SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4nc6'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1G5Y_B_9CRB501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4nc6 RAB
GTPASE-ACTIVATING
PROTEIN 1
(Homo
sapiens) 		5 / 12 ALA A 760
LEU A 763
LEU A 748
LEU A 731
ILE A 756
 None
 1.21A 1g5yB-4nc6A:
undetectable		 1g5yB-4nc6A:
23.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_2
(HMG-COA REDUCTASE)		 4nc6 RAB
GTPASE-ACTIVATING
PROTEIN 1
(Homo
sapiens) 		4 / 8 GLU A 699
LEU A 718
ALA A 779
LEU A 780
 None
 0.93A 1hwiD-4nc6A:
undetectable		 1hwiD-4nc6A:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_B_THAB2_1
(LIVER
CARBOXYLESTERASE I)		 4nc6 RAB
GTPASE-ACTIVATING
PROTEIN 1
(Homo
sapiens) 		5 / 11 LEU A 631
VAL A 741
LEU A 660
LEU A 738
LEU A 659
 None
 1.23A 1mx1B-4nc6A:
undetectable		 1mx1B-4nc6A:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JJ8_C_AZZC1211_1
(DEOXYNUCLEOSIDE
KINASE)		 4nc6 RAB
GTPASE-ACTIVATING
PROTEIN 1
(Homo
sapiens) 		5 / 12 ILE A 706
TRP A 727
LEU A 787
PHE A 783
ALA A 720
 None
 1.24A 2jj8C-4nc6A:
undetectable		 2jj8C-4nc6A:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UXO_B_TACB1211_1
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR TTGR)		 4nc6 RAB
GTPASE-ACTIVATING
PROTEIN 1
(Homo
sapiens) 		5 / 11 LEU A 680
LEU A 749
LEU A 683
VAL A 755
ILE A 756
 None
 1.19A 2uxoB-4nc6A:
undetectable		 2uxoB-4nc6A:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_A_SVRA508_1
(PHOSPHOLIPASE A2)		 4nc6 RAB
GTPASE-ACTIVATING
PROTEIN 1
(Homo
sapiens) 		4 / 5 VAL A 589
GLN A 577
PHE A 676
ARG A 593
 None
 1.39A 3bjwE-4nc6A:
undetectable		 3bjwE-4nc6A:
16.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KF9_A_ACTA407_0
(GLUTATHIONE
S-TRANSFERASE
PROTEIN)		 4nc6 RAB
GTPASE-ACTIVATING
PROTEIN 1
(Homo
sapiens) 		3 / 3 GLU A 569
ARG A 572
HIS A 661
 None
 0.68A 4kf9A-4nc6A:
undetectable		 4kf9A-4nc6A:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7P_C_CHDC401_0
(BILE SALT HYDROLASE)		 4nc6 RAB
GTPASE-ACTIVATING
PROTEIN 1
(Homo
sapiens) 		4 / 8 ILE A 596
LEU A 671
ALA A 667
LEU A 659
 None
 0.88A 5y7pC-4nc6A:
undetectable		 5y7pC-4nc6A:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6N_A_SREA508_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN,GP1
ENVELOPE
GLYCOPROTEIN)		 4nc6 RAB
GTPASE-ACTIVATING
PROTEIN 1
(Homo
sapiens) 		5 / 10 VAL A 563
LEU A 559
LEU A 544
LEU A 578
LEU A 579
 None
 0.95A 6f6nA-4nc6A:
undetectable
6f6nB-4nc6A:
undetectable		 6f6nA-4nc6A:
13.42
6f6nB-4nc6A:
12.75