SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4nd4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1CET_A_CLQA1001_0
(PROTEIN (L-LACTATE
DEHYDROGENASE))		 4nd4 LACTATE
DEHYDROGENASE,
ADJACENT GENE
ENCODES PREDICTED
MALATE DEHYDROGENASE
(Cryptosporidium
parvum) 		6 / 9 GLY A  28
ASP A  53
ILE A  54
TYR A  85
ALA A  98
ILE A 119
 NAD  A 401 ( 3.9A)
NAD  A 401 (-2.7A)
NAD  A 401 (-4.0A)
None
NAD  A 401 (-3.5A)
NAD  A 401 (-3.9A)
 0.65A 1cetA-4nd4A:
43.7		 1cetA-4nd4A:
44.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HPV_B_478B200_2
(HIV-1 PROTEASE)		 4nd4 LACTATE
DEHYDROGENASE,
ADJACENT GENE
ENCODES PREDICTED
MALATE DEHYDROGENASE
(Cryptosporidium
parvum) 		5 / 9 ALA A  46
VAL A  93
ILE A  39
VAL A  26
ILE A  24
 None
 1.10A 1hpvB-4nd4A:
undetectable		 1hpvB-4nd4A:
17.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A1M_B_CAMB2422_0
(CYTOCHROME P450-CAM)		 4nd4 LACTATE
DEHYDROGENASE,
ADJACENT GENE
ENCODES PREDICTED
MALATE DEHYDROGENASE
(Cryptosporidium
parvum) 		4 / 8 THR A 291
VAL A 166
GLY A 165
ILE A 136
 None
 0.56A 2a1mB-4nd4A:
undetectable		 2a1mB-4nd4A:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B17_A_DIFA701_1
(PHOSPHOLIPASE A2
VRV-PL-VIIIA)		 4nd4 LACTATE
DEHYDROGENASE,
ADJACENT GENE
ENCODES PREDICTED
MALATE DEHYDROGENASE
(Cryptosporidium
parvum) 		5 / 10 ALA A 254
ILE A  95
GLY A 162
HIS A 195
ASP A 143
 None
None
None
NAD  A 401 (-3.7A)
GOL  A 405 (-3.8A)
 1.39A 2b17A-4nd4A:
undetectable		 2b17A-4nd4A:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QL8_A_BEZA143_0
(PUTATIVE REDOX
PROTEIN)		 4nd4 LACTATE
DEHYDROGENASE,
ADJACENT GENE
ENCODES PREDICTED
MALATE DEHYDROGENASE
(Cryptosporidium
parvum) 		4 / 7 ALA A 240
THR A 245
ALA A 246
PRO A 105
 None
PYR  A 402 ( 3.8A)
PYR  A 402 ( 3.6A)
None
 1.00A 2ql8A-4nd4A:
undetectable
2ql8B-4nd4A:
3.5		 2ql8A-4nd4A:
19.81
2ql8B-4nd4A:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GYQ_B_SAMB270_0
(RRNA
(ADENOSINE-2'-O-)-ME
THYLTRANSFERASE)		 4nd4 LACTATE
DEHYDROGENASE,
ADJACENT GENE
ENCODES PREDICTED
MALATE DEHYDROGENASE
(Cryptosporidium
parvum) 		5 / 11 LEU A 219
ILE A 220
SER A 213
LEU A 212
VAL A 210
 None
 1.25A 3gyqB-4nd4A:
3.5		 3gyqB-4nd4A:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IV6_C_SAMC301_0
(PUTATIVE
ZN-DEPENDENT ALCOHOL
DEHYDROGENASE)		 4nd4 LACTATE
DEHYDROGENASE,
ADJACENT GENE
ENCODES PREDICTED
MALATE DEHYDROGENASE
(Cryptosporidium
parvum) 		5 / 12 GLY A  33
THR A  97
ASP A  65
ILE A  66
LEU A  51
 None
 1.36A 3iv6C-4nd4A:
4.8		 3iv6C-4nd4A:
23.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N23_A_OBNA1_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 4nd4 LACTATE
DEHYDROGENASE,
ADJACENT GENE
ENCODES PREDICTED
MALATE DEHYDROGENASE
(Cryptosporidium
parvum) 		5 / 11 GLN A  60
PRO A  59
ASP A  53
VAL A 123
ILE A 119
 None
None
NAD  A 401 (-2.7A)
None
NAD  A 401 (-3.9A)
 1.26A 3n23A-4nd4A:
undetectable		 3n23A-4nd4A:
16.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NU9_A_478A401_1
(PROTEASE)		 4nd4 LACTATE
DEHYDROGENASE,
ADJACENT GENE
ENCODES PREDICTED
MALATE DEHYDROGENASE
(Cryptosporidium
parvum) 		4 / 8 ALA A  46
VAL A  93
ILE A  39
VAL A  26
 None
 0.75A 3nu9A-4nd4A:
undetectable		 3nu9A-4nd4A:
16.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UBO_A_ADNA353_1
