SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4nf2'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ETB_2_T442129_1
(TRANSTHYRETIN)		 4nf2 ORNITHINE
CARBAMOYLTRANSFERASE
(Bacillus
anthracis) 		4 / 6 LEU A 173
THR A 207
ALA A 176
LEU A 172
 None
 1.25A 1etb2-4nf2A:
undetectable		 1etb2-4nf2A:
15.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B25_B_SAMB602_0
(HYPOTHETICAL PROTEIN)		 4nf2 ORNITHINE
CARBAMOYLTRANSFERASE
(Bacillus
anthracis) 		5 / 12 SER A  63
GLY A  67
MET A  68
ASP A  54
ILE A  52
 None
 1.18A 2b25B-4nf2A:
3.8		 2b25B-4nf2A:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PXC_A_SAMA500_0
(GENOME POLYPROTEIN
[CONTAINS: CAPSID
PROTEIN C (CORE
PROTEIN)
ENVELOPE PROTEIN M
(MATRIX PROTEIN)
MAJOR ENVELOPE
PROTEIN E
NON-STRUCTURAL
PROTEIN 1 (NS1)
NON-STRUCTURAL
PROTEIN 2A (NS2A)
FLAVIVIRIN PROTEASE
NS2B REGULATORY
SUBUNIT
FLAVIVIRIN PROTEASE
NS3 CATALYTIC
SUBUNIT
NON-STRUCTURAL
PROTEIN 4A (NS4A)
NON-STRUCTURAL
PROTEIN 4B (NS4B)
RNA-DIRECTED RNA
POLYMERASE (EC
2.7.7.48) (NS5)])		 4nf2 ORNITHINE
CARBAMOYLTRANSFERASE
(Bacillus
anthracis) 		6 / 12 GLY A  46
GLY A 104
GLY A  73
ASP A  13
ASP A 103
ILE A 124
 None
 1.23A 2pxcA-4nf2A:
3.0		 2pxcA-4nf2A:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN5_A_FUNA1356_1
(THYROXINE-BINDING
GLOBULIN)		 4nf2 ORNITHINE
CARBAMOYLTRANSFERASE
(Bacillus
anthracis) 		5 / 11 SER A 170
ALA A 174
LEU A   9
LEU A  28
LEU A 140
 None
 1.00A 2xn5A-4nf2A:
undetectable		 2xn5A-4nf2A:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HM1_A_J3ZA2_1
(ESTROGEN RECEPTOR)		 4nf2 ORNITHINE
CARBAMOYLTRANSFERASE
(Bacillus
anthracis) 		5 / 12 LEU A 304
LEU A  71
LEU A  44
LEU A  49
LEU A  35
 None
 1.11A 3hm1A-4nf2A:
undetectable		 3hm1A-4nf2A:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MEK_A_SAMA510_0
(SET AND MYND
DOMAIN-CONTAINING
PROTEIN 3)		 4nf2 ORNITHINE
CARBAMOYLTRANSFERASE
(Bacillus
anthracis) 		5 / 12 ARG A  59
GLY A 295
ASN A 296
GLU A 292
HIS A 268
 CP  A 401 (-3.6A)
None
None
None
None
 1.46A 3mekA-4nf2A:
undetectable		 3mekA-4nf2A:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJW_A_SRYA2001_2
(TRANSCRIPTIONAL
REGULATOR TCAR)		 4nf2 ORNITHINE
CARBAMOYLTRANSFERASE
(Bacillus
anthracis) 		4 / 6 GLU A 195
ILE A 196
ASN A 193
VAL A 115
 None
 1.13A 4ejwB-4nf2A:
undetectable		 4ejwB-4nf2A:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O2B_D_LOCD503_2
(TUBULIN BETA-2B
CHAIN)		 4nf2 ORNITHINE
CARBAMOYLTRANSFERASE
(Bacillus
anthracis) 		5 / 12 LEU A 173
ASN A 193
ILE A 211
ALA A 200
ILE A 213
 None
 0.95A 4o2bD-4nf2A:
undetectable		 4o2bD-4nf2A:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1K_D_LOCD502_2
(TUBULIN BETA CHAIN)		 4nf2 ORNITHINE
CARBAMOYLTRANSFERASE
(Bacillus
anthracis) 		5 / 12 ASN A 222
ALA A 159
VAL A 161
ALA A 185
ILE A 227
 None
 1.04A 4x1kD-4nf2A:
undetectable		 4x1kD-4nf2A:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1Y_D_LOCD502_2
(TUBULIN BETA CHAIN)		 4nf2 ORNITHINE
CARBAMOYLTRANSFERASE
(Bacillus
anthracis) 		5 / 12 ASN A 222
ALA A 159
VAL A 161
ALA A 185
ILE A 227
 None
 1.06A 4x1yD-4nf2A:
2.6		 4x1yD-4nf2A:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XYZ_A_ACTA103_0
(POLYUBIQUITIN-C)		 4nf2 ORNITHINE
CARBAMOYLTRANSFERASE
(Bacillus
anthracis) 		4 / 4 LEU A 270
ILE A 283
HIS A 268
VAL A 290
 None
None
None
CL  A 403 (-4.9A)
 1.00A 4xyzA-4nf2A:
undetectable		 4xyzA-4nf2A:
11.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YSH_B_GLYB401_0
(GLYCINE OXIDASE)		 4nf2 ORNITHINE
CARBAMOYLTRANSFERASE
(Bacillus
anthracis) 		4 / 6 PHE A 247
GLY A 162
TYR A 250
ALA A 185
 None
 1.15A 4yshB-4nf2A:
undetectable		 4yshB-4nf2A:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AXD_A_RBVA502_2
(ADENOSYLHOMOCYSTEINA
SE)		 4nf2 ORNITHINE
CARBAMOYLTRANSFERASE
(Bacillus
anthracis) 		3 / 3 THR A  11
HIS A 169
LEU A 173
 None
