SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4ng3'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FBM_B_RTLB951_0
(PROTEIN (CARTILAGE
OLIGOMERIC MATRIX
PROTEIN))
4ng3 5-CARBOXYVANILLATE
DECARBOXYLASE

(Sphingomonas
paucimobilis)
4 / 4 THR A  87
LEU A  91
LEU A  98
GLN A 101
None
0.59A 1fbmA-4ng3A:
undetectable
1fbmA-4ng3A:
11.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1K5Q_B_PACB559_0
(PENICILLIN G ACYLASE
ALPHA SUBUNIT
PENICILLIN G ACYLASE
BETA SUBUNIT)
4ng3 5-CARBOXYVANILLATE
DECARBOXYLASE

(Sphingomonas
paucimobilis)
4 / 7 SER A 144
PRO A 174
ALA A 176
SER A 202
None
1.04A 1k5qA-4ng3A:
undetectable
1k5qB-4ng3A:
undetectable
1k5qA-4ng3A:
22.55
1k5qB-4ng3A:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T7I_A_017A200_2
(POL POLYPROTEIN)
4ng3 5-CARBOXYVANILLATE
DECARBOXYLASE

(Sphingomonas
paucimobilis)
4 / 7 ASP A 296
VAL A 273
GLY A 198
THR A 269
MN  A 401 ( 2.5A)
None
None
None
0.58A 1t7iB-4ng3A:
undetectable
1t7iB-4ng3A:
14.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T7J_A_478A200_2
(POL POLYPROTEIN)
4ng3 5-CARBOXYVANILLATE
DECARBOXYLASE

(Sphingomonas
paucimobilis)
4 / 7 ASP A 296
VAL A 273
GLY A 198
THR A 269
MN  A 401 ( 2.5A)
None
None
None
0.54A 1t7jB-4ng3A:
undetectable
1t7jB-4ng3A:
14.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T9W_A_NFNA6001_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)
4ng3 5-CARBOXYVANILLATE
DECARBOXYLASE

(Sphingomonas
paucimobilis)
3 / 3 SER A  53
GLY A  50
ARG A  20
None
0.66A 1t9wA-4ng3A:
undetectable
1t9wA-4ng3A:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F16_2_BO221405_1
(PROTEASOME COMPONENT
PRE3)
4ng3 5-CARBOXYVANILLATE
DECARBOXYLASE

(Sphingomonas
paucimobilis)
5 / 11 THR A  87
THR A  89
ALA A  85
ARG A 175
GLY A  79
None
1.22A 2f162-4ng3A:
undetectable
2f162-4ng3A:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F16_N_BO2N1404_1
(PROTEASOME COMPONENT
PRE3)
4ng3 5-CARBOXYVANILLATE
DECARBOXYLASE

(Sphingomonas
paucimobilis)
5 / 11 THR A  87
THR A  89
ALA A  85
ARG A 175
GLY A  79
None
1.21A 2f16N-4ng3A:
undetectable
2f16N-4ng3A:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OKC_A_SAMA500_0
(TYPE I RESTRICTION
ENZYME STYSJI M
PROTEIN)
4ng3 5-CARBOXYVANILLATE
DECARBOXYLASE

(Sphingomonas
paucimobilis)
5 / 12 TYR A 171
ALA A 327
THR A 269
VAL A 223
ASN A 138
None
1.15A 2okcA-4ng3A:
undetectable
2okcA-4ng3A:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZZN_B_SAMB402_0
(UNCHARACTERIZED
PROTEIN MJ0883)
4ng3 5-CARBOXYVANILLATE
DECARBOXYLASE

(Sphingomonas
paucimobilis)
5 / 12 PHE A 266
LEU A 279
GLY A 228
ILE A 222
PHE A 331
None
1.31A 2zznB-4ng3A:
undetectable
2zznB-4ng3A:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BPX_B_SALB258_1
(TRANSCRIPTIONAL
REGULATOR)
4ng3 5-CARBOXYVANILLATE
DECARBOXYLASE

(Sphingomonas
paucimobilis)
5 / 11 ALA A 267
LEU A 286
ILE A 231
PRO A 232
GLY A 228
None
1.46A 3bpxA-4ng3A:
undetectable
3bpxB-4ng3A:
undetectable
3bpxA-4ng3A:
17.25
3bpxB-4ng3A:
17.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DL9_B_V2HB602_0
(CYTOCHROME P450 2R1)
4ng3 5-CARBOXYVANILLATE
DECARBOXYLASE

