SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4nfu'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FO4_A_SALA3005_1
(XANTHINE
DEHYDROGENASE)		 4nfu SENESCENCE-ASSOCIATE
D CARBOXYLESTERASE
101
(Arabidopsis
thaliana) 		5 / 9 LEU B  22
SER B  25
PHE B 175
THR B 143
LEU B 171
 None
 1.07A 1fo4A-4nfuB:
undetectable		 1fo4A-4nfuB:
17.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KB9_A_PCFA514_0
(CYTOCHROME B
CYTOCHROME C1, HEME
PROTEIN
UBIQUINOL-CYTOCHROME
C REDUCTASE COMPLEX
CORE PROTEIN I
UBIQUINOL-CYTOCHROME
C REDUCTASE
IRON-SULFUR SUBUNIT)		 4nfu EDS1
(Arabidopsis
thaliana) 		4 / 8 ILE A 588
PHE A 595
VAL A 567
SER A 542
 None
 1.11A 1kb9A-4nfuA:
undetectable
1kb9C-4nfuA:
undetectable
1kb9D-4nfuA:
undetectable
1kb9E-4nfuA:
undetectable		 1kb9A-4nfuA:
22.36
1kb9C-4nfuA:
20.91
1kb9D-4nfuA:
15.52
1kb9E-4nfuA:
12.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_B_SAMB200_0
(METHIONINE REPRESSOR)		 4nfu EDS1
(Arabidopsis
thaliana) 		4 / 4 HIS A 168
ALA A 169
PHE A 166
GLY A 171
 None
None
None
BGC  A 701 ( 3.8A)
 1.43A 1mjoA-4nfuA:
undetectable		 1mjoA-4nfuA:
10.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_A_SAMA200_0
(METHIONINE REPRESSOR)		 4nfu EDS1
(Arabidopsis
thaliana) 		5 / 11 LEU A  66
PRO A  72
HIS A 168
ALA A 169
GLY A 171
 None
None
None
None
BGC  A 701 ( 3.8A)
 1.35A 1mjqA-4nfuA:
0.7
1mjqB-4nfuA:
undetectable		 1mjqA-4nfuA:
10.03
1mjqB-4nfuA:
10.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_C_THAC3_1
(LIVER
CARBOXYLESTERASE I)		 4nfu EDS1
SENESCENCE-ASSOCIATE
D CARBOXYLESTERASE
101
(Arabidopsis
thaliana) 		5 / 12 LEU A 262
VAL B 201
LEU B 220
LEU B 171
LEU B 199
 None
 1.12A 1mx1C-4nfuA:
4.0		 1mx1C-4nfuA:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QHY_A_CLMA888_0
(CHLORAMPHENICOL
PHOSPHOTRANSFERASE)		 4nfu EDS1
(Arabidopsis
thaliana) 		4 / 6 PRO A  72
MET A  74
ALA A 169
GLU A 173
 None
 1.40A 1qhyA-4nfuA:
undetectable		 1qhyA-4nfuA:
14.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SQN_B_NDRB2001_0
(PROGESTERONE
RECEPTOR)		 4nfu EDS1
SENESCENCE-ASSOCIATE
D CARBOXYLESTERASE
101
(Arabidopsis
thaliana;
Arabidopsis
thaliana) 		5 / 12 LEU B 171
LEU A 258
LEU A 255
LEU B  22
LEU B 220
 None
 1.12A 1sqnB-4nfuB:
undetectable		 1sqnB-4nfuB:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRL_F_TFPF211_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 4nfu SENESCENCE-ASSOCIATE
D CARBOXYLESTERASE
101
(Arabidopsis
thaliana) 		4 / 7 LEU B  98
PHE B 106
LEU B 189
SER B 150
 None
 1.06A 1wrlE-4nfuB:
undetectable
1wrlF-4nfuB:
undetectable		 1wrlE-4nfuB:
9.26
1wrlF-4nfuB:
9.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZGY_A_BRLA503_1
(PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
GAMMA)		 4nfu SENESCENCE-ASSOCIATE
D CARBOXYLESTERASE
101
(Arabidopsis
thaliana) 		5 / 12 GLY B 176
SER B 150
HIS B 109
LEU B 240
LEU B 147
 None
 1.33A 1zgyA-4nfuB:
undetectable		 1zgyA-4nfuB:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_D_SAMD301_1
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 4nfu SENESCENCE-ASSOCIATE
D CARBOXYLESTERASE
101
(Arabidopsis
thaliana) 		3 / 3 LYS B 345
ASP B 450
ASP B 389
 None
 0.95A 2br4D-4nfuB:
undetectable		 2br4D-4nfuB:
17.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C2B_A_SAMA500_0
(THREONINE SYNTHASE
1, CHLOROPLASTIC)		 4nfu SENESCENCE-ASSOCIATE
D CARBOXYLESTERASE
101
(Arabidopsis
thaliana) 		5 / 10 SER B  71
GLY B 148
SER B 150
SER B 177
TRP B  26
 None
 1.36A 2c2bA-4nfuB:
0.1
2c2bB-4nfuB:
0.0		 2c2bA-4nfuB:
21.03
2c2bB-4nfuB:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C2B_B_SAMB500_0
(THREONINE SYNTHASE
1, CHLOROPLASTIC)		 4nfu SENESCENCE-ASSOCIATE
D CARBOXYLESTERASE
101
(Arabidopsis
thaliana) 		5 / 10 TRP B  26
SER B  71
GLY B 148
SER B 150
SER B 177
 None
 1.35A 2c2bA-4nfuB:
0.1
2c2bB-4nfuB:
undetectable		 2c2bA-4nfuB:
21.03
2c2bB-4nfuB:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C2B_E_SAME500_0
(THREONINE SYNTHASE
1, CHLOROPLASTIC)		 4nfu SENESCENCE-ASSOCIATE
D CARBOXYLESTERASE
101
(Arabidopsis
thaliana) 		5 / 11 SER B  71
GLY B 148
SER B 150
SER B 177
TRP B  26
 None
 1.34A 2c2bE-4nfuB:
undetectable
2c2bF-4nfuB:
undetectable		 2c2bE-4nfuB:
21.03
2c2bF-4nfuB:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C2B_F_SAMF500_0
(THREONINE SYNTHASE
1, CHLOROPLASTIC)		 4nfu SENESCENCE-ASSOCIATE
D CARBOXYLESTERASE
101
(Arabidopsis
thaliana) 		5 / 10 TRP B  26
SER B  71
GLY B 148
SER B 150
SER B 177
 None
 1.33A 2c2bE-4nfuB:
0.0
2c2bF-4nfuB:
0.2		 2c2bE-4nfuB:
21.03
2c2bF-4nfuB:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CBR_A_A80A201_1
(PROTEIN (CRABP-I))		 4nfu EDS1
(Arabidopsis
thaliana) 		5 / 12 LEU A  93
THR A 193
VAL A  85
GLY A 126
LEU A 204
 None
 1.17A 2cbrA-4nfuA:
undetectable		 2cbrA-4nfuA:
12.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DU8_G_BEZG2352_0
(D-AMINO-ACID OXIDASE)		 4nfu SENESCENCE-ASSOCIATE
D CARBOXYLESTERASE
101
(Arabidopsis
thaliana) 		4 / 5 TYR B 393
TYR B 394
ILE B 453
GLY B 405
 None
None
None
IPA  B 602 (-4.0A)
 1.33A 2du8G-4nfuB:
undetectable		 2du8G-4nfuB:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIN_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4nfu SENESCENCE-ASSOCIATE
D CARBOXYLESTERASE
101
(Arabidopsis
thaliana) 		4 / 7 LEU B 189
GLN B 186
LEU B 157
PHE B  95
 None
 1.07A 2einC-4nfuB:
2.9
2einJ-4nfuB:
undetectable		 2einC-4nfuB:
18.15
2einJ-4nfuB:
7.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIN_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4nfu SENESCENCE-ASSOCIATE
D CARBOXYLESTERASE
101
(Arabidopsis
thaliana) 		4 / 6 LEU B 189
GLN B 186
LEU B 157
PHE B  95
 None
 1.07A 2einP-4nfuB:
2.9
2einW-4nfuB:
undetectable		 2einP-4nfuB:
18.15
2einW-4nfuB:
7.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OTF_A_2TNA201_1
(PHOSPHOLIPASE A2
VRV-PL-VIIIA)		 4nfu SENESCENCE-ASSOCIATE
D CARBOXYLESTERASE
101
(Arabidopsis
thaliana) 		4 / 5 LEU B 157
ILE B 188
GLY B 181
HIS B 200
 None
 1.00A 2otfA-4nfuB:
undetectable		 2otfA-4nfuB:
12.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6O_B_SAMB500_0
(HYPOTHETICAL PROTEIN)		 4nfu SENESCENCE-ASSOCIATE
D CARBOXYLESTERASE
101
(Arabidopsis
thaliana) 		4 / 6 VAL B  68
PHE B  65
PRO B 139
THR B 133
 None
 1.26A 2q6oB-4nfuB:
undetectable		 2q6oB-4nfuB:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q7L_A_TESA155_1
(ANDROGEN RECEPTOR)		 4nfu EDS1
(Arabidopsis
thaliana) 		5 / 12 LEU A 345
