SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4nfy'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MUI_B_AB1B100_2
(PROTEASE)		 4nfy D-3-PHOSPHOGLYCERATE
DEHYDROGENASE,
PUTATIVE
(Entamoeba
histolytica) 		5 / 12 GLY A  67
ASP A  50
ILE A   3
ILE A   6
VAL A  95
 None
 0.82A 1muiB-4nfyA:
undetectable		 1muiB-4nfyA:
16.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RXC_C_URFC2081_1
(URIDINE
PHOSPHORYLASE)		 4nfy D-3-PHOSPHOGLYCERATE
DEHYDROGENASE,
PUTATIVE
(Entamoeba
histolytica) 		4 / 7 GLY A 210
MET A 230
ILE A 184
VAL A 183
 None
 0.99A 1rxcC-4nfyA:
undetectable		 1rxcC-4nfyA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RXC_D_URFD2021_1
(URIDINE
PHOSPHORYLASE)		 4nfy D-3-PHOSPHOGLYCERATE
DEHYDROGENASE,
PUTATIVE
(Entamoeba
histolytica) 		4 / 7 GLY A 210
MET A 230
ILE A 184
VAL A 183
 None
 1.00A 1rxcD-4nfyA:
2.1		 1rxcD-4nfyA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RXC_F_URFF2001_1
(URIDINE
PHOSPHORYLASE)		 4nfy D-3-PHOSPHOGLYCERATE
DEHYDROGENASE,
PUTATIVE
(Entamoeba
histolytica) 		4 / 7 GLY A 210
MET A 230
ILE A 184
VAL A 183
 None
 1.02A 1rxcF-4nfyA:
undetectable		 1rxcF-4nfyA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RXC_L_URFL2071_1
(URIDINE
PHOSPHORYLASE)		 4nfy D-3-PHOSPHOGLYCERATE
DEHYDROGENASE,
PUTATIVE
(Entamoeba
histolytica) 		4 / 7 GLY A 210
MET A 230
ILE A 184
VAL A 183
 None
 1.04A 1rxcL-4nfyA:
undetectable		 1rxcL-4nfyA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DTJ_B_THRB402_0
(ASPARTOKINASE)		 4nfy D-3-PHOSPHOGLYCERATE
DEHYDROGENASE,
PUTATIVE
(Entamoeba
histolytica) 		5 / 9 ILE A 158
GLY A 153
GLU A 152
ALA A 151
THR A 134
 None
 1.39A 2dtjA-4nfyA:
undetectable
2dtjB-4nfyA:
undetectable		 2dtjA-4nfyA:
23.10
2dtjB-4nfyA:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJ3_A_GBNA2414_1
(BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE)		 4nfy D-3-PHOSPHOGLYCERATE
DEHYDROGENASE,
PUTATIVE
(Entamoeba
histolytica) 		4 / 8 GLY A  77
GLY A 276
ALA A 278
ALA A 279
 None
 0.57A 2ej3A-4nfyA:
undetectable		 2ej3A-4nfyA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJ3_B_GBNB914_1
(BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE)		 4nfy D-3-PHOSPHOGLYCERATE
DEHYDROGENASE,
PUTATIVE
(Entamoeba
histolytica) 		5 / 10 ARG A 103
GLY A  77
GLY A 276
ALA A 278
ALA A 279
 None
 1.04A 2ej3B-4nfyA:
undetectable		 2ej3B-4nfyA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DEU_A_SALA303_1
(TRANSCRIPTIONAL
REGULATOR SLYA)		 4nfy D-3-PHOSPHOGLYCERATE
DEHYDROGENASE,
PUTATIVE
(Entamoeba
histolytica) 		4 / 4 ARG A 217
VAL A 242
LYS A 218
GLU A 219
 None
 1.32A 3deuA-4nfyA:
0.0		 3deuA-4nfyA:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DEU_B_SALB304_1
