SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4nfa'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OD9_A_NCAA3721_0
(NAD-DEPENDENT
DEACETYLASE HST2)		 4nfa PROTEIN CASC5
(Homo
sapiens) 		3 / 3 PHE A2134
PHE A2121
PHE A2123
 None
 0.86A 2od9A-4nfaA:
undetectable		 2od9A-4nfaA:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEU_A_ACTA142_0
(PUTATIVE
CARBOXYMUCONOLACTONE
DECARBOXYLASE)		 4nfa PROTEIN CASC5
(Homo
sapiens) 		4 / 5 GLU A2216
ILE A2217
GLY A2214
LYS A2298
 None
 1.08A 2qeuA-4nfaA:
undetectable
2qeuC-4nfaA:
undetectable		 2qeuA-4nfaA:
18.50
2qeuC-4nfaA:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQG_A_NCAA3721_0
(NAD-DEPENDENT
DEACETYLASE HST2)		 4nfa PROTEIN CASC5
(Homo
sapiens) 		3 / 3 PHE A2134
PHE A2121
PHE A2123
 None
 0.86A 2qqgA-4nfaA:
undetectable		 2qqgA-4nfaA:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_K_CHDK103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 4nfa PROTEIN CASC5
(Homo
sapiens) 		5 / 11 GLU A2215
LEU A2213
LEU A2297
LEU A2239
LEU A2258
 None
 1.13A 4wg0I-4nfaA:
undetectable
4wg0J-4nfaA:
undetectable
4wg0K-4nfaA:
undetectable		 4wg0I-4nfaA:
4.41
4wg0J-4nfaA:
4.41
4wg0K-4nfaA:
4.41