SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4ncn'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CD2_A_FOLA307_1
(DIHYDROFOLATE
REDUCTASE)		 4ncn EUKARYOTIC
TRANSLATION
INITIATION FACTOR
5B-LIKE PROTEIN
(Chaetomium
thermophilum) 		3 / 3 GLU A 552
ILE A 556
ARG A 605
 MG  A1002 ( 4.0A)
GTP  A1001 ( 3.7A)
None
 0.66A 1cd2A-4ncnA:
undetectable		 1cd2A-4ncnA:
16.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICU_A_NIOA221_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 4ncn EUKARYOTIC
TRANSLATION
INITIATION FACTOR
5B-LIKE PROTEIN
(Chaetomium
thermophilum) 		4 / 6 SER A 667
PHE A 700
GLU A 721
GLY A 722
 None
 1.14A 1icuA-4ncnA:
undetectable
1icuB-4ncnA:
undetectable		 1icuA-4ncnA:
20.00
1icuB-4ncnA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICU_B_NIOB219_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 4ncn EUKARYOTIC
TRANSLATION
INITIATION FACTOR
5B-LIKE PROTEIN
(Chaetomium
thermophilum) 		4 / 6 PHE A 700
GLU A 721
GLY A 722
SER A 667
 None
 1.15A 1icuA-4ncnA:
undetectable
1icuB-4ncnA:
undetectable		 1icuA-4ncnA:
20.00
1icuB-4ncnA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQB_A_BEZA524_0
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 4ncn EUKARYOTIC
TRANSLATION
INITIATION FACTOR
5B-LIKE PROTEIN
(Chaetomium
thermophilum) 		4 / 6 SER A 667
PHE A 700
GLU A 721
GLY A 722
 None
 1.15A 1kqbA-4ncnA:
undetectable
1kqbB-4ncnA:
undetectable		 1kqbA-4ncnA:
18.54
1kqbB-4ncnA:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N2X_B_SAMB402_0
(S-ADENOSYL-METHYLTRA
NSFERASE MRAW)		 4ncn EUKARYOTIC
TRANSLATION
INITIATION FACTOR
5B-LIKE PROTEIN
(Chaetomium
thermophilum) 		5 / 12 THR A 537
GLY A 535
GLY A 530
GLY A 555
ASN A 547
 MG  A1002 ( 3.1A)
GTP  A1001 (-3.1A)
None
NA  A1003 ( 4.6A)
GOL  A1006 (-3.8A)
 0.92A 1n2xB-4ncnA:
undetectable		 1n2xB-4ncnA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NSI_A_H4BA600_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))		 4ncn EUKARYOTIC
TRANSLATION
INITIATION FACTOR
5B-LIKE PROTEIN
(Chaetomium
thermophilum) 		4 / 6 ARG A 637
ILE A 630
PHE A 695
GLU A 692
 None
 1.39A 1nsiA-4ncnA:
undetectable
1nsiB-4ncnA:
undetectable		 1nsiA-4ncnA:
20.99
1nsiB-4ncnA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NSI_B_H4BB601_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))		 4ncn EUKARYOTIC
TRANSLATION
INITIATION FACTOR
5B-LIKE PROTEIN
(Chaetomium
thermophilum) 		4 / 6 PHE A 695
GLU A 692
ARG A 637
ILE A 630
 None
 1.44A 1nsiA-4ncnA:
undetectable
1nsiB-4ncnA:
undetectable		 1nsiA-4ncnA:
20.99
1nsiB-4ncnA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NSI_C_H4BC602_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))		 4ncn EUKARYOTIC
TRANSLATION
INITIATION FACTOR
5B-LIKE PROTEIN
(Chaetomium
thermophilum) 		4 / 6 ARG A 637
