SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4ncc'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1H8S_A_AICA1000_1
(MUTANT AL2 6E7P9G)		 4ncc FAB FRAGMENT HEAVY
FAB FRAGMENT LIGHT
(Mus
musculus) 		6 / 12 GLN L  88
TYR L  93
PHE L  97
VAL H  37
ALA H  97
TRP H 109
 None
 0.81A 1h8sA-4nccL:
20.9		 1h8sA-4nccL:
38.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD2_A_CHDA2_0
(FERROCHELATASE)		 4ncc FAB FRAGMENT HEAVY
FAB FRAGMENT LIGHT
(Mus
musculus;
Mus
musculus) 		4 / 8 MET L 174
LEU L 135
SER H 184
VAL L 158
 None
 1.01A 2qd2A-4nccL:
undetectable		 2qd2A-4nccL:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V2G_A_BEZA1222_0
(PEROXIREDOXIN 6)		 4ncc FAB FRAGMENT HEAVY
FAB FRAGMENT LIGHT
(Mus
musculus;
Mus
musculus) 		4 / 7 THR H  61
PRO H  62
SER H  63
PRO L  94
 None
 0.82A 2v2gA-4nccH:
undetectable
2v2gB-4nccH:
undetectable		 2v2gA-4nccH:
20.40
2v2gB-4nccH:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V2G_B_BEZB1220_0
(PEROXIREDOXIN 6)		 4ncc FAB FRAGMENT HEAVY
FAB FRAGMENT LIGHT
(Mus
musculus;
Mus
musculus) 		4 / 7 PRO L  94
THR H  61
PRO H  62
SER H  63
 None
 0.83A 2v2gA-4nccL:
undetectable
2v2gB-4nccL:
undetectable		 2v2gA-4nccL:
20.72
2v2gB-4nccL:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V2G_C_BEZC1222_0
(PEROXIREDOXIN 6)		 4ncc FAB FRAGMENT HEAVY
FAB FRAGMENT LIGHT
(Mus
musculus;
Mus
musculus) 		4 / 7 THR H  61
PRO H  62
SER H  63
PRO L  94
 None
 0.82A 2v2gC-4nccH:
undetectable
2v2gD-4nccH:
undetectable		 2v2gC-4nccH:
20.40
2v2gD-4nccH:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V2G_D_BEZD1221_0
(PEROXIREDOXIN 6)		 4ncc FAB FRAGMENT HEAVY
FAB FRAGMENT LIGHT
(Mus
musculus;
Mus
musculus) 		4 / 7 PRO L  94
THR H  61
PRO H  62
SER H  63
 None
 0.82A 2v2gC-4nccL:
undetectable
2v2gD-4nccL:
undetectable		 2v2gC-4nccL:
20.72
2v2gD-4nccL:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V32_A_BEZA1222_0
(PEROXIREDOXIN 6)		 4ncc FAB FRAGMENT HEAVY
FAB FRAGMENT LIGHT
(Mus
musculus;
Mus
musculus) 		4 / 8 THR H  61
PRO H  62
SER H  63
PRO L  94
 None
 0.84A 2v32A-4nccH:
undetectable
2v32B-4nccH:
undetectable		 2v32A-4nccH:
20.40
2v32B-4nccH:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V32_B_BEZB1220_0
(PEROXIREDOXIN 6)		 4ncc FAB FRAGMENT HEAVY
FAB FRAGMENT LIGHT
(Mus
musculus;
Mus
musculus) 		4 / 8 PRO L  94
THR H  61
PRO H  62
SER H  63
 None
 0.84A 2v32A-4nccL:
undetectable
2v32B-4nccL:
undetectable		 2v32A-4nccL:
20.72
2v32B-4nccL:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V32_C_BEZC1222_0
(PEROXIREDOXIN 6)		 4ncc FAB FRAGMENT HEAVY
FAB FRAGMENT LIGHT
(Mus
musculus;
Mus
musculus) 		4 / 8 THR H  61
PRO H  62
SER H  63
PRO L  94
 None
 0.84A 2v32C-4nccH:
undetectable
2v32D-4nccH:
undetectable		 2v32C-4nccH:
20.40
