SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4nf1'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HRK_B_CHDB2503_0
(FERROCHELATASE)		 4nf1 ACETYLGLUTAMATE
KINASE
(Xylella
fastidiosa) 		4 / 4 LEU A 344
PRO A 351
LEU A 330
ARG A 295
 None
 1.36A 1hrkB-4nf1A:
undetectable		 1hrkB-4nf1A:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JFF_B_TA1B601_1
(TUBULIN BETA CHAIN)		 4nf1 ACETYLGLUTAMATE
KINASE
(Xylella
fastidiosa) 		5 / 12 VAL A 334
LEU A 436
LEU A 319
THR A 318
ARG A 316
 None
NLG  A 501 ( 4.7A)
None
None
None
 1.15A 1jffB-4nf1A:
undetectable		 1jffB-4nf1A:
14.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HRC_B_CHDB1604_0
(FERROCHELATASE)		 4nf1 ACETYLGLUTAMATE
KINASE
(Xylella
fastidiosa) 		4 / 4 LEU A 344
PRO A 351
LEU A 330
ARG A 295
 None
 1.32A 2hrcB-4nf1A:
undetectable		 2hrcB-4nf1A:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HXF_B_TA1B601_1
(TUBULIN BETA CHAIN)		 4nf1 ACETYLGLUTAMATE
KINASE
(Xylella
fastidiosa) 		5 / 12 VAL A 334
LEU A 436
LEU A 319
THR A 318
ARG A 316
 None
NLG  A 501 ( 4.7A)
None
None
None
 1.15A 2hxfB-4nf1A:
undetectable		 2hxfB-4nf1A:
14.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HXH_B_TA1B601_1
(TUBULIN BETA CHAIN)		 4nf1 ACETYLGLUTAMATE
KINASE
(Xylella
fastidiosa) 		5 / 12 VAL A 334
LEU A 436
LEU A 319
THR A 318
ARG A 316
 None
NLG  A 501 ( 4.7A)
None
None
None
 1.15A 2hxhB-4nf1A:
undetectable		 2hxhB-4nf1A:
14.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2P4N_B_TA1B601_1
(TUBULIN BETA CHAIN)		 4nf1 ACETYLGLUTAMATE
KINASE
(Xylella
fastidiosa) 		5 / 12 VAL A 334
LEU A 436
LEU A 319
THR A 318
ARG A 316
 None
NLG  A 501 ( 4.7A)
None
None
None
 1.15A 2p4nB-4nf1A:
undetectable		 2p4nB-4nf1A:
14.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD2_A_CHDA426_0
(FERROCHELATASE)		 4nf1 ACETYLGLUTAMATE
KINASE
(Xylella
fastidiosa) 		4 / 4 LEU A 344
PRO A 351
LEU A 330
ARG A 295
 None
 1.40A 2qd2A-4nf1A:
undetectable		 2qd2A-4nf1A:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WBE_B_TA1B1439_1
(TUBULIN BETA-2B
CHAIN)		 4nf1 ACETYLGLUTAMATE
KINASE
(Xylella
fastidiosa) 		5 / 12 VAL A 334
LEU A 436
LEU A 319
THR A 318
ARG A 316
 None
NLG  A 501 ( 4.7A)
None
None
None
 1.15A 2wbeB-4nf1A:
undetectable		 2wbeB-4nf1A:
14.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DCO_B_TA1B601_1
(BOVINE BETA TUBULIN)		 4nf1 ACETYLGLUTAMATE
KINASE
(Xylella
fastidiosa) 		5 / 12 VAL A 334
LEU A 436
LEU A 319
THR A 318
ARG A 316
 None
NLG  A 501 ( 4.7A)
None
None
None
 1.15A 3dcoB-4nf1A:
undetectable		 3dcoB-4nf1A:
14.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EDL_B_TA1B601_1
(BETA TUBULIN)		 4nf1 ACETYLGLUTAMATE
KINASE
(Xylella
fastidiosa) 		5 / 12 VAL A 334
LEU A 436
LEU A 319
THR A 318
ARG A 316
 None
NLG  A 501 ( 4.7A)
None
None
None
 1.14A 3edlB-4nf1A:
undetectable		 3edlB-4nf1A:
14.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IZ0_B_TA1B820_1
(BETA TUBULIN, CHAIN
B FROM PDB 1JFF)		 4nf1 ACETYLGLUTAMATE
KINASE
(Xylella
fastidiosa) 		5 / 12 VAL A 334
LEU A 436
LEU A 319
THR A 318
ARG A 316
 None
NLG  A 501 ( 4.7A)
None
None
None
 1.14A 3iz0B-4nf1A:
undetectable		 3iz0B-4nf1A:
14.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JQ1_B_NPSB401_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 4nf1 ACETYLGLUTAMATE
KINASE
(Xylella
fastidiosa) 		4 / 8 VAL A 371
VAL A 293
ILE A 294
LEU A 307
 None
 0.92A 4jq1B-4nf1A:
undetectable		 4jq1B-4nf1A:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L1W_B_STRB402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 4nf1 ACETYLGLUTAMATE
KINASE
(Xylella
fastidiosa) 		4 / 6 VAL A 371
VAL A 293
ILE A 294
LEU A 307
 None
 0.95A 4l1wB-4nf1A:
undetectable		 4l1wB-4nf1A:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PCL_A_SAMA301_0
(O-METHYLTRANSFERASE
FAMILY PROTEIN)		 4nf1 ACETYLGLUTAMATE
KINASE
(Xylella
fastidiosa) 		5 / 12 LEU A 353
GLY A 368
GLU A 365
ALA A 362
ALA A 340
 NLG  A 501 (-4.6A)
CL  A 503 (-3.5A)
None
None
None
 1.20A 4pclA-4nf1A:
undetectable		 4pclA-4nf1A:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HNW_B_TA1B902_1
(TUBULIN BETA-2B
CHAIN)		 4nf1 ACETYLGLUTAMATE
KINASE
(Xylella
fastidiosa) 		5 / 12 VAL A 334
LEU A 436
LEU A 319
THR A 318
ARG A 316
 None
NLG  A 501 ( 4.7A)
None
None
None
 1.08A 5hnwB-4nf1A:
undetectable		 5hnwB-4nf1A:
16.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HNY_B_TA1B601_1
(TUBULIN BETA-2B
CHAIN)		 4nf1 ACETYLGLUTAMATE
KINASE
(Xylella
fastidiosa) 		5 / 12 VAL A 334
LEU A 436
LEU A 319
THR A 318
ARG A 316
 None
NLG  A 501 ( 4.7A)
None
None
None
 1.13A 5hnyB-4nf1A:
undetectable		 5hnyB-4nf1A:
14.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_B_ACTB308_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 4nf1 ACETYLGLUTAMATE
KINASE
(Xylella
fastidiosa) 		3 / 3 LEU A 329
ILE A 343
TYR A 338
 None
 0.66A 5uunB-4nf1A:
undetectable		 5uunB-4nf1A:
17.97