SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4nes'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JG3_A_ADNA500_1
(PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE)		 4nes UDP-N-ACETYLGLUCOSAM
INE 2-EPIMERASE
(Methanocaldococc
us
jannaschii) 		5 / 11 GLY A 354
ARG A 356
ILE A 360
LEU A 361
THR A 170
 None
 1.10A 1jg3A-4nesA:
undetectable		 1jg3A-4nesA:
24.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JG3_B_ADNB550_1
(PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE)		 4nes UDP-N-ACETYLGLUCOSAM
INE 2-EPIMERASE
(Methanocaldococc
us
jannaschii) 		5 / 11 GLY A 354
ARG A 356
ILE A 360
LEU A 361
THR A 170
 None
 1.07A 1jg3B-4nesA:
undetectable		 1jg3B-4nesA:
24.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ODI_E_ADNE1237_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 4nes UDP-N-ACETYLGLUCOSAM
INE 2-EPIMERASE
(Methanocaldococc
us
jannaschii) 		5 / 11 THR A 147
GLY A 119
GLU A 117
GLU A 293
ASN A 153
 None
 1.31A 1odiE-4nesA:
undetectable		 1odiE-4nesA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XR2_B_C2FB1201_0
(5-METHYLTETRAHYDROPT
EROYLTRIGLUTAMATE--H
OMOCYSTEINE
METHYLTRANSFERASE)		 4nes UDP-N-ACETYLGLUCOSAM
INE 2-EPIMERASE
(Methanocaldococc
us
jannaschii) 		4 / 8 THR A  96
SER A 122
ARG A 311
GLU A 157
 UD1  A 400 (-4.1A)
None
None
None
 1.49A 1xr2B-4nesA:
2.6		 1xr2B-4nesA:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJT_A_SAMA501_0
(N(2),N(2)-DIMETHYLGU
ANOSINE TRNA
METHYLTRANSFERASE)		 4nes UDP-N-ACETYLGLUCOSAM
INE 2-EPIMERASE
(Methanocaldococc
us
jannaschii) 		5 / 12 LEU A 120
ILE A 131
ASN A 153
ALA A 150
ASP A  95
 None
None
None
None
UD1  A 400 ( 4.8A)
 1.16A 2ejtA-4nesA:
undetectable		 2ejtA-4nesA:
25.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HYY_A_STIA600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4nes UDP-N-ACETYLGLUCOSAM
INE 2-EPIMERASE
(Methanocaldococc
us
jannaschii) 		4 / 6 LEU A  23
VAL A 166
VAL A 116
ILE A 360
 None
 0.91A 2hyyA-4nesA:
undetectable		 2hyyA-4nesA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2L8M_A_CAMA415_0
(CAMPHOR
5-MONOOXYGENASE)		 4nes UDP-N-ACETYLGLUCOSAM
INE 2-EPIMERASE
(Methanocaldococc
us
jannaschii) 		5 / 9 THR A  71
LEU A  75
VAL A 105
VAL A  92
ILE A   6
 None
 1.30A 2l8mA-4nesA:
undetectable		 2l8mA-4nesA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEO_A_LNRA200_1
(D7R4 PROTEIN)		 4nes UDP-N-ACETYLGLUCOSAM
INE 2-EPIMERASE
(Methanocaldococc
us
jannaschii) 		5 / 12 GLU A 293
ARG A 311
ILE A  14
ASP A  95
GLU A 117
 None
None
UDP  A 401 (-3.8A)
UD1  A 400 ( 4.8A)
None
 1.29A 2qeoA-4nesA:
undetectable		 2qeoA-4nesA:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZQ9_A_CLSA11_1
(BETA-LACTAMASE
TOHO-1)		 4nes UDP-N-ACETYLGLUCOSAM
INE 2-EPIMERASE
(Methanocaldococc
us
jannaschii) 		4 / 4 GLU A 250
ARG A 247
ASN A 214
ASP A 213
 None
 1.50A 2zq9A-4nesA:
undetectable		 2zq9A-4nesA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_B_SVRB512_2
(PHOSPHOLIPASE A2)		 4nes UDP-N-ACETYLGLUCOSAM
INE 2-EPIMERASE
(Methanocaldococc
us
jannaschii) 		4 / 7 VAL A  90
ILE A  19
GLY A 354
ARG A 356
 None
 0.91A 3bjwB-4nesA:
undetectable		 3bjwB-4nesA:
15.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_H_SVRH511_3
(PHOSPHOLIPASE A2)		 4nes UDP-N-ACETYLGLUCOSAM
INE 2-EPIMERASE
(Methanocaldococc
us
jannaschii) 		4 / 7 VAL A  90
ILE A  19
