SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4nbq'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CQE_A_FLPA1650_1
(PROTEIN
(PROSTAGLANDIN H2
SYNTHASE-1))		 4nbq POLYRIBONUCLEOTIDE
NUCLEOTIDYLTRANSFERA
SE
(Coxiella
burnetii) 		5 / 12 VAL A  60
LEU A  58
ILE A 130
GLY A 132
ALA A 133
 None
 1.06A 1cqeA-4nbqA:
4.6		 1cqeA-4nbqA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N13_B_AG2B7011_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN)		 4nbq POLYRIBONUCLEOTIDE
NUCLEOTIDYLTRANSFERA
SE
(Coxiella
burnetii) 		4 / 5 GLU A  64
ARG A 152
ASP A 126
LEU A  93
 None
 1.24A 1n13B-4nbqA:
undetectable
1n13C-4nbqA:
undetectable		 1n13B-4nbqA:
9.83
1n13C-4nbqA:
6.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OIP_A_VIVA1278_1
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 4nbq POLYRIBONUCLEOTIDE
NUCLEOTIDYLTRANSFERA
SE
(Coxiella
burnetii) 		4 / 5 SER A 445
SER A 441
PHE A 381
PHE A 385
 None
SO4  A 701 (-3.7A)
None
None
 1.46A 1oipA-4nbqA:
2.6		 1oipA-4nbqA:
16.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V3Q_E_2DIE290_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 4nbq POLYRIBONUCLEOTIDE
NUCLEOTIDYLTRANSFERA
SE
(Coxiella
burnetii) 		5 / 10 GLY A 500
GLU A 197
VAL A 505
GLY A 504
VAL A 498
 None
 1.10A 1v3qE-4nbqA:
undetectable		 1v3qE-4nbqA:
17.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WG8_B_SAMB3141_1
(PREDICTED
S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)		 4nbq POLYRIBONUCLEOTIDE
NUCLEOTIDYLTRANSFERA
SE
(Coxiella
burnetii) 		3 / 3 HIS A 406
ASP A  95
ASN A  61
 SO4  A 701 ( 4.9A)
None
None
 0.87A 1wg8B-4nbqA:
undetectable		 1wg8B-4nbqA:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA3_A_STRA1001_1
(MINERALOCORTICOID
RECEPTOR)		 4nbq POLYRIBONUCLEOTIDE
NUCLEOTIDYLTRANSFERA
SE
(Coxiella
burnetii) 		5 / 12 LEU A 201
ALA A 529
GLN A 528
LEU A 471
MET A 494
 None
 1.41A 1ya3A-4nbqA:
undetectable		 1ya3A-4nbqA:
16.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YC5_A_NCAA2001_0
(NAD-DEPENDENT
DEACETYLASE)		 4nbq POLYRIBONUCLEOTIDE
NUCLEOTIDYLTRANSFERA
SE
(Coxiella
burnetii) 		4 / 7 ALA A 589
ILE A 600
ASP A 591
ILE A 582
 None
 0.99A 1yc5A-4nbqA:
undetectable		 1yc5A-4nbqA:
16.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z9H_D_IMND476_1
(MEMBRANE-ASSOCIATED
PROSTAGLANDIN E
SYNTHASE-2)		 4nbq POLYRIBONUCLEOTIDE
NUCLEOTIDYLTRANSFERA
SE
(Coxiella
burnetii) 		5 / 12 THR A 460
ILE A 428
VAL A 430
SER A 449
VAL A 458
 None
 1.08A 1z9hD-4nbqA:
2.9		 1z9hD-4nbqA:
18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_C_SAMC301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 4nbq POLYRIBONUCLEOTIDE
NUCLEOTIDYLTRANSFERA
SE
(Coxiella
burnetii) 		5 / 12 LEU A  98
LEU A 148
GLY A 138
ALA A 136
ALA A  29
 None
 1.16A 2bm9C-4nbqA:
undetectable		 2bm9C-4nbqA:
15.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_D_SAMD301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 4nbq POLYRIBONUCLEOTIDE
NUCLEOTIDYLTRANSFERA
SE
(Coxiella
burnetii) 		5 / 12 LEU A  98
LEU A 148
GLY A 138
ALA A 136
ALA A  29
 None
 1.11A 2bm9D-4nbqA:
undetectable		 2bm9D-4nbqA:
15.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_E_SAME301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 4nbq POLYRIBONUCLEOTIDE
NUCLEOTIDYLTRANSFERA
SE
(Coxiella
burnetii) 		5 / 12 LEU A  98
LEU A 148
GLY A 138
ALA A 136
ALA A  29
 None
 1.18A 2br4E-4nbqA:
undetectable		 2br4E-4nbqA:
15.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_A_SC2A1290_1
(FICOLIN-2)		 4nbq POLYRIBONUCLEOTIDE
NUCLEOTIDYLTRANSFERA
SE
(Coxiella
burnetii) 		4 / 5 SER A 437
LEU A 485
GLY A 486
ARG A 328
 SO4  A 701 (-2.9A)
None
None
None
 1.18A 2j2pA-4nbqA:
undetectable
2j2pB-4nbqA:
undetectable		 2j2pA-4nbqA:
13.94
2j2pB-4nbqA:
13.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEK_B_DIFB1374_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 4nbq POLYRIBONUCLEOTIDE
NUCLEOTIDYLTRANSFERA
SE
(Coxiella
burnetii) 		4 / 6 TYR A  10
PRO A 128
ILE A  94
LEU A 148
 None
 1.35A 2wekB-4nbqA:
undetectable		 2wekB-4nbqA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A50_D_VD3D2001_1
(VITAMIN D
HYDROXYLASE)		 4nbq POLYRIBONUCLEOTIDE
NUCLEOTIDYLTRANSFERA
SE
(Coxiella
burnetii) 		5 / 12 PRO A  97
ILE A 137
LEU A  98
LEU A 131
ILE A 218
 None
 1.08A 3a50D-4nbqA:
4.3		 3a50D-4nbqA:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CYX_A_ROCA201_4
(HIV-1 PROTEASE)		 4nbq POLYRIBONUCLEOTIDE
NUCLEOTIDYLTRANSFERA
SE
(Coxiella
burnetii) 		4 / 4 LEU A 371
ASP A 167
VAL A 123
THR A  37
 None
 1.30A 3cyxB-4nbqA:
undetectable		 3cyxB-4nbqA:
9.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM0_B_CHDB500_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 4nbq POLYRIBONUCLEOTIDE
NUCLEOTIDYLTRANSFERA
SE
(Coxiella
burnetii) 		4 / 7 THR A  16
GLU A  18
VAL A  31
VAL A  38
 None
 0.56A 3em0B-4nbqA:
undetectable		 3em0B-4nbqA:
12.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H5G_A_LEIA16_0
(COIL SER L16D-PEN)		 4nbq POLYRIBONUCLEOTIDE
NUCLEOTIDYLTRANSFERA
SE
(Coxiella
burnetii) 		4 / 6 GLN A 524
LEU A 526
GLU A 523
LEU A 201
 None
 0.91A 3h5gA-4nbqA:
undetectable
3h5gC-4nbqA:
undetectable		 3h5gA-4nbqA:
3.90
3h5gC-4nbqA:
3.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KK6_A_CELA701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 4nbq POLYRIBONUCLEOTIDE
NUCLEOTIDYLTRANSFERA
SE
(Coxiella
burnetii) 		5 / 12 VAL A  60
LEU A  58
ILE A 130
GLY A 132
ALA A 133
 None
 1.04A 3kk6A-4nbqA:
undetectable		 3kk6A-4nbqA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KK6_B_CELB1701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 4nbq POLYRIBONUCLEOTIDE
NUCLEOTIDYLTRANSFERA
SE
(Coxiella
burnetii) 		5 / 12 GLN A 209
