SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4nen'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FDU_D_ESTD352_1
(17-BETA-HYDROXYSTERO
ID DEHYDROGENASE)		 4nen INTEGRIN BETA-2
(Homo
sapiens) 		4 / 6 SER B 281
VAL B 282
GLY B 283
GLU B 313
 None
 0.70A 1fduD-4nenB:
4.9		 1fduD-4nenB:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_1
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		 4nen INTEGRIN BETA-2
(Homo
sapiens) 		5 / 10 PHE B  93
VAL B 391
VAL B 417
VAL B 419
LEU B 356
 None
 1.23A 1fe2A-4nenB:
undetectable		 1fe2A-4nenB:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FOH_D_IPHD802_0
(PHENOL HYDROXYLASE)		 4nen INTEGRIN ALPHA-X
(Homo
sapiens) 		5 / 10 ASP A 240
GLY A 270
MET A 151
VAL A 269
ILE A 143
 MG  A1116 ( 3.9A)
None
None
None
None
 1.06A 1fohD-4nenA:
undetectable		 1fohD-4nenA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JOL_B_FFOB361_0
(DIHYDROFOLATE
REDUCTASE)		 4nen INTEGRIN ALPHA-X
(Homo
sapiens) 		5 / 12 ALA A 744
LEU A 662
LEU A 700
PRO A 701
THR A 743
 None
 1.13A 1jolB-4nenA:
undetectable		 1jolB-4nenA:
8.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MAA_B_DMEB996_1
(ACETYLCHOLINESTERASE)		 4nen INTEGRIN ALPHA-X
INTEGRIN BETA-2
(Homo
sapiens) 		4 / 6 TYR A 385
ILE B 256
TYR B 279
GLY B 249
 None
 1.12A 1maaB-4nenA:
2.1
1maaD-4nenA:
undetectable		 1maaB-4nenA:
20.13
1maaD-4nenA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TYR_B_9CRB130_1
(TRANSTHYRETIN)		 4nen INTEGRIN BETA-2
(Homo
sapiens) 		4 / 7 THR B  65
ALA B  63
SER B  61
VAL B  81
 None
 0.87A 1tyrB-4nenB:
undetectable		 1tyrB-4nenB:
11.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TZ8_C_DESC129_1
(TRANSTHYRETIN)		 4nen INTEGRIN ALPHA-X
(Homo
sapiens) 		4 / 6 LYS A 413
ALA A 405
LEU A 403
SER A 338
 None
 1.06A 1tz8C-4nenA:
undetectable
1tz8D-4nenA:
2.2		 1tz8C-4nenA:
8.66
1tz8D-4nenA:
8.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRL_A_TFPA204_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 4nen INTEGRIN ALPHA-X
(Homo
sapiens) 		4 / 7 PHE A 742
PHE A 717
VAL A 720
SER A 654
 None
 1.09A 1wrlA-4nenA:
undetectable
1wrlB-4nenA:
undetectable		 1wrlA-4nenA:
6.85
1wrlB-4nenA:
6.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FL5_B_RBFB202_1
(IMMUNOGLOBULIN IGG1
LAMBDA LIGHT CHAIN
IMMUNOGLOBULIN IGG1
HEAVY CHAIN)		 4nen INTEGRIN ALPHA-X
(Homo
sapiens) 		5 / 11 GLY A 470
TYR A 535
ARG A 552
GLU A 494
GLU A 528
 None
 1.28A 2fl5A-4nenA:
3.0
2fl5B-4nenA:
4.2
2fl5F-4nenA:
4.3		 2fl5A-4nenA:
12.37
2fl5B-4nenA:
11.79
2fl5F-4nenA:
11.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HS2_B_017B203_1
(PROTEASE)		 4nen INTEGRIN ALPHA-X
(Homo
sapiens) 		4 / 6 LEU A 775
LYS A 902
ARG A 874
GLY A 872
 None
 0.95A 2hs2B-4nenA:
undetectable		 2hs2B-4nenA:
10.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6K_A_ADNA699_1
(CHLORINASE)		 4nen INTEGRIN ALPHA-X
(Homo
sapiens) 		4 / 7 ASP A 706
PHE A 748
PRO A 710
THR A 712
 None
 1.40A 2q6kA-4nenA:
undetectable		 2q6kA-4nenA:
13.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R2V_D_ACTD36_0
(GCN4 LEUCINE ZIPPER)		 4nen INTEGRIN ALPHA-X
