SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4ncj'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DG5_A_TOPA201_1
(DIHYDROFOLATE
REDUCTASE)		 4ncj DNA DOUBLE-STRAND
BREAK REPAIR RAD50
ATPASE
(Pyrococcus
furiosus) 		5 / 11 ALA A 135
ILE A 816
PHE A 132
LEU A   3
ILE A 820
 None
 1.18A 1dg5A-4ncjA:
undetectable		 1dg5A-4ncjA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_A_THAA1_1
(LIVER
CARBOXYLESTERASE I)		 4ncj DNA DOUBLE-STRAND
BREAK REPAIR RAD50
ATPASE
(Pyrococcus
furiosus) 		5 / 11 LEU A 802
GLY A 801
VAL A 769
LEU A 778
LEU A 806
 None
 1.14A 1mx1A-4ncjA:
undetectable		 1mx1A-4ncjA:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UXP_B_CLMB1211_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR TTGR)		 4ncj DNA DOUBLE-STRAND
BREAK REPAIR RAD50
ATPASE
(Pyrococcus
furiosus) 		5 / 11 ALA A 752
MET A 808
GLY A 801
ILE A 146
VAL A 776
 None
 1.25A 2uxpB-4ncjA:
undetectable		 2uxpB-4ncjA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PGY_A_GLYA510_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 4ncj DNA DOUBLE-STRAND
BREAK REPAIR RAD50
ATPASE
(Pyrococcus
furiosus) 		4 / 6 GLU A 805
ILE A 138
ALA A 145
ASN A 134
 None
 0.96A 3pgyA-4ncjA:
undetectable
3pgyB-4ncjA:
undetectable		 3pgyA-4ncjA:
21.25
3pgyB-4ncjA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QFX_A_CP6A602_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4ncj DNA DOUBLE-STRAND
BREAK REPAIR RAD50
ATPASE
(Pyrococcus
furiosus) 		5 / 12 ALA A 135
ILE A 816
PHE A 132
LEU A   3
ILE A 820
 None
 1.15A 3qfxA-4ncjA:
undetectable		 3qfxA-4ncjA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QFX_B_CP6B702_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4ncj DNA DOUBLE-STRAND
BREAK REPAIR RAD50
ATPASE
(Pyrococcus
furiosus) 		5 / 12 ALA A 135
ILE A 816
PHE A 132
LEU A   3
ILE A 820
 None
 1.11A 3qfxB-4ncjA:
undetectable		 3qfxB-4ncjA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_A_ZPCA1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 4ncj DNA DOUBLE-STRAND
BREAK REPAIR RAD50
ATPASE
(Pyrococcus
furiosus) 		4 / 7 GLU A 786
GLU A 766
PHE A 779
VAL A 157
 None
 0.98A 4a97A-4ncjA:
undetectable		 4a97A-4ncjA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_D_ZPCD1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 4ncj DNA DOUBLE-STRAND
BREAK REPAIR RAD50
ATPASE
(Pyrococcus
furiosus) 		4 / 7 GLU A 786
GLU A 766
PHE A 779
VAL A 157
 None
 1.02A 4a97D-4ncjA:
undetectable		 4a97D-4ncjA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_C_CHDC102_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 4ncj DNA DOUBLE-STRAND
BREAK REPAIR RAD50
ATPASE
(Pyrococcus
furiosus) 		4 / 7 GLU A 796
LEU A 800
LEU A 147
LEU A 778
 None
 0.75A 4wg0B-4ncjA:
undetectable
4wg0C-4ncjA:
undetectable		 4wg0B-4ncjA:
4.08
4wg0C-4ncjA:
4.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_L_CHDL103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 4ncj DNA DOUBLE-STRAND
BREAK REPAIR RAD50
ATPASE
(Pyrococcus
furiosus) 		4 / 7 LEU A 147
LEU A 778
GLU A 796
LEU A 800
 None
 0.78A 4wg0L-4ncjA:
undetectable
4wg0M-4ncjA:
undetectable		 4wg0L-4ncjA:
4.08
4wg0M-4ncjA:
4.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XK8_A_PQNA845_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1)		 4ncj DNA DOUBLE-STRAND
BREAK REPAIR RAD50
ATPASE
(Pyrococcus
furiosus) 		4 / 8 MET A 808
PHE A 804
ALA A 145
GLY A 801
 None
 0.80A 4xk8a-4ncjA:
undetectable		 4xk8a-4ncjA:
17.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HV1_A_RFPA902_1
(PHOSPHOENOLPYRUVATE
SYNTHASE)		 4ncj DNA DOUBLE-STRAND
BREAK REPAIR RAD50
ATPASE
(Pyrococcus
furiosus) 		5 / 12 VAL A 769
ALA A 752
VAL A 767
LEU A 789
LEU A 812
 None
 1.14A 5hv1A-4ncjA:
undetectable		 5hv1A-4ncjA:
18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGY_A_ERYA403_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 4ncj DNA DOUBLE-STRAND
BREAK REPAIR RAD50
ATPASE
(Pyrococcus
furiosus) 		4 / 6 ASP A  41
ILE A  71
ARG A  86
TYR A 129
 None
 1.24A 5igyA-4ncjA:
undetectable		 5igyA-4ncjA:
23.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ONL_A_010A302_0
(YNDL)		 4ncj DNA DOUBLE-STRAND
BREAK REPAIR RAD50
ATPASE
(Pyrococcus
furiosus) 		4 / 5 GLU A   4
LYS A  81
GLU A  76
GLU A  23
 None
 1.29A 5onlA-4ncjA:
undetectable		 5onlA-4ncjA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HRJ_A_010A302_0
(YNDL)		 4ncj DNA DOUBLE-STRAND
BREAK REPAIR RAD50
ATPASE
(Pyrococcus
furiosus) 		4 / 5 GLU A   4
LYS A  81
GLU A  76
GLU A  23
 None
 1.31A 6hrjA-4ncjA:
undetectable		 6hrjA-4ncjA:
20.41