SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4nbt'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FBM_B_RTLB951_1
(PROTEIN (CARTILAGE
OLIGOMERIC MATRIX
PROTEIN))		 4nbt 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
REDUCTASE
(Acholeplasma
laidlawii) 		4 / 4 THR A 183
LEU A 186
VAL A 189
LEU A 193
 NAD  A 301 (-2.7A)
None
None
None
 0.94A 1fbmB-4nbtA:
undetectable		 1fbmB-4nbtA:
10.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FDU_A_ESTA351_1
(17-BETA-HYDROXYSTERO
ID DEHYDROGENASE)		 4nbt 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
REDUCTASE
(Acholeplasma
laidlawii) 		5 / 12 SER A 133
VAL A 134
TYR A 146
GLY A 179
LEU A 193
 NAD  A 301 (-2.7A)
None
NAD  A 301 (-4.3A)
NAD  A 301 (-4.3A)
None
 1.02A 1fduA-4nbtA:
26.6		 1fduA-4nbtA:
25.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SG9_A_SAMA301_1
(HEMK PROTEIN)		 4nbt 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
REDUCTASE
(Acholeplasma
laidlawii) 		4 / 4 THR A 183
GLY A  14
ASP A  37
ALA A  82
 NAD  A 301 (-2.7A)
None
NAD  A 301 (-2.5A)
NAD  A 301 (-3.6A)
 1.24A 1sg9A-4nbtA:
6.0		 1sg9A-4nbtA:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1U70_A_MTXA187_2
(DIHYDROFOLATE
REDUCTASE)		 4nbt 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
REDUCTASE
(Acholeplasma
laidlawii) 		4 / 4 SER A 132
ILE A 131
VAL A 234
THR A 201
 None
NAD  A 301 (-3.9A)
None
None
 1.15A 1u70A-4nbtA:
undetectable		 1u70A-4nbtA:
21.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1UAY_A_ADNA1001_1
(TYPE II
3-HYDROXYACYL-COA
DEHYDROGENASE)		 4nbt 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
REDUCTASE
(Acholeplasma
laidlawii) 		7 / 11 GLY A  13
ALA A  15
ASP A  37
LEU A  38
VAL A  55
ALA A  82
VAL A 104
 NAD  A 301 (-3.0A)
NAD  A 301 ( 3.9A)
NAD  A 301 (-2.5A)
NAD  A 301 (-4.4A)
NAD  A 301 (-3.7A)
NAD  A 301 (-3.6A)
NAD  A 301 ( 3.7A)
 0.41A 1uayA-4nbtA:
30.4		 1uayA-4nbtA:
35.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1UAY_B_ADNB1002_1
(TYPE II
3-HYDROXYACYL-COA
DEHYDROGENASE)		 4nbt 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
REDUCTASE
(Acholeplasma
laidlawii) 		7 / 10 GLY A  13
ALA A  15
ASP A  37
LEU A  38
VAL A  55
ALA A  82
VAL A 104
 NAD  A 301 (-3.0A)
NAD  A 301 ( 3.9A)
NAD  A 301 (-2.5A)
NAD  A 301 (-4.4A)
NAD  A 301 (-3.7A)
NAD  A 301 (-3.6A)
NAD  A 301 ( 3.7A)
 0.44A 1uayB-4nbtA:
31.0		 1uayB-4nbtA:
35.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYU_B_SAMB201_0
(PUTATIVE RIBOSOMAL
RNA
METHYLTRANSFERASE 2)		 4nbt 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
REDUCTASE
(Acholeplasma
laidlawii) 		5 / 12 GLY A  13
ALA A  15
LEU A  38
VAL A  55
THR A  56
 NAD  A 301 (-3.0A)
NAD  A 301 ( 3.9A)
NAD  A 301 (-4.4A)
NAD  A 301 (-3.7A)
NAD  A 301 ( 3.5A)
 0.69A 2nyuB-4nbtA:
9.6		 2nyuB-4nbtA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QE6_A_SAMA400_0
(UNCHARACTERIZED