(Homo
sapiens) 		3 / 3 SER A 437
TYR A 464
HIS A 463
 None
 0.82A 2r2vD-4nenA:
undetectable		 2r2vD-4nenA:
3.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_C_KLNC1499_1
(CYTOCHROME P450 3A4)		 4nen INTEGRIN ALPHA-X
(Homo
sapiens) 		4 / 7 PHE A 748
LEU A 698
PHE A 673
ILE A 635
 None
 0.84A 2v0mC-4nenA:
undetectable		 2v0mC-4nenA:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VDM_B_AGGB1462_1
(INTEGRIN ALPHA-IIB
INTEGRIN BETA-3)		 4nen INTEGRIN BETA-2
(Homo
sapiens) 		5 / 12 PHE B 146
TYR B 109
LEU B 237
SER B 116
SER B 114
 None
None
None
MG  B 707 ( 2.0A)
MG  B 707 (-2.1A)
 1.26A 2vdmA-4nenB:
undetectable
2vdmB-4nenB:
34.0		 2vdmA-4nenB:
20.87
2vdmB-4nenB:
36.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VDM_B_AGGB1462_1
(INTEGRIN ALPHA-IIB
INTEGRIN BETA-3)		 4nen INTEGRIN BETA-2
(Homo
sapiens) 		6 / 12 SER B 114
TYR B 115
SER B 116
ASN B 207
ALA B 210
GLU B 212
 MG  B 707 (-2.1A)
None
MG  B 707 ( 2.0A)
CA  B 705 (-2.8A)
None
CA  B 705 ( 3.2A)
 0.27A 2vdmA-4nenB:
undetectable
2vdmB-4nenB:
34.0		 2vdmA-4nenB:
20.87
2vdmB-4nenB:
36.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VDY_A_HCYA1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		 4nen INTEGRIN ALPHA-X
(Homo
sapiens) 		5 / 12 SER A 767
VAL A 786
THR A 842
PHE A 802
HIS A 804
 None
 1.35A 2vdyA-4nenA:
undetectable		 2vdyA-4nenA:
16.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VDY_B_HCYB1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		 4nen INTEGRIN ALPHA-X
(Homo
sapiens) 		5 / 12 SER A 767
VAL A 786
THR A 842
PHE A 802
HIS A 804
 None
 1.26A 2vdyB-4nenA:
undetectable		 2vdyB-4nenA:
16.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VH3_B_DAHB2_1
(RANASMURFIN)		 4nen INTEGRIN ALPHA-X
INTEGRIN BETA-2
(Homo
sapiens) 		4 / 8 ALA A 505
GLY B 249
SER A 442
ALA A 441
 None
 0.84A 2vh3B-4nenA:
undetectable		 2vh3B-4nenA:
7.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WD9_C_IBPC1570_1
(ACYL-COENZYME A
SYNTHETASE ACSM2A,
MITOCHONDRIAL)		 4nen INTEGRIN ALPHA-X
(Homo
sapiens) 		5 / 10 THR A 207
ILE A 143
VAL A 297
GLY A 268
GLY A 270
 MG  A1116 ( 2.9A)
None
None
None
None
 1.29A 2wd9C-4nenA:
4.1		 2wd9C-4nenA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_D_ACHD1211_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 4nen INTEGRIN ALPHA-X
(Homo
sapiens) 		4 / 8 THR A 239
ASP A 240
TYR A 208
SER A 142
 None
MG  A1116 ( 3.9A)
None
MG  A1116 ( 2.0A)
 1.21A 2xz5C-4nenA:
2.5
2xz5D-4nenA:
2.6		 2xz5C-4nenA:
11.93
2xz5D-4nenA:
11.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZW9_A_SAMA801_0
(LEUCINE CARBOXYL
METHYLTRANSFERASE 2)		 4nen INTEGRIN ALPHA-X
(Homo
sapiens) 		5 / 12 ILE A 857
GLN A 856
ASN A 790
SER A 795
GLY A 853
 None
 1.14A 2zw9A-4nenA:
13.3		 2zw9A-4nenA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_D_DHID8_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 4nen INTEGRIN ALPHA-X
(Homo
sapiens) 		4 / 4 SER A 353
GLY A 352
GLY A 359
GLY A 349
 None
 0.85A 3bogB-4nenA:
undetectable
3bogD-4nenA:
undetectable		 3bogB-4nenA:
undetectable