VAL A 204
LEU A 205
TYR A 160
LEU A 176
 None
 1.25A 3kk6B-4nbqA:
0.4		 3kk6B-4nbqA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OF4_B_ACTB313_0
(NITROREDUCTASE)		 4nbq POLYRIBONUCLEOTIDE
NUCLEOTIDYLTRANSFERA
SE
(Coxiella
burnetii) 		3 / 3 ALA A 479
VAL A 480
GLN A 528
 None
 0.66A 3of4B-4nbqA:
undetectable		 3of4B-4nbqA:
14.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3N_A_MIYA2001_1
(TETX2 PROTEIN)		 4nbq POLYRIBONUCLEOTIDE
NUCLEOTIDYLTRANSFERA
SE
(Coxiella
burnetii) 		5 / 11 GLY A 439
SER A 437
PHE A 385
GLY A 407
ASN A 384
 SO4  A 701 (-4.2A)
SO4  A 701 (-2.9A)
None
None
None
 1.15A 3v3nA-4nbqA:
undetectable		 3v3nA-4nbqA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3N_D_MIYD2001_1
(TETX2 PROTEIN)		 4nbq POLYRIBONUCLEOTIDE
NUCLEOTIDYLTRANSFERA
SE
(Coxiella
burnetii) 		5 / 11 GLY A 439
SER A 437
PHE A 385
GLY A 407
ASN A 384
 SO4  A 701 (-4.2A)
SO4  A 701 (-2.9A)
None
None
None
 1.15A 3v3nD-4nbqA:
undetectable		 3v3nD-4nbqA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FWD_A_BO2A801_1
(TTC1975 PEPTIDASE)		 4nbq POLYRIBONUCLEOTIDE
NUCLEOTIDYLTRANSFERA
SE
(Coxiella
burnetii) 		5 / 9 GLU A 377
VAL A 427
ILE A 428
SER A 449
ALA A 452
 None
 1.21A 4fwdA-4nbqA:
2.9		 4fwdA-4nbqA:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LTW_A_486A303_1
(ANCESTRAL STEROID
RECEPTOR 2)		 4nbq POLYRIBONUCLEOTIDE
NUCLEOTIDYLTRANSFERA
SE
(Coxiella
burnetii) 		5 / 9 LEU A 117
ALA A  68
TYR A  62
THR A 115
LEU A  39
 None
 1.29A 4ltwA-4nbqA:
undetectable		 4ltwA-4nbqA:
14.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJV_A_RITA500_1
(PROTEASE)		 4nbq POLYRIBONUCLEOTIDE
NUCLEOTIDYLTRANSFERA
SE
(Coxiella
burnetii) 		5 / 12 GLY A 132
ALA A 133
VAL A  60
THR A  90
ILE A  94
 None
 0.99A 4njvA-4nbqA:
undetectable		 4njvA-4nbqA:
10.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJV_D_RITD500_2
(PROTEASE)		 4nbq POLYRIBONUCLEOTIDE
NUCLEOTIDYLTRANSFERA
SE
(Coxiella
burnetii) 		5 / 12 GLY A 132
ALA A 133
VAL A  60
THR A  90
ILE A  94
 None
 1.09A 4njvD-4nbqA:
undetectable		 4njvD-4nbqA:
10.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RET_A_DGXA1107_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 4nbq POLYRIBONUCLEOTIDE
NUCLEOTIDYLTRANSFERA
SE
(Coxiella
burnetii) 		5 / 12 LEU A 354
GLU A 433
ALA A 413
PHE A 381
ARG A 429
 None
 1.28A 4retA-4nbqA:
undetectable		 4retA-4nbqA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RET_C_DGXC2005_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 4nbq POLYRIBONUCLEOTIDE
NUCLEOTIDYLTRANSFERA
SE
(Coxiella
burnetii) 		5 / 12 LEU A 354
GLU A 433
ALA A 413
PHE A 381
ARG A 429
 None
 1.28A 4retC-4nbqA:
undetectable		 4retC-4nbqA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OCS_A_ACTA402_0
(PUTATIVE
NADH-DEPENTDENT
FLAVIN
OXIDOREDUCTASE)		 4nbq POLYRIBONUCLEOTIDE
NUCLEOTIDYLTRANSFERA