(ADENOSINE KINASE)		 4nd4 LACTATE
DEHYDROGENASE,
ADJACENT GENE
ENCODES PREDICTED
MALATE DEHYDROGENASE
(Cryptosporidium
parvum) 		5 / 12 ASP A 143
GLY A 194
GLY A 196
GLY A 165
ASP A 168
 GOL  A 405 (-3.8A)
GOL  A 405 (-3.8A)
GOL  A 405 (-3.5A)
None
None
 0.98A 3uboA-4nd4A:
6.6		 3uboA-4nd4A:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KOE_F_TR6F101_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B
E-SITE DNA2)		 4nd4 LACTATE
DEHYDROGENASE,
ADJACENT GENE
ENCODES PREDICTED
MALATE DEHYDROGENASE
(Cryptosporidium
parvum) 		4 / 6 SER A 205
GLY A 165
ASP A 168
GLY A 193
 None
 0.96A 4koeA-4nd4A:
undetectable
4koeB-4nd4A:
undetectable
4koeC-4nd4A:
2.1		 4koeA-4nd4A:
21.85
4koeB-4nd4A:
21.85
4koeC-4nd4A:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KOE_F_TR6F101_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B
E-SITE DNA2)		 4nd4 LACTATE
DEHYDROGENASE,
ADJACENT GENE
ENCODES PREDICTED
MALATE DEHYDROGENASE
(Cryptosporidium
parvum) 		4 / 6 SER A 205
GLY A 165
ASP A 168
GLY A 288
 None
 0.78A 4koeA-4nd4A:
undetectable
4koeB-4nd4A:
undetectable
4koeC-4nd4A:
2.1		 4koeA-4nd4A:
21.85
4koeB-4nd4A:
21.85
4koeC-4nd4A:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KOE_H_TR6H101_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B
E-SITE DNA4)		 4nd4 LACTATE
DEHYDROGENASE,
ADJACENT GENE
ENCODES PREDICTED
MALATE DEHYDROGENASE
(Cryptosporidium
parvum) 		4 / 7 SER A 205
GLY A 165
ASP A 168
GLY A 288
 None
 0.79A 4koeA-4nd4A:
undetectable
4koeB-4nd4A:
undetectable
4koeD-4nd4A:
2.4		 4koeA-4nd4A:
21.85
4koeB-4nd4A:
21.85
4koeD-4nd4A:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LJ0_A_ACTA505_0
(NAB2)		 4nd4 LACTATE
DEHYDROGENASE,
ADJACENT GENE
ENCODES PREDICTED
MALATE DEHYDROGENASE
(Cryptosporidium
parvum) 		3 / 3 LEU A 243
LYS A 244
THR A 244
 None
 0.62A 4lj0A-4nd4A:
undetectable		 4lj0A-4nd4A:
11.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OBW_B_SAMB601_0
(2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL)		 4nd4 LACTATE
DEHYDROGENASE,
ADJACENT GENE
ENCODES PREDICTED
MALATE DEHYDROGENASE
(Cryptosporidium
parvum) 		5 / 12 ALA A  37
GLY A  33
ASP A  53
ILE A  39
GLY A  41
 None
None
NAD  A 401 (-2.7A)
None
None
 0.99A 4obwB-4nd4A:
3.7		 4obwB-4nd4A:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RTM_A_SAMA301_0
(DNA ADENINE
METHYLASE)		 4nd4 LACTATE
DEHYDROGENASE,
ADJACENT GENE
ENCODES PREDICTED
MALATE DEHYDROGENASE
(Cryptosporidium
parvum) 		5 / 12 GLY A 193
GLY A 194
GLY A 165
ALA A 164
SER A 188
 None
GOL  A 405 (-3.8A)
None
NAD  A 401 ( 4.5A)
None
 0.87A 4rtmA-4nd4A:
undetectable		 4rtmA-4nd4A:
24.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCI_A_SAMA2409_0
(RNA-DIRECTED RNA
POLYMERASE L)		 4nd4 LACTATE
DEHYDROGENASE,
ADJACENT GENE
ENCODES PREDICTED
MALATE DEHYDROGENASE
(Cryptosporidium
parvum) 		5 / 12 GLY A  28
GLY A  30
GLY A  34
ASN A  35
ALA A  98
 NAD  A 401 ( 3.9A)
NAD  A 401 (-3.3A)
None
None
NAD  A 401 (-3.5A)
 1.01A 4uciA-4nd4A:
undetectable		 4uciA-4nd4A:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUE_B_SAMB303_0
(CATECHOL
O-METHYLTRANSFERASE)		 4nd4 LACTATE
DEHYDROGENASE,
ADJACENT GENE
ENCODES PREDICTED
MALATE DEHYDROGENASE
(Cryptosporidium
parvum) 		5 / 12 VAL A 146
GLY A 194
TYR A 286
SER A 272
ASN A 320
 None
GOL  A 405 (-3.8A)
None
None
None
 1.11A 4xueB-4nd4A:
5.5		 4xueB-4nd4A:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z53_F_TR6F101_1
(DNA TOPOISOMERASE 4
SUBUNIT B,DNA
TOPOISOMERASE 4
SUBUNIT A
E-SITE DNA)		 4nd4 LACTATE
DEHYDROGENASE,
ADJACENT GENE
ENCODES PREDICTED
MALATE DEHYDROGENASE
(Cryptosporidium
parvum) 		4 / 6 GLY A 165
ASP A 168
GLY A 193
SER A 205
 None
 0.96A 4z53A-4nd4A:
2.4
4z53B-4nd4A:
1.7		 4z53A-4nd4A:
18.16
4z53B-4nd4A:
18.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z53_F_TR6F101_1
(DNA TOPOISOMERASE 4
SUBUNIT B,DNA
TOPOISOMERASE 4
SUBUNIT A
E-SITE DNA)		 4nd4 LACTATE
DEHYDROGENASE,
ADJACENT GENE
ENCODES PREDICTED
MALATE DEHYDROGENASE
(Cryptosporidium
parvum) 		4 / 6 GLY A 165
ASP A 168
GLY A 288
SER A 205
 None
 0.73A 4z53A-4nd4A:
2.4
4z53B-4nd4A:
1.7		 4z53A-4nd4A:
18.16
4z53B-4nd4A:
18.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z53_H_TR6H101_1
(DNA TOPOISOMERASE 4
SUBUNIT B,DNA
TOPOISOMERASE 4
SUBUNIT A
E-SITE DNA)		 4nd4 LACTATE
DEHYDROGENASE,
ADJACENT GENE
ENCODES PREDICTED
MALATE DEHYDROGENASE
(Cryptosporidium
parvum) 		4 / 7 GLY A 165
ASP A 168
GLY A 288
SER A 205
 None
 0.75A 4z53A-4nd4A:
2.4
4z53B-4nd4A:
1.8		 4z53A-4nd4A:
18.16
4z53B-4nd4A:
18.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L66_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA
TYPE-8,PROTEASOME
SUBUNIT BETA TYPE-5
PROTEASOME SUBUNIT
BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA TYPE-6)		 4nd4 LACTATE
DEHYDROGENASE,
ADJACENT GENE
ENCODES PREDICTED
MALATE DEHYDROGENASE
(Cryptosporidium
parvum) 		5 / 10 ALA A 202
SER A 205
MET A 199
GLY A 193
SER A 169
 None
 1.01A 5l66K-4nd4A:
undetectable
5l66L-4nd4A:
undetectable		 5l66K-4nd4A:
22.22
5l66L-4nd4A:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L66_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA
TYPE-8,PROTEASOME
SUBUNIT BETA TYPE-5
PROTEASOME SUBUNIT
BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA TYPE-6)		 4nd4 LACTATE
DEHYDROGENASE,
ADJACENT GENE
ENCODES PREDICTED
MALATE DEHYDROGENASE
(Cryptosporidium
parvum) 		5 / 10 ALA A 202
SER A 205
MET A 199
GLY A 193
SER A 169
 None
 1.01A 5l66Y-4nd4A:
undetectable
5l66Z-4nd4A:
undetectable		 5l66Y-4nd4A:
22.22
5l66Z-4nd4A:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_A_CVIA301_1
(REGULATORY PROTEIN
TETR)		 4nd4 LACTATE
DEHYDROGENASE,
ADJACENT GENE
ENCODES PREDICTED
MALATE DEHYDROGENASE
(Cryptosporidium
parvum) 		4 / 8 GLY A  41
ARG A  20
VAL A  49
ASP A  48
 None
 0.95A 5vlmA-4nd4A:
undetectable		 5vlmA-4nd4A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM2_B_CYZB1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 4nd4 LACTATE
DEHYDROGENASE,
ADJACENT GENE
ENCODES PREDICTED
MALATE DEHYDROGENASE
(Cryptosporidium
parvum) 		5 / 10 SER A 188
LEU A 307
SER A 204
ILE A 192
PRO A 290
 None
 1.44A 6dm2B-4nd4A:
2.1
6dm2C-4nd4A:
2.2		 6dm2B-4nd4A:
15.41
6dm2C-4nd4A:
15.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM2_D_CYZD1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 4nd4 LACTATE
DEHYDROGENASE,
ADJACENT GENE
ENCODES PREDICTED
MALATE DEHYDROGENASE
(Cryptosporidium
parvum) 		5 / 10 ILE A 192
PRO A 290
SER A 188
LEU A 307
SER A 204
 None
 1.45A 6dm2A-4nd4A:
2.2
6dm2D-4nd4A:
5.7		 6dm2A-4nd4A:
15.41
6dm2D-4nd4A:
15.41