3bogD-4nenA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_B_D2VB602_1
(CYTOCHROME P450 2R1)		 4nen INTEGRIN ALPHA-X
(Homo
sapiens) 		5 / 12 PHE A 221
ALA A 212
ALA A 257
ILE A 137
THR A 180
 None
 1.10A 3czhB-4nenA:
undetectable		 3czhB-4nenA:
16.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM0_A_CHDA153_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 4nen INTEGRIN ALPHA-X
(Homo
sapiens) 		4 / 5 ILE A 263
THR A 167
PHE A 169
PHE A 135
 None
 1.23A 3em0A-4nenA:
undetectable		 3em0A-4nenA:
9.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM4_V_DR7V100_2
(PROTEASE)		 4nen INTEGRIN BETA-2
(Homo
sapiens) 		5 / 10 ASP B 151
ASP B 250
ILE B 256
GLY B 254
LEU B 155
 CA  B 705 (-3.4A)
None
None
None
None
 1.09A 3em4V-4nenB:
undetectable		 3em4V-4nenB:
10.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GN8_A_DEXA247_2
(GLUCOCORTICOID
RECEPTOR 2)		 4nen INTEGRIN BETA-2
(Homo
sapiens) 		3 / 3 MET B 304
MET B 111
PHE B 245
 None
 1.33A 3gn8A-4nenB:
undetectable		 3gn8A-4nenB:
16.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IV6_A_SAMA301_0
(PUTATIVE
ZN-DEPENDENT ALCOHOL
DEHYDROGENASE)		 4nen INTEGRIN ALPHA-X
INTEGRIN BETA-2
(Homo
sapiens;
Homo
sapiens) 		5 / 12 ASN B 518
GLY B 486
THR A 709
ASP B 515
ILE B 507
 None
 1.24A 3iv6A-4nenB:
undetectable		 3iv6A-4nenB:
16.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JW5_A_TOPA208_1
(DIHYDROFOLATE
REDUCTASE)		 4nen INTEGRIN ALPHA-X
(Homo
sapiens) 		5 / 11 LEU A 303
VAL A 158
ILE A 238
PHE A 135
THR A 167
 None
 1.33A 3jw5A-4nenA:
2.3		 3jw5A-4nenA:
8.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K9F_H_LFXH0_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B)		 4nen INTEGRIN ALPHA-X
(Homo
sapiens) 		4 / 6 ARG A 552
GLY A 493
GLU A 528
GLU A 527
 None
 0.88A 3k9fA-4nenA:
undetectable
3k9fB-4nenA:
undetectable
3k9fD-4nenA:
2.3		 3k9fA-4nenA:
18.52
3k9fB-4nenA:
18.52
3k9fD-4nenA:
12.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ME6_C_CGEC501_1
(CYTOCHROME P450 2B4)		 4nen INTEGRIN ALPHA-X
(Homo
sapiens) 		5 / 9 VAL A  32
PHE A  18
PHE A  11
ALA A  56
THR A  54
 None
 1.05A 3me6C-4nenA:
undetectable		 3me6C-4nenA:
17.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NAI_C_URFC521_1
(RNA DEPENDENT RNA
POLYMERASE)		 4nen INTEGRIN ALPHA-X
(Homo
sapiens) 		4 / 5 ASP A 451
ASP A 449
ASP A 455
ARG A 480
 CA  A1115 (-2.7A)
CA  A1115 (-2.9A)
CA  A1115 (-2.0A)
None
 1.43A 3naiC-4nenA:
undetectable		 3naiC-4nenA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDV_D_AICD374_1
(BETA-PEPTIDYL
AMINOPEPTIDASE)		 4nen INTEGRIN BETA-2
(Homo
sapiens) 		5 / 11 LEU B 131
LEU B 132
GLY B 142
LEU B 107
LEU B 188
 None
 1.41A 3ndvC-4nenB:
undetectable
3ndvD-4nenB:
undetectable		 3ndvC-4nenB:
19.14
3ndvD-4nenB:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NVK_J_SAMJ228_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE
NOP5/NOP56 RELATED
PROTEIN)		 4nen INTEGRIN ALPHA-X
(Homo
sapiens) 		5 / 12 TYR A 464
GLY A 503
ALA A 524
VAL A 473
GLN A 472
 None
 1.26A 3nvkF-4nenA:
undetectable
3nvkJ-4nenA:
undetectable		 3nvkF-4nenA:
16.25
3nvkJ-4nenA:
12.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3REM_A_SALA301_1
(SALICYLATE
BIOSYNTHESIS PROTEIN
PCHB)		 4nen INTEGRIN ALPHA-X
(Homo
sapiens) 		4 / 8 VAL A 905
VAL A 938
ILE A1053
GLN A1062
 None
 0.97A 3remA-4nenA:
undetectable		 3remA-4nenA:
6.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3REM_B_SALB301_1
(SALICYLATE
BIOSYNTHESIS PROTEIN
PCHB)		 4nen INTEGRIN ALPHA-X
(Homo
sapiens) 		4 / 8 VAL A 905
VAL A 938
ILE A1053
GLN A1062
 None
 0.94A 3remB-4nenA:
undetectable		 3remB-4nenA:
6.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3S_B_9PLB1_1
(CYTOCHROME P450 2A13)		 4nen INTEGRIN ALPHA-X
(Homo
sapiens) 		4 / 6 PHE A  18
PHE A  11
ALA A  56
THR A  54
 None
 0.98A 3t3sB-4nenA:
undetectable		 3t3sB-4nenA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3S_E_9PLE1_1
(CYTOCHROME P450 2A13)		 4nen INTEGRIN ALPHA-X
(Homo
sapiens) 		4 / 8 PHE A  18
PHE A  11
ALA A  56
THR A  54
 None
 0.99A 3t3sE-4nenA:
undetectable		 3t3sE-4nenA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TVX_B_PNXB902_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4A)		 4nen INTEGRIN ALPHA-X
(Homo
sapiens) 		4 / 7 TYR A 265
ILE A 234
GLN A 131
PHE A 162
 None
 1.12A 3tvxB-4nenA:
undetectable		 3tvxB-4nenA:
15.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_A_W9TA1001_1
(HEMOLYTIC LECTIN
CEL-III)		 4nen INTEGRIN ALPHA-X
(Homo
sapiens) 		4 / 5 ASP A 515
VAL A 540
GLY A 539
ASP A 511
 CA  A1113 (-2.6A)
None
None
CA  A1113 (-3.2A)
 1.18A 3w9tA-4nenA:
undetectable		 3w9tA-4nenA:
18.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_B_W9TB503_1
(HEMOLYTIC LECTIN
CEL-III)		 4nen INTEGRIN ALPHA-X
(Homo
sapiens) 		4 / 5 ASP A 515
VAL A 540
GLY A 539
ASP A 511
 CA  A1113 (-2.6A)
None
None
CA  A1113 (-3.2A)
 1.18A 3w9tB-4nenA:
undetectable		 3w9tB-4nenA:
18.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_C_W9TC1001_1
(HEMOLYTIC LECTIN
CEL-III)		 4nen INTEGRIN ALPHA-X
(Homo
sapiens) 		4 / 5 ASP A 515
VAL A 540
GLY A 539
ASP A 511
 CA  A1113 (-2.6A)
None
None
CA  A1113 (-3.2A)
 1.18A 3w9tC-4nenA:
undetectable		 3w9tC-4nenA:
18.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_D_W9TD502_1
(HEMOLYTIC LECTIN
CEL-III)		 4nen INTEGRIN ALPHA-X
(Homo
sapiens) 		4 / 5 ASP A 515
VAL A 540
GLY A 539
ASP A 511
 CA  A1113 (-2.6A)
None
None
CA  A1113 (-3.2A)
 1.18A 3w9tD-4nenA:
undetectable		 3w9tD-4nenA:
18.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_E_W9TE504_1
(HEMOLYTIC LECTIN
CEL-III)		 4nen INTEGRIN ALPHA-X
(Homo
sapiens) 		4 / 5 ASP A 515
VAL A 540
GLY A 539
ASP A 511
 CA  A1113 (-2.6A)
None
None
CA  A1113 (-3.2A)
 1.18A 3w9tE-4nenA:
undetectable		 3w9tE-4nenA:
18.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_F_W9TF504_1
(HEMOLYTIC LECTIN
CEL-III)		 4nen INTEGRIN ALPHA-X
(Homo
sapiens) 		4 / 5 ASP A 515
VAL A 540
GLY A 539
ASP A 511
 CA  A1113 (-2.6A)
None
None
CA  A1113 (-3.2A)
 1.18A 3w9tF-4nenA:
undetectable		 3w9tF-4nenA:
18.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_G_W9TG504_1
(HEMOLYTIC LECTIN
CEL-III)		 4nen INTEGRIN ALPHA-X
(Homo
sapiens) 		4 / 5 ASP A 515
VAL A 540
GLY A 539
ASP A 511
