SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4nb0'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DDS_B_MTXB201_1
(DIHYDROFOLATE
REDUCTASE)		 4nb0 METALLOTHIOL
TRANSFERASE FOSB
(Staphylococcus
aureus) 		5 / 12 ILE A  71
ALA A  43
LEU A 114
ILE A  25
LEU A  83
 None
 1.08A 1ddsB-4nb0A:
undetectable		 1ddsB-4nb0A:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DYI_B_FOLB161_0
(DIHYDROFOLATE
REDUCTASE)		 4nb0 METALLOTHIOL
TRANSFERASE FOSB
(Staphylococcus
aureus) 		5 / 12 ILE A  71
ALA A  43
LEU A 114
ILE A  25
LEU A  83
 None
 1.12A 1dyiB-4nb0A:
undetectable		 1dyiB-4nb0A:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JOL_B_FFOB361_0
(DIHYDROFOLATE
REDUCTASE)		 4nb0 METALLOTHIOL
TRANSFERASE FOSB
(Staphylococcus
aureus) 		5 / 12 ILE A  71
ALA A  43
LEU A 114
ILE A  25
LEU A  83
 None
 1.11A 1jolB-4nb0A:
undetectable		 1jolB-4nb0A:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UPF_A_URFA999_1
(URACIL
PHOSPHORIBOSYLTRANSF
ERASE)		 4nb0 METALLOTHIOL
TRANSFERASE FOSB
(Staphylococcus
aureus) 		4 / 5 ALA A  38
TYR A  22
ILE A  19
ASP A 108
 None
 1.05A 1upfA-4nb0A:
undetectable		 1upfA-4nb0A:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UPF_C_URFC999_1
(URACIL
PHOSPHORIBOSYLTRANSF
ERASE)		 4nb0 METALLOTHIOL
TRANSFERASE FOSB
(Staphylococcus
aureus) 		4 / 5 ALA A  38
TYR A  22
ILE A  19
ASP A 108
 None
 0.99A 1upfC-4nb0A:
undetectable		 1upfC-4nb0A:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QL0_A_FOLA160_0
(DIHYDROFOLATE
REDUCTASE)		 4nb0 METALLOTHIOL
TRANSFERASE FOSB
(Staphylococcus
aureus) 		5 / 12 ILE A  71
ALA A  43
LEU A 114
ILE A  25
LEU A  83
 None
 1.07A 3ql0A-4nb0A:
undetectable		 3ql0A-4nb0A:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_R_CLMR221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4nb0 METALLOTHIOL
TRANSFERASE FOSB
(Staphylococcus
aureus) 		5 / 10 PHE A  69
PHE A 106
PHE A  21
LEU A  49
VAL A  12
 None
 1.43A 3u9fR-4nb0A:
undetectable		 3u9fR-4nb0A:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GH8_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 4nb0 METALLOTHIOL
TRANSFERASE FOSB
(Staphylococcus
aureus) 		5 / 12 ILE A  71
ALA A  43
LEU A 114
ILE A  25
LEU A  83
 None
 1.06A 4gh8A-4nb0A:
undetectable		 4gh8A-4nb0A:
23.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4IR0_A_FCNA202_1
(METALLOTHIOL
TRANSFERASE FOSB 2)		 4nb0 METALLOTHIOL
TRANSFERASE FOSB
(Staphylococcus
aureus) 		5 / 11 HIS A   7
CYH A   9
TRP A  46
ALA A  48
ASN A  50
 None
 0.45A 4ir0A-4nb0A:
15.0
4ir0B-4nb0A:
15.5		 4ir0A-4nb0A:
62.07
4ir0B-4nb0A:
62.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4IR0_B_FCNB202_1
(METALLOTHIOL
TRANSFERASE FOSB 2)		 4nb0 METALLOTHIOL
TRANSFERASE FOSB
(Staphylococcus
aureus) 		5 / 11 HIS A   7
CYH A   9
TRP A  46
ALA A  48
ASN A  50
 None
 0.50A 4ir0A-4nb0A:
15.0
4ir0B-4nb0A:
15.5		 4ir0A-4nb0A:
62.07
4ir0B-4nb0A:
62.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4JD1_A_FCNA202_1
(METALLOTHIOL
TRANSFERASE FOSB 2)		 4nb0 METALLOTHIOL
TRANSFERASE FOSB
(Staphylococcus
aureus) 		6 / 12 HIS A   7
CYH A   9
TYR A  39
TRP A  46
ALA A  48
ASN A  50
 None
