SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4nbv'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_A_SAMA385_1
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 4nbv 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
REDUCTASE PUTATIVE
SHORT-CHAIN
DEHYDROGENASES/REDUC
TASES (SDR) FAMILY
PROTEIN
(Cupriavidus
taiwanensis) 		4 / 8 ALA A 213
GLU A 217
ILE A 221
ILE A 238
 None
 0.75A 1rg9B-4nbvA:
undetectable		 1rg9B-4nbvA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_B_SAMB485_0
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 4nbv 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
REDUCTASE PUTATIVE
SHORT-CHAIN
DEHYDROGENASES/REDUC
TASES (SDR) FAMILY
PROTEIN
(Cupriavidus
taiwanensis) 		4 / 8 ALA A 213
GLU A 217
ILE A 221
ILE A 238
 None
 0.76A 1rg9A-4nbvA:
undetectable		 1rg9A-4nbvA:
21.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1UAY_A_ADNA1001_1
(TYPE II
3-HYDROXYACYL-COA
DEHYDROGENASE)		 4nbv 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
REDUCTASE PUTATIVE
SHORT-CHAIN
DEHYDROGENASES/REDUC
TASES (SDR) FAMILY
PROTEIN
(Cupriavidus
taiwanensis) 		7 / 11 GLY A  12
ALA A  14
ASP A  36
ASP A  62
VAL A  63
ALA A  90
VAL A 112
 None
 0.43A 1uayA-4nbvA:
30.4		 1uayA-4nbvA:
33.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1UAY_B_ADNB1002_1
(TYPE II
3-HYDROXYACYL-COA
DEHYDROGENASE)		 4nbv 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
REDUCTASE PUTATIVE
SHORT-CHAIN
DEHYDROGENASES/REDUC
TASES (SDR) FAMILY
PROTEIN
(Cupriavidus
taiwanensis) 		7 / 10 GLY A  12
ALA A  14
ASP A  36
ASP A  62
VAL A  63
ALA A  90
VAL A 112
 None
 0.41A 1uayB-4nbvA:
31.3		 1uayB-4nbvA:
33.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_E_SAME301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 4nbv 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
REDUCTASE PUTATIVE
SHORT-CHAIN
DEHYDROGENASES/REDUC
TASES (SDR) FAMILY
PROTEIN
(Cupriavidus
taiwanensis) 		5 / 12 GLY A  12
ASP A  36
ASP A  62
ASN A  89
ALA A  90
 None
 0.94A 2bm9E-4nbvA:
5.7		 2bm9E-4nbvA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CYX_A_ROCA201_4
(HIV-1 PROTEASE)		 4nbv 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
REDUCTASE PUTATIVE
SHORT-CHAIN
DEHYDROGENASES/REDUC
TASES (SDR) FAMILY
PROTEIN
(Cupriavidus
taiwanensis) 		4 / 4 LEU A  34
ASP A  84
VAL A  87
THR A  21
 None
 1.24A 3cyxB-4nbvA:
undetectable		 3cyxB-4nbvA:
15.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NMU_J_SAMJ228_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE
NOP5/NOP56 RELATED
PROTEIN)		 4nbv 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
REDUCTASE PUTATIVE
SHORT-CHAIN
DEHYDROGENASES/REDUC
TASES (SDR) FAMILY
PROTEIN
(Cupriavidus
taiwanensis) 		5 / 11 GLY A  18
ALA A  15
ILE A  17
ALA A 219
GLN A  23
 None
 1.18A 3nmuB-4nbvA:
undetectable
3nmuJ-4nbvA:
8.0		 3nmuB-4nbvA:
21.99
3nmuJ-4nbvA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S56_A_ROCA201_1
(PROTEASE)		 4nbv 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
REDUCTASE PUTATIVE
SHORT-CHAIN
DEHYDROGENASES/REDUC
TASES (SDR) FAMILY
PROTEIN
(Cupriavidus
taiwanensis) 		5 / 12 GLY A 126
ALA A 125
VAL A 179
GLY A 134
ILE A   9
 None
 1.02A 3s56A-4nbvA:
undetectable		 3s56A-4nbvA:
17.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_J_CLMJ221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4nbv 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
REDUCTASE PUTATIVE
SHORT-CHAIN
DEHYDROGENASES/REDUC
TASES (SDR) FAMILY
PROTEIN
(Cupriavidus
taiwanensis) 		5 / 12 SER A 141
TYR A 154
PHE A 186
LEU A 192
VAL A 195
 None
 1.22A 3u9fJ-4nbvA:
undetectable
3u9fK-4nbvA:
undetectable		 3u9fJ-4nbvA:
21.40
3u9fK-4nbvA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UBO_B_ADNB353_2
(ADENOSINE KINASE)		 4nbv 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
REDUCTASE PUTATIVE
SHORT-CHAIN
DEHYDROGENASES/REDUC
TASES (SDR) FAMILY
PROTEIN
(Cupriavidus
taiwanensis) 		4 / 5 SER A 141
ILE A  17
TYR A 154
GLY A 185
 None
 1.01A 3uboB-4nbvA:
6.8		 3uboB-4nbvA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UY4_A_PAUA302_0
(PANTOTHENATE
SYNTHETASE)		 4nbv 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
REDUCTASE PUTATIVE
SHORT-CHAIN
DEHYDROGENASES/REDUC
TASES (SDR) FAMILY
PROTEIN
(Cupriavidus
taiwanensis) 		4 / 8 VAL A 143
VAL A 142
ASP A  95
GLN A 151
 None
 1.13A 3uy4A-4nbvA:
