SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4nef'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JG4_A_SAMA500_0
(PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE)		 4nef AQUAPORIN-2
(Homo
sapiens) 		5 / 12 VAL A  90
GLY A  51
THR A  20
ALA A  19
LEU A  55
 None
 1.08A 1jg4A-4nefA:
undetectable		 1jg4A-4nefA:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXQ_A_IMNA2001_1
(SERUM ALBUMIN)		 4nef AQUAPORIN-2
(Homo
sapiens) 		5 / 10 ALA A  45
PHE A  48
ALA A  31
LEU A  32
LEU A  28
 None
 1.05A 2bxqA-4nefA:
undetectable		 2bxqA-4nefA:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QM9_A_TDZA201_1
(FATTY ACID-BINDING
PROTEIN, ADIPOCYTE)		 4nef AQUAPORIN-2
(Homo
sapiens) 		5 / 12 VAL A  90
ALA A 186
SER A 182
THR A 138
ALA A  70
 None
 1.22A 2qm9A-4nefA:
undetectable		 2qm9A-4nefA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V3K_A_SAMA1254_0
(ESSENTIAL FOR
MITOTIC GROWTH 1)		 4nef AQUAPORIN-2
(Homo
sapiens) 		6 / 10 PHE A  26
GLY A  96
GLY A  27
LEU A  28
LEU A 104
ALA A 101
 None
 1.21A 2v3kA-4nefA:
undetectable		 2v3kA-4nefA:
24.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WD9_A_IBPA1570_1
(ACYL-COENZYME A
SYNTHETASE ACSM2A,
MITOCHONDRIAL)		 4nef AQUAPORIN-2
(Homo
sapiens) 		4 / 7 ILE A  67
VAL A 168
GLY A 165
GLY A  51
 None
 0.82A 2wd9A-4nefA:
undetectable		 2wd9A-4nefA:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ILT_H_TRUH800_1
(GLUTAMATE RECEPTOR 2)		 4nef AQUAPORIN-2
(Homo
sapiens) 		3 / 3 ILE A  52
SER A 167
SER A 163
 None
None
CD  A 301 ( 4.4A)
 0.57A 3iltH-4nefA:
undetectable		 3iltH-4nefA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KPD_C_SAMC1000_0
(UNCHARACTERIZED
PROTEIN MJ0100)		 4nef AQUAPORIN-2
(Homo
sapiens) 		3 / 3 ASN A 184
ASN A 119
GLU A 134
 None
 0.87A 3kpdB-4nefA:
undetectable		 3kpdB-4nefA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDV_A_AICA375_1
(BETA-PEPTIDYL
AMINOPEPTIDASE)		 4nef AQUAPORIN-2
(Homo
sapiens) 		5 / 11 GLY A 211
ASN A 220
LEU A 143
LEU A 217
LEU A 214
 None
 1.40A 3ndvA-4nefA:
undetectable
3ndvB-4nefA:
undetectable		 3ndvA-4nefA:
22.51
3ndvB-4nefA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDV_B_AICB376_1
(BETA-PEPTIDYL
AMINOPEPTIDASE)		 4nef AQUAPORIN-2
(Homo
sapiens) 		5 / 11 LEU A 217
LEU A 214
GLY A 211
ASN A 220
LEU A 143
 None
 1.38A 3ndvA-4nefA:
undetectable
3ndvB-4nefA:
undetectable		 3ndvA-4nefA:
22.51
3ndvB-4nefA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDV_C_AICC375_1
(BETA-PEPTIDYL
AMINOPEPTIDASE)		 4nef AQUAPORIN-2
(Homo
sapiens) 		5 / 11 GLY A 211
ASN A 220
LEU A 143
LEU A 217
LEU A 214
 None
 1.39A 3ndvC-4nefA:
undetectable
3ndvD-4nefA:
undetectable		 3ndvC-4nefA:
22.51
3ndvD-4nefA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDV_D_AICD374_1
(BETA-PEPTIDYL
AMINOPEPTIDASE)		 4nef AQUAPORIN-2
(Homo
sapiens) 		5 / 11 LEU A 217
LEU A 214
GLY A 211
ASN A 220
