SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4nbu'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L5R_A_RBFA859_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 4nbu 3-OXOACYL-(ACYL-CARR
IER-PROTEIN)
REDUCTASE
(Bacillus
sp.
SG-1) 		5 / 11 PHE A  62
ALA A  21
GLY A  20
ARG A  83
PHE A  84
 None
None
NAI  A 301 (-3.3A)
None
None
 1.35A 1l5rA-4nbuA:
4.3		 1l5rA-4nbuA:
14.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1UAY_A_ADNA1001_1
(TYPE II
3-HYDROXYACYL-COA
DEHYDROGENASE)		 4nbu 3-OXOACYL-(ACYL-CARR
IER-PROTEIN)
REDUCTASE
(Bacillus
sp.
SG-1) 		7 / 11 GLY A  20
ALA A  22
ASP A  44
ASP A  66
VAL A  67
ALA A  94
VAL A 116
 NAI  A 301 (-3.3A)
NAI  A 301 ( 4.2A)
NAI  A 301 (-2.9A)
NAI  A 301 (-3.6A)
NAI  A 301 (-3.7A)
NAI  A 301 (-3.7A)
NAI  A 301 ( 4.2A)
 0.33A 1uayA-4nbuA:
31.9		 1uayA-4nbuA:
35.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1UAY_B_ADNB1002_1
(TYPE II
3-HYDROXYACYL-COA
DEHYDROGENASE)		 4nbu 3-OXOACYL-(ACYL-CARR
IER-PROTEIN)
REDUCTASE
(Bacillus
sp.
SG-1) 		7 / 10 GLY A  20
ALA A  22
ASP A  44
ASP A  66
VAL A  67
ALA A  94
VAL A 116
 NAI  A 301 (-3.3A)
NAI  A 301 ( 4.2A)
NAI  A 301 (-2.9A)
NAI  A 301 (-3.6A)
NAI  A 301 (-3.7A)
NAI  A 301 (-3.7A)
NAI  A 301 ( 4.2A)
 0.31A 1uayB-4nbuA:
32.1		 1uayB-4nbuA:
35.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_E_SAME301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 4nbu 3-OXOACYL-(ACYL-CARR
IER-PROTEIN)
REDUCTASE
(Bacillus
sp.
SG-1) 		5 / 12 GLY A  20
ASP A  44
ASP A  66
ASN A  93
ALA A  94
 NAI  A 301 (-3.3A)
NAI  A 301 (-2.9A)
NAI  A 301 (-3.6A)
NAI  A 301 (-3.4A)
NAI  A 301 (-3.7A)
 0.90A 2bm9E-4nbuA:
5.6		 2bm9E-4nbuA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNK_A_ROCA401_1
(PROTEASE)		 4nbu 3-OXOACYL-(ACYL-CARR
IER-PROTEIN)
REDUCTASE
(Bacillus
sp.
SG-1) 		5 / 12 GLY A 120
ASP A  66
GLY A  20
VAL A  77
VAL A  73
 None
NAI  A 301 (-3.6A)
NAI  A 301 (-3.3A)
None
None
 0.95A 2nnkA-4nbuA:
undetectable		 2nnkA-4nbuA:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PLW_A_SAMA203_0
(RIBOSOMAL RNA
METHYLTRANSFERASE,
PUTATIVE)		 4nbu 3-OXOACYL-(ACYL-CARR
IER-PROTEIN)
REDUCTASE
(Bacillus
sp.
SG-1) 		5 / 12 ALA A  49
GLY A  20
GLY A  24
ALA A  43
LEU A  76
 None
NAI  A 301 (-3.3A)
NAI  A 301 (-3.5A)
None
None
 1.11A 2plwA-4nbuA:
3.6		 2plwA-4nbuA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PLW_A_SAMA203_0
(RIBOSOMAL RNA
METHYLTRANSFERASE,
PUTATIVE)		 4nbu 3-OXOACYL-(ACYL-CARR
IER-PROTEIN)
REDUCTASE
(Bacillus
sp.
