SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4nap'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YVP_B_ACTB2002_0
(60-KDA SS-A/RO
RIBONUCLEOPROTEIN)		 4nap EXTRACELLULAR
SOLUTE-BINDING
PROTEIN, FAMILY 7
(Desulfovibrio
alaskensis) 		4 / 6 SER A 212
ALA A 151
SER A 150
THR A 211
 DTR  A 401 (-3.3A)
None
DTR  A 401 ( 4.6A)
DTR  A 401 (-3.0A)
 1.21A 1yvpB-4napA:
undetectable		 1yvpB-4napA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CFL_A_5CHA693_1
(LACTOTRANSFERRIN)		 4nap EXTRACELLULAR
SOLUTE-BINDING
PROTEIN, FAMILY 7
(Desulfovibrio
alaskensis) 		4 / 4 THR A 118
VAL A 277
GLY A 270
THR A 269
 None
 0.95A 3cflA-4napA:
2.1		 3cflA-4napA:
23.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PP7_B_SVRB499_1
(PYRUVATE KINASE)		 4nap EXTRACELLULAR
SOLUTE-BINDING
PROTEIN, FAMILY 7
(Desulfovibrio
alaskensis) 		5 / 10 THR A 149
PRO A 152
GLY A 116
GLY A 270
ALA A 120
 None
 1.31A 3pp7B-4napA:
undetectable		 3pp7B-4napA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DO3_B_0LAB602_1
(FATTY-ACID AMIDE
HYDROLASE 1)		 4nap EXTRACELLULAR
SOLUTE-BINDING
PROTEIN, FAMILY 7
(Desulfovibrio
alaskensis) 		4 / 6 LEU A 164
LEU A 167
ILE A 172
THR A 229
 None
 1.00A 4do3B-4napA:
2.0		 4do3B-4napA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NED_A_PFNA709_1
(LACTOTRANSFERRIN)		 4nap EXTRACELLULAR
SOLUTE-BINDING
PROTEIN, FAMILY 7
(Desulfovibrio
alaskensis) 		4 / 6 VAL A 215
ASP A 214
SER A 153
PHE A 148
 None
DTR  A 401 (-3.3A)
None
None
 1.18A 4nedA-4napA:
2.1		 4nedA-4napA:
23.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C6P_A_4YHA601_1
(PROTEIN C)		 4nap EXTRACELLULAR
SOLUTE-BINDING
PROTEIN, FAMILY 7
(Desulfovibrio
alaskensis) 		4 / 6 ALA A 120
SER A 124
GLN A  50
ASP A 214
 None
None
None
DTR  A 401 (-3.3A)
 1.22A 5c6pA-4napA:
undetectable		 5c6pA-4napA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5U6M_A_SALA503_1
(UDP-GLYCOSYLTRANSFER
ASE 74F2)		 4nap EXTRACELLULAR
SOLUTE-BINDING
PROTEIN, FAMILY 7
(Desulfovibrio
alaskensis) 		4 / 7 THR A  45
PHE A 238
MET A 219
THR A 211
 DTR  A 401 ( 3.7A)
DTR  A 401 (-4.7A)
DTR  A 401 ( 4.7A)
DTR  A 401 (-3.0A)
 1.41A 5u6mA-4napA:
undetectable		 5u6mA-4napA:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B58_A_ACTA608_0
(FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT)		 4nap EXTRACELLULAR
SOLUTE-BINDING
PROTEIN, FAMILY 7
(Desulfovibrio
alaskensis) 		3 / 3 GLY A 169
THR A 188
GLU A 171
 None
 0.54A 6b58A-4napA:
undetectable		 6b58A-4napA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CNJ_D_NCTD402_1
(NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
ALPHA-4
NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
BETA-2)		 4nap EXTRACELLULAR
SOLUTE-BINDING
PROTEIN, FAMILY 7
(Desulfovibrio
alaskensis) 		4 / 8 TYR A  37
TRP A  54
THR A 146
LEU A 258
 None
 1.28A 6cnjD-4napA:
undetectable
6cnjE-4napA:
2.1		 6cnjD-4napA:
14.10
6cnjE-4napA:
14.38