None
 0.95A 4kszA-4naeA:
undetectable		 4kszA-4naeA:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BPH_A_ACTA403_0
(D-ALANINE--D-ALANINE
LIGASE)		 4nae HEPTAPRENYLGLYCERYL
PHOSPHATE SYNTHASE
(Geobacillus
kaustophilus) 		4 / 6 TYR A 213
LYS A  17
GLY A  38
LEU A  13
 None
 1.05A 5bphA-4naeA:
undetectable		 5bphA-4naeA:
23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BPH_D_ACTD403_0
(D-ALANINE--D-ALANINE
LIGASE)		 4nae HEPTAPRENYLGLYCERYL
PHOSPHATE SYNTHASE
(Geobacillus
kaustophilus) 		4 / 6 TYR A 213
LYS A  17
GLY A  38
LEU A  13
 None
 1.04A 5bphD-4naeA:
undetectable		 5bphD-4naeA:
23.62