SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4nbr'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GMK_A_DVAA6_0
(GRAMICIDIN A)		 4nbr HYPOTHETICAL
3-OXOACYL-(ACYL-CARR
IER PROTEIN)
REDUCTASE
(Brucella
abortus) 		3 / 3 ALA A 119
VAL A 115
TRP A 116
 None
 1.01A 1gmkA-4nbrA:
undetectable
1gmkB-4nbrA:
undetectable		 1gmkA-4nbrA:
5.74
1gmkB-4nbrA:
5.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GMK_C_DVAC6_0
(GRAMICIDIN A)		 4nbr HYPOTHETICAL
3-OXOACYL-(ACYL-CARR
IER PROTEIN)
REDUCTASE
(Brucella
abortus) 		3 / 3 ALA A 119
VAL A 115
TRP A 116
 None
 1.00A 1gmkC-4nbrA:
undetectable
1gmkD-4nbrA:
undetectable		 1gmkC-4nbrA:
5.74
1gmkD-4nbrA:
5.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1UAY_A_ADNA1001_1
(TYPE II
3-HYDROXYACYL-COA
DEHYDROGENASE)		 4nbr HYPOTHETICAL
3-OXOACYL-(ACYL-CARR
IER PROTEIN)
REDUCTASE
(Brucella
abortus) 		7 / 11 GLY A  26
ALA A  28
ASP A  50
ASP A  77
VAL A  78
ALA A 102
VAL A 129
 None
 0.55A 1uayA-4nbrA:
27.7		 1uayA-4nbrA:
33.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1UAY_A_ADNA1001_1
(TYPE II
3-HYDROXYACYL-COA
DEHYDROGENASE)		 4nbr HYPOTHETICAL
3-OXOACYL-(ACYL-CARR
IER PROTEIN)
REDUCTASE
(Brucella
abortus) 		7 / 11 GLY A  26
ALA A  28
ASP A  50
LEU A  51
ASP A  77
VAL A  78
VAL A 129
 None
 0.64A 1uayA-4nbrA:
27.7		 1uayA-4nbrA:
33.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1UAY_B_ADNB1002_1
(TYPE II
3-HYDROXYACYL-COA
DEHYDROGENASE)		 4nbr HYPOTHETICAL
3-OXOACYL-(ACYL-CARR
IER PROTEIN)
REDUCTASE
(Brucella
abortus) 		7 / 10 GLY A  26
ALA A  28
ASP A  50
ASP A  77
VAL A  78
ALA A 102
VAL A 129
 None
 0.52A 1uayB-4nbrA:
28.4		 1uayB-4nbrA:
33.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1UAY_B_ADNB1002_1
(TYPE II
3-HYDROXYACYL-COA
DEHYDROGENASE)		 4nbr HYPOTHETICAL
3-OXOACYL-(ACYL-CARR
IER PROTEIN)
REDUCTASE
(Brucella
abortus) 		7 / 10 GLY A  26
ALA A  28
ASP A  50
LEU A  51
ASP A  77
VAL A  78
VAL A 129
 None
 0.66A 1uayB-4nbrA:
28.4		 1uayB-4nbrA:
33.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2I30_A_SALA1200_1
(SERUM ALBUMIN)		 4nbr HYPOTHETICAL
3-OXOACYL-(ACYL-CARR
IER PROTEIN)
REDUCTASE
(Brucella
abortus) 		4 / 4 LEU A  63
ILE A  24
ILE A  35
ALA A  34
 None
 0.76A 2i30A-4nbrA:
undetectable		 2i30A-4nbrA:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYU_A_SAMA201_0
(PUTATIVE RIBOSOMAL
RNA
METHYLTRANSFERASE 2)		 4nbr HYPOTHETICAL
3-OXOACYL-(ACYL-CARR
IER PROTEIN)
REDUCTASE
(Brucella
abortus) 		5 / 12 GLY A  26
ALA A  28
ALA A  34
LEU A  51
VAL A  78
 None
 0.88A 2nyuA-4nbrA:
7.8		 2nyuA-4nbrA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DMF_A_SAMA388_0
(PROBABLE RIBOSOMAL
RNA SMALL SUBUNIT
METHYLTRANSFERASE)		 4nbr HYPOTHETICAL
3-OXOACYL-(ACYL-CARR
IER PROTEIN)
REDUCTASE
(Brucella
abortus) 		5 / 12 GLY A  26
