SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4nfn'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AV2_D_DVAD8_0
(GRAMICIDIN A)		 4nfn TAU-TUBULIN KINASE 1
(Homo
sapiens) 		3 / 3 VAL A  30
VAL A  36
TRP A  34
 None
 0.70A 1av2C-4nfnA:
undetectable
1av2D-4nfnA:
undetectable		 1av2C-4nfnA:
4.45
1av2D-4nfnA:
4.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICR_A_NIOA604_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 4nfn TAU-TUBULIN KINASE 1
(Homo
sapiens) 		4 / 5 SER A 129
THR A 130
PHE A 308
GLU A 306
 None
 1.27A 1icrA-4nfnA:
undetectable
1icrB-4nfnA:
undetectable		 1icrA-4nfnA:
20.87
1icrB-4nfnA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICR_B_NIOB602_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 4nfn TAU-TUBULIN KINASE 1
(Homo
sapiens) 		4 / 5 GLU A 306
SER A 129
THR A 130
PHE A 308
 None
 1.31A 1icrA-4nfnA:
undetectable
1icrB-4nfnA:
undetectable		 1icrA-4nfnA:
20.87
1icrB-4nfnA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICV_C_NIOC708_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 4nfn TAU-TUBULIN KINASE 1
(Homo
sapiens) 		4 / 5 SER A 129
THR A 130
PHE A 308
GLU A 306
 None
 1.23A 1icvC-4nfnA:
undetectable
1icvD-4nfnA:
undetectable		 1icvC-4nfnA:
20.87
1icvD-4nfnA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICV_D_NIOD706_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 4nfn TAU-TUBULIN KINASE 1
(Homo
sapiens) 		4 / 5 GLU A 306
SER A 129
THR A 130
PHE A 308
 None
 1.18A 1icvC-4nfnA:
undetectable
1icvD-4nfnA:
undetectable		 1icvC-4nfnA:
20.87
1icvD-4nfnA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MOG_A_RBFA200_1
(DODECIN)		 4nfn TAU-TUBULIN KINASE 1
(Homo
sapiens) 		3 / 3 PHE A 126
TRP A 310
GLU A 311
 None
 0.98A 1mogA-4nfnA:
undetectable		 1mogA-4nfnA:
13.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W5U_D_DVAD8_0
(GRAMICIDIN D)		 4nfn TAU-TUBULIN KINASE 1
(Homo
sapiens) 		3 / 3 VAL A  30
VAL A  36
TRP A  34
 None
 0.77A 1w5uC-4nfnA:
undetectable
1w5uD-4nfnA:
undetectable		 1w5uC-4nfnA:
4.45
1w5uD-4nfnA:
4.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WOP_A_FFOA2888_0
(AMINOMETHYLTRANSFERA
SE)		 4nfn TAU-TUBULIN KINASE 1
(Homo
sapiens) 		5 / 10 LEU A 225
LEU A 229
ILE A 138
GLU A 294
LEU A 132
 None
 1.21A 1wopA-4nfnA:
2.2		 1wopA-4nfnA:
23.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IZQ_A_DVAA8_0
(GRAMICIDIN D)		 4nfn TAU-TUBULIN KINASE 1
(Homo
sapiens) 		3 / 3 VAL A  36
TRP A  34
VAL A  30
 None
 0.72A 2izqA-4nfnA:
undetectable
2izqB-4nfnA:
undetectable		 2izqA-4nfnA:
4.45
2izqB-4nfnA:
4.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQD_A_AG2A671_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 4nfn TAU-TUBULIN KINASE 1
(Homo
sapiens) 		4 / 7 LEU A 222
ASP A 221
LEU A 151
ILE A 145
 None
 1.05A 2qqdA-4nfnA:
undetectable
2qqdE-4nfnA:
undetectable		 2qqdA-4nfnA:
9.03
2qqdE-4nfnA:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_A_KLNA1500_1
(CYTOCHROME P450 3A4)		 4nfn TAU-TUBULIN KINASE 1
(Homo
sapiens) 		5 / 11 SER A 224
PHE A 199
ALA A 210
ARG A 240
GLU A 231
 None
None
None
SO4  A 403 (-4.1A)
SO4  A 403 ( 4.9A)
 1.36A 2v0mA-4nfnA:
undetectable		 2v0mA-4nfnA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GP0_A_NILA1_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 11)		 4nfn TAU-TUBULIN KINASE 1