GLY A 354
ARG A 356
 None
 0.91A 3bjwH-4nesA:
undetectable		 3bjwH-4nesA:
15.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DH0_B_SAMB300_0
(SAM DEPENDENT
METHYLTRANSFERASE)		 4nes UDP-N-ACETYLGLUCOSAM
INE 2-EPIMERASE
(Methanocaldococc
us
jannaschii) 		5 / 12 LEU A  51
GLY A 270
PHE A  48
VAL A 188
LEU A 277
 None
UDP  A 401 ( 4.7A)
None
None
None
 1.13A 3dh0B-4nesA:
3.0		 3dh0B-4nesA:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB2_A_SAMA1101_1
(STRUCTURAL PROTEIN
VP3)		 4nes UDP-N-ACETYLGLUCOSAM
INE 2-EPIMERASE
(Methanocaldococc
us
jannaschii) 		3 / 3 GLU A 129
ASP A 124
ASP A 287
 UD1  A 400 (-3.6A)
None
None
 0.78A 3jb2A-4nesA:
2.4		 3jb2A-4nesA:
16.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_B_SALB3003_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 4nes UDP-N-ACETYLGLUCOSAM
INE 2-EPIMERASE
(Methanocaldococc
us
jannaschii) 		4 / 6 ILE A 321
VAL A 323
LEU A 305
LEU A 285
 None
 0.87A 3kp6A-4nesA:
undetectable
3kp6B-4nesA:
undetectable		 3kp6A-4nesA:
19.84
3kp6B-4nesA:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QOW_A_SAMA417_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE)		 4nes UDP-N-ACETYLGLUCOSAM
INE 2-EPIMERASE
(Methanocaldococc
us
jannaschii) 		3 / 3 THR A 244
ASP A 287
GLU A 129
 None
None
UD1  A 400 (-3.6A)
 0.70A 3qowA-4nesA:
undetectable		 3qowA-4nesA:
24.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SJ4_X_DXCX75_0
(CYTOCHROME C7)		 4nes UDP-N-ACETYLGLUCOSAM
INE 2-EPIMERASE
(Methanocaldococc
us
jannaschii) 		5 / 9 ILE A 225
LEU A 285
LYS A 329
ILE A 331
GLY A 324
 None
 1.37A 3sj4X-4nesA:
undetectable		 3sj4X-4nesA:
11.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUD_C_SUEC1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 4nes UDP-N-ACETYLGLUCOSAM
INE 2-EPIMERASE
(Methanocaldococc
us
jannaschii) 		5 / 12 GLN A 292
GLY A 289
ASP A  95
ILE A 149
ALA A 150
 None
UDP  A 401 (-3.7A)
UD1  A 400 ( 4.8A)
None
None
 0.92A 3sudC-4nesA:
undetectable		 3sudC-4nesA:
18.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UJ6_A_SAMA300_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 4nes UDP-N-ACETYLGLUCOSAM
INE 2-EPIMERASE
(Methanocaldococc
us
jannaschii) 		5 / 12 ILE A 231
GLY A 224
ILE A 331
ILE A 221
LEU A 204
 None
 0.93A 3uj6A-4nesA:
undetectable		 3uj6A-4nesA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_E_ACTE502_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 4nes UDP-N-ACETYLGLUCOSAM
INE 2-EPIMERASE
(Methanocaldococc
us
jannaschii) 		3 / 3 LYS A 234
ARG A 342
LEU A 338
 None
 1.41A 3v4tE-4nesA:
undetectable		 3v4tE-4nesA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DQF_B_017B101_1
(ASPARTYL PROTEASE)		 4nes UDP-N-ACETYLGLUCOSAM
INE 2-EPIMERASE
(Methanocaldococc
us
jannaschii) 		6 / 12 LEU A  82
ALA A 101
ILE A  62
GLY A   8
VAL A  81
ILE A  78
 None
 1.37A 4dqfA-4nesA:
undetectable		 4dqfA-4nesA:
15.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KLR_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4nes UDP-N-ACETYLGLUCOSAM
INE 2-EPIMERASE
(Methanocaldococc
us
jannaschii) 		4 / 8 LEU A 179
SER A  17
VAL A 269
GLY A 270
 None
None
UDP  A 401 (-3.8A)
UDP  A 401 ( 4.7A)
 0.82A 4klrB-4nesA:
2.8		 4klrB-4nesA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RYA_A_MTLA501_0
(ABC TRANSPORTER
SUBSTRATE BINDING
PROTEIN (SORBITOL))		 4nes UDP-N-ACETYLGLUCOSAM
INE 2-EPIMERASE