SG-1) 		5 / 12 ALA A  53
GLY A  20
GLY A  24
ALA A  43
LEU A  76
 None
NAI  A 301 (-3.3A)
NAI  A 301 (-3.5A)
None
None
 1.06A 2plwA-4nbuA:
3.6		 2plwA-4nbuA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AY0_A_ADNA401_1
(UNCHARACTERIZED
PROTEIN MJ0883)		 4nbu 3-OXOACYL-(ACYL-CARR
IER-PROTEIN)
REDUCTASE
(Bacillus
sp.
SG-1) 		5 / 10 ASP A  44
ASN A  46
ALA A  22
ASP A  66
VAL A  67
 NAI  A 301 (-2.9A)
None
NAI  A 301 ( 4.2A)
NAI  A 301 (-3.6A)
NAI  A 301 (-3.7A)
 0.92A 3ay0A-4nbuA:
6.7		 3ay0A-4nbuA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UBO_B_ADNB353_2
(ADENOSINE KINASE)		 4nbu 3-OXOACYL-(ACYL-CARR
IER-PROTEIN)
REDUCTASE
(Bacillus
sp.
SG-1) 		4 / 5 SER A 145
ILE A  25
TYR A 158
GLY A 189
 NAI  A 301 (-3.3A)
NAI  A 301 (-3.8A)
NAI  A 301 (-4.5A)
NAI  A 301 (-4.8A)
 0.93A 3uboB-4nbuA:
7.1		 3uboB-4nbuA:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HXY_B_ACAB502_1
(PLM1)		 4nbu 3-OXOACYL-(ACYL-CARR
IER-PROTEIN)
REDUCTASE
(Bacillus
sp.
SG-1) 		4 / 7 SER A 145
GLN A 155
TYR A 158
MET A 195
 NAI  A 301 (-3.3A)
None
NAI  A 301 (-4.5A)
NAI  A 301 (-3.6A)
 0.51A 4hxyB-4nbuA:
20.3		 4hxyB-4nbuA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WH5_A_3QBA204_1
(LINCOSAMIDE
RESISTANCE PROTEIN)		 4nbu 3-OXOACYL-(ACYL-CARR
IER-PROTEIN)
REDUCTASE
(Bacillus
sp.
SG-1) 		5 / 12 GLY A  26
ASP A  44
PHE A  62
ILE A  42
ALA A  53
 None
NAI  A 301 (-2.9A)
None
None
None
 1.15A 4wh5A-4nbuA:
undetectable		 4wh5A-4nbuA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BKL_G_EU7G101_0
(MATRIX PROTEIN 2)		 4nbu 3-OXOACYL-(ACYL-CARR
IER-PROTEIN)
REDUCTASE
(Bacillus
sp.
SG-1) 		5 / 9 ALA A  30
ALA A  22
GLY A  26
ALA A  43
GLY A  20
 None
NAI  A 301 ( 4.2A)
None
None
NAI  A 301 (-3.3A)
 0.98A 6bklE-4nbuA:
undetectable
6bklF-4nbuA:
undetectable
6bklG-4nbuA:
undetectable
6bklH-4nbuA:
undetectable		 6bklE-4nbuA:
7.00
6bklF-4nbuA:
7.00
6bklG-4nbuA:
7.00
6bklH-4nbuA:
7.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GSD_A_STRA401_0
(PROGESTERONE
5-BETA-REDUCTASE)		 4nbu 3-OXOACYL-(ACYL-CARR
IER-PROTEIN)
REDUCTASE
(Bacillus
sp.
SG-1) 		5 / 12 VAL A 128
ASN A 142
MET A 168
VAL A 183
ILE A 181
 None
 1.33A 6gsdA-4nbuA:
19.0		 6gsdA-4nbuA:
17.20