(Sphingomonas
paucimobilis)
5 / 12 MET A 292
THR A 269
ALA A 169
ALA A 327
GLU A   7
None
None
None
None
MN  A 401 ( 3.3A)
1.20A 3dl9B-4ng3A:
undetectable
3dl9B-4ng3A:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DL9_B_V2HB602_0
(CYTOCHROME P450 2R1)
4ng3 5-CARBOXYVANILLATE
DECARBOXYLASE

(Sphingomonas
paucimobilis)
5 / 12 MET A 292
THR A 269
ALA A 327
GLU A   7
THR A 115
None
None
None
MN  A 401 ( 3.3A)
None
1.18A 3dl9B-4ng3A:
undetectable
3dl9B-4ng3A:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDR_B_GJZB506_1
(CHOLESTEROL
24-HYDROXYLASE)
4ng3 5-CARBOXYVANILLATE
DECARBOXYLASE

(Sphingomonas
paucimobilis)
4 / 6 ILE A 330
ALA A 327
THR A   6
THR A 269
None
0.98A 3mdrB-4ng3A:
undetectable
3mdrB-4ng3A:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MG0_N_BO2N1404_1
(PROTEASOME COMPONENT
PRE3)
4ng3 5-CARBOXYVANILLATE
DECARBOXYLASE

(Sphingomonas
paucimobilis)
5 / 11 THR A  87
THR A  89
ALA A  85
ARG A 175
GLY A  79
None
1.19A 3mg0N-4ng3A:
undetectable
3mg0N-4ng3A:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S8P_A_SAMA500_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H1)
4ng3 5-CARBOXYVANILLATE
DECARBOXYLASE

(Sphingomonas
paucimobilis)
3 / 3 HIS A 173
SER A 202
GLU A 229
MN  A 401 ( 3.4A)
None
None
0.86A 3s8pA-4ng3A:
undetectable
3s8pA-4ng3A:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SG9_B_KANB305_1
(APH(2'')-ID)
4ng3 5-CARBOXYVANILLATE
DECARBOXYLASE

(Sphingomonas
paucimobilis)
4 / 8 ASN A 143
SER A 271
HIS A 226
GLU A   8
None
None
1DF  A 402 (-4.2A)
None
1.04A 3sg9B-4ng3A:
undetectable
3sg9B-4ng3A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UM5_A_CP6A609_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)
4ng3 5-CARBOXYVANILLATE
DECARBOXYLASE

(Sphingomonas
paucimobilis)
5 / 10 ILE A 128
VAL A 131
PHE A 116
ILE A 172
ILE A 163
None
1.39A 3um5A-4ng3A:
undetectable
3um5A-4ng3A:
17.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FIA_A_0U9A601_1
(CHOLESTEROL
24-HYDROXYLASE)
4ng3 5-CARBOXYVANILLATE
DECARBOXYLASE

(Sphingomonas
paucimobilis)
5 / 12 LEU A  34
VAL A  38
ARG A 175
THR A  11
ALA A  77
1DF  A 402 (-4.5A)
None
None
None
1DF  A 402 (-3.7A)
1.28A 4fiaA-4ng3A:
undetectable
4fiaA-4ng3A:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FIA_A_198A602_1
(CHOLESTEROL
24-HYDROXYLASE)
4ng3 5-CARBOXYVANILLATE
DECARBOXYLASE

(Sphingomonas
paucimobilis)
5 / 12 LEU A  34
VAL A  38
ARG A 175
THR A  11
ALA A  77
1DF  A 402 (-4.5A)
None
None
None
1DF  A 402 (-3.7A)
1.28A 4fiaA-4ng3A:
undetectable
4fiaA-4ng3A:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G10_A_ACTA301_0
(GLUTATHIONE
S-TRANSFERASE
HOMOLOG)
4ng3 5-CARBOXYVANILLATE
DECARBOXYLASE

(Sphingomonas
paucimobilis)
4 / 6 PRO A 118
ILE A 163
TYR A 151
PHE A 160
None
0.98A 4g10A-4ng3A:
undetectable
4g10A-4ng3A:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G5J_A_0WMA1103_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)
4ng3 5-CARBOXYVANILLATE
DECARBOXYLASE