 0.78A 5axdA-4nf2A:
4.5		 5axdA-4nf2A:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CCL_A_SAMA504_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SMYD3)		 4nf2 ORNITHINE
CARBAMOYLTRANSFERASE
(Bacillus
anthracis) 		5 / 12 ARG A  59
GLY A 295
ASN A 296
GLU A 292
HIS A 268
 CP  A 401 (-3.6A)
None
None
None
None
 1.12A 5cclA-4nf2A:
undetectable		 5cclA-4nf2A:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CCM_A_SAMA504_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SMYD3)		 4nf2 ORNITHINE
CARBAMOYLTRANSFERASE
(Bacillus
anthracis) 		5 / 12 ARG A  59
GLY A 295
ASN A 296
GLU A 292
HIS A 268
 CP  A 401 (-3.6A)
None
None
None
None
 1.43A 5ccmA-4nf2A:
undetectable		 5ccmA-4nf2A:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KOC_B_SAMB401_0
(PAVINE
N-METHYLTRANSFERASE)		 4nf2 ORNITHINE
CARBAMOYLTRANSFERASE
(Bacillus
anthracis) 		5 / 12 SER A 234
GLY A 162
GLY A 164
THR A 186
VAL A 231
 NVA  A 402 ( 2.8A)
None
None
None
None
 1.13A 5kocB-4nf2A:
undetectable		 5kocB-4nf2A:
23.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V37_A_SAMA504_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SMYD3)		 4nf2 ORNITHINE
CARBAMOYLTRANSFERASE
(Bacillus
anthracis) 		5 / 12 ARG A  59
GLY A 295
ASN A 296
GLU A 292
HIS A 268
 CP  A 401 (-3.6A)
None
None
None
None
 1.13A 5v37A-4nf2A:
undetectable		 5v37A-4nf2A:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ1_D_SAMD601_0
(NS5
METHYLTRANSFERASE)		 4nf2 ORNITHINE
CARBAMOYLTRANSFERASE
(Bacillus
anthracis) 		6 / 12 GLY A  46
GLY A 104
GLY A  73
ASP A  13
ASP A 103
ILE A 124
 None
 1.26A 5wz1D-4nf2A:
3.1		 5wz1D-4nf2A:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ1_G_SAMG601_0
(NS5
METHYLTRANSFERASE)		 4nf2 ORNITHINE
CARBAMOYLTRANSFERASE
(Bacillus
anthracis) 		6 / 12 GLY A  46
GLY A 104
GLY A  73
ASP A  13
ASP A 103
ILE A 124
 None
 1.27A 5wz1G-4nf2A:
3.2		 5wz1G-4nf2A:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIW_D_LOCD503_2
(TUBULIN BETA CHAIN)		 4nf2 ORNITHINE
CARBAMOYLTRANSFERASE
(Bacillus
anthracis) 		5 / 12 LEU A  17
LEU A 171
ALA A 139
LEU A 143
THR A 150
 None
 1.24A 5xiwD-4nf2A:
undetectable		 5xiwD-4nf2A:
12.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XXD_A_SAMA501_0
(SMYD3
METHYLTRANSFERASE)		 4nf2 ORNITHINE
CARBAMOYLTRANSFERASE
(Bacillus
anthracis) 		5 / 12 ARG A  59
GLY A 295
ASN A 296
GLU A 292
HIS A 268
 CP  A 401 (-3.6A)
None
None
None
None
 1.49A 5xxdA-4nf2A:
undetectable		 5xxdA-4nf2A:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XXG_A_SAMA502_0
(SMYD3)		 4nf2 ORNITHINE
CARBAMOYLTRANSFERASE
(Bacillus
anthracis) 		5 / 12 ARG A  59
GLY A 295
ASN A 296
GLU A 292
HIS A 268
 CP  A 401 (-3.6A)
None
None
None
None
 1.42A 5xxgA-4nf2A:
undetectable		 5xxgA-4nf2A:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YJO_A_SAMA505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SMYD3)		 4nf2 ORNITHINE
CARBAMOYLTRANSFERASE
(Bacillus
anthracis) 		5 / 12 ARG A  59
GLY A 295
ASN A 296
GLU A 292
HIS A 268
 CP  A 401 (-3.6A)
None
None
None
None
 1.38A 5yjoA-4nf2A:
undetectable		 5yjoA-4nf2A:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B54_A_OAQA302_0
(SULFOTRANSFERASE)		 4nf2 ORNITHINE
CARBAMOYLTRANSFERASE
(Bacillus
anthracis) 		5 / 12 ILE A  25
LEU A  20
THR A 207
THR A  16
LEU A  14
 None
 1.25A 6b54A-4nf2A:
undetectable		 6b54A-4nf2A:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_B_SUEB1202_1
(NS3 PROTEASE)		 4nf2 ORNITHINE
CARBAMOYLTRANSFERASE
(Bacillus
anthracis) 		5 / 9 LEU A 118
ALA A  95
VAL A  97
SER A  99
ASP A  93
 None
 1.03A 6c2mB-4nf2A:
undetectable		 6c2mB-4nf2A:
13.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_1
(-)		 4nf2 ORNITHINE
CARBAMOYLTRANSFERASE
(Bacillus
anthracis) 		5 / 12 LEU A 171
VAL A 167
THR A 207
GLY A 208
ASN A 165
 None
None
None
None
NVA  A 402 (-3.8A)
 1.18A 6gngA-4nf2A:
2.1		 6gngA-4nf2A:
21.26