SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4nex'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HRK_B_CHDB2503_0
(FERROCHELATASE)		 4nex ACETYLGLUTAMATE
KINASE
(Xylella
fastidiosa) 		4 / 4 LEU A 344
PRO A 351
LEU A 330
ARG A 295
 None
 1.45A 1hrkB-4nexA:
undetectable		 1hrkB-4nexA:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGN_A_PCFA1179_1
(WNT INHIBITORY
FACTOR 1)		 4nex ACETYLGLUTAMATE
KINASE
(Xylella
fastidiosa) 		4 / 5 ILE A 437
PRO A 321
VAL A 371
PHE A 324
 None
 1.15A 2ygnA-4nexA:
undetectable		 2ygnA-4nexA:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_B_ACTB308_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 4nex ACETYLGLUTAMATE
KINASE
(Xylella
fastidiosa) 		3 / 3 LEU A 329
ILE A 343
TYR A 338
 None
 0.69A 5uunB-4nexA:
undetectable		 5uunB-4nexA:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6APH_A_ADNA501_2
(ADENOSYLHOMOCYSTEINA
SE)		 4nex ACETYLGLUTAMATE
KINASE
(Xylella
fastidiosa) 		4 / 5 GLN A 431
THR A 430
THR A 435
LEU A 347
 None
None
SO4  A 601 (-3.4A)
None
 1.22A 6aphA-4nexA:
undetectable		 6aphA-4nexA:
15.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJZ_C_GMJC301_1
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)		 4nex ACETYLGLUTAMATE
KINASE
(Xylella
fastidiosa) 		4 / 6 TRP A 409
LEU A 319
TYR A 352
GLN A 431
 None
 0.93A 6djzC-4nexA:
undetectable		 6djzC-4nexA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GBN_B_ADNB501_2
(-)		 4nex ACETYLGLUTAMATE
KINASE
(Xylella
fastidiosa) 		4 / 5 GLN A 431
THR A 430
THR A 435
LEU A 347
 None
None
SO4  A 601 (-3.4A)
None
 1.23A 6gbnB-4nexA:
undetectable		 6gbnB-4nexA:
17.00