(TRANSCRIPTIONAL
REGULATOR SLYA)		 4nfy D-3-PHOSPHOGLYCERATE
DEHYDROGENASE,
PUTATIVE
(Entamoeba
histolytica) 		4 / 4 ARG A 217
VAL A 242
LYS A 218
GLU A 219
 None
 1.39A 3deuB-4nfyA:
0.0		 3deuB-4nfyA:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM0_B_CHDB153_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 4nfy D-3-PHOSPHOGLYCERATE
DEHYDROGENASE,
PUTATIVE
(Entamoeba
histolytica) 		4 / 7 ILE A 203
PHE A 257
TYR A 238
GLY A 210
 None
 0.90A 3em0B-4nfyA:
undetectable		 3em0B-4nfyA:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_N_TFPN201_1
(PROTEIN S100-A4)		 4nfy D-3-PHOSPHOGLYCERATE
DEHYDROGENASE,
PUTATIVE
(Entamoeba
histolytica) 		5 / 10 GLY A 209
GLY A 127
CYH A 213
ILE A 239
PHE A 253
 None
 1.47A 3ko0L-4nfyA:
undetectable
3ko0N-4nfyA:
undetectable		 3ko0L-4nfyA:
15.67
3ko0N-4nfyA:
15.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KPD_B_SAMB1000_1
(UNCHARACTERIZED
PROTEIN MJ0100)		 4nfy D-3-PHOSPHOGLYCERATE
DEHYDROGENASE,
PUTATIVE
(Entamoeba
histolytica) 		3 / 3 ASN A 102
ASN A 272
GLU A 267
 None
 0.93A 3kpdC-4nfyA:
undetectable		 3kpdC-4nfyA:
17.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVV_A_URFA254_1
(URIDINE
PHOSPHORYLASE)		 4nfy D-3-PHOSPHOGLYCERATE
DEHYDROGENASE,
PUTATIVE
(Entamoeba
histolytica) 		4 / 6 GLY A 210
MET A 230
ILE A 184
VAL A 183
 None
 1.09A 3kvvA-4nfyA:
undetectable		 3kvvA-4nfyA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVV_B_URFB254_1
(URIDINE
PHOSPHORYLASE)		 4nfy D-3-PHOSPHOGLYCERATE
DEHYDROGENASE,
PUTATIVE
(Entamoeba
histolytica) 		4 / 6 GLY A 210
MET A 230
ILE A 184
VAL A 183
 None
 1.05A 3kvvB-4nfyA:
undetectable		 3kvvB-4nfyA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVV_C_URFC254_1
(URIDINE
PHOSPHORYLASE)		 4nfy D-3-PHOSPHOGLYCERATE
DEHYDROGENASE,
PUTATIVE
(Entamoeba
histolytica) 		4 / 6 GLY A 210
MET A 230
ILE A 184
VAL A 183
 None
 1.09A 3kvvC-4nfyA:
undetectable		 3kvvC-4nfyA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVV_F_URFF254_1
(URIDINE
PHOSPHORYLASE)		 4nfy D-3-PHOSPHOGLYCERATE
DEHYDROGENASE,
PUTATIVE
(Entamoeba
histolytica) 		4 / 6 GLY A 210
MET A 230
ILE A 184
VAL A 183
 None
 1.09A 3kvvF-4nfyA:
undetectable		 3kvvF-4nfyA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S53_A_017A201_2
(PROTEASE)		 4nfy D-3-PHOSPHOGLYCERATE
DEHYDROGENASE,
PUTATIVE
(Entamoeba
histolytica) 		5 / 11 ASP A  57
ILE A  59
ILE A  72
ILE A  85
ILE A  83
 None
 0.95A 3s53B-4nfyA:
undetectable		 3s53B-4nfyA:
17.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7U_A_ALEA1001_1
(SUPEROXIDE DISMUTASE
[CU-ZN])		 4nfy D-3-PHOSPHOGLYCERATE
DEHYDROGENASE,
PUTATIVE
(Entamoeba
histolytica) 		4 / 6 GLU A  68
LYS A  47
LYS A  65
