SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4nf8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1PB9_A_4AXA901_1
(N-METHYL-D-ASPARTATE
RECEPTOR SUBUNIT 1)		 4nf8 GLUTAMATE RECEPTOR
IONOTROPIC, NMDA 1
(Rattus
norvegicus) 		9 / 9 PHE A  92
LEU A 125
THR A 126
ARG A 131
SER A 179
SER A 180
VAL A 181
TRP A 223
ASP A 224
 GLY  A1001 (-3.7A)
GLY  A1001 (-4.5A)
GLY  A1001 (-3.9A)
GLY  A1001 (-2.8A)
GLY  A1001 (-4.7A)
GLY  A1001 (-3.2A)
None
None
GLY  A1001 (-3.1A)
 0.31A 1pb9A-4nf8A:
44.6		 1pb9A-4nf8A:
99.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AOB_C_RFPC2002_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 4nf8 GLUTAMATE RECEPTOR
IONOTROPIC, NMDA 1
(Rattus
norvegicus) 		5 / 12 PHE A  16
ALA A 123
THR A 126
GLY A 253
LEU A  74
 None
None
GLY  A1001 (-3.9A)
None
None
 1.42A 3aobC-4nf8A:
undetectable		 3aobC-4nf8A:
16.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NBQ_C_URFC400_1
(URIDINE
PHOSPHORYLASE 1)		 4nf8 GLUTAMATE RECEPTOR
IONOTROPIC, NMDA 1
(Rattus
norvegicus) 		4 / 8 GLY A 111
LEU A 113
LEU A 114
ILE A 135
 None
 0.93A 3nbqC-4nf8A:
undetectable		 3nbqC-4nf8A:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_F_W9TF512_1
(HEMOLYTIC LECTIN
CEL-III)		 4nf8 GLUTAMATE RECEPTOR
IONOTROPIC, NMDA 1
(Rattus
norvegicus) 		4 / 6 THR A  94
ASN A 107
GLY A 111
ILE A 121
 None
 0.88A 3w9tF-4nf8A:
undetectable		 3w9tF-4nf8A:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TJY_A_BEZA304_0
(4-HYDROXY-TETRAHYDRO
DIPICOLINATE
REDUCTASE)		 4nf8 GLUTAMATE RECEPTOR
IONOTROPIC, NMDA 1
(Rattus
norvegicus) 		3 / 3 MET A 110
GLU A 130
ARG A 131
 None
None
GLY  A1001 (-2.8A)
 1.13A 5tjyA-4nf8A:
undetectable		 5tjyA-4nf8A:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TJZ_A_BEZA302_0
(4-HYDROXY-TETRAHYDRO
DIPICOLINATE
REDUCTASE)		 4nf8 GLUTAMATE RECEPTOR
IONOTROPIC, NMDA 1
(Rattus
norvegicus) 		3 / 3 MET A 110
GLU A 130
ARG A 131
 None
None
GLY  A1001 (-2.8A)
 1.07A 5tjzA-4nf8A:
undetectable		 5tjzA-4nf8A:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_D_CVID301_1
(REGULATORY PROTEIN
TETR)		 4nf8 GLUTAMATE RECEPTOR
IONOTROPIC, NMDA 1
(Rattus
norvegicus) 		4 / 8 GLN A 178
GLY A  93
GLU A 112
TRP A 223
 None
 1.05A 5vlmD-4nf8A:
undetectable		 5vlmD-4nf8A:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A94_B_ZOTB3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		 4nf8 GLUTAMATE RECEPTOR
IONOTROPIC, NMDA 1
(Rattus
norvegicus) 		5 / 12 THR A 126
LEU A 228
GLY A 145
SER A 248
PHE A 141
 GLY  A1001 (-3.9A)
None
None
None
None
 1.10A 6a94B-4nf8A:
undetectable		 6a94B-4nf8A:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EFN_A_SAMA501_0
(SPORULATION KILLING
FACTOR MATURATION
PROTEIN SKFB)		 4nf8 GLUTAMATE RECEPTOR
IONOTROPIC, NMDA 1
(Rattus
norvegicus) 		5 / 11 PHE A 171
THR A 241
THR A 240
LEU A 228
ALA A 232
 None
 1.35A 6efnA-4nf8A:
undetectable		 6efnA-4nf8A:
21.65