ILE A 630
PHE A 695
GLU A 692
 None
 1.44A 1nsiC-4ncnA:
undetectable
1nsiD-4ncnA:
undetectable		 1nsiC-4ncnA:
20.99
1nsiD-4ncnA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NSI_D_H4BD603_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))		 4ncn EUKARYOTIC
TRANSLATION
INITIATION FACTOR
5B-LIKE PROTEIN
(Chaetomium
thermophilum) 		4 / 6 PHE A 695
GLU A 692
ARG A 637
ILE A 630
 None
 1.42A 1nsiC-4ncnA:
undetectable
1nsiD-4ncnA:
undetectable		 1nsiC-4ncnA:
20.99
1nsiD-4ncnA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZQ9_A_SAMA4000_0
(PROBABLE
DIMETHYLADENOSINE
TRANSFERASE)		 4ncn EUKARYOTIC
TRANSLATION
INITIATION FACTOR
5B-LIKE PROTEIN
(Chaetomium
thermophilum) 		5 / 12 ILE A 768
GLY A 822
LEU A 797
LEU A 805
ILE A 793
 None
 1.15A 1zq9A-4ncnA:
undetectable		 1zq9A-4ncnA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8D_A_BEZA1002_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 4ncn EUKARYOTIC
TRANSLATION
INITIATION FACTOR
5B-LIKE PROTEIN
(Chaetomium
thermophilum) 		5 / 10 GLY A 589
LEU A 590
ILE A 592
LEU A 727
ILE A 570
 None
 1.11A 2f8dA-4ncnA:
undetectable		 2f8dA-4ncnA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8D_B_BEZB1003_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 4ncn EUKARYOTIC
TRANSLATION
INITIATION FACTOR
5B-LIKE PROTEIN
(Chaetomium
thermophilum) 		5 / 10 GLY A 589
LEU A 590
ILE A 592
LEU A 727
ILE A 570
 None
 1.11A 2f8dB-4ncnA:
undetectable		 2f8dB-4ncnA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NSI_A_H4BA600_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))		 4ncn EUKARYOTIC
TRANSLATION
INITIATION FACTOR
5B-LIKE PROTEIN
(Chaetomium
thermophilum) 		4 / 7 ARG A 637
ILE A 630
PHE A 695
GLU A 692
 None
 1.37A 2nsiA-4ncnA:
undetectable
2nsiB-4ncnA:
undetectable		 2nsiA-4ncnA:
20.99
2nsiB-4ncnA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NSI_B_H4BB601_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))		 4ncn EUKARYOTIC
TRANSLATION
INITIATION FACTOR
5B-LIKE PROTEIN
(Chaetomium
thermophilum) 		4 / 7 PHE A 695
GLU A 692
ARG A 637
ILE A 630
 None
 1.40A 2nsiA-4ncnA:
undetectable
2nsiB-4ncnA:
undetectable		 2nsiA-4ncnA:
20.99
2nsiB-4ncnA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NSI_C_H4BC602_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))		 4ncn EUKARYOTIC
TRANSLATION
INITIATION FACTOR
5B-LIKE PROTEIN
(Chaetomium
thermophilum) 		4 / 7 ARG A 637
ILE A 630
PHE A 695
GLU A 692
 None
 1.40A 2nsiC-4ncnA:
undetectable
2nsiD-4ncnA:
undetectable		 2nsiC-4ncnA:
20.99
2nsiD-4ncnA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NSI_D_H4BD603_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))		 4ncn EUKARYOTIC
TRANSLATION
INITIATION FACTOR
5B-LIKE PROTEIN
(Chaetomium
thermophilum) 		4 / 7 PHE A 695
GLU A 692
ARG A 637