(Sphingomonas
paucimobilis)
4 / 5 ASN A 244
MET A 241
HIS A 242
LEU A 238
EDO  A 403 ( 3.6A)
EDO  A 403 (-4.7A)
None
None
1.29A 4g5jA-4ng3A:
undetectable
4g5jA-4ng3A:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_I_ACTI507_0
(RNA POLYMERASE
3D-POL)
4ng3 5-CARBOXYVANILLATE
DECARBOXYLASE

(Sphingomonas
paucimobilis)
3 / 3 LYS A 257
PRO A 258
SER A 259
None
0.37A 4k50I-4ng3A:
undetectable
4k50I-4ng3A:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K7G_B_ACTB902_0
(3-HYDROXYPROLINE
DEHYDRATSE)
4ng3 5-CARBOXYVANILLATE
DECARBOXYLASE

(Sphingomonas
paucimobilis)
4 / 7 PRO A  78
ASP A  31
SER A  29
HIS A 145
None
1.28A 4k7gB-4ng3A:
undetectable
4k7gB-4ng3A:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LAJ_B_ACAB512_1
(HIV-1 YU2 GP120
ENVELOPE
GLYCOPROTEIN)
4ng3 5-CARBOXYVANILLATE
DECARBOXYLASE

(Sphingomonas
paucimobilis)
4 / 6 ARG A  20
GLY A  40
ASP A  17
ARG A  24
None
1.18A 4lajA-4ng3A:
undetectable
4lajB-4ng3A:
undetectable
4lajA-4ng3A:
21.25
4lajB-4ng3A:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OR0_A_NPSA601_1
(SERUM ALBUMIN)
4ng3 5-CARBOXYVANILLATE
DECARBOXYLASE

(Sphingomonas
paucimobilis)
5 / 11 ASN A 143
TYR A  39
VAL A  80
THR A 115
LEU A  75
None
1.48A 4or0A-4ng3A:
undetectable
4or0A-4ng3A:
19.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OR0_A_NPSA601_1
(SERUM ALBUMIN)
4ng3 5-CARBOXYVANILLATE
DECARBOXYLASE

(Sphingomonas
paucimobilis)
5 / 11 PHE A  83
TYR A  39
GLY A  88
THR A 115
LEU A  75
None
1.48A 4or0A-4ng3A:
undetectable
4or0A-4ng3A:
19.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVN_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)
4ng3 5-CARBOXYVANILLATE
DECARBOXYLASE

(Sphingomonas
paucimobilis)
5 / 12 THR A  87
THR A  89
ALA A  85
ARG A 175
GLY A  79
None
1.21A 4qvnV-4ng3A:
undetectable
4qvnb-4ng3A:
undetectable
4qvnV-4ng3A:
22.04
4qvnb-4ng3A:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVN_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)
4ng3 5-CARBOXYVANILLATE
DECARBOXYLASE

(Sphingomonas
paucimobilis)
5 / 12 THR A  87
THR A  89
ALA A  85
ARG A 175
GLY A  79
None
1.21A 4qvnH-4ng3A:
undetectable
4qvnN-4ng3A:
undetectable
4qvnH-4ng3A:
22.04
4qvnN-4ng3A:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TVT_A_ASCA303_0
(THAUMATIN-1)
4ng3 5-CARBOXYVANILLATE
DECARBOXYLASE

(Sphingomonas
paucimobilis)
4 / 7 LEU A 168
SER A 166
ILE A 128
VAL A 159
None
1.16A 4tvtA-4ng3A:
undetectable
4tvtA-4ng3A:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TYJ_A_0LIA801_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)
4ng3 5-CARBOXYVANILLATE
DECARBOXYLASE

(Sphingomonas
paucimobilis)
5 / 6 LEU A 137
VAL A 131
ILE A 172
ARG A 216
ILE A 222
None
1.01A 4tyjA-4ng3A:
undetectable
4tyjA-4ng3A:
25.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G5G_C_ACTC1740_0
(PUTATIVE XANTHINE
DEHYDROGENASE YAGS
FAD-BINDING SUBUNIT)
4ng3 5-CARBOXYVANILLATE
DECARBOXYLASE