(Homo
sapiens) 		6 / 12 ALA A  61
GLU A  77
LEU A  81
HIS A 152
ALA A 161
LEU A 175
 2KC  A 401 (-2.7A)
2KC  A 401 (-1.9A)
None
None
None
2KC  A 401 ( 3.9A)
 1.21A 3gp0A-4nfnA:
18.8		 3gp0A-4nfnA:
25.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L8L_B_DVAB8_0
(GRAMICIDIN D)		 4nfn TAU-TUBULIN KINASE 1
(Homo
sapiens) 		3 / 3 VAL A  30
VAL A  36
TRP A  34
 None
 0.81A 3l8lA-4nfnA:
undetectable
3l8lB-4nfnA:
undetectable		 3l8lA-4nfnA:
4.45
3l8lB-4nfnA:
4.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_E_CLME221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4nfn TAU-TUBULIN KINASE 1
(Homo
sapiens) 		5 / 10 PHE A  93
LEU A  62
VAL A  64
PHE A 102
VAL A  30
 None
 1.38A 3u9fE-4nfnA:
undetectable		 3u9fE-4nfnA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_I_CLMI221_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4nfn TAU-TUBULIN KINASE 1
(Homo
sapiens) 		5 / 10 PHE A  93
LEU A  62
VAL A  64
PHE A 102
VAL A  30
 None
 1.39A 3u9fI-4nfnA:
undetectable		 3u9fI-4nfnA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_N_CLMN221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4nfn TAU-TUBULIN KINASE 1
(Homo
sapiens) 		5 / 11 PHE A  93
LEU A  62
VAL A  64
PHE A 102
VAL A  30
 None
 1.35A 3u9fN-4nfnA:
undetectable
3u9fO-4nfnA:
undetectable		 3u9fN-4nfnA:
20.83
3u9fO-4nfnA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FFW_B_715B801_1
(DIPEPTIDYL PEPTIDASE
4)		 4nfn TAU-TUBULIN KINASE 1
(Homo
sapiens) 		5 / 12 ARG A 119
GLU A 231
PHE A 126
SER A 158
TYR A 205
 SO4  A 403 (-4.6A)
SO4  A 403 ( 4.9A)
None
2KC  A 401 ( 3.1A)
None
 1.30A 4ffwB-4nfnA:
3.4		 4ffwB-4nfnA:
17.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AXD_A_RBVA502_2
(ADENOSYLHOMOCYSTEINA
SE)		 4nfn TAU-TUBULIN KINASE 1
(Homo
sapiens) 		3 / 3 THR A 184
HIS A  89
LEU A  84
 None
 0.80A 5axdA-4nfnA:
undetectable		 5axdA-4nfnA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_A_P06A801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 4nfn TAU-TUBULIN KINASE 1
(Homo
sapiens) 		4 / 7 GLY A  41
PHE A  93
ASP A 176
PHE A 177
 2KC  A 401 ( 3.2A)
None
2KC  A 401 (-2.7A)
None
 0.77A 5hieA-4nfnA:
4.6		 5hieA-4nfnA:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_A_P06A801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 4nfn TAU-TUBULIN KINASE 1
(Homo
sapiens) 		4 / 7 ILE A  40
GLY A  41
PHE A  93
ASP A 176
 2KC  A 401 ( 3.9A)
2KC  A 401 ( 3.2A)
None
2KC  A 401 (-2.7A)
 0.66A 5hieA-4nfnA:
4.6		 5hieA-4nfnA:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LW1_H_ADNH401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 8)		 4nfn TAU-TUBULIN KINASE 1
(Homo
sapiens) 		5 / 9 ALA A  61
MET A 107
LEU A 109
ASN A 113
LEU A 175
 2KC  A 401 (-2.7A)
2KC  A 401 (-4.1A)
2KC  A 401 ( 4.7A)
None
2KC  A 401 ( 3.9A)
 0.89A 5lw1H-4nfnA:
19.1		 5lw1H-4nfnA:
11.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LW1_H_ADNH401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 8)		 4nfn TAU-TUBULIN KINASE 1
(Homo
sapiens) 		5 / 9 GLY A  41
ALA A  61
MET A 107
LEU A 109
LEU A 175
 2KC  A 401 ( 3.2A)
2KC  A 401 (-2.7A)
2KC  A 401 (-4.1A)
2KC  A 401 ( 4.7A)
2KC  A 401 ( 3.9A)
 0.99A 5lw1H-4nfnA:
19.1		 5lw1H-4nfnA:
11.73