ASN A 346
LEU A 348
GLY A 349
THR A 352
 None
 1.12A 2q7lA-4nfuA:
undetectable		 2q7lA-4nfuA:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W98_A_P1ZA1351_1
(PROSTAGLANDIN
REDUCTASE 2)		 4nfu EDS1
(Arabidopsis
thaliana) 		5 / 10 PHE A 275
MET A 293
TYR A 229
VAL A 350
LEU A 348
 None
 1.39A 2w98A-4nfuA:
undetectable		 2w98A-4nfuA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_E_ACHE1211_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 4nfu SENESCENCE-ASSOCIATE
D CARBOXYLESTERASE
101
(Arabidopsis
thaliana) 		4 / 7 GLN B 132
ILE B  59
SER B 128
TYR B 125
 None
 1.39A 2xz5D-4nfuB:
undetectable
2xz5E-4nfuB:
undetectable		 2xz5D-4nfuB:
16.36
2xz5E-4nfuB:
16.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AX9_B_SALB1340_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 4nfu SENESCENCE-ASSOCIATE
D CARBOXYLESTERASE
101
(Arabidopsis
thaliana) 		4 / 8 LEU B  22
SER B  25
PHE B 175
THR B 143
 None
 0.68A 3ax9B-4nfuB:
undetectable		 3ax9B-4nfuB:
17.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NS1_L_PM6L1_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 4nfu SENESCENCE-ASSOCIATE
D CARBOXYLESTERASE
101
(Arabidopsis
thaliana) 		4 / 8 SER B  25
PHE B 175
THR B 143
LEU B 171
 None
 1.01A 3ns1L-4nfuB:
undetectable		 3ns1L-4nfuB:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUF_B_SUEB1201_2
(NS3 PROTEASE, NS4A
PROTEIN)		 4nfu EDS1
(Arabidopsis
thaliana) 		3 / 3 TYR A 496
LEU A 468
ARG A 462
 None
 0.68A 3sufB-4nfuA:
undetectable		 3sufB-4nfuA:
15.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UNA_A_SALA1340_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 4nfu SENESCENCE-ASSOCIATE
D CARBOXYLESTERASE
101
(Arabidopsis
thaliana) 		5 / 9 LEU B  22
SER B  25
PHE B 175
THR B 143
LEU B 171
 None
 1.05A 3unaA-4nfuB:
undetectable		 3unaA-4nfuB:
17.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UNA_B_SALB1340_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 4nfu SENESCENCE-ASSOCIATE
D CARBOXYLESTERASE
101
(Arabidopsis
thaliana) 		5 / 9 LEU B  22
SER B  25
PHE B 175
THR B 143
LEU B 171
 None
 1.03A 3unaB-4nfuB:
undetectable		 3unaB-4nfuB:
17.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UNC_A_SALA1338_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 4nfu SENESCENCE-ASSOCIATE
D CARBOXYLESTERASE
101
(Arabidopsis
thaliana) 		5 / 9 LEU B  22
SER B  25
PHE B 175
THR B 143
LEU B 171
 None
 1.07A 3uncA-4nfuB:
undetectable		 3uncA-4nfuB:
17.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UNC_B_SALB1338_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 4nfu SENESCENCE-ASSOCIATE
D CARBOXYLESTERASE
101
(Arabidopsis
thaliana) 		5 / 9 LEU B  22
SER B  25
PHE B 175
THR B 143
LEU B 171
 None
 1.08A 3uncB-4nfuB:
undetectable		 3uncB-4nfuB:
17.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K39_A_SAMA504_0
(ANAEROBIC
SULFATASE-MATURATING
ENZYME)		 4nfu EDS1
SENESCENCE-ASSOCIATE
D CARBOXYLESTERASE
101
(Arabidopsis
thaliana;
Arabidopsis
thaliana) 		5 / 12 PHE A 295
TYR A 296
GLN A 356
LEU B   7
VAL A 244
 None
 1.45A 4k39A-4nfuA:
undetectable		 4k39A-4nfuA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4S0V_A_SUVA2001_2
(HUMAN OREXIN
RECEPTOR TYPE 2
FUSION PROTEIN TO P.