3.0		 3uy4A-4nbvA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DF3_A_SAMA301_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 4nbv 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
REDUCTASE PUTATIVE
SHORT-CHAIN
DEHYDROGENASES/REDUC
TASES (SDR) FAMILY
PROTEIN
(Cupriavidus
taiwanensis) 		5 / 12 GLY A  29
ALA A  26
THR A  52
ALA A   8
VAL A  32
 None
 0.98A 4df3A-4nbvA:
9.1		 4df3A-4nbvA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EOH_A_TEPA402_1
(PYRIDOXAL KINASE)		 4nbv 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
REDUCTASE PUTATIVE
SHORT-CHAIN
DEHYDROGENASES/REDUC
TASES (SDR) FAMILY
PROTEIN
(Cupriavidus
taiwanensis) 		4 / 5 GLY A  12
THR A  64
VAL A  61
ASP A  36
 None
 1.14A 4eohA-4nbvA:
6.9		 4eohA-4nbvA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_A_SAMA401_1
(METHYLTRANSFERASE
NSUN4)		 4nbv 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
REDUCTASE PUTATIVE
SHORT-CHAIN
DEHYDROGENASES/REDUC
TASES (SDR) FAMILY
PROTEIN
(Cupriavidus
taiwanensis) 		3 / 3 ASP A  36
ARG A  41
ASP A  62
 None
 0.87A 4fp9A-4nbvA:
7.2		 4fp9A-4nbvA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_C_SAMC401_1
(METHYLTRANSFERASE
NSUN4)		 4nbv 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
REDUCTASE PUTATIVE
SHORT-CHAIN
DEHYDROGENASES/REDUC
TASES (SDR) FAMILY
PROTEIN
(Cupriavidus
taiwanensis) 		3 / 3 ASP A  36
ARG A  41
ASP A  62
 None
 0.69A 4fp9C-4nbvA:
7.2		 4fp9C-4nbvA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_F_SAMF401_1
(METHYLTRANSFERASE
NSUN4)		 4nbv 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
REDUCTASE PUTATIVE
SHORT-CHAIN
DEHYDROGENASES/REDUC
TASES (SDR) FAMILY
PROTEIN
(Cupriavidus
taiwanensis) 		3 / 3 ASP A  36
ARG A  41
ASP A  62
 None
 0.69A 4fp9F-4nbvA:
6.1		 4fp9F-4nbvA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KTT_C_SAMC404_1
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 4nbv 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
REDUCTASE PUTATIVE
SHORT-CHAIN
DEHYDROGENASES/REDUC
TASES (SDR) FAMILY
PROTEIN
(Cupriavidus
taiwanensis) 		4 / 8 ALA A 213
GLU A 217
ILE A 221
ILE A 238
 None
 0.81A 4kttD-4nbvA:
undetectable		 4kttD-4nbvA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LB2_A_DM5A602_1
(SERUM ALBUMIN)		 4nbv 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
REDUCTASE PUTATIVE
SHORT-CHAIN
DEHYDROGENASES/REDUC
TASES (SDR) FAMILY
PROTEIN
(Cupriavidus
taiwanensis) 		4 / 7 VAL A   7
ALA A  30
PHE A  25
TYR A 222
 None
 1.16A 4lb2A-4nbvA:
undetectable		 4lb2A-4nbvA:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OAD_A_CLMA206_0
(GNAT SUPERFAMILY
ACETYLTRANSFERASE
PA4794)		 4nbv 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
REDUCTASE PUTATIVE
SHORT-CHAIN
DEHYDROGENASES/REDUC
TASES (SDR) FAMILY
PROTEIN
(Cupriavidus
taiwanensis) 		4 / 4 ALA A  71
ALA A  74
ALA A  75
ALA A  78
 None
 0.12A 4oadA-4nbvA:
undetectable		 4oadA-4nbvA:
26.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PH9_A_IBPA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4nbv 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
REDUCTASE PUTATIVE
SHORT-CHAIN
DEHYDROGENASES/REDUC
TASES (SDR) FAMILY
PROTEIN
(Cupriavidus
taiwanensis) 		5 / 10 VAL A  32
LEU A  49
GLY A  12
ALA A  13
LEU A  34
 None
 1.07A 4ph9A-4nbvA:
undetectable		 4ph9A-4nbvA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PH9_B_IBPB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4nbv 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
REDUCTASE PUTATIVE
SHORT-CHAIN
DEHYDROGENASES/REDUC
TASES (SDR) FAMILY
PROTEIN
(Cupriavidus
taiwanensis) 		5 / 10 VAL A  32
LEU A  49
GLY A  12
ALA A  13
LEU A  34
 None
 1.06A 4ph9B-4nbvA:
undetectable		 4ph9B-4nbvA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E26_B_PAUB601_0
(PANTOTHENATE KINASE
2, MITOCHONDRIAL)		 4nbv 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
REDUCTASE PUTATIVE
SHORT-CHAIN
DEHYDROGENASES/REDUC
TASES (SDR) FAMILY
PROTEIN
(Cupriavidus
taiwanensis) 		4 / 7 TYR A 222
ALA A  20
GLY A  16
GLY A  12
 None
 0.87A 5e26A-4nbvA:
undetectable
5e26B-4nbvA:
undetectable		 5e26A-4nbvA:
21.04
5e26B-4nbvA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E26_C_PAUC602_0
(PANTOTHENATE KINASE
2, MITOCHONDRIAL)		 4nbv 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
REDUCTASE PUTATIVE
SHORT-CHAIN
DEHYDROGENASES/REDUC
TASES (SDR) FAMILY
PROTEIN
(Cupriavidus
taiwanensis) 		4 / 7 GLY A  16
GLY A  12
TYR A 222
ALA A  20
 None
 0.78A 5e26C-4nbvA:
2.2
5e26D-4nbvA:
undetectable		 5e26C-4nbvA:
21.04
5e26D-4nbvA:
21.04