ALA A  34
ASP A  77
VAL A  78
VAL A 129
 None
 0.81A 3dmfA-4nbrA:
6.6		 3dmfA-4nbrA:
24.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB2_A_SAMA1101_0
(STRUCTURAL PROTEIN
VP3)		 4nbr HYPOTHETICAL
3-OXOACYL-(ACYL-CARR
IER PROTEIN)
REDUCTASE
(Brucella
abortus) 		5 / 12 PRO A 166
GLY A 203
VAL A 236
ILE A 205
GLU A 235
 None
GOL  A 301 (-4.7A)
None
None
None
 1.47A 3jb2A-4nbrA:
3.4		 3jb2A-4nbrA:
13.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MBH_B_PXLB400_1
(PUTATIVE
PHOSPHOMETHYLPYRIMID
INE KINASE)		 4nbr HYPOTHETICAL
3-OXOACYL-(ACYL-CARR
IER PROTEIN)
REDUCTASE
(Brucella
abortus) 		5 / 12 ASP A  77
VAL A 129
SER A  79
LEU A  51
ASP A 128
 None
 1.23A 3mbhB-4nbrA:
6.7		 3mbhB-4nbrA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MBH_C_PXLC400_1
(PUTATIVE
PHOSPHOMETHYLPYRIMID
INE KINASE)		 4nbr HYPOTHETICAL
3-OXOACYL-(ACYL-CARR
IER PROTEIN)
REDUCTASE
(Brucella
abortus) 		5 / 12 ASP A  77
VAL A 129
SER A  79
LEU A  51
ASP A 128
 None
 1.20A 3mbhC-4nbrA:
6.8		 3mbhC-4nbrA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MBH_D_PXLD400_1
(PUTATIVE
PHOSPHOMETHYLPYRIMID
INE KINASE)		 4nbr HYPOTHETICAL
3-OXOACYL-(ACYL-CARR
IER PROTEIN)
REDUCTASE
(Brucella
abortus) 		5 / 12 ASP A  77
VAL A 129
SER A  79
LEU A  51
ASP A 128
 None
 1.20A 3mbhD-4nbrA:
6.7		 3mbhD-4nbrA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MBH_E_PXLE400_1
(PUTATIVE
PHOSPHOMETHYLPYRIMID
INE KINASE)		 4nbr HYPOTHETICAL
3-OXOACYL-(ACYL-CARR
IER PROTEIN)
REDUCTASE
(Brucella
abortus) 		5 / 12 ASP A  77
VAL A 129
SER A  79
LEU A  51
ASP A 128
 None
 1.21A 3mbhE-4nbrA:
6.8		 3mbhE-4nbrA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q87_B_SAMB300_0
(N6 ADENINE SPECIFIC
DNA METHYLASE)		 4nbr HYPOTHETICAL
3-OXOACYL-(ACYL-CARR
IER PROTEIN)
REDUCTASE
(Brucella
abortus) 		5 / 12 GLY A  26
ILE A  35
ASP A  50
LEU A  51
ASP A  77
 None
 0.61A 3q87B-4nbrA:
6.1		 3q87B-4nbrA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q87_B_SAMB300_0
(N6 ADENINE SPECIFIC
DNA METHYLASE)		 4nbr HYPOTHETICAL
3-OXOACYL-(ACYL-CARR
IER PROTEIN)
REDUCTASE
(Brucella
abortus) 		6 / 12 THR A 207
GLY A  26
ILE A  31
ASP A  50
LEU A  51
ASP A  77
 None
 1.43A 3q87B-4nbrA:
6.1		 3q87B-4nbrA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UBO_B_ADNB353_2
(ADENOSINE KINASE)		 4nbr HYPOTHETICAL
3-OXOACYL-(ACYL-CARR
IER PROTEIN)
REDUCTASE
(Brucella
abortus) 		4 / 5 SER A 158
ILE A  31
TYR A 172
GLY A 203
 GOL  A 301 ( 3.8A)
None
GOL  A 301 ( 4.7A)
GOL  A 301 (-4.7A)
 0.99A 3uboB-4nbrA:
6.4		 3uboB-4nbrA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AC9_B_DXCB1473_0
(MJ0495-LIKE PROTEIN)		 4nbr HYPOTHETICAL
3-OXOACYL-(ACYL-CARR
IER PROTEIN)
REDUCTASE
(Brucella
abortus) 		5 / 11 ILE A  35
ILE A  31
GLY A  30
VAL A 258
GLY A 231
 None
 1.03A 4ac9B-4nbrA:
6.0
4ac9C-4nbrA:
5.7		 4ac9B-4nbrA:
22.89
4ac9C-4nbrA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OAD_A_CLMA205_0
(GNAT SUPERFAMILY
ACETYLTRANSFERASE
PA4794)		 4nbr HYPOTHETICAL
3-OXOACYL-(ACYL-CARR
IER PROTEIN)
REDUCTASE
(Brucella
abortus) 		5 / 12 GLU A 235
ARG A 229
ALA A 259
GLY A 203
LEU A 262
 None
None
None
GOL  A 301 (-4.7A)
None
 1.34A 4oadA-4nbrA:
undetectable		 4oadA-4nbrA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OAE_A_CLMA207_0
(GNAT SUPERFAMILY
ACETYLTRANSFERASE
PA4794)		 4nbr HYPOTHETICAL
3-OXOACYL-(ACYL-CARR
IER PROTEIN)
REDUCTASE
(Brucella
abortus) 		6 / 12 GLU A 235
ALA A 206
ARG A 229
ALA A 259
GLY A 203
LEU A 262
 None
None
None
None
GOL  A 301 (-4.7A)
None
 1.42A 4oaeA-4nbrA:
undetectable		 4oaeA-4nbrA:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4POO_A_SAMA301_0
(PUTATIVE RNA
METHYLASE)		 4nbr HYPOTHETICAL
3-OXOACYL-(ACYL-CARR
IER PROTEIN)
REDUCTASE
(Brucella
abortus) 		5 / 12 GLY A 133
ASN A 136
ILE A 179
SER A 157
THR A 175
 None
 1.21A 4pooA-4nbrA:
5.5		 4pooA-4nbrA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XDR_A_ADNA402_1
(FAD:PROTEIN FMN
TRANSFERASE)		 4nbr HYPOTHETICAL
3-OXOACYL-(ACYL-CARR
IER PROTEIN)
REDUCTASE
(Brucella
abortus) 		5 / 12 LEU A  51
ASP A  50
GLY A  26
ALA A 102
ILE A 104
 None
 0.85A 4xdrA-4nbrA:
undetectable		 4xdrA-4nbrA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZJ8_A_SUVA2001_2
(HUMAN OX1R FUSION
PROTEIN TO P.ABYSII
GLYCOGEN SYNTHASE)		 4nbr HYPOTHETICAL
3-OXOACYL-(ACYL-CARR
IER PROTEIN)
REDUCTASE
(Brucella
abortus) 		4 / 6 ILE A 205
PRO A 233
ILE A  24
VAL A  99
 None
 0.93A 4zj8A-4nbrA:
5.6		 4zj8A-4nbrA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BYJ_A_OQRA302_0
(SULFOTRANSFERASE)		 4nbr HYPOTHETICAL
3-OXOACYL-(ACYL-CARR
IER PROTEIN)
REDUCTASE
(Brucella
abortus) 		5 / 12 ILE A  35
LEU A 243
GLY A  47
PHE A  39
THR A 244
 None
 1.19A 5byjA-4nbrA:
1.6		 5byjA-4nbrA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UVM_B_ADNB207_1
(HISTIDINE TRIAD
(HIT) PROTEIN)		 4nbr HYPOTHETICAL
3-OXOACYL-(ACYL-CARR
IER PROTEIN)
REDUCTASE
(Brucella
abortus) 		6 / 12 VAL A  22
PHE A  39
ILE A  24
ILE A  35
ASN A 198
HIS A  17
 None
 1.40A 5uvmB-4nbrA:
undetectable		 5uvmB-4nbrA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRF_D_EVPD101_1
()		 4nbr HYPOTHETICAL
3-OXOACYL-(ACYL-CARR
IER PROTEIN)
REDUCTASE
(Brucella
abortus) 		4 / 5 GLY A  26
ASP A  50
ARG A  29
GLN A  37
 None
 1.33A 5zrfB-4nbrA:
2.6		 5zrfB-4nbrA:
15.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6IEY_A_CLMA401_0
(ESTERASE)		 4nbr HYPOTHETICAL
3-OXOACYL-(ACYL-CARR
IER PROTEIN)
REDUCTASE
(Brucella
abortus) 		5 / 11 ILE A  74
ALA A 102
GLY A 133
SER A  79
ALA A  83
 None
 1.12A 6ieyA-4nbrA:
4.6
6ieyB-4nbrA:
4.9		 6ieyA-4nbrA:
23.19
6ieyB-4nbrA:
23.19