SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4nc1'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQU_B_ACTB1424_0
(FPRA)		 4nc1 A20.1 VHH
(Lama
glama) 		4 / 4 ALA C  99
ARG C  45
GLN C  46
GLU C  53
 None
 1.37A 1lquB-4nc1C:
undetectable		 1lquB-4nc1C:
14.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ARU_A_PNXA606_1
(CHITINASE A)		 4nc1 A20.1 VHH
(Lama
glama) 		4 / 7 GLY C 109
ASP C 115
TRP C 120
ARG C  52
 None
 1.24A 3aruA-4nc1C:
6.4		 3aruA-4nc1C:
14.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QXT_A_MTXA2000_1
(ANTI-METHOTREXATE
CDR1-3 GRAFT VHH)		 4nc1 A20.1 VHH
(Lama
glama) 		7 / 12 VAL C   9
ALA C  31
MET C  41
ARG C  79
ASN C  84
VAL C  86
ALA C 105
 None
 1.01A 3qxtA-4nc1C:
21.9		 3qxtA-4nc1C:
70.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QXT_B_MTXB2000_1
(ANTI-METHOTREXATE
CDR1-3 GRAFT VHH)		 4nc1 A20.1 VHH
(Lama
glama) 		8 / 12 VAL C   9
LEU C  11
ALA C  31
MET C  41
ARG C  79
VAL C  86
ALA C 105
TYR C 119
 None
 0.87A 3qxtB-4nc1C:
22.3		 3qxtB-4nc1C:
70.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QXV_A_MTXA2000_1
(ANTI-METHOTREXATE
CDR1-4 GRAFT VHH)		 4nc1 A20.1 VHH
(Lama
glama) 		8 / 12 VAL C   9
ALA C  31
MET C  41
ARG C  79
ASN C  81
VAL C  86
ALA C 105
TYR C 119
 None
 0.90A 3qxvA-4nc1C:
21.7		 3qxvA-4nc1C:
70.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QXV_B_MTXB2000_1
(ANTI-METHOTREXATE
CDR1-4 GRAFT VHH)		 4nc1 A20.1 VHH
(Lama
glama) 		7 / 12 VAL C   9
ALA C  31
MET C  41
ARG C  79
VAL C  86
ALA C 105
TYR C 119
 None
 0.93A 3qxvB-4nc1C:
22.1		 3qxvB-4nc1C:
70.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QXV_C_MTXC2000_1
(ANTI-METHOTREXATE
CDR1-4 GRAFT VHH)		 4nc1 A20.1 VHH
(Lama
glama) 		7 / 11 VAL C   9
ALA C  31
MET C  41
ARG C  79
ASN C  81
VAL C  86
ALA C 105
 None
 0.93A 3qxvC-4nc1C:
22.2		 3qxvC-4nc1C:
70.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QXV_D_MTXD2000_1
(ANTI-METHOTREXATE
CDR1-4 GRAFT VHH)		 4nc1 A20.1 VHH
(Lama
glama) 		7 / 12 VAL C   9
ALA C  31
MET C  41
ARG C  79
VAL C  86
ALA C 105
TYR C 119
 None
 0.90A 3qxvD-4nc1C:
22.0		 3qxvD-4nc1C:
70.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QXV_E_MTXE2000_1
(ANTI-METHOTREXATE
CDR1-4 GRAFT VHH)		 4nc1 A20.1 VHH
(Lama
glama) 		6 / 12 ALA C  31
MET C  41
ARG C  79
VAL C  86
ALA C 105
TYR C 119
 None
 0.98A 3qxvE-4nc1C:
18.3		 3qxvE-4nc1C:
70.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CJK_B_ACTB302_0
(IMMUNOGLOBULIN FAB
HEAVY CHAIN)		 4nc1 A26.8 VHH
(Lama
glama) 		3 / 3 TYR E  60
GLY E  66
THR E  69
 None
 0.15A 6cjkB-4nc1E:
19.1		 6cjkB-4nc1E:
29.31