SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4nff'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ETR_H_MITH1_1
(EPSILON-THROMBIN)		 4nff KALLIKREIN-2
(Homo
sapiens) 		5 / 12 HIS A  57
ASP A 189
SER A 195
TRP A 215
GLY A 216
 0G6  A 301 (-2.7A)
0G6  A 301 (-3.0A)
0G6  A 301 (-1.4A)
0G6  A 301 (-3.7A)
0G6  A 301 (-3.4A)
 0.82A 1etrH-4nffA:
33.4		 1etrH-4nffA:
34.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2P16_A_GG2A298_1
(COAGULATION FACTOR X
(EC 3.4.21.6)
(STUART FACTOR)
(STUART-PROWER
FACTOR))		 4nff KALLIKREIN-2
(Homo
sapiens) 		5 / 12 ASP A 189
SER A 195
TRP A 215
GLY A 216
TYR A 228
 0G6  A 301 (-3.0A)
0G6  A 301 (-1.4A)
0G6  A 301 (-3.7A)
0G6  A 301 (-3.4A)
None
 0.47A 2p16A-4nffA:
13.2		 2p16A-4nffA:
34.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2W26_A_RIVA1001_1
(ACTIVATED FACTOR XA
HEAVY CHAIN)		 4nff KALLIKREIN-2
(Homo
sapiens) 		5 / 12 ASP A 189
SER A 195
TRP A 215
GLY A 216
TYR A 228
 0G6  A 301 (-3.0A)
0G6  A 301 (-1.4A)
0G6  A 301 (-3.7A)
0G6  A 301 (-3.4A)
None
 0.37A 2w26A-4nffA:
12.1		 2w26A-4nffA:
34.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ARU_A_PNXA608_1
(CHITINASE A)		 4nff KALLIKREIN-2
(Homo
sapiens) 		4 / 6 TRP A 141
SER A 139
ALA A 138
ASP A 194
 None
 1.22A 3aruA-4nffA:
undetectable		 3aruA-4nffA:
17.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3GY3_A_PNTA246_0
(CATIONIC TRYPSIN)		 4nff KALLIKREIN-2
(Homo
sapiens) 		5 / 11 HIS A  57
ASP A 189
SER A 195
TRP A 215
GLY A 216
 0G6  A 301 (-2.7A)
0G6  A 301 (-3.0A)
0G6  A 301 (-1.4A)
0G6  A 301 (-3.7A)
0G6  A 301 (-3.4A)
 0.63A 3gy3A-4nffA:
38.5		 3gy3A-4nffA:
43.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_C_PCFC1803_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 4nff KALLIKREIN-2
(Homo
sapiens) 		4 / 8 SER A  86
PHE A  89
HIS A  48
ILE A 242
 None
 1.03A 5vkqB-4nffA:
undetectable
5vkqC-4nffA:
undetectable		 5vkqB-4nffA:
8.93
5vkqC-4nffA:
8.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X80_C_SALC201_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		 4nff KALLIKREIN-2
(Homo
sapiens) 		4 / 7 VAL A 200
VAL A 231
PRO A 124
GLY A 122
 None
 1.01A 5x80C-4nffA:
undetectable
5x80D-4nffA:
undetectable		 5x80C-4nffA:
22.92
5x80D-4nffA:
22.92