 CA  A1113 (-2.6A)
None
None
CA  A1113 (-3.2A)
 1.19A 3w9tG-4nenA:
undetectable		 3w9tG-4nenA:
18.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WEM_A_ACRA1001_1
(ALPHA-GLUCOSIDASE)		 4nen INTEGRIN ALPHA-X
INTEGRIN BETA-2
(Homo
sapiens) 		5 / 12 ASP A 663
PHE A 608
ILE B 482
ASP A 706
ARG A 670
 None
 1.24A 3wemA-4nenA:
3.0		 3wemA-4nenA:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WEO_A_ACRA1001_1
(ALPHA-GLUCOSIDASE)		 4nen INTEGRIN ALPHA-X
INTEGRIN BETA-2
(Homo
sapiens) 		5 / 12 ASP A 663
PHE A 608
ILE B 482
ASP A 706
ARG A 670
 None
 1.25A 3weoA-4nenA:
2.5		 3weoA-4nenA:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CP3_B_RBTB1129_1
(B-CELL LYMPHOMA 6
PROTEIN)		 4nen INTEGRIN ALPHA-X
INTEGRIN BETA-2
(Homo
sapiens) 		5 / 7 ARG A 407
LEU B 253
GLY A 387
TYR A 388
SER A 389
 None
 1.19A 4cp3A-4nenA:
undetectable
4cp3B-4nenA:
undetectable		 4cp3A-4nenA:
8.78
4cp3B-4nenA:
8.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CP3_B_RBTB1129_1
(B-CELL LYMPHOMA 6
PROTEIN)		 4nen INTEGRIN ALPHA-X
INTEGRIN BETA-2
(Homo
sapiens) 		5 / 7 ARG A 407
LEU B 253
GLY A 404
TYR A 388
SER A 389
 None
 1.16A 4cp3A-4nenA:
undetectable
4cp3B-4nenA:
undetectable		 4cp3A-4nenA:
8.78
4cp3B-4nenA:
8.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DXU_A_ACAA711_1
(LACTOTRANSFERRIN)		 4nen INTEGRIN ALPHA-X
(Homo
sapiens) 		4 / 6 GLY A 105
VAL A  93
PRO A  91
GLY A  74
 None
 0.66A 4dxuA-4nenA:
undetectable		 4dxuA-4nenA:
15.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGL_C_CLQC303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 4nen INTEGRIN ALPHA-X
INTEGRIN BETA-2
(Homo
sapiens;
Homo
sapiens) 		4 / 8 GLY A 412
PHE B 247
ILE A 435
PHE B 245
 None
 0.82A 4fglD-4nenA:
4.3		 4fglD-4nenA:
11.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGL_D_CLQD303_0
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 4nen INTEGRIN ALPHA-X
INTEGRIN BETA-2
(Homo
sapiens;
Homo
sapiens) 		4 / 7 GLY A 412
PHE B 247
ILE A 435
PHE B 245
 None
 0.77A 4fglC-4nenA:
undetectable		 4fglC-4nenA:
11.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FOR_A_FLPA711_1
(LACTOTRANSFERRIN)		 4nen INTEGRIN ALPHA-X
(Homo
sapiens) 		4 / 7 GLY A 105
VAL A  93
PRO A  91
GLY A  74
 None
 0.64A 4forA-4nenA:
undetectable		 4forA-4nenA:
15.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_J_SASJ804_1
(SEPIAPTERIN
REDUCTASE)		 4nen INTEGRIN BETA-2
(Homo
sapiens) 		5 / 12 LEU B 333
LEU B 110
PRO B 296
ASP B 242
ASP B 243
 None
None
None
CA  B 706 ( 3.4A)
None
 1.19A 4j7xJ-4nenB:
4.3		 4j7xJ-4nenB:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KR4_C_AICC401_1
(OUTER MEMBRANE
PROTEIN F)		 4nen INTEGRIN ALPHA-X
INTEGRIN BETA-2
(Homo
sapiens) 		4 / 8 TYR B 308
ASP B 151
GLU A 318
ARG A 407
 None
CA  B 705 (-3.4A)
MG  B 707 (-3.1A)
None
 1.05A 4kr4C-4nenB:
undetectable		 4kr4C-4nenB:
17.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMC_A_29JA604_1
(TRANSPORTER)		 4nen INTEGRIN ALPHA-X
(Homo
sapiens) 		4 / 7 ILE A 553
PHE A 565
LEU A 594
THR A 507
 None
 1.02A 4mmcA-4nenA:
undetectable		 4mmcA-4nenA:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QKN_A_JMSA602_1
