SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4nez'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2KOT_A_ANWA99_0
(PROTEIN S100-A13)		 4nez ENGINEERED PROTEIN
OR276
(synthetic
construct) 		4 / 7 MET A  88
VAL A 156
PHE A  91
ARG A 125
 4NE  A 202 ( 4.8A)
None
None
None
 1.27A 2kotA-4nezA:
undetectable		 2kotA-4nezA:
23.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NM5_B_LOCB502_2
(TUBULIN BETA-2B
CHAIN)		 4nez ENGINEERED PROTEIN
OR276
(synthetic
construct) 		5 / 12 LEU A 103
LEU A 148
ILE A  89
ALA A 145
ILE A 130
 None
 1.14A 5nm5B-4nezA:
undetectable		 5nm5B-4nezA:
16.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIW_B_LOCB504_2
(TUBULIN BETA CHAIN)		 4nez ENGINEERED PROTEIN
OR276
(synthetic
construct) 		6 / 12 LEU A 126
LEU A 148
ALA A 102
ILE A  89
ALA A 145
ILE A 130
 None
 1.42A 5xiwB-4nezA:
undetectable		 5xiwB-4nezA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIW_D_LOCD503_2
(TUBULIN BETA CHAIN)		 4nez ENGINEERED PROTEIN
OR276
(synthetic
construct) 		5 / 12 LEU A 103
LEU A 148
ILE A  89
ALA A 145
ILE A 130
 None
 1.14A 5xiwD-4nezA:
undetectable		 5xiwD-4nezA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FK2_A_SORA302_0
(GALECTIN-3)		 4nez ENGINEERED PROTEIN
OR276
(synthetic
construct) 		4 / 4 ARG A  46
GLU A  35
GLU A  86
ARG A 129
 None
4NE  A 202 ( 4.6A)
None
4NE  A 202 ( 4.1A)
 0.96A 6fk2A-4nezA:
undetectable		 6fk2A-4nezA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FK2_A_SORA302_0
(GALECTIN-3)		 4nez ENGINEERED PROTEIN
OR276
(synthetic
construct) 		4 / 4 ARG A 129
GLU A  86
GLU A  35
ARG A  46
 4NE  A 202 ( 4.1A)
None
4NE  A 202 ( 4.6A)
None
 1.02A 6fk2A-4nezA:
undetectable		 6fk2A-4nezA:
17.65