SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4nar'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DLS_A_MTXA188_1
(DIHYDROFOLATE
REDUCTASE)		 4nar PUTATIVE URONATE
ISOMERASE
(Thermotoga
maritima) 		5 / 12 ILE A 306
ALA A 271
PHE A 373
ILE A 188
PRO A 189
 None
 1.24A 1dlsA-4narA:
undetectable		 1dlsA-4narA:
17.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OQ5_A_CELA701_2
(CARBONIC ANHYDRASE
II)		 4nar PUTATIVE URONATE
ISOMERASE
(Thermotoga
maritima) 		4 / 4 HIS A 180
VAL A 176
THR A 157
LEU A 163
 SO4  A 501 (-4.0A)
None
None
None
 1.50A 1oq5A-4narA:
undetectable		 1oq5A-4narA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OSV_B_CHCB201_2
(BILE ACID RECEPTOR)		 4nar PUTATIVE URONATE
ISOMERASE
(Thermotoga
maritima) 		4 / 5 MET A 320
HIS A 352
ILE A 202
HIS A 154
 None
None
None
SO4  A 502 (-4.0A)
 1.48A 1osvB-4narA:
undetectable		 1osvB-4narA:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XZX_X_T3X500_2
(THYROID HORMONE
RECEPTOR BETA-1)		 4nar PUTATIVE URONATE
ISOMERASE
(Thermotoga
maritima) 		3 / 3 PHE A 101
ARG A 136
ASN A 135
 None
 0.71A 1xzxX-4narA:
undetectable		 1xzxX-4narA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OTH_A_NIMA300_1
(PHOSPHOLIPASE A2
VRV-PL-VIIIA)		 4nar PUTATIVE URONATE
ISOMERASE
(Thermotoga
maritima) 		4 / 5 LEU A  33
ALA A 216
ILE A 214
SER A 218
 None
 1.06A 2othA-4narA:
undetectable		 2othA-4narA:
13.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R2V_C_ACTC36_0
(GCN4 LEUCINE ZIPPER)		 4nar PUTATIVE URONATE
ISOMERASE
(Thermotoga
maritima) 		5 / 10 HIS A 180
ALA A 199
ALA A 182
ALA A 183
SER A 156
 SO4  A 501 (-4.0A)
None
None
None
None
 1.36A 2r2vC-4narA:
undetectable
2r2vF-4narA:
undetectable
2r2vG-4narA:
undetectable		 2r2vC-4narA:
5.88
2r2vF-4narA:
5.88
2r2vG-4narA:
5.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3A_A_TOPA1190_1
(DIHYDROFOLATE
REDUCTASE)		 4nar PUTATIVE URONATE
ISOMERASE
(Thermotoga
maritima) 		5 / 11 ILE A 306
ALA A 271
PHE A 373
ILE A 188
PRO A 189
 None
 1.15A 2w3aA-4narA:
undetectable		 2w3aA-4narA:
17.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C6G_A_VD3A701_2
(CYTOCHROME P450 2R1)		 4nar PUTATIVE URONATE
ISOMERASE
(Thermotoga
maritima) 		3 / 3 MET A 298
VAL A 375
GLU A 372
 None
 0.90A 3c6gA-4narA:
undetectable		 3c6gA-4narA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E9X_A_NIMA1_1
(LACTOTRANSFERRIN')		 4nar PUTATIVE URONATE
ISOMERASE
(Thermotoga
maritima) 		4 / 4 GLU A 372
GLY A 360
THR A 361
GLU A 369
 None
 1.03A 3e9xA-4narA:
undetectable		 3e9xA-4narA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T7V_A_SAMA992_0
(METHYLORNITHINE
SYNTHASE PYLB)		 4nar PUTATIVE URONATE
ISOMERASE
(Thermotoga
maritima) 		5 / 12 GLY A 358
GLY A 360
TYR A 334
LEU A 339
VAL A 353
 None
 1.11A 3t7vA-4narA:
undetectable		 3t7vA-4narA:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A3U_B_ACTB1358_0
(NADH:FLAVIN
OXIDOREDUCTASE/NADH
OXIDASE)		 4nar PUTATIVE URONATE
ISOMERASE
(Thermotoga
maritima) 		4 / 7 PRO A 189
ILE A 188
GLN A 293
GLY A 358
 None
 0.99A 4a3uB-4narA:
undetectable		 4a3uB-4narA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EYS_A_ACTA402_0
(MCCC FAMILY PROTEIN)		 4nar PUTATIVE URONATE
ISOMERASE
(Thermotoga
maritima) 		4 / 6 ASP A  38
ASP A 280
ARG A  74
GLU A  80
 None
 0.89A 4eysA-4narA:
undetectable		 4eysA-4narA:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J24_B_ESTB600_1
(ESTROGEN RECEPTOR
BETA)		 4nar PUTATIVE URONATE
ISOMERASE
(Thermotoga
maritima) 		5 / 12 MET A 223
LEU A 236
LEU A   5
ILE A 148