(ALPHA-KETOGLUTARATE-
DEPENDENT
DIOXYGENASE FTO)		 4nen INTEGRIN ALPHA-X
(Homo
sapiens) 		4 / 8 LEU A 941
THR A 907
VAL A 909
SER A 910
 None
 1.02A 4qknA-4nenA:
undetectable		 4qknA-4nenA:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOG_B_ML1B302_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 4nen INTEGRIN ALPHA-X
INTEGRIN BETA-2
(Homo
sapiens) 		4 / 6 GLY A 412
PHE B 247
ILE A 435
PHE B 245
 None
 0.78A 4qogA-4nenA:
4.5
4qogB-4nenA:
4.5		 4qogA-4nenA:
11.30
4qogB-4nenA:
11.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UIL_H_QI9H1223_0
(FAB 314.1)		 4nen INTEGRIN ALPHA-X
INTEGRIN BETA-2
(Homo
sapiens;
Homo
sapiens) 		5 / 12 ALA B 255
GLY A 336
GLY A 352
LEU A 103
PRO B 156
 None
 1.28A 4uilH-4nenB:
4.9
4uilL-4nenB:
4.1		 4uilH-4nenB:
14.98
4uilL-4nenB:
15.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNU_D_QDND602_1
(CYTOCHROME P450 2D6)		 4nen INTEGRIN ALPHA-X
(Homo
sapiens) 		5 / 10 PHE A 361
GLY A  90
LEU A  87
ALA A 339
ALA A 350
 None
 1.29A 4wnuD-4nenA:
undetectable		 4wnuD-4nenA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YVG_A_SAMA301_0
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)		 4nen INTEGRIN ALPHA-X
(Homo
sapiens) 		5 / 12 GLY A 440
GLY A 404
ILE A 522
LEU A 458
GLY A 460
 None
 0.94A 4yvgA-4nenA:
undetectable		 4yvgA-4nenA:
13.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZBR_A_NPSA602_1
(SERUM ALBUMIN)		 4nen INTEGRIN ALPHA-X
(Homo
sapiens) 		5 / 12 PHE A 371
LEU A 330
GLY A 359
SER A 357
SER A 327
 NAG  A1105 (-4.7A)
None
None
NAG  A1105 (-3.2A)
MAN  A1110 (-3.5A)
 1.50A 4zbrA-4nenA:
undetectable		 4zbrA-4nenA:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DQF_A_CZEA613_1
(SERUM ALBUMIN)		 4nen INTEGRIN ALPHA-X
(Homo
sapiens) 		5 / 9 ALA A  88
LEU A  75
GLY A  90
LEU A  73
LEU A  47
 None
 1.04A 5dqfA-4nenA:
undetectable		 5dqfA-4nenA:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DXB_A_ESTA1000_1
(ESTROGEN RECEPTOR)		 4nen INTEGRIN ALPHA-X
INTEGRIN BETA-2
(Homo
sapiens) 		5 / 10 LEU B 253
ALA B 255
LEU A  75
GLY A 105
LEU A 103
 None
 1.31A 5dxbA-4nenB:
undetectable		 5dxbA-4nenB:
17.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HP1_C_PPFC601_1
(HIV-1 REVERSE
TRANSCRIPTASE P66
SUBUNIT)		 4nen INTEGRIN ALPHA-X
(Homo
sapiens) 		4 / 6 ARG A 480
GLY A 542
ASP A 449
LYS A 868
 None
None
CA  A1115 (-2.9A)
None
 1.21A 5hp1C-4nenA:
undetectable		 5hp1C-4nenA:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEP_A_VDYA201_1
(CDL2.3B)		 4nen INTEGRIN ALPHA-X
(Homo
sapiens) 		5 / 12 LEU A 401
PHE A 417
PHE A 361
ALA A 350
LEU A 330
 None
 1.08A 5iepA-4nenA:
undetectable		 5iepA-4nenA:
10.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IFU_B_GBMB801_1
(PROLINE--TRNA LIGASE)		 4nen INTEGRIN ALPHA-X
(Homo
sapiens) 		5 / 9 TYR A  25
ILE A  60
LEU A  62
THR A 116
GLY A 111
 None
 1.09A 5ifuB-4nenA:
2.8		 5ifuB-4nenA:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5INZ_D_DVAD15_0
(THETA DEFENSIN-2,
D-PEPTIDE
THETA DEFENSIN-2,
L-PEPTIDE)		 4nen INTEGRIN ALPHA-X
(Homo
sapiens) 		3 / 3 GLY A  55