ABYSII GLYCOGEN
SYNTHASE)		 4nfu EDS1
(Arabidopsis
thaliana) 		4 / 5 ILE A 309
PRO A 310
HIS A 206
VAL A 189
 None
 1.36A 4s0vA-4nfuA:
undetectable		 4s0vA-4nfuA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WCX_C_SAMC503_1
(BIOTIN AND THIAMIN
SYNTHESIS ASSOCIATED)		 4nfu EDS1
(Arabidopsis
thaliana) 		4 / 6 ASN A 404
LEU A 590
GLU A 587
TYR A 395
 None
 1.27A 4wcxC-4nfuA:
3.1		 4wcxC-4nfuA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X5I_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 4nfu EDS1
SENESCENCE-ASSOCIATE
D CARBOXYLESTERASE
101
(Arabidopsis
thaliana;
Arabidopsis
thaliana) 		3 / 3 ASP B 299
ARG A 425
ARG A 493
 None
 0.85A 4x5iA-4nfuB:
undetectable		 4x5iA-4nfuB:
16.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YMG_A_SAMA1001_0
(PUTATIVE
SAM-DEPENDENT
O-METHYLTRANFERASE)		 4nfu EDS1
SENESCENCE-ASSOCIATE
D CARBOXYLESTERASE
101
(Arabidopsis
thaliana;
Arabidopsis
thaliana) 		5 / 12 LYS B 301
MET B 300
GLY A 430
ALA A 429
TYR A 461
 None
 1.08A 4ymgA-4nfuB:
undetectable		 4ymgA-4nfuB:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZB_D_ACTD403_0
(PROTON-GATED ION
CHANNEL)		 4nfu SENESCENCE-ASSOCIATE
D CARBOXYLESTERASE
101
(Arabidopsis
thaliana) 		4 / 4 ILE B 486
ARG B 402
TYR B 482
GLU B 447
 None
 1.28A 4zzbD-4nfuB:
2.2		 4zzbD-4nfuB:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EAJ_B_FOLB201_1
(DIHYDROFOLATE
REDUCTASE)		 4nfu EDS1
SENESCENCE-ASSOCIATE
D CARBOXYLESTERASE
101
(Arabidopsis
thaliana;
Arabidopsis
thaliana) 		3 / 3 ASP B 299
ARG A 425
ARG A 493
 None
 0.86A 5eajB-4nfuB:
undetectable		 5eajB-4nfuB:
16.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ERG_B_SAMB401_1
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
CATALYTIC SUBUNIT
TRM61)		 4nfu EDS1
(Arabidopsis
thaliana) 		4 / 7 GLY A  78
GLU A 449
ASP A 446
ASP A  81
 None
None
BGC  A 701 (-3.6A)
None
 0.83A 5ergB-4nfuA:
undetectable		 5ergB-4nfuA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_C_SAMC301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 4nfu EDS1
(Arabidopsis
thaliana) 		5 / 12 ALA A  88
PRO A 159
THR A 155
PHE A  89
THR A 133
 None
 1.22A 5hfjC-4nfuA:
undetectable		 5hfjC-4nfuA:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_G_SAMG301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 4nfu EDS1
(Arabidopsis
thaliana) 		5 / 12 ALA A  88
PRO A 159
THR A 155
PHE A  89
THR A 133
 None
 1.20A 5hfjG-4nfuA:
undetectable		 5hfjG-4nfuA:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_H_SAMH301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 4nfu EDS1
(Arabidopsis
thaliana) 		5 / 12 ALA A  88
PRO A 159
THR A 155
PHE A  89