SE
(Coxiella
burnetii) 		4 / 5 CYH A 389
ILE A 434
HIS A 406
TYR A 383
 None
None
SO4  A 701 ( 4.9A)
None
 1.45A 5ocsA-4nbqA:
undetectable		 5ocsA-4nbqA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OCS_C_ACTC402_0
(PUTATIVE
NADH-DEPENTDENT
FLAVIN
OXIDOREDUCTASE)		 4nbq POLYRIBONUCLEOTIDE
NUCLEOTIDYLTRANSFERA
SE
(Coxiella
burnetii) 		4 / 5 CYH A 389
ILE A 434
HIS A 406
TYR A 383
 None
None
SO4  A 701 ( 4.9A)
None
 1.44A 5ocsC-4nbqA:
undetectable		 5ocsC-4nbqA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TIW_B_OAQB302_0
(SULFOTRANSFERASE)		 4nbq POLYRIBONUCLEOTIDE
NUCLEOTIDYLTRANSFERA
SE
(Coxiella
burnetii) 		5 / 12 ILE A  94
VAL A  43
ILE A 113
LEU A  39
THR A 115
 None
 0.99A 5tiwB-4nbqA:
undetectable		 5tiwB-4nbqA:
15.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_B_CVIB301_0
(REGULATORY PROTEIN
TETR)		 4nbq POLYRIBONUCLEOTIDE
NUCLEOTIDYLTRANSFERA
SE
(Coxiella
burnetii) 		5 / 12 GLN A 509
GLU A 191
LEU A 508
VAL A 446
CYH A 447
 None
 1.17A 5vlmB-4nbqA:
2.5		 5vlmB-4nbqA:
13.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_A_C2FA3001_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 4nbq POLYRIBONUCLEOTIDE
NUCLEOTIDYLTRANSFERA
SE
(Coxiella
burnetii) 		5 / 12 ARG A  92
VAL A  41
LEU A  39
ARG A 412
ILE A  94
 None
 1.14A 5vooA-4nbqA:
undetectable		 5vooA-4nbqA:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_C_C2FC702_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 4nbq POLYRIBONUCLEOTIDE
NUCLEOTIDYLTRANSFERA
SE
(Coxiella
burnetii) 		5 / 12 ARG A  92
VAL A  41
LEU A  39
ARG A 412
ILE A  94
 None
 1.16A 5vooC-4nbqA:
undetectable		 5vooC-4nbqA:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7P_E_CHDE401_0
(BILE SALT HYDROLASE)		 4nbq POLYRIBONUCLEOTIDE
NUCLEOTIDYLTRANSFERA
SE
(Coxiella
burnetii) 		4 / 8 PHE A 346
LEU A 345
LEU A 451
ALA A 452
 None
 0.86A 5y7pE-4nbqA:
undetectable		 5y7pE-4nbqA:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AZ3_1_PAR11803_1
(RRNA ALPHA
RIBOSOMAL PROTEIN
EL18)		 4nbq POLYRIBONUCLEOTIDE
NUCLEOTIDYLTRANSFERA
SE
(Coxiella
burnetii) 		3 / 3 SER A 121
LYS A 122
SER A 165
 SO4  A 707 (-2.6A)
SO4  A 707 ( 4.4A)
None
 0.84A 6az3P-4nbqA:
undetectable		 6az3P-4nbqA:
7.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MXT_A_K5YA1401_1
(ENDOLYSIN, BETA-2
ADRENERGIC RECEPTOR
CHIMERA)		 4nbq POLYRIBONUCLEOTIDE
NUCLEOTIDYLTRANSFERA
SE
(Coxiella
burnetii) 		3 / 3 ASP A 489
SER A 441
SER A 437
 None
SO4  A 701 (-3.7A)
SO4  A 701 (-2.9A)
 0.83A 6mxtA-4nbqA:
undetectable		 6mxtA-4nbqA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NM4_B_SAMB402_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
PRDM9)		 4nbq POLYRIBONUCLEOTIDE
NUCLEOTIDYLTRANSFERA
SE
(Coxiella
burnetii) 		5 / 9 ILE A  94
ALA A 133
GLY A 132
LEU A 131
GLY A 146
 None
 1.14A 6nm4B-4nbqA:
undetectable		 6nm4B-4nbqA:
13.94