CYH A  57
CYH A  50
 None
 0.75A 5inzB-4nenA:
undetectable		 5inzB-4nenA:
1.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KB5_A_ADNA401_1
(ADENOSINE KINASE)		 4nen INTEGRIN ALPHA-X
(Homo
sapiens) 		5 / 12 LEU A  86
GLY A  45
GLY A  46
ALA A  88
GLY A  17
 None
 0.92A 5kb5A-4nenA:
undetectable		 5kb5A-4nenA:
15.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MZJ_A_TEPA2401_1
(ADENOSINE RECEPTOR
A2A,SOLUBLE
CYTOCHROME
B562,ADENOSINE
RECEPTOR A2A)		 4nen INTEGRIN ALPHA-X
(Homo
sapiens) 		4 / 8 LEU A 443
GLU A 429
LEU A 386
MET A 374
 None
 0.70A 5mzjA-4nenA:
undetectable		 5mzjA-4nenA:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NNW_D_GCSD302_1
(25 KDA PROTEIN
ELICITOR)		 4nen INTEGRIN ALPHA-X
(Homo
sapiens) 		4 / 7 ASP A 519
GLY A 539
HIS A 538
ASP A 511
 CA  A1113 (-2.0A)
None
None
CA  A1113 (-3.2A)
 1.05A 5nnwD-4nenA:
undetectable		 5nnwD-4nenA:
5.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NUN_A_Z80A201_1
(BETA-LACTOGLOBULIN)		 4nen INTEGRIN BETA-2
(Homo
sapiens) 		6 / 9 ALA B  91
VAL B 393
ILE B 406
ASN B  94
PHE B  93
ALA B  63
 None
None
None
NAG  B 701 (-1.8A)
None
None
 1.19A 5nunA-4nenB:
undetectable		 5nunA-4nenB:
7.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC3_B_486B801_1
(GLUCOCORTICOID
RECEPTOR)		 4nen INTEGRIN ALPHA-X
INTEGRIN BETA-2
(Homo
sapiens) 		5 / 12 MET B 218
LEU B 215
GLY B 213
ARG A 407
PHE B 245
 None
 1.49A 5uc3B-4nenB:
undetectable		 5uc3B-4nenB:
8.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_A_C2FA3001_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 4nen INTEGRIN BETA-2
(Homo
sapiens) 		5 / 12 GLU B 212
GLY B 213
LEU B 165
GLY B 206
SER B 114
 CA  B 705 ( 3.2A)
None
None
None
MG  B 707 (-2.1A)
 1.09A 5vooA-4nenB:
2.3		 5vooA-4nenB:
19.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_B_C2FB702_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 4nen INTEGRIN BETA-2
(Homo
sapiens) 		5 / 12 GLU B 212
GLY B 213
LEU B 165
GLY B 206
SER B 114
 CA  B 705 ( 3.2A)
None
None
None
MG  B 707 (-2.1A)
 1.10A 5vooB-4nenB:
undetectable		 5vooB-4nenB:
19.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_C_C2FC702_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 4nen INTEGRIN BETA-2
(Homo
sapiens) 		5 / 12 GLU B 212
GLY B 213
LEU B 165
GLY B 206
SER B 114
 CA  B 705 ( 3.2A)
None
None
None
MG  B 707 (-2.1A)
 1.09A 5vooC-4nenB:
2.1		 5vooC-4nenB:
19.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_D_C2FD3001_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 4nen INTEGRIN BETA-2
(Homo
sapiens) 		5 / 12 GLU B 212
GLY B 213
LEU B 165
GLY B 206
SER B 114
 CA  B 705 ( 3.2A)
None
None
None
MG  B 707 (-2.1A)
 1.11A 5vooD-4nenB:
2.6		 5vooD-4nenB:
19.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_E_C2FE3001_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 4nen INTEGRIN BETA-2
(Homo
sapiens) 		5 / 12 GLU B 212
GLY B 213
LEU B 165
GLY B 206
SER B 114
 CA  B 705 ( 3.2A)
None
None
None
MG  B 707 (-2.1A)
 1.15A 5vooE-4nenB:
2.4		 5vooE-4nenB:
19.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_F_C2FF3001_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 4nen INTEGRIN BETA-2
(Homo
sapiens) 		5 / 12 GLU B 212
GLY B 213
LEU B 165
GLY B 206
SER B 114
 CA  B 705 ( 3.2A)
None
None
None
MG  B 707 (-2.1A)
 1.14A 5vooF-4nenB:
2.5		 5vooF-4nenB:
19.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOP_B_C2FB3001_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 4nen INTEGRIN BETA-2
(Homo
sapiens) 		5 / 12 GLU B 212
GLY B 213
LEU B 165
GLY B 206
SER B 114
 CA  B 705 ( 3.2A)
None
None
None
MG  B 707 (-2.1A)
 1.18A 5vopB-4nenB:
undetectable		 5vopB-4nenB:
19.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W7P_A_SAMA501_1
(OXAC)		 4nen INTEGRIN ALPHA-X
(Homo
sapiens) 		4 / 5 TYR A  52
ASP A 578
ASP A   4
ARG A 650
 None
CA  A1114 (-2.9A)
None
None
 1.27A 5w7pA-4nenA:
undetectable		 5w7pA-4nenA:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WYQ_A_SAMA401_0
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)		 4nen INTEGRIN ALPHA-X
(Homo
sapiens) 		5 / 12 GLY A 440
GLY A 404
ILE A 522
LEU A 458
GLY A 460
 None
 1.04A 5wyqA-4nenA:
3.3		 5wyqA-4nenA:
13.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X6Y_C_SAMC902_0
(MRNA CAPPING ENZYME
P5)		 4nen INTEGRIN ALPHA-X
INTEGRIN BETA-2
(Homo
sapiens;
Homo
sapiens) 		5 / 12 GLY B 213
PRO B 211
HIS A 410
ASP B 151
PHE B 182
 None
CA  B 705 (-4.7A)
None
CA  B 705 (-3.4A)
None
 1.16A 5x6yC-4nenB:
undetectable		 5x6yC-4nenB:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDX_C_CHDC308_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT VIIA-HEART)		 4nen INTEGRIN BETA-2
(Homo
sapiens) 		4 / 5 LEU B  76
PHE B 411
LEU B 347
PHE B 389
 None
 1.27A 5xdxC-4nenB:
undetectable
5xdxJ-4nenB:
undetectable		 5xdxC-4nenB:
16.77
5xdxJ-4nenB:
7.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y80_A_IREA402_0
(CYCLIN-G-ASSOCIATED
KINASE)		 4nen INTEGRIN ALPHA-X
INTEGRIN BETA-2
(Homo
sapiens;
Homo
sapiens) 		5 / 11 ALA A 611
ASP A 760
SER A 885
THR A 798
ILE B 482
 None
 1.34A 5y80A-4nenA:
undetectable		 5y80A-4nenA:
6.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BRD_B_RFPB502_1
(RIFAMPIN
MONOOXYGENASE)		 4nen INTEGRIN ALPHA-X
INTEGRIN BETA-2
(Homo
sapiens) 		5 / 12 GLY B 283
VAL B 282
PHE B 245
THR A 411
GLY A 412
 None
 1.01A 6brdB-4nenB:
undetectable		 6brdB-4nenB:
8.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_G_EY4G501_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 4nen INTEGRIN ALPHA-X
(Homo
sapiens) 		4 / 7 ILE A 995
GLN A1042
VAL A1045
THR A1075
 None
 0.99A 6cduF-4nenA:
3.3
6cduG-4nenA:
3.3		 6cduF-4nenA:
15.46
6cduG-4nenA:
15.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EQP_A_BUWA601_1
(CHOLINESTERASE)		 4nen INTEGRIN ALPHA-X
(Homo
sapiens) 		4 / 8 GLY A 352
GLN A 334
SER A 357
PHE A 371
 None
None
NAG  A1105 (-3.2A)
NAG  A1105 (-4.7A)
 0.93A 6eqpA-4nenA:
undetectable		 6eqpA-4nenA:
6.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MHT_D_SAMD328_0
(CYTOSINE-SPECIFIC
METHYLTRANSFERASE
HHAI)		 4nen INTEGRIN ALPHA-X
(Homo
sapiens) 		5 / 12 GLY A 139
LEU A 203
GLY A 205
ASN A 147
SER A 175
 None
 0.99A 6mhtA-4nenA:
2.8		 6mhtA-4nenA:
14.97