SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4nax'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK1_A_T44A3004_1
(SERUM ALBUMIN)		 4nax GLUTATHIONE
S-TRANSFERASE,
N-TERMINAL DOMAIN
PROTEIN
(Pseudomonas
putida) 		4 / 6 GLU A  99
LEU A  97
VAL A  34
MET A  37
 None
 1.01A 1hk1A-4naxA:
3.1		 1hk1A-4naxA:
16.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TW4_B_CHDB1130_0
(FATTY ACID-BINDING
PROTEIN)		 4nax GLUTATHIONE
S-TRANSFERASE,
N-TERMINAL DOMAIN
PROTEIN
(Pseudomonas
putida) 		5 / 12 LEU A  94
LEU A 104
ILE A  36
ARG A 220
ILE A  74
 None
 1.26A 1tw4B-4naxA:
undetectable		 1tw4B-4naxA:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_B_SC2B1290_1
(FICOLIN-2)		 4nax GLUTATHIONE
S-TRANSFERASE,
N-TERMINAL DOMAIN
PROTEIN
(Pseudomonas
putida) 		4 / 8 LEU A 227
LEU A 218
ARG A 190
GLU A 194
 None
 1.07A 2j2pA-4naxA:
undetectable
2j2pB-4naxA:
undetectable		 2j2pA-4naxA:
19.14
2j2pB-4naxA:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZB7_A_NCAA901_0
(PROSTAGLANDIN
REDUCTASE 2)		 4nax GLUTATHIONE
S-TRANSFERASE,
N-TERMINAL DOMAIN
PROTEIN
(Pseudomonas
putida) 		4 / 5 TYR A  96
ILE A  74
LEU A  38
LEU A  43
 None
 1.18A 2zb7A-4naxA:
undetectable		 2zb7A-4naxA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZB8_A_IMNA800_1
(PROSTAGLANDIN
REDUCTASE 2)		 4nax GLUTATHIONE
S-TRANSFERASE,
N-TERMINAL DOMAIN
PROTEIN
(Pseudomonas
putida) 		5 / 9 THR A 115
TYR A 178
LEU A 168
VAL A 210
LEU A 164
 None
 1.39A 2zb8A-4naxA:
undetectable		 2zb8A-4naxA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BVA_A_T3A1314_1
(THIOMORPHOLINE-CARBO
XYLATE DEHYDROGENASE)		 4nax GLUTATHIONE
S-TRANSFERASE,
N-TERMINAL DOMAIN
PROTEIN
(Pseudomonas
putida) 		5 / 12 PHE A 139
GLY A 131
VAL A 133
HIS A 137
ARG A 195
 None
GDS  A 301 (-3.4A)
None
FMT  A 303 (-3.7A)
None
 1.45A 4bvaA-4naxA:
undetectable		 4bvaA-4naxA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LB0_B_ACTB401_0
(UNCHARACTERIZED
PROTEIN)		 4nax GLUTATHIONE
S-TRANSFERASE,
N-TERMINAL DOMAIN
PROTEIN
(Pseudomonas
putida) 		4 / 5 GLU A 194
VAL A 193
LEU A 214
PHE A 204
 None
 1.05A 4lb0B-4naxA:
undetectable		 4lb0B-4naxA:
21.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MF6_A_BEZA303_0
(GLUTATHIONE
S-TRANSFERASE DOMAIN)		 4nax GLUTATHIONE
S-TRANSFERASE,
N-TERMINAL DOMAIN
PROTEIN
(Pseudomonas
putida) 		5 / 5 THR A  28
PRO A  29
PHE A 139
ASN A 191
TYR A 196
 GDS  A 301 (-3.5A)
GDS  A 301 ( 4.5A)
None
None
None
 0.30A 4mf6A-4naxA:
36.9		 4mf6A-4naxA:
65.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R38_C_RBFC201_1
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 4nax GLUTATHIONE
S-TRANSFERASE,
N-TERMINAL DOMAIN
PROTEIN
(Pseudomonas
putida) 		5 / 12 GLN A 111
ALA A 181
ILE A 180
GLY A 102
GLN A 107
 None
 1.09A 4r38C-4naxA:
undetectable		 4r38C-4naxA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R38_D_RBFD201_1
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 4nax GLUTATHIONE
S-TRANSFERASE,
N-TERMINAL DOMAIN
PROTEIN
(Pseudomonas
putida) 		5 / 12 GLN A 111
ALA A 181
ILE A 180
GLY A 102
GLN A 107
 None
 1.13A 4r38D-4naxA:
undetectable		 4r38D-4naxA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4F_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 4nax GLUTATHIONE
S-TRANSFERASE,
N-TERMINAL DOMAIN
PROTEIN
(Pseudomonas
putida) 		4 / 7 LEU A  23
PRO A 230
LEU A  38
GLU A  39
 None
 0.90A 4z4fA-4naxA:
undetectable		 4z4fA-4naxA:
15.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T7B_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 4nax GLUTATHIONE
S-TRANSFERASE,
N-TERMINAL DOMAIN
PROTEIN
(Pseudomonas
putida) 		4 / 7 LEU A  23
PRO A 230
LEU A  38
GLU A  39
 None
 0.97A 5t7bA-4naxA:
undetectable		 5t7bA-4naxA:
15.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5UUN_A_ACTA303_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 4nax GLUTATHIONE
S-TRANSFERASE,
N-TERMINAL DOMAIN
PROTEIN
(Pseudomonas
putida) 		3 / 3 GLU A 177
TYR A 178
ARG A 220
 None
 0.57A 5uunA-4naxA:
26.9		 5uunA-4naxA:
34.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5UUN_B_ACTB305_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 4nax GLUTATHIONE
S-TRANSFERASE,
N-TERMINAL DOMAIN
PROTEIN
(Pseudomonas
putida) 		3 / 3 GLU A 177
TYR A 178
ARG A 220
 None
 0.58A 5uunB-4naxA:
27.2		 5uunB-4naxA:
34.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X6Y_A_SAMA901_0
(MRNA CAPPING ENZYME
P5)		 4nax GLUTATHIONE
S-TRANSFERASE,
N-TERMINAL DOMAIN
PROTEIN
(Pseudomonas
putida) 		5 / 11 VAL A 133
GLY A 134
ALA A 198
LEU A 192
ASN A 191
 None
 1.17A 5x6yA-4naxA:
undetectable		 5x6yA-4naxA:
14.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X6Y_C_SAMC901_0
(MRNA CAPPING ENZYME
P5)		 4nax GLUTATHIONE
S-TRANSFERASE,
N-TERMINAL DOMAIN
PROTEIN
(Pseudomonas
putida) 		5 / 11 VAL A 133
GLY A 134
ALA A 198
LEU A 192
ASN A 191
 None
 1.15A 5x6yC-4naxA:
undetectable		 5x6yC-4naxA:
14.98