SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4nat'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RF4_A_FUNA201_1
(MACROPHAGE MIGRATION
INHIBITORY FACTOR)		 4nat PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE
(Staphylococcus
aureus) 		5 / 11 SER A 144
ILE A 143
VAL A 133
VAL A 136
ILE A 128
 None
 1.29A 3rf4A-4natA:
undetectable
3rf4C-4natA:
undetectable		 3rf4A-4natA:
18.83
3rf4C-4natA:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RF4_B_FUNB202_1
(MACROPHAGE MIGRATION
INHIBITORY FACTOR)		 4nat PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE
(Staphylococcus
aureus) 		5 / 11 ILE A 128
SER A 144
ILE A 143
VAL A 133
VAL A 136
 None
 1.31A 3rf4A-4natA:
undetectable
3rf4B-4natA:
undetectable		 3rf4A-4natA:
18.83
3rf4B-4natA:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RF4_C_FUNC203_1
(MACROPHAGE MIGRATION
INHIBITORY FACTOR)		 4nat PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE
(Staphylococcus
aureus) 		5 / 11 ILE A 128
SER A 144
ILE A 143
VAL A 133
VAL A 136
 None
 1.33A 3rf4B-4natA:
undetectable
3rf4C-4natA:
undetectable		 3rf4B-4natA:
18.83
3rf4C-4natA:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_B_W9TB513_1
(HEMOLYTIC LECTIN
CEL-III)		 4nat PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE
(Staphylococcus
aureus) 		4 / 6 THR A 123
ASN A 124
ASP A  21
ILE A  22
 None
 1.26A 3w9tB-4natA:
undetectable		 3w9tB-4natA:
15.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_B_HCYB1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		 4nat PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE
(Staphylococcus
aureus) 		5 / 12 SER A  11
VAL A  37
GLN A  58
ILE A  56
SER A  59
 ADP  A 203 (-3.0A)
None
None
None
None
 1.49A 4c49B-4natA:
undetectable		 4c49B-4natA:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LB2_A_DM5A602_1
(SERUM ALBUMIN)		 4nat PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE
(Staphylococcus
aureus) 		4 / 7 PRO A  14
VAL A 133
ALA A 137
PHE A 159
 None
 0.77A 4lb2A-4natA:
undetectable		 4lb2A-4natA:
12.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_A_CUA602_0
(THIOCYANATE
DEHYDROGENASE)		 4nat PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE
(Staphylococcus
aureus) 		3 / 3 LYS A  67
HIS A  34
HIS A  69
 None
 1.01A 5oexA-4natA:
undetectable		 5oexA-4natA:
15.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_B_CUB602_0
(THIOCYANATE
DEHYDROGENASE)		 4nat PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE
(Staphylococcus
aureus) 		3 / 3 LYS A  67
HIS A  34
HIS A  69
 None
 1.00A 5oexB-4natA:
undetectable		 5oexB-4natA:
15.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_C_CUC603_0
(THIOCYANATE
DEHYDROGENASE)		 4nat PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE
(Staphylococcus
aureus) 		3 / 3 LYS A  67
HIS A  34
HIS A  69
 None
 1.01A 5oexC-4natA:
undetectable		 5oexC-4natA:
15.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_D_CUD603_0
(THIOCYANATE
DEHYDROGENASE)		 4nat PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE
(Staphylococcus
aureus) 		3 / 3 LYS A  67
HIS A  34
HIS A  69
 None
 0.97A 5oexD-4natA:
undetectable		 5oexD-4natA:
15.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6JMJ_A_ASCA201_0
(PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE)		 4nat PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE
(Staphylococcus
aureus) 		4 / 5 GLY A  10
HIS A  19
SER A 129
SER A 130
 ADP  A 203 (-3.3A)
ADP  A 203 (-4.0A)
None
ADP  A 203 ( 4.6A)
 0.36A 6jmjA-4natA:
24.5		 6jmjA-4natA:
43.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6JNH_A_ASCA201_0
(PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE)		 4nat PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE
(Staphylococcus
aureus) 		5 / 7 GLY A  10
PHE A  12
HIS A  19
SER A 129
SER A 130
 ADP  A 203 (-3.3A)
ADP  A 203 (-4.4A)
ADP  A 203 (-4.0A)
None
ADP  A 203 ( 4.6A)
 0.34A 6jnhA-4natA:
24.5		 6jnhA-4natA:
43.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6JOG_A_ASCA201_0
(PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE)		 4nat PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE
(Staphylococcus
aureus) 		4 / 6 GLY A  10
HIS A  19
SER A 129
SER A 130
 ADP  A 203 (-3.3A)
ADP  A 203 (-4.0A)
None
ADP  A 203 ( 4.6A)
 0.39A 6jogA-4natA:
24.5		 6jogA-4natA:
43.12