LEU A 143
 None
 1.39A 3ndvC-4nefA:
undetectable
3ndvD-4nefA:
undetectable		 3ndvC-4nefA:
22.51
3ndvD-4nefA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4COX_A_IMNA701_1
(CYCLOOXYGENASE-2)		 4nef AQUAPORIN-2
(Homo
sapiens) 		5 / 12 LEU A  21
VAL A  98
GLY A 100
ALA A 101
LEU A  28
 None
 1.08A 4coxA-4nefA:
undetectable		 4coxA-4nefA:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4COX_B_IMNB701_1
(CYCLOOXYGENASE-2)		 4nef AQUAPORIN-2
(Homo
sapiens) 		5 / 12 LEU A  21
VAL A  98
GLY A 100
ALA A 101
LEU A  28
 None
 1.08A 4coxB-4nefA:
undetectable		 4coxB-4nefA:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4COX_D_IMND701_1
(CYCLOOXYGENASE-2)		 4nef AQUAPORIN-2
(Homo
sapiens) 		5 / 12 LEU A  21
VAL A  98
GLY A 100
ALA A 101
LEU A  28
 None
 1.09A 4coxD-4nefA:
undetectable		 4coxD-4nefA:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JLG_A_SAMA401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 4nef AQUAPORIN-2
(Homo
sapiens) 		5 / 12 ILE A  44
ALA A  31
GLY A  29
GLY A 114
TRP A  34
 None
 1.18A 4jlgA-4nefA:
undetectable		 4jlgA-4nefA:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRW_D_LURD705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4nef AQUAPORIN-2
(Homo
sapiens) 		5 / 12 LEU A  21
VAL A  98
GLY A 100
ALA A 101
LEU A  28
 None
 1.04A 4rrwD-4nefA:
undetectable		 4rrwD-4nefA:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRZ_D_LURD705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4nef AQUAPORIN-2
(Homo
sapiens) 		5 / 12 LEU A  21
VAL A  98
GLY A 100
ALA A 101
LEU A  28
 None
 1.04A 4rrzD-4nefA:
undetectable		 4rrzD-4nefA:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3C_B_AC2B301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 4nef AQUAPORIN-2
(Homo
sapiens) 		5 / 10 SER A 182
GLY A 207
ALA A 127
VAL A 131
ILE A 206
 None
 1.14A 5i3cB-4nefA:
undetectable		 5i3cB-4nefA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JGL_A_SAMA301_0
(UBIE/COQ5 FAMILY
METHYLTRANSFERASE,
PUTATIVE)		 4nef AQUAPORIN-2
(Homo
sapiens) 		5 / 12 ALA A  97
LEU A 189
SER A 188
PHE A  25
GLY A 100
 None
 1.26A 5jglA-4nefA:
undetectable		 5jglA-4nefA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXC_A_ZITA307_1
(PREDICTED
AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		 4nef AQUAPORIN-2
(Homo
sapiens) 		4 / 5 PRO A  69
GLU A  16
ARG A  85
THR A  72
 None
 1.35A 5uxcA-4nefA:
undetectable		 5uxcA-4nefA:
26.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XXI_A_LSNA503_1
(CYTOCHROME P450 2C9)		 4nef AQUAPORIN-2
(Homo
sapiens) 		5 / 12 ILE A 164
GLN A  93
LEU A 209
PRO A 208
LEU A 141
 None
 1.24A 5xxiA-4nefA:
undetectable		 5xxiA-4nefA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_C_ACRC605_0
(ALPHA-AMYLASE)		 4nef AQUAPORIN-2
(Homo
sapiens) 		4 / 8 GLY A 207
ILE A 206
ASP A 200
HIS A 201
 None
 0.96A 6ag0C-4nefA:
undetectable		 6ag0C-4nefA:
19.40