2v32D-4nccH:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V32_D_BEZD1221_0
(PEROXIREDOXIN 6)		 4ncc FAB FRAGMENT HEAVY
FAB FRAGMENT LIGHT
(Mus
musculus;
Mus
musculus) 		4 / 8 PRO L  94
THR H  61
PRO H  62
SER H  63
 None
 0.79A 2v32C-4nccL:
undetectable
2v32D-4nccL:
undetectable		 2v32C-4nccL:
20.72
2v32D-4nccL:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V41_C_BEZC1218_0
(PEROXIREDOXIN 6.)		 4ncc FAB FRAGMENT HEAVY
FAB FRAGMENT LIGHT
(Mus
musculus;
Mus
musculus) 		4 / 8 THR H  61
PRO H  62
SER H  63
PRO L  94
 None
 0.85A 2v41C-4nccH:
undetectable
2v41D-4nccH:
undetectable		 2v41C-4nccH:
20.40
2v41D-4nccH:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V41_D_BEZD1222_0
(PEROXIREDOXIN 6.)		 4ncc FAB FRAGMENT HEAVY
FAB FRAGMENT LIGHT
(Mus
musculus;
Mus
musculus) 		4 / 8 PRO L  94
THR H  61
PRO H  62
SER H  63
 None
 0.87A 2v41C-4nccL:
undetectable
2v41D-4nccL:
undetectable		 2v41C-4nccL:
20.72
2v41D-4nccL:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V41_E_BEZE1222_0
(PEROXIREDOXIN 6.)		 4ncc FAB FRAGMENT HEAVY
FAB FRAGMENT LIGHT
(Mus
musculus;
Mus
musculus) 		4 / 7 THR H  61
PRO H  62
SER H  63
PRO L  94
 None
 0.87A 2v41E-4nccH:
undetectable
2v41F-4nccH:
undetectable		 2v41E-4nccH:
20.40
2v41F-4nccH:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V41_F_BEZF1222_0
(PEROXIREDOXIN 6.)		 4ncc FAB FRAGMENT HEAVY
FAB FRAGMENT LIGHT
(Mus
musculus;
Mus
musculus) 		4 / 7 PRO L  94
THR H  61
PRO H  62
SER H  63
 None
 0.90A 2v41E-4nccL:
undetectable
2v41F-4nccL:
undetectable		 2v41E-4nccL:
20.72
2v41F-4nccL:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V41_H_BEZH1222_0
(PEROXIREDOXIN 6.)		 4ncc FAB FRAGMENT HEAVY
FAB FRAGMENT LIGHT
(Mus
musculus;
Mus
musculus) 		4 / 8 PRO L  94
THR H  61
PRO H  62
SER H  63
 None
 0.75A 2v41G-4nccL:
undetectable
2v41H-4nccL:
undetectable		 2v41G-4nccL:
20.72
2v41H-4nccL:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7K_B_SALB1305_1
(LYSR-TYPE REGULATORY
PROTEIN)		 4ncc FAB FRAGMENT LIGHT
(Mus
musculus) 		4 / 5 SER L  75
ARG L  76
PRO L  15
GLY L  16
 None
 1.48A 2y7kB-4nccL:
undetectable		 2y7kB-4nccL:
17.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7P_A_SALA1001_1
(LYSR-TYPE REGULATORY
PROTEIN)		 4ncc FAB FRAGMENT LIGHT
(Mus
musculus) 		4 / 6 SER L  75
ARG L  76
PRO L  15
GLY L  16
 None
 1.41A 2y7pA-4nccL:
undetectable		 2y7pA-4nccL:
17.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIW_D_LOCD503_1
(TUBULIN ALPHA-1B
CHAIN
TUBULIN BETA CHAIN)		 4ncc FAB FRAGMENT HEAVY
(Mus
musculus) 		3 / 3 SER H 209
ALA H 204
VAL H 203
 None
 0.54A 5xiwC-4nccH:
undetectable		 5xiwC-4nccH:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA819_0
(GEPHYRIN)		 4ncc FAB FRAGMENT LIGHT
(Mus
musculus) 		3 / 3 ARG L  76
GLY L  16
GLU L  17
 None
 0.55A 6fgdA-4nccL:
undetectable		 6fgdA-4nccL:
17.33