ILE A 630
 None
 1.39A 2nsiC-4ncnA:
undetectable
2nsiD-4ncnA:
undetectable		 2nsiC-4ncnA:
20.99
2nsiD-4ncnA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7H_B_SAMB530_0
(TYPE I RESTRICTION
ENZYME ECOKI M
PROTEIN)		 4ncn EUKARYOTIC
TRANSLATION
INITIATION FACTOR
5B-LIKE PROTEIN
(Chaetomium
thermophilum) 		5 / 12 ILE A 789
ALA A 835
GLY A 784
ASN A 603
LEU A 604
 None
 0.98A 2y7hB-4ncnA:
undetectable		 2y7hB-4ncnA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E7G_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 4ncn EUKARYOTIC
TRANSLATION
INITIATION FACTOR
5B-LIKE PROTEIN
(Chaetomium
thermophilum) 		4 / 7 ARG A 637
ILE A 630
PHE A 695
GLU A 692
 None
 1.39A 3e7gA-4ncnA:
undetectable
3e7gB-4ncnA:
undetectable		 3e7gA-4ncnA:
21.12
3e7gB-4ncnA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E7G_B_H4BB1902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 4ncn EUKARYOTIC
TRANSLATION
INITIATION FACTOR
5B-LIKE PROTEIN
(Chaetomium
thermophilum) 		4 / 7 PHE A 695
GLU A 692
ARG A 637
ILE A 630
 None
 1.41A 3e7gA-4ncnA:
undetectable
3e7gB-4ncnA:
undetectable		 3e7gA-4ncnA:
21.12
3e7gB-4ncnA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E7G_C_H4BC2902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 4ncn EUKARYOTIC
TRANSLATION
INITIATION FACTOR
5B-LIKE PROTEIN
(Chaetomium
thermophilum) 		4 / 7 ARG A 637
ILE A 630
PHE A 695
GLU A 692
 None
 1.40A 3e7gC-4ncnA:
0.5
3e7gD-4ncnA:
undetectable		 3e7gC-4ncnA:
21.12
3e7gD-4ncnA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E7G_D_H4BD3902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 4ncn EUKARYOTIC
TRANSLATION
INITIATION FACTOR
5B-LIKE PROTEIN
(Chaetomium
thermophilum) 		4 / 8 PHE A 695
GLU A 692
ARG A 637
ILE A 630
 None
 1.42A 3e7gC-4ncnA:
0.5
3e7gD-4ncnA:
undetectable		 3e7gC-4ncnA:
21.12
3e7gD-4ncnA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GLQ_A_RABA602_2
(ADENOSYLHOMOCYSTEINA
SE)		 4ncn EUKARYOTIC
TRANSLATION
INITIATION FACTOR
5B-LIKE PROTEIN
(Chaetomium
thermophilum) 		4 / 5 GLN A 549
THR A 557
GLU A 804
THR A 563
 GTP  A1001 (-3.8A)
MG  A1002 ( 3.0A)
None
None
 1.37A 3glqA-4ncnA:
4.1		 3glqA-4ncnA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N58_A_ADNA500_2
(ADENOSYLHOMOCYSTEINA
SE)		 4ncn EUKARYOTIC
TRANSLATION
INITIATION FACTOR
5B-LIKE PROTEIN
(Chaetomium
thermophilum) 		4 / 5 GLN A 549
THR A 557
GLU A 804
THR A 563
 GTP  A1001 (-3.8A)
MG  A1002 ( 3.0A)
None
None
 1.44A 3n58A-4ncnA:
undetectable		 3n58A-4ncnA:
24.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACA_C_DXCC1475_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 4ncn EUKARYOTIC
TRANSLATION
INITIATION FACTOR
5B-LIKE PROTEIN
(Chaetomium
thermophilum) 		4 / 8 ILE A 592
ASP A 594
ILE A 528
VAL A 644
 None
MG  A1002 ( 4.1A)
None
None
 0.75A 4acaC-4ncnA:
19.2		 4acaC-4ncnA:
26.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACB_C_DXCC1475_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 4ncn EUKARYOTIC
TRANSLATION
INITIATION FACTOR
5B-LIKE PROTEIN
(Chaetomium
thermophilum) 		4 / 8 ILE A 592
ASP A 594
ILE A 528
VAL A 644
 None
MG  A1002 ( 4.1A)
None
None
 0.76A 4acbC-4ncnA:
19.2		 4acbC-4ncnA:
26.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G1B_B_ECNB403_1
(FLAVOHEMOGLOBIN)		 4ncn EUKARYOTIC
TRANSLATION
INITIATION FACTOR
5B-LIKE PROTEIN
(Chaetomium
thermophilum) 		5 / 11 ILE A 780
LEU A 839
THR A 751
VAL A 767
LEU A 774
 None
 1.14A 4g1bB-4ncnA:
2.5		 4g1bB-4ncnA:
24.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G1B_D_ECND403_1
(FLAVOHEMOGLOBIN)		 4ncn EUKARYOTIC
TRANSLATION
INITIATION FACTOR
5B-LIKE PROTEIN
(Chaetomium
thermophilum) 		5 / 12 ILE A 780
GLN A 749
LEU A 839
VAL A 767
LEU A 774
 None
 1.07A 4g1bD-4ncnA:
2.3		 4g1bD-4ncnA:
24.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LB0_B_ACTB401_0
(UNCHARACTERIZED
PROTEIN)		 4ncn EUKARYOTIC
TRANSLATION
INITIATION FACTOR
5B-LIKE PROTEIN
(Chaetomium
thermophilum) 		4 / 5 VAL A 686
LEU A 712
VAL A 710
PHE A 690
 None
 1.06A 4lb0B-4ncnA:
undetectable		 4lb0B-4ncnA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MV7_A_PPFA501_1
(BIOTIN CARBOXYLASE)		 4ncn EUKARYOTIC
TRANSLATION
INITIATION FACTOR
5B-LIKE PROTEIN
(Chaetomium
thermophilum) 		4 / 7 GLN A 549
VAL A 548
GLU A 552
ARG A 806
 GTP  A1001 (-3.8A)
None
MG  A1002 ( 4.0A)
None
 1.23A 4mv7A-4ncnA:
undetectable		 4mv7A-4ncnA:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PAH_A_LNRA600_1
(PHENYLALANINE
HYDROXYLASE)		 4ncn EUKARYOTIC
TRANSLATION
INITIATION FACTOR
5B-LIKE PROTEIN
(Chaetomium
thermophilum) 		4 / 6 LEU A 647
PHE A 664
TYR A 701
GLU A 702
 None
 1.09A 4pahA-4ncnA:
undetectable		 4pahA-4ncnA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FHZ_B_REAB602_1
(ALDEHYDE
DEHYDROGENASE FAMILY
1 MEMBER A3)		 4ncn EUKARYOTIC
TRANSLATION
INITIATION FACTOR
5B-LIKE PROTEIN
(Chaetomium
thermophilum) 		5 / 9 ILE A 528
GLY A 530
THR A 629
LEU A 636
LEU A 633
 None
 1.27A 5fhzB-4ncnA:
undetectable		 5fhzB-4ncnA:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TE0_A_XINA401_2
(AP2-ASSOCIATED
PROTEIN KINASE 1)		 4ncn EUKARYOTIC
TRANSLATION
INITIATION FACTOR
5B-LIKE PROTEIN
(Chaetomium
thermophilum) 		4 / 5 LEU A 729
VAL A 644
CYH A 734
CYH A 526
 None
 1.45A 5te0A-4ncnA:
undetectable		 5te0A-4ncnA:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDH_C_DAHC60_1
(PUTATIVE CYTOCHROME
C)		 4ncn EUKARYOTIC
TRANSLATION
INITIATION FACTOR
5B-LIKE PROTEIN
(Chaetomium
thermophilum) 		4 / 6 GLN A 735
MET A 726
VAL A 731
LEU A 727
 None
 1.18A 5xdhA-4ncnA:
undetectable
5xdhC-4ncnA:
undetectable		 5xdhA-4ncnA:
12.23
5xdhC-4ncnA:
12.23