PROTEIN TFU_2867)		 4nbt 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
REDUCTASE
(Acholeplasma
laidlawii) 		5 / 12 ILE A  22
ALA A  21
GLY A  17
ILE A 212
GLY A  13
 None
None
NAD  A 301 (-3.4A)
None
NAD  A 301 (-3.0A)
 0.86A 2qe6A-4nbtA:
6.1		 2qe6A-4nbtA:
24.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QE6_B_SAMB400_0
(UNCHARACTERIZED
PROTEIN TFU_2867)		 4nbt 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
REDUCTASE
(Acholeplasma
laidlawii) 		5 / 12 ILE A  22
ALA A  21
GLY A  17
ILE A 212
GLY A  13
 None
None
NAD  A 301 (-3.4A)
None
NAD  A 301 (-3.0A)
 0.89A 2qe6B-4nbtA:
5.9		 2qe6B-4nbtA:
24.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UY4_A_PAUA302_0
(PANTOTHENATE
SYNTHETASE)		 4nbt 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
REDUCTASE
(Acholeplasma
laidlawii) 		4 / 8 VAL A 135
VAL A 134
ASP A  87
GLN A 143
 None
 1.18A 3uy4A-4nbtA:
3.0		 3uy4A-4nbtA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XDR_A_ADNA402_1
(FAD:PROTEIN FMN
TRANSFERASE)		 4nbt 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
REDUCTASE
(Acholeplasma
laidlawii) 		5 / 12 LEU A  38
ASP A  37
GLY A  13
ALA A  82
ILE A  84
 NAD  A 301 (-4.4A)
NAD  A 301 (-2.5A)
NAD  A 301 (-3.0A)
NAD  A 301 (-3.6A)
NAD  A 301 ( 4.5A)
 1.01A 4xdrA-4nbtA:
undetectable		 4xdrA-4nbtA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XT8_A_TMQA302_1
(RV2671)		 4nbt 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
REDUCTASE
(Acholeplasma
laidlawii) 		5 / 12 ASN A  80
ILE A 128
SER A 127
GLY A 126
TYR A  26
 None
 1.23A 4xt8A-4nbtA:
undetectable		 4xt8A-4nbtA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZJ8_A_SUVA2001_2
(HUMAN OX1R FUSION
PROTEIN TO P.ABYSII
GLYCOGEN SYNTHASE)		 4nbt 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
REDUCTASE
(Acholeplasma
laidlawii) 		4 / 6 ILE A 181
PRO A 209
ILE A  11
VAL A  79
 NAD  A 301 (-4.4A)
None
None
None
 0.96A 4zj8A-4nbtA:
5.4		 4zj8A-4nbtA:
17.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J7W_C_MTXC402_1
(THYMIDYLATE SYNTHASE)		 4nbt 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
REDUCTASE
(Acholeplasma
laidlawii) 		5 / 12 LEU A 186
LEU A  18
GLY A  17
ILE A 212
ALA A 213
 None
NAD  A 301 (-3.3A)
NAD  A 301 (-3.4A)
None
None
 1.29A 5j7wC-4nbtA:
undetectable		 5j7wC-4nbtA:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VEU_A_RITA602_1
(CYTOCHROME P450 3A5)		 4nbt 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
REDUCTASE
(Acholeplasma
laidlawii) 		5 / 12 PHE A 218
ILE A 232
ALA A 175
ALA A 161
GLY A 126
 None
 1.08A 5veuA-4nbtA:
undetectable		 5veuA-4nbtA:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VEU_B_RITB602_1
(CYTOCHROME P450 3A5)		 4nbt 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
REDUCTASE
(Acholeplasma
laidlawii) 		5 / 12 PHE A 218
ILE A 232
ALA A 175
ALA A 161
GLY A 126
 None
 1.03A 5veuB-4nbtA:
undetectable		 5veuB-4nbtA:
18.89