SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4ng4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK3_A_T44A3003_1
(SERUM ALBUMIN)		 4ng4 PHOSPHOGLYCERATE
KINASE
(Coxiella
burnetii) 		3 / 4 LYS A  49
ALA A  50
MET A   9
 None
 1.05A 1hk3A-4ng4A:
undetectable		 1hk3A-4ng4A:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KT4_A_RTLA184_0
(PLASMA
RETINOL-BINDING
PROTEIN)		 4ng4 PHOSPHOGLYCERATE
KINASE
(Coxiella
burnetii) 		5 / 12 LEU A 214
LEU A 188
ALA A 176
ALA A 180
VAL A 211
 None
 1.26A 1kt4A-4ng4A:
undetectable		 1kt4A-4ng4A:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RL8_A_RITA9001_1
(PROTEASE RETROPEPSIN)		 4ng4 PHOSPHOGLYCERATE
KINASE
(Coxiella
burnetii) 		6 / 12 ASP A 293
GLY A 329
ASP A 264
VAL A 279
ALA A 277
ILE A 266
 MG  A 401 (-2.9A)
MG  A 401 ( 4.0A)
None
None
None
None
 1.09A 1rl8A-4ng4A:
undetectable		 1rl8A-4ng4A:
14.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F81_A_017A302_1
(POL POLYPROTEIN)		 4ng4 PHOSPHOGLYCERATE
KINASE
(Coxiella
burnetii) 		5 / 12 ASP A 293
GLY A 329
ASP A 264
VAL A 279
ILE A 266
 MG  A 401 (-2.9A)
MG  A 401 ( 4.0A)
None
None
None
 1.02A 2f81A-4ng4A:
undetectable		 2f81A-4ng4A:
14.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H42_C_VIAC903_2
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 4ng4 PHOSPHOGLYCERATE
KINASE
(Coxiella
burnetii) 		3 / 3 ASN A 315
ILE A 312
MET A 364
 ADP  A 402 (-3.1A)
None
None
 0.79A 2h42C-4ng4A:
undetectable		 2h42C-4ng4A:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PKK_A_2FAA501_1
(ADENOSINE KINASE)		 4ng4 PHOSPHOGLYCERATE
KINASE
(Coxiella
burnetii) 		5 / 12 SER A 299
GLY A 295
ALA A 332
GLN A 328
ASP A 293
 None
None
None
None
MG  A 401 (-2.9A)
 0.95A 2pkkA-4ng4A:
4.5		 2pkkA-4ng4A:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UVN_B_ECNB1406_1
(CYTOCHROME P450 130)		 4ng4 PHOSPHOGLYCERATE
KINASE
(Coxiella
burnetii) 		5 / 11 ASP A 283
GLY A 295
THR A 298
LEU A 225
VAL A 263
 None
 1.22A 2uvnB-4ng4A:
undetectable		 2uvnB-4ng4A:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D1Z_B_017B201_2
(HIV-1 PROTEASE)		 4ng4 PHOSPHOGLYCERATE
KINASE
(Coxiella
burnetii) 		5 / 12 ASP A 293
GLY A 329
ASP A 264
VAL A 279
ILE A 266
 MG  A 401 (-2.9A)
MG  A 401 ( 4.0A)
None
None
None
 1.07A 3d1zB-4ng4A:
undetectable		 3d1zB-4ng4A:
14.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D20_A_017A201_1
(HIV-1 PROTEASE)		 4ng4 PHOSPHOGLYCERATE
KINASE
(Coxiella
burnetii) 		5 / 12 ASP A 293
GLY A 329
ASP A 264
VAL A 279
ILE A 266
 MG  A 401 (-2.9A)
MG  A 401 ( 4.0A)
None
None
None
 1.05A 3d20A-4ng4A:
undetectable		 3d20A-4ng4A:
14.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DCJ_B_THHB401_0
(PROBABLE
5'-PHOSPHORIBOSYLGLY
CINAMIDE
FORMYLTRANSFERASE
PURN)		 4ng4 PHOSPHOGLYCERATE
KINASE
(Coxiella
burnetii) 		4 / 8 LEU A 207
LEU A 214
ASN A 315
VAL A 192
 None
None
ADP  A 402 (-3.1A)
None
 0.87A 3dcjB-4ng4A:
3.7		 3dcjB-4ng4A:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKT_B_017B200_2
(PROTEASE)		 4ng4 PHOSPHOGLYCERATE
KINASE
(Coxiella
burnetii) 		5 / 9 ASP A 293
ASP A 264
VAL A 279
ALA A 277
ILE A 266
 MG  A 401 (-2.9A)
None
None
None
None
 0.99A 3ektB-4ng4A:
undetectable		 3ektB-4ng4A:
14.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKT_D_017D200_2
(PROTEASE)		 4ng4 PHOSPHOGLYCERATE
KINASE
(Coxiella
burnetii) 		5 / 11 ASP A 293
GLY A 329
ASP A 264
VAL A 279
ILE A 266
 MG  A 401 (-2.9A)
MG  A 401 ( 4.0A)
None
None
None
 1.07A 3ektD-4ng4A:
undetectable		 3ektD-4ng4A:
14.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_P_TFPP201_1
(PROTEIN S100-A4)		 4ng4 PