SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4nee'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERE_A_ESTA600_1
(ESTROGEN RECEPTOR)		 4nee AP-2 COMPLEX SUBUNIT
ALPHA-2
(Rattus
norvegicus) 		5 / 9 MET G 353
ALA G 389
LEU G 377
HIS G 369
LEU G 338
 None
 1.11A 1ereA-4neeG:
undetectable		 1ereA-4neeG:
23.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERE_B_ESTB600_1
(ESTROGEN RECEPTOR)		 4nee AP-2 COMPLEX SUBUNIT
ALPHA-2
(Rattus
norvegicus) 		5 / 9 MET G 353
ALA G 389
LEU G 377
HIS G 369
LEU G 338
 None
 1.12A 1ereB-4neeG:
undetectable		 1ereB-4neeG:
23.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERE_D_ESTD600_1
(ESTROGEN RECEPTOR)		 4nee AP-2 COMPLEX SUBUNIT
ALPHA-2
(Rattus
norvegicus) 		5 / 9 MET G 353
ALA G 389
LEU G 377
HIS G 369
LEU G 338
 None
 1.12A 1ereD-4neeG:
undetectable		 1ereD-4neeG:
23.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK3_A_T44A3001_1
(SERUM ALBUMIN)		 4nee AP-2 COMPLEX SUBUNIT
ALPHA-2
(Rattus
norvegicus) 		5 / 11 PRO G 271
LEU G 280
LEU G 316
HIS G 319
ARG G 263
 None
 1.47A 1hk3A-4neeG:
undetectable		 1hk3A-4neeG:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PCG_B_ESTB2_1
(ESTROGEN RECEPTOR)		 4nee AP-2 COMPLEX SUBUNIT
ALPHA-2
(Rattus
norvegicus) 		5 / 10 MET G 353
ALA G 389
LEU G 377
HIS G 369
LEU G 338
 None
 1.08A 1pcgB-4neeG:
undetectable		 1pcgB-4neeG:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WSV_B_THHB4001_0
(AMINOMETHYLTRANSFERA
SE)		 4nee AP-2 COMPLEX SUBUNIT
ALPHA-2
(Rattus
norvegicus) 		5 / 12 LEU G 288
ILE G 287
VAL G 309
CYH G 283
LEU G 326
 None
 1.09A 1wsvB-4neeG:
undetectable		 1wsvB-4neeG:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DAT_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 4nee AP-2 COMPLEX SUBUNIT
ALPHA-2
(Rattus
norvegicus) 		5 / 12 ALA G 365
LEU G 356
GLN G 336
ILE G 317
LEU G 288
 None
 1.15A 3datA-4neeG:
undetectable		 3datA-4neeG:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL0_A_1UNA201_2
(PROTEASE)		 4nee AP-2 COMPLEX SUBUNIT
ALPHA-2
(Rattus
norvegicus) 		5 / 9 LEU G 257
VAL G 309
ILE G 287
PRO G 253
ALA G 254
 None
 1.01A 3el0B-4neeG:
undetectable		 3el0B-4neeG:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM6_A_017A200_2
(PROTEASE)		 4nee AP-2 COMPLEX SUBUNIT
ALPHA-2
(Rattus
norvegicus) 		5 / 12 LEU G  63
ALA G  79
ILE G 112
LEU G 130
VAL G 100
 None
 0.95A 3em6B-4neeG:
undetectable		 3em6B-4neeG:
13.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GYQ_B_SAMB270_0
(RRNA
(ADENOSINE-2'-O-)-ME
THYLTRANSFERASE)		 4nee AP-2 COMPLEX SUBUNIT
ALPHA-2
(Rattus
norvegicus) 		5 / 11 LEU G 175
ALA G 169
ILE G 151
SER G 167
LEU G 132
 None
 1.07A 3gyqB-4neeG:
undetectable		 3gyqB-4neeG:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OLS_A_ESTA600_1
(ESTROGEN RECEPTOR
BETA)		 4nee AP-2 COMPLEX SUBUNIT
ALPHA-2
(Rattus
norvegicus) 		5 / 12 MET G 353
ALA G 389
LEU G 377
HIS G 369
LEU G 338
 None
 1.07A 3olsA-4neeG:
undetectable		 3olsA-4neeG:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OLS_B_ESTB600_1
(ESTROGEN RECEPTOR
BETA)		 4nee AP-2 COMPLEX SUBUNIT
ALPHA-2
(Rattus
norvegicus) 		5 / 12 MET G 353
ALA G 389
LEU G 377
HIS G 369
LEU G 338
 None
 1.09A 3olsB-4neeG:
undetectable		 3olsB-4neeG:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_A_W9TA1001_1
(HEMOLYTIC LECTIN
CEL-III)		 4nee AP-2 COMPLEX SUBUNIT
ALPHA-2
(Rattus
norvegicus) 		4 / 5 ASP G 198
VAL G 204
GLY G 202
ASP G 162
 None
 1.44A 3w9tA-4neeG:
undetectable		 3w9tA-4neeG:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_B_W9TB503_1
(HEMOLYTIC LECTIN
CEL-III)		 4nee AP-2 COMPLEX SUBUNIT
ALPHA-2
(Rattus
norvegicus) 		4 / 5 ASP G 198
VAL G 204
GLY G 202
ASP G 162
 None
 1.43A 3w9tB-4neeG:
undetectable		 3w9tB-4neeG:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_C_W9TC1001_1
(HEMOLYTIC LECTIN
CEL-III)		 4nee AP-2 COMPLEX SUBUNIT
ALPHA-2
(Rattus
norvegicus) 		4 / 5 ASP G 198
VAL G 204
GLY G 202
ASP G 162
 None
 1.44A 3w9tC-4neeG:
undetectable		 3w9tC-4neeG:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_D_W9TD502_1
(HEMOLYTIC LECTIN
CEL-III)		 4nee AP-2 COMPLEX SUBUNIT
ALPHA-2
(Rattus
norvegicus) 		4 / 5 ASP G 198
VAL G 204
GLY G 202
ASP G 162
 None
 1.43A 3w9tD-4neeG:
undetectable		 3w9tD-4neeG:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_E_W9TE504_1
(HEMOLYTIC LECTIN
CEL-III)		 4nee AP-2 COMPLEX SUBUNIT
ALPHA-2
(Rattus
norvegicus) 		4 / 5 ASP G 198
VAL G 204
GLY G 202
ASP G 162
 None
 1.43A 3w9tE-4neeG:
undetectable		 3w9tE-4neeG:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_F_W9TF504_1
(HEMOLYTIC LECTIN
CEL-III)		 4nee AP-2 COMPLEX SUBUNIT
ALPHA-2
(Rattus
norvegicus) 		4 / 5 ASP G 198
VAL G 204
GLY G 202
ASP G 162
 None
 1.44A 3w9tF-4neeG:
undetectable		 3w9tF-4neeG:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_G_W9TG504_1
(HEMOLYTIC LECTIN
CEL-III)		 4nee AP-2 COMPLEX SUBUNIT
ALPHA-2
(Rattus
norvegicus) 		4 / 5 ASP G 198
VAL G 204
GLY G 202
ASP G 162
 None
 1.43A 3w9tG-4neeG:
undetectable		 3w9tG-4neeG:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G8Z_X_TOPX301_1
(DIHYDROFOLATE
REDUCTASE)		 4nee AP-2 COMPLEX SUBUNIT
ALPHA-2
(Rattus
norvegicus) 		5 / 10 ILE G 314
ALA G 349
LEU G 345
SER G 303
PRO G 295
 None
 1.20A 4g8zX-4neeG:
undetectable		 4g8zX-4neeG:
18.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWZ_B_CQAB303_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 4nee AP-2 COMPLEX SUBUNIT
ALPHA-2
(Rattus
norvegicus) 		4 / 8 GLY G  94
GLU G 107
LEU G 108
LEU G 111
 None
 0.65A 4mwzB-4neeG:
undetectable		 4mwzB-4neeG:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DQF_A_LCRA612_1
(SERUM ALBUMIN)		 4nee AP-2 COMPLEX SUBUNIT
ALPHA-2
(Rattus
norvegicus) 		5 / 9 LEU G 334
GLY G 335
LEU G 338
LEU G 350
ALA G 349
 None
 0.88A 5dqfA-4neeG:
undetectable		 5dqfA-4neeG:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DXB_B_ESTB601_1
(ESTROGEN RECEPTOR)		 4nee AP-2 COMPLEX SUBUNIT
ALPHA-2
(Rattus
norvegicus) 		5 / 11 MET G 353
ALA G 389
LEU G 377
HIS G 369
LEU G 338
 None
 1.12A 5dxbB-4neeG:
undetectable		 5dxbB-4neeG:
23.99