SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4nc2'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UDT_A_VIAA1000_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 4nc2 B39 VHH
(Lama
glama) 		5 / 12 TYR B 109
ALA B  50
ILE B  51
LEU B  27
GLN B  78
 None
 1.24A 1udtA-4nc2B:
undetectable		 1udtA-4nc2B:
13.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QXT_A_MTXA2000_1
(ANTI-METHOTREXATE
CDR1-3 GRAFT VHH)		 4nc2 B39 VHH
(Lama
glama) 		5 / 12 ALA B  24
MET B  34
ARG B  71
ASN B  76
ALA B  97
 None
 0.95A 3qxtA-4nc2B:
23.1		 3qxtA-4nc2B:
71.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QXT_B_MTXB2000_1
(ANTI-METHOTREXATE
CDR1-3 GRAFT VHH)		 4nc2 B39 VHH
(Lama
glama) 		6 / 12 LEU B   4
ALA B  24
MET B  34
ARG B  71
ALA B  97
TYR B 111
 None
 0.61A 3qxtB-4nc2B:
23.7		 3qxtB-4nc2B:
71.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QXT_B_MTXB2000_1
(ANTI-METHOTREXATE
CDR1-3 GRAFT VHH)		 4nc2 B39 VHH
(Lama
glama) 		6 / 12 VAL B   2
LEU B   4
MET B  34
ARG B  71
ALA B  97
TYR B 111
 None
 0.55A 3qxtB-4nc2B:
23.7		 3qxtB-4nc2B:
71.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QXV_A_MTXA2000_1
(ANTI-METHOTREXATE
CDR1-4 GRAFT VHH)		 4nc2 B39 VHH
(Lama
glama) 		7 / 12 VAL B   2
ALA B  24
MET B  34
ARG B  71
ASN B  73
ALA B  97
TYR B 111
 None
 0.75A 3qxvA-4nc2B:
22.8		 3qxvA-4nc2B:
70.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QXV_B_MTXB2000_1
(ANTI-METHOTREXATE
CDR1-4 GRAFT VHH)		 4nc2 B39 VHH
(Lama
glama) 		6 / 12 VAL B   2
ALA B  24
MET B  34
ARG B  71
ALA B  97
TYR B 111
 None
 0.82A 3qxvB-4nc2B:
22.8		 3qxvB-4nc2B:
70.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QXV_C_MTXC2000_1
(ANTI-METHOTREXATE
CDR1-4 GRAFT VHH)		 4nc2 B39 VHH
(Lama
glama) 		6 / 11 VAL B   2
ALA B  24
MET B  34
ARG B  71
ASN B  73
ALA B  97
 None
 0.73A 3qxvC-4nc2B:
23.2		 3qxvC-4nc2B:
70.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QXV_D_MTXD2000_1
(ANTI-METHOTREXATE
CDR1-4 GRAFT VHH)		 4nc2 B39 VHH
(Lama
glama) 		5 / 12 ALA B  24
MET B  34
ARG B  71
ALA B  97
TYR B 111
 None
 0.75A 3qxvD-4nc2B:
22.8		 3qxvD-4nc2B:
70.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QXV_D_MTXD2000_1
(ANTI-METHOTREXATE
CDR1-4 GRAFT VHH)		 4nc2 B39 VHH
(Lama
glama) 		5 / 12 VAL B   2
MET B  34
ARG B  71
ALA B  97
TYR B 111
 None
 0.63A 3qxvD-4nc2B:
22.8		 3qxvD-4nc2B:
70.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QXV_E_MTXE2000_1
(ANTI-METHOTREXATE
CDR1-4 GRAFT VHH)		 4nc2 B39 VHH
(Lama
glama) 		5 / 12 ALA B  24
MET B  34
ARG B  71
ALA B  97
TYR B 111
 None
 0.81A 3qxvE-4nc2B:
19.2		 3qxvE-4nc2B:
70.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RV5_A_DXCA92_0
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 4nc2 TOXIN B
(Clostridioides
difficile) 		4 / 4 LYS A  63
PHE A  62
PHE A 115
VAL A 106
 None
 1.32A 3rv5A-4nc2A:
undetectable
3rv5B-4nc2A:
undetectable		 3rv5A-4nc2A:
20.63
3rv5B-4nc2A:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EIX_A_NIMA201_1
(PHOSPHOLIPASE A2
VRV-PL-VIIIA)		 4nc2 TOXIN B
(Clostridioides
difficile) 		4 / 4 LEU A  88
ALA A  66
ILE A  53
LYS A  91
 None
 1.49A 4eixA-4nc2A:
undetectable		 4eixA-4nc2A:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZB_C_ACTC401_0
(PROTON-GATED ION
CHANNEL)		 4nc2 TOXIN B
B39 VHH
(Clostridioides
difficile;
Lama
glama) 		4 / 7 ILE B  51
ARG B  71
VAL B  33
GLU A  39
 None
 0.95A 4zzbC-4nc2B:
undetectable
4zzbD-4nc2B:
undetectable		 4zzbC-4nc2B:
16.25
4zzbD-4nc2B:
16.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECM_D_LEUD602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 4nc2 B39 VHH
(Lama
glama) 		4 / 7 ALA B  91
THR B  90
VAL B 118
GLU B  88
 None
 0.75A 5ecmD-4nc2B:
undetectable		 5ecmD-4nc2B:
12.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECO_D_LEUD602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 4nc2 B39 VHH
(Lama
glama) 		4 / 7 ALA B  91
THR B  90
VAL B 118
GLU B  88
 None
 0.84A 5ecoD-4nc2B:
undetectable		 5ecoD-4nc2B:
12.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y9Y_A_ACTA412_0
(UNCHARACTERIZED
PROTEIN KDOO)		 4nc2 TOXIN B
B39 VHH
(Clostridioides
difficile;
Lama
glama) 		3 / 3 ARG B 104
PHE A  18
ARG A  12
 None
 1.24A 5y9yA-4nc2B:
undetectable		 5y9yA-4nc2B:
21.29