THR A 133
 None
 1.09A 5hfjH-4nfuA:
undetectable		 5hfjH-4nfuA:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGY_A_ERYA403_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 4nfu EDS1
(Arabidopsis
thaliana) 		5 / 12 ILE A 142
GLY A 510
ASN A 509
GLU A 447
ILE A  77
 None
None
None
BGC  A 701 ( 4.5A)
None
 1.15A 5igyA-4nfuA:
undetectable		 5igyA-4nfuA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKQ_A_JMSA602_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4nfu SENESCENCE-ASSOCIATE
D CARBOXYLESTERASE
101
(Arabidopsis
thaliana) 		3 / 3 VAL B 355
SER B 377
MET B 384
 None
 0.57A 5ikqA-4nfuB:
undetectable		 5ikqA-4nfuB:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IWU_A_ACTA402_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 4nfu SENESCENCE-ASSOCIATE
D CARBOXYLESTERASE
101
(Arabidopsis
thaliana) 		4 / 6 PHE B 219
VAL B 202
MET B 210
ILE B 208
 None
 1.25A 5iwuA-4nfuB:
undetectable		 5iwuA-4nfuB:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KOX_A_RFPA502_2
(PENTACHLOROPHENOL
4-MONOOXYGENASE)		 4nfu SENESCENCE-ASSOCIATE
D CARBOXYLESTERASE
101
(Arabidopsis
thaliana) 		3 / 3 VAL B  16
ARG B 194
PRO B 170
 None
 0.80A 5koxA-4nfuB:
undetectable		 5koxA-4nfuB:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SXQ_A_NIZA808_1
(CATALASE-PEROXIDASE)		 4nfu EDS1
(Arabidopsis
thaliana) 		4 / 8 VAL A 180
GLY A  11
LEU A  13
THR A  15
 None
 0.97A 5sxqA-4nfuA:
0.7		 5sxqA-4nfuA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUD_A_ERMA2001_2
(5-HYDROXYTRYPTAMINE
RECEPTOR 2B,SOLUBLE
CYTOCHROME B562
CHIMERA)		 4nfu EDS1
(Arabidopsis
thaliana) 		4 / 7 THR A 248
LEU A 291
ASN A 286
VAL A 284
 None
 1.09A 5tudA-4nfuA:
undetectable		 5tudA-4nfuA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCG_A_08YA602_1
(CYTOCHROME P450 3A4)		 4nfu EDS1
(Arabidopsis
thaliana) 		5 / 12 ASP A 187
PHE A 182
SER A  17
ILE A  14
THR A 133
 None
 1.25A 5vcgA-4nfuA:
undetectable		 5vcgA-4nfuA:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X66_F_MTXF402_1
(THYMIDYLATE SYNTHASE)		 4nfu SENESCENCE-ASSOCIATE
D CARBOXYLESTERASE
101
(Arabidopsis
thaliana) 		5 / 12 ILE B 221
LEU B 258
GLY B 226
PHE B 223
VAL B  16
 None
 1.16A 5x66F-4nfuB:
undetectable		 5x66F-4nfuB:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X6Y_A_SAMA902_0
(MRNA CAPPING ENZYME
P5)		 4nfu SENESCENCE-ASSOCIATE
D CARBOXYLESTERASE
101
(Arabidopsis
thaliana) 		5 / 12 GLY B 149
ALA B  72
PHE B 198
THR B 174
VAL B 202
 None
 1.30A 5x6yA-4nfuB:
undetectable		 5x6yA-4nfuB:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIP_C_HFGC1003_0
(PROLYL-TRNA
SYNTHETASE, PUTATIVE)		 4nfu EDS1
(Arabidopsis