LEU A  47
 None
 1.21A 4j24B-4narA:
undetectable		 4j24B-4narA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YHA_F_MZMF302_1
(ALPHA-CARBONIC
ANHYDRASE)		 4nar PUTATIVE URONATE
ISOMERASE
(Thermotoga
maritima) 		5 / 10 ASP A 177
ASN A 348
HIS A 154
VAL A 176
THR A 157
 None
SO4  A 501 (-3.5A)
SO4  A 502 (-4.0A)
None
None
 1.46A 4yhaF-4narA:
undetectable		 4yhaF-4narA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JKV_A_ASDA602_1
(AROMATASE)		 4nar PUTATIVE URONATE
ISOMERASE
(Thermotoga
maritima) 		5 / 12 ILE A 210
PHE A 211
ILE A 167
ALA A 171
VAL A  35
 None
 1.15A 5jkvA-4narA:
undetectable		 5jkvA-4narA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L0Z_A_SAMA304_0
(PROBABLE RNA
METHYLTRANSFERASE,
TRMH FAMILY)		 4nar PUTATIVE URONATE
ISOMERASE
(Thermotoga
maritima) 		6 / 12 GLY A 302
ARG A 266
ILE A 264
ASP A 406
SER A 409
LEU A 410
 None
 1.10A 5l0zA-4narA:
undetectable		 5l0zA-4narA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ODI_D_ACTD202_0
(METHYL-VIOLOGEN
REDUCING
HYDROGENASE, SUBUNIT
D)		 4nar PUTATIVE URONATE
ISOMERASE
(Thermotoga
maritima) 		3 / 3 HIS A 315
GLU A 281
TRP A 283
 None
None
SO4  A 501 (-4.2A)
 0.93A 5odiD-4narA:
undetectable		 5odiD-4narA:
12.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ODQ_D_ACTD202_0
(METHYL-VIOLOGEN
REDUCING
HYDROGENASE, SUBUNIT
D)		 4nar PUTATIVE URONATE
ISOMERASE
(Thermotoga
maritima) 		3 / 3 HIS A 315
GLU A 281
TRP A 283
 None
None
SO4  A 501 (-4.2A)
 0.96A 5odqD-4narA:
undetectable		 5odqD-4narA:
12.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ODR_D_ACTD202_0
(METHYL-VIOLOGEN
REDUCING
HYDROGENASE, SUBUNIT
D)		 4nar PUTATIVE URONATE
ISOMERASE
(Thermotoga
maritima) 		3 / 3 HIS A 315
GLU A 281
TRP A 283
 None
None
SO4  A 501 (-4.2A)
 0.91A 5odrD-4narA:
undetectable		 5odrD-4narA:
12.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VEU_B_RITB602_1
(CYTOCHROME P450 3A5)		 4nar PUTATIVE URONATE
ISOMERASE
(Thermotoga
maritima) 		5 / 12 LEU A  52
PHE A 245
ALA A 216
ILE A 214
GLY A 241
 None
 1.04A 5veuB-4narA:
undetectable		 5veuB-4narA:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_E_C2FE3001_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 4nar PUTATIVE URONATE
ISOMERASE
(Thermotoga
maritima) 		5 / 12 ARG A 247
GLY A 241
VAL A  48
LEU A  52
ILE A 238
 None
 1.09A 5vooE-4narA:
undetectable		 5vooE-4narA:
23.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GBN_C_ADNC501_2
(-)		 4nar PUTATIVE URONATE
ISOMERASE
(Thermotoga
maritima) 		4 / 5 THR A 157
THR A 284
HIS A  73
GLY A 150
 None
None
SO4  A 501 (-4.6A)
ACT  A 504 (-4.2A)
 1.15A 6gbnC-4narA:
2.6		 6gbnC-4narA:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_D_AM2D301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 4nar PUTATIVE URONATE
ISOMERASE
(Thermotoga
maritima) 		4 / 8 HIS A  73
ARG A 313
GLU A 281
ASP A 280
 SO4  A 501 (-4.6A)
None
None
None
 1.19A 6mn4D-4narA:
2.2		 6mn4D-4narA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MVX_A_K4DA1304_0
(ION TRANSPORT
PROTEIN)		 4nar PUTATIVE URONATE
ISOMERASE
(Thermotoga
maritima) 		4 / 6 LEU A  52
MET A 223
THR A  37
LEU A  33
 None
 1.06A 6mvxA-4narA:
undetectable
6mvxB-4narA:
undetectable
6mvxC-4narA:
undetectable		 6mvxA-4narA:
20.32
6mvxB-4narA:
20.32
6mvxC-4narA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6QXS_B_FOZB403_0
(THYMIDYLATE SYNTHASE)		 4nar PUTATIVE URONATE
ISOMERASE
(Thermotoga
maritima) 		5 / 12 LEU A  67
ILE A 170
ASN A 149
TYR A 242
ILE A 210
 None
 1.09A 6qxsB-4narA:
undetectable		 6qxsB-4narA:
22.70