 0.53A 4jd1A-4nb0A:
15.0
4jd1B-4nb0A:
15.1		 4jd1A-4nb0A:
62.07
4jd1B-4nb0A:
62.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4JD1_B_FCNB203_1
(METALLOTHIOL
TRANSFERASE FOSB 2)		 4nb0 METALLOTHIOL
TRANSFERASE FOSB
(Staphylococcus
aureus) 		6 / 12 HIS A   7
CYH A   9
TYR A  39
TRP A  46
ALA A  48
ASN A  50
 None
 0.48A 4jd1A-4nb0A:
15.0
4jd1B-4nb0A:
15.1		 4jd1A-4nb0A:
62.07
4jd1B-4nb0A:
62.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4JH3_A_FCNA204_1
(METALLOTHIOL
TRANSFERASE FOSB)		 4nb0 METALLOTHIOL
TRANSFERASE FOSB
(Staphylococcus
aureus) 		6 / 12 HIS A   7
CYH A   9
TYR A  39
TRP A  46
ALA A  48
ASN A  50
 None
 0.33A 4jh3A-4nb0A:
16.3
4jh3B-4nb0A:
16.3		 4jh3A-4nb0A:
60.42
4jh3B-4nb0A:
60.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4JH3_B_FCNB203_1
(METALLOTHIOL
TRANSFERASE FOSB)		 4nb0 METALLOTHIOL
TRANSFERASE FOSB
(Staphylococcus
aureus) 		5 / 11 HIS A   7
CYH A   9
TRP A  46
ALA A  48
ASN A  50
 None
 0.35A 4jh3A-4nb0A:
16.3
4jh3B-4nb0A:
16.3		 4jh3A-4nb0A:
60.42
4jh3B-4nb0A:
60.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4JH4_A_FCNA202_1
(METALLOTHIOL
TRANSFERASE FOSB)		 4nb0 METALLOTHIOL
TRANSFERASE FOSB
(Staphylococcus
aureus) 		5 / 11 HIS A   7
CYH A   9
TRP A  46
ALA A  48
ASN A  50
 None
 0.31A 4jh4A-4nb0A:
16.3
4jh4B-4nb0A:
16.3		 4jh4A-4nb0A:
60.42
4jh4B-4nb0A:
60.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4JH4_B_FCNB202_1
(METALLOTHIOL
TRANSFERASE FOSB)		 4nb0 METALLOTHIOL
TRANSFERASE FOSB
(Staphylococcus
aureus) 		5 / 11 HIS A   7
CYH A   9
TRP A  46
ALA A  48
ASN A  50
 None
 0.33A 4jh4A-4nb0A:
16.3
4jh4B-4nb0A:
16.3		 4jh4A-4nb0A:
60.42
4jh4B-4nb0A:
60.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4JH5_A_FCNA202_1
(METALLOTHIOL
TRANSFERASE FOSB)		 4nb0 METALLOTHIOL
TRANSFERASE FOSB
(Staphylococcus
aureus) 		5 / 11 HIS A   7
CYH A   9
TRP A  46
ALA A  48
ASN A  50
 None
 0.35A 4jh5A-4nb0A:
16.3
4jh5B-4nb0A:
16.2		 4jh5A-4nb0A:
60.42
4jh5B-4nb0A:
60.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4JH5_B_FCNB203_1
(METALLOTHIOL
TRANSFERASE FOSB)		 4nb0 METALLOTHIOL
TRANSFERASE FOSB
(Staphylococcus
aureus) 		5 / 11 HIS A   7
CYH A   9
TRP A  46
ALA A  48
ASN A  50
 None
 0.37A 4jh5A-4nb0A:
16.3
4jh5B-4nb0A:
16.2		 4jh5A-4nb0A:
60.42
4jh5B-4nb0A:
60.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QLF_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4nb0 METALLOTHIOL
TRANSFERASE FOSB
(Staphylococcus
aureus) 		5 / 11 ILE A  71
ALA A  43
LEU A 114
ILE A  25
LEU A  83
 None
 1.12A 4qlfA-4nb0A:
undetectable		 4qlfA-4nb0A:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RGC_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4nb0 METALLOTHIOL
TRANSFERASE FOSB
(Staphylococcus
aureus) 		5 / 12 ILE A  71
ALA A  43
LEU A 114
ILE A  25
LEU A  83
 None
 1.18A 4rgcA-4nb0A:
undetectable		 4rgcA-4nb0A:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A5Y_D_9CRD501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4nb0 METALLOTHIOL
TRANSFERASE FOSB
(Staphylococcus
aureus) 		3 / 3 ASN A  89
VAL A  12
HIS A 112
 None
 0.67A 6a5yD-4nb0A:
undetectable		 6a5yD-4nb0A:
21.55