GLU A  62
 None
 1.45A 4a7uA-4nfyA:
undetectable		 4a7uA-4nfyA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1V_F_URFF1301_1
(URIDINE
PHOSPHORYLASE)		 4nfy D-3-PHOSPHOGLYCERATE
DEHYDROGENASE,
PUTATIVE
(Entamoeba
histolytica) 		4 / 6 GLY A 210
MET A 230
ILE A 184
VAL A 183
 None
 1.04A 4e1vF-4nfyA:
undetectable		 4e1vF-4nfyA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1V_G_URFG1301_1
(URIDINE
PHOSPHORYLASE)		 4nfy D-3-PHOSPHOGLYCERATE
DEHYDROGENASE,
PUTATIVE
(Entamoeba
histolytica) 		4 / 8 GLY A 210
MET A 230
ILE A 184
VAL A 183
 None
 0.98A 4e1vG-4nfyA:
undetectable		 4e1vG-4nfyA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KRH_B_SAMB900_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
2)		 4nfy D-3-PHOSPHOGLYCERATE
DEHYDROGENASE,
PUTATIVE
(Entamoeba
histolytica) 		5 / 12 GLY A 139
GLY A 144
LEU A 186
SER A 185
ILE A 174
 None
 1.16A 4krhB-4nfyA:
6.5		 4krhB-4nfyA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_2_BEZ2801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
BEZ-LEU-LEU)		 4nfy D-3-PHOSPHOGLYCERATE
DEHYDROGENASE,
PUTATIVE
(Entamoeba
histolytica) 		4 / 4 LEU A 202
ARG A 233
ILE A 203
ILE A 229
 None
 1.42A 5dzk2-4nfyA:
undetectable
5dzkM-4nfyA:
undetectable
5dzkN-4nfyA:
undetectable		 5dzk2-4nfyA:
1.08
5dzkM-4nfyA:
20.85
5dzkN-4nfyA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_V_BEZV801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
BEZ-LEU-LEU)		 4nfy D-3-PHOSPHOGLYCERATE
DEHYDROGENASE,
PUTATIVE
(Entamoeba
histolytica) 		4 / 4 ILE A 203
ILE A 229
ARG A 233
LEU A 202
 None
 1.17A 5dzkh-4nfyA:
undetectable
5dzkn-4nfyA:
undetectable
5dzkv-4nfyA:
undetectable		 5dzkh-4nfyA:
20.85
5dzkn-4nfyA:
20.85
5dzkv-4nfyA:
1.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EWJ_B_QELB503_1
(NMDA GLUTAMATE
RECEPTOR SUBUNIT
GLUTAMATE RECEPTOR
IONOTROPIC, NMDA 2B)		 4nfy D-3-PHOSPHOGLYCERATE
DEHYDROGENASE,
PUTATIVE
(Entamoeba
histolytica) 		5 / 11 ALA A 279
GLN A 282
ILE A 283
PHE A 286
PRO A  99
 None
 1.03A 5ewjA-4nfyA:
6.0
5ewjB-4nfyA:
6.5		 5ewjA-4nfyA:
22.41
5ewjB-4nfyA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GP2_B_DAHB126_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
BETA CHAIN)		 4nfy D-3-PHOSPHOGLYCERATE
DEHYDROGENASE,
PUTATIVE
(Entamoeba
histolytica) 		5 / 11 GLY A 276
ILE A  19
PHE A  11
ILE A   3
ILE A 283
 None
 1.06A 6gp2B-4nfyA:
undetectable		 6gp2B-4nfyA:
17.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD6_A_STIA603_1
(TYROSINE-PROTEIN
KINASE ABL1)		 4nfy D-3-PHOSPHOGLYCERATE
DEHYDROGENASE,
PUTATIVE
(Entamoeba
histolytica) 		4 / 5 LEU A 130
ILE A 220
MET A 113
GLY A 117
 None
 1.08A 6hd6A-4nfyA:
undetectable		 6hd6A-4nfyA:
14.29