SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4nas'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y4L_B_SVRB301_2
(PHOSPHOLIPASE A2
HOMOLOG 2)		 4nas RIBULOSE-BISPHOSPHAT
E CARBOXYLASE
(Alicyclobacillus
acidocaldarius) 		5 / 11 LEU A  94
LEU A  93
VAL A 286
GLY A 288
ARG A 292
 None
 1.13A 1y4lB-4nasA:
undetectable		 1y4lB-4nasA:
14.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_D_BEZD2385_0
(CES1 PROTEIN)		 4nas RIBULOSE-BISPHOSPHAT
E CARBOXYLASE
(Alicyclobacillus
acidocaldarius) 		4 / 5 LEU A 223
LEU A 238
LEU A 239
LEU A 253
 None
None
KCX  A 175 ( 4.4A)
None
 1.11A 1yajD-4nasA:
undetectable		 1yajD-4nasA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_F_SVRF502_2
(PHOSPHOLIPASE A2)		 4nas RIBULOSE-BISPHOSPHAT
E CARBOXYLASE
(Alicyclobacillus
acidocaldarius) 		4 / 5 ILE A 339
SER A 336
PRO A 335
PRO A 302
 None
 1.20A 3bjwC-4nasA:
undetectable		 3bjwC-4nasA:
11.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3J7Z_A_ERYA9000_0
(23S RRNA
50S RIBOSOMAL
PROTEIN L22
ERMCL NASCENT CHAIN)		 4nas RIBULOSE-BISPHOSPHAT
E CARBOXYLASE
(Alicyclobacillus
acidocaldarius) 		3 / 3 LYS A 406
ILE A 147
PHE A 148
 None
KCX  A 175 ( 3.9A)
None
 0.94A 3j7zS-4nasA:
undetectable
3j7za-4nasA:
undetectable		 3j7zS-4nasA:
14.82
3j7za-4nasA:
3.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZJQ_B_NCAB300_0
(PROTOGLOBIN)		 4nas RIBULOSE-BISPHOSPHAT
E CARBOXYLASE
(Alicyclobacillus
acidocaldarius) 		4 / 7 TYR A 195
VAL A 174
PHE A 148
ILE A 202
 None
KCX  A 175 ( 3.0A)
None
None
 0.98A 3zjqB-4nasA:
undetectable		 3zjqB-4nasA:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KQ8_A_ASDA602_1
(CYTOCHROME P450 19A1)		 4nas RIBULOSE-BISPHOSPHAT
E CARBOXYLASE
(Alicyclobacillus
acidocaldarius) 		5 / 10 ILE A 263
ALA A 296
ASP A 297
VAL A 356
LEU A 173
 None
 1.48A 4kq8A-4nasA:
undetectable		 4kq8A-4nasA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O33_A_TZNA501_1
(PHOSPHOGLYCERATE
KINASE 1)		 4nas RIBULOSE-BISPHOSPHAT
E CARBOXYLASE
(Alicyclobacillus
acidocaldarius) 		5 / 12 GLY A 369
ALA A 370
GLY A 373
PHE A 377
GLY A 365
 None
 0.80A 4o33A-4nasA:
undetectable		 4o33A-4nasA:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZF8_A_MYTA502_1
(BIFUNCTIONAL
P-450/NADPH-P450
REDUCTASE)		 4nas RIBULOSE-BISPHOSPHAT
E CARBOXYLASE
(Alicyclobacillus
acidocaldarius) 		4 / 6 LEU A 101
ILE A  32
ALA A  33
THR A  37
 None
 0.76A 4zf8A-4nasA:
undetectable		 4zf8A-4nasA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N9X_A_THRA601_0
(ADENYLATION DOMAIN)		 4nas RIBULOSE-BISPHOSPHAT
E CARBOXYLASE
(Alicyclobacillus
acidocaldarius) 		4 / 7 ASP A 379
PHE A 378
GLY A 169
GLY A 373
 None
 0.92A 5n9xA-4nasA:
undetectable		 5n9xA-4nasA:
25.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ODI_D_ACTD202_0
(METHYL-VIOLOGEN
REDUCING
HYDROGENASE, SUBUNIT
D)		 4nas RIBULOSE-BISPHOSPHAT
E CARBOXYLASE
(Alicyclobacillus
acidocaldarius) 		3 / 3 HIS A 386
GLU A 385
TRP A 382
 None
 0.85A 5odiD-4nasA:
undetectable		 5odiD-4nasA:
14.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ODQ_D_ACTD202_0
(METHYL-VIOLOGEN
REDUCING
HYDROGENASE, SUBUNIT
D)		 4nas RIBULOSE-BISPHOSPHAT
E CARBOXYLASE
(Alicyclobacillus
acidocaldarius) 		3 / 3 HIS A 386
GLU A 385
TRP A 382
 None
 0.82A 5odqD-4nasA:
undetectable		 5odqD-4nasA:
14.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ODR_D_ACTD202_0
(METHYL-VIOLOGEN
REDUCING
HYDROGENASE, SUBUNIT
D)		 4nas RIBULOSE-BISPHOSPHAT
E CARBOXYLASE
(Alicyclobacillus
acidocaldarius) 		3 / 3 HIS A 386
GLU A 385
TRP A 382
 None
 0.78A 5odrD-4nasA:
undetectable		 5odrD-4nasA:
14.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OV9_A_CVIA608_0
(ACETYLCHOLINESTERASE)		 4nas RIBULOSE-BISPHOSPHAT
E CARBOXYLASE
(Alicyclobacillus
acidocaldarius) 		4 / 7 THR A 155
LEU A 156
VAL A 192
TYR A 195
 None
 0.85A 5ov9A-4nasA:
undetectable		 5ov9A-4nasA:
24.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_A_ZITA501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		 4nas RIBULOSE-BISPHOSPHAT
E CARBOXYLASE
(Alicyclobacillus
acidocaldarius) 		4 / 7 GLU A 189
ALA A 231
GLY A 234
TYR A 212
 None
 1.08A 5uxdA-4nasA:
undetectable		 5uxdA-4nasA:
26.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_G_EY4G502_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 4nas RIBULOSE-BISPHOSPHAT
E CARBOXYLASE
(Alicyclobacillus
acidocaldarius) 		4 / 8 ILE A 298
VAL A 129
PRO A 262
TYR A 139
 None
 0.87A 6cduG-4nasA:
undetectable
6cduH-4nasA:
undetectable		 6cduG-4nasA:
21.93
6cduH-4nasA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6IFT_A_SAMA301_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE A)		 4nas RIBULOSE-BISPHOSPHAT
E CARBOXYLASE
(Alicyclobacillus
acidocaldarius) 		5 / 12 ILE A 298
GLY A 299
ALA A 294
LEU A 287
VAL A 356
 None
 1.05A 6iftA-4nasA:
undetectable		 6iftA-4nasA:
21.90