thaliana) 		5 / 12 LEU A 555
VAL A 563
THR A 569
PHE A 517
GLY A 523
 None
 1.12A 5xipC-4nfuA:
undetectable		 5xipC-4nfuA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZSF_A_6T0A910_0
(TOLL-LIKE RECEPTOR 7)		 4nfu EDS1
(Arabidopsis
thaliana) 		4 / 7 THR A 236
LEU A 194
ILE A 192
THR A 193
 None
 0.95A 5zsfA-4nfuA:
undetectable
5zsfB-4nfuA:
undetectable		 5zsfA-4nfuA:
8.56
5zsfB-4nfuA:
8.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AYB_A_KKKA508_1
(CYP51, STEROL
14ALPHA-DEMETHYLASE)		 4nfu EDS1
(Arabidopsis
thaliana) 		5 / 12 PHE A 275
ALA A 270
THR A 193
ILE A 188
LEU A 294
 None
 1.20A 6aybA-4nfuA:
2.6		 6aybA-4nfuA:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DRX_A_H8GA1201_0
(5HT2B RECEPTOR, BRIL
CHIMERA)		 4nfu EDS1
(Arabidopsis
thaliana) 		5 / 12 LEU A 211
PHE A  52
ALA A 127
VAL A 183
TYR A 320
 None
 1.44A 6drxA-4nfuA:
2.9		 6drxA-4nfuA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MB5_A_NMYA301_0
(AAC(3)-IIIB PROTEIN)		 4nfu EDS1
(Arabidopsis
thaliana) 		5 / 11 TYR A 494
ASP A 469
TYR A 461
THR A 492
GLY A 430
 None
 1.04A 6mb5A-4nfuA:
undetectable		 6mb5A-4nfuA:
9.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MB7_A_PARA900_0
(AAC(3)-IIIB PROTEIN)		 4nfu EDS1
(Arabidopsis
thaliana) 		5 / 10 TYR A 494
ASP A 469
TYR A 461
THR A 492
GLY A 430
 None
 1.01A 6mb7A-4nfuA:
undetectable		 6mb7A-4nfuA:
9.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MB9_A_NMYA303_0
(AAC(3)-IIIB PROTEIN)		 4nfu EDS1
(Arabidopsis
thaliana) 		5 / 10 TYR A 494
ASP A 469
TYR A 461
THR A 492
GLY A 430
 None
 1.03A 6mb9A-4nfuA:
undetectable		 6mb9A-4nfuA:
9.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MB9_B_NMYB302_0
(AAC(3)-IIIB PROTEIN)		 4nfu EDS1
(Arabidopsis
thaliana) 		5 / 10 TYR A 494
ASP A 469
TYR A 461
THR A 492
GLY A 430
 None
 1.03A 6mb9B-4nfuA:
undetectable		 6mb9B-4nfuA:
9.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MB9_C_NMYC302_0
(AAC(3)-IIIB PROTEIN)		 4nfu EDS1
(Arabidopsis
thaliana) 		5 / 10 TYR A 494
ASP A 469
TYR A 461
THR A 492
GLY A 430
 None
 1.02A 6mb9C-4nfuA:
undetectable		 6mb9C-4nfuA:
9.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MB9_D_NMYD302_0
(AAC(3)-IIIB PROTEIN)		 4nfu EDS1
(Arabidopsis
thaliana) 		5 / 10 TYR A 494
ASP A 469
TYR A 461
THR A 492
GLY A 430
 None
 1.04A 6mb9D-4nfuA:
undetectable		 6mb9D-4nfuA:
9.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NJ9_K_SAMK500_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-79
SPECIFIC)		 4nfu EDS1
(Arabidopsis
thaliana) 		5 / 12 GLY A 126
VAL A 189
ALA A 270
ASP A 163
PHE A  52
 None
 0.96A 6nj9K-4nfuA:
undetectable		 6nj9K-4nfuA:
20.55