(Sphingomonas
paucimobilis)
4 / 4 VAL A 131
GLU A 127
GLY A 114
LEU A 137
None
1.15A 5g5gC-4ng3A:
undetectable
5g5gC-4ng3A:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M0I_B_ACTB303_0
(SWI5-DEPENDENT HO
EXPRESSION PROTEIN 2)
4ng3 5-CARBOXYVANILLATE
DECARBOXYLASE

(Sphingomonas
paucimobilis)
4 / 5 VAL A  80
THR A 115
ASN A  96
LEU A  75
None
1.30A 5m0iB-4ng3A:
undetectable
5m0iB-4ng3A:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_F_SAMF501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)
4ng3 5-CARBOXYVANILLATE
DECARBOXYLASE

(Sphingomonas
paucimobilis)
5 / 10 LEU A  75
GLY A 114
GLU A 127
ARG A  93
ALA A  95
None
1.18A 5o96E-4ng3A:
undetectable
5o96F-4ng3A:
undetectable
5o96E-4ng3A:
21.43
5o96F-4ng3A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OS7_B_ACTB401_0
(CASEIN KINASE II
SUBUNIT ALPHA)
4ng3 5-CARBOXYVANILLATE
DECARBOXYLASE

(Sphingomonas
paucimobilis)
4 / 5 ARG A 310
LEU A   3
ASN A  66
VAL A 306
None
1.44A 5os7B-4ng3A:
undetectable
5os7B-4ng3A:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GMD_A_ACTA401_0
(CASEIN KINASE II
SUBUNIT ALPHA)
4ng3 5-CARBOXYVANILLATE
DECARBOXYLASE

(Sphingomonas
paucimobilis)
4 / 5 ARG A 310
LEU A   3
ASN A  66
VAL A 306
None
1.44A 6gmdA-4ng3A:
undetectable
6gmdA-4ng3A:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HWD_B_BO2B201_0
(PROTEASOME SUBUNIT
BETA TYPE-1
PROTEASOME SUBUNIT
BETA TYPE-2)
4ng3 5-CARBOXYVANILLATE
DECARBOXYLASE

(Sphingomonas
paucimobilis)
5 / 12 THR A  87
THR A  89
ALA A  85
ARG A 175
GLY A  79
None
1.22A 6hwdV-4ng3A:
undetectable
6hwdb-4ng3A:
undetectable
6hwdV-4ng3A:
16.01
6hwdb-4ng3A:
13.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HWD_N_BO2N201_0
(PROTEASOME SUBUNIT
BETA TYPE-1
PROTEASOME SUBUNIT
BETA TYPE-2)
4ng3 5-CARBOXYVANILLATE
DECARBOXYLASE

(Sphingomonas
paucimobilis)
5 / 12 THR A  87
THR A  89
ALA A  85
ARG A 175
GLY A  79
None
1.22A 6hwdH-4ng3A:
undetectable
6hwdN-4ng3A:
undetectable
6hwdH-4ng3A:
16.01
6hwdN-4ng3A:
13.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6R2E_B_FFOB403_0
(THYMIDYLATE SYNTHASE)
4ng3 5-CARBOXYVANILLATE
DECARBOXYLASE

(Sphingomonas
paucimobilis)
5 / 10 ILE A 209
ASN A 265
ASP A 215
LEU A 254
GLY A 212
None
1.45A 6r2eB-4ng3A:
undetectable
6r2eB-4ng3A:
23.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6R2E_C_FFOC404_0
(THYMIDYLATE SYNTHASE)
4ng3 5-CARBOXYVANILLATE
DECARBOXYLASE

(Sphingomonas
paucimobilis)
5 / 10 ILE A 209
ASN A 265
ASP A 215
LEU A 254
GLY A 212
None
1.43A 6r2eC-4ng3A:
undetectable
6r2eC-4ng3A:
23.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6R2E_D_FFOD403_0
(THYMIDYLATE SYNTHASE)
4ng3 5-CARBOXYVANILLATE
DECARBOXYLASE

(Sphingomonas
paucimobilis)
5 / 10 ILE A 209
ASN A 265
ASP A 215
LEU A 254
GLY A 212
None
1.42A 6r2eD-4ng3A:
undetectable
6r2eD-4ng3A:
23.94