(Methanocaldococc
us
jannaschii) 		5 / 12 ASN A 346
GLY A 290
ALA A 319
VAL A 317
GLN A 292
 None
UDP  A 401 (-3.6A)
None
None
None
 1.22A 4ryaA-4nesA:
1.2		 4ryaA-4nesA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z3O_F_MFXF101_1
(DNA TOPOISOMERASE 4
SUBUNIT
B,PARE30-PARC55
FUSED TOPO IV FROM
S. PNEUMONIAE
E-SITE DNA)		 4nes UDP-N-ACETYLGLUCOSAM
INE 2-EPIMERASE
(Methanocaldococc
us
jannaschii) 		4 / 5 ARG A  10
GLY A 289
GLU A 310
SER A 239
 UDP  A 401 (-3.5A)
UDP  A 401 (-3.7A)
None
UDP  A 401 (-2.7A)
 1.24A 4z3oA-4nesA:
undetectable
4z3oB-4nesA:
undetectable		 4z3oA-4nesA:
20.56
4z3oB-4nesA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FA8_A_SAMA301_1
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE,
PUTATIVE)		 4nes UDP-N-ACETYLGLUCOSAM
INE 2-EPIMERASE
(Methanocaldococc
us
jannaschii) 		3 / 3 THR A 244
ASP A 287
GLU A 129
 None
None
UD1  A 400 (-3.6A)
 0.68A 5fa8A-4nesA:
undetectable		 5fa8A-4nesA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H5F_A_SAMA301_1
(PROTEIN ARGININE
N-METHYLTRANSFERASE
SFM1)		 4nes UDP-N-ACETYLGLUCOSAM
INE 2-EPIMERASE
(Methanocaldococc
us
jannaschii) 		4 / 5 GLY A   8
THR A  35
GLN A  70
THR A  96
 None
None
UD1  A 400 ( 4.0A)
UD1  A 400 (-4.1A)
 1.14A 5h5fA-4nesA:
undetectable		 5h5fA-4nesA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I1N_G_DVAG9_0
(D-VILLIN HEADPIECE
SUBDOMAIN
VILLIN-1)		 4nes UDP-N-ACETYLGLUCOSAM
INE 2-EPIMERASE
(Methanocaldococc
us
jannaschii) 		3 / 3 ALA A 150
ASN A 153
LEU A 154
 None
 0.40A 5i1nB-4nesA:
undetectable		 5i1nB-4nesA:
6.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I73_A_68PA705_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		 4nes UDP-N-ACETYLGLUCOSAM
INE 2-EPIMERASE
(Methanocaldococc
us
jannaschii) 		5 / 9 ARG A  10
PHE A 274
LEU A 203
ILE A 237
PHE A 238
 UDP  A 401 (-3.5A)
UDP  A 401 (-3.4A)
None
None
None
 1.34A 5i73A-4nesA:
undetectable		 5i73A-4nesA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGZ_A_SPRA404_2
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 4nes UDP-N-ACETYLGLUCOSAM
INE 2-EPIMERASE
(Methanocaldococc
us
jannaschii) 		5 / 9 LEU A  16
ILE A   6
ILE A 357
GLU A 355
GLU A 117
 None
 1.08A 5igzA-4nesA:
undetectable		 5igzA-4nesA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KBW_A_RBFA201_1
(RIBOFLAVIN
TRANSPORTER RIBU)		 4nes UDP-N-ACETYLGLUCOSAM
INE 2-EPIMERASE
(Methanocaldococc
us
jannaschii) 		5 / 12 LEU A  16
ASP A 173
GLY A 354
LEU A 361
ALA A 114
 None
 1.22A 5kbwA-4nesA:
undetectable		 5kbwA-4nesA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KR1_B_017B101_1
(PROTEASE PR5-DRV)		 4nes UDP-N-ACETYLGLUCOSAM
INE 2-EPIMERASE
(Methanocaldococc
us
jannaschii) 		6 / 10 LEU A  82
ALA A 101
ILE A  62
GLY A   8
VAL A  81
ILE A  78
 None
 1.30A 5kr1A-4nesA:
undetectable		 5kr1A-4nesA:
15.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TIX_B_OQRB302_0
(SULFOTRANSFERASE)		 4nes UDP-N-ACETYLGLUCOSAM
INE 2-EPIMERASE
(Methanocaldococc
us
jannaschii) 		5 / 10 ILE A 303
LEU A 203
VAL A 300
LEU A 298
GLU A 294
 None
None
None
None
UDP  A 401 (-2.7A)
 1.14A 5tixB-4nesA:
undetectable		 5tixB-4nesA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUD_A_ERMA2001_1
(5-HYDROXYTRYPTAMINE
RECEPTOR 2B,SOLUBLE
CYTOCHROME B562
CHIMERA)		 4nes UDP-N-ACETYLGLUCOSAM
INE 2-EPIMERASE
(Methanocaldococc
us
jannaschii) 		5 / 12 SER A 140
VAL A 358
ALA A 106
LEU A  16
VAL A 116
 None
 1.09A 5tudA-4nesA:
undetectable		 5tudA-4nesA:
25.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUD_D_ERMD1201_1
(5-HYDROXYTRYPTAMINE
RECEPTOR 2B,SOLUBLE
CYTOCHROME B562
CHIMERA)		 4nes UDP-N-ACETYLGLUCOSAM
INE 2-EPIMERASE
(Methanocaldococc
us
jannaschii) 		5 / 12 SER A 140
VAL A 358
ALA A 106
LEU A  16
VAL A 116
 None
 1.07A 5tudD-4nesA:
undetectable		 5tudD-4nesA:
25.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UIG_A_EDTA501_0
(ADENOSINE RECEPTOR
A2A,SOLUBLE
CYTOCHROME
B562,ADENOSINE
RECEPTOR A2A)		 4nes UDP-N-ACETYLGLUCOSAM
INE 2-EPIMERASE
(Methanocaldococc
us
jannaschii) 		4 / 6 ASN A  97
THR A  71
ILE A 131
GLU A 129
 UD1  A 400 (-3.4A)
None
None
UD1  A 400 (-3.6A)
 1.34A 5uigA-4nesA:
undetectable		 5uigA-4nesA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXC_A_ZITA307_1
(PREDICTED
AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		 4nes UDP-N-ACETYLGLUCOSAM
INE 2-EPIMERASE
(Methanocaldococc
us
jannaschii) 		4 / 5 ASP A 307
PRO A 312
ARG A 208
THR A 309
 None
None
UDP  A 401 ( 3.2A)
None
 1.38A 5uxcA-4nesA:
undetectable		 5uxcA-4nesA:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_A_EY4A502_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 4nes UDP-N-ACETYLGLUCOSAM
INE 2-EPIMERASE
(Methanocaldococc
us
jannaschii) 		4 / 7 ALA A 101
THR A  98
VAL A 105
PRO A  87
 None
 0.87A 6cduA-4nesA:
undetectable
6cduE-4nesA:
undetectable		 6cduA-4nesA:
21.65
6cduE-4nesA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_B_EY4B500_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 4nes UDP-N-ACETYLGLUCOSAM
INE 2-EPIMERASE
(Methanocaldococc
us
jannaschii) 		4 / 6 VAL A 105
PRO A  87
ALA A 101
THR A  98
 None
 0.92A 6cduB-4nesA:
undetectable
6cduC-4nesA:
undetectable		 6cduB-4nesA:
21.65
6cduC-4nesA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_F_EY4F500_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 4nes UDP-N-ACETYLGLUCOSAM
INE 2-EPIMERASE
(Methanocaldococc
us
jannaschii) 		4 / 7 ALA A 101
THR A  98
VAL A 105
PRO A  87
 None
 0.90A 6cduF-4nesA:
undetectable
6cduJ-4nesA:
undetectable		 6cduF-4nesA:
21.65
6cduJ-4nesA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_H_EY4H500_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 4nes UDP-N-ACETYLGLUCOSAM
INE 2-EPIMERASE
(Methanocaldococc
us
jannaschii) 		4 / 7 VAL A 105
PRO A  87
ALA A 101
THR A  98
 None
 0.88A 6cduH-4nesA:
undetectable
6cduI-4nesA:
undetectable		 6cduH-4nesA:
21.65
6cduI-4nesA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6D8P_A_ACTA814_0
(UNCHARACTERIZED
PROTEIN)		 4nes UDP-N-ACETYLGLUCOSAM
INE 2-EPIMERASE
(Methanocaldococc
us
jannaschii) 		4 / 5 GLN A 292
ASN A 320
THR A 304
LEU A 322
 None
 1.05A 6d8pA-4nesA:
3.9		 6d8pA-4nesA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ECF_I_DVAI3010_0
(VLM2
DODECADEPSIPEPTIDE)		 4nes UDP-N-ACETYLGLUCOSAM
INE 2-EPIMERASE
(Methanocaldococc
us
jannaschii) 		3 / 3 PHE A 348
ARG A 311
ALA A 150
 None
 0.94A 6ecfB-4nesA:
5.2		 6ecfB-4nesA:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_C_AM2C301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 4nes UDP-N-ACETYLGLUCOSAM
INE 2-EPIMERASE
(Methanocaldococc
us
jannaschii) 		4 / 8 ASP A 137
ARG A 133
GLU A 117
GLU A 129
 None
None
None
UD1  A 400 (-3.6A)
 1.30A 6mn4C-4nesA:
1.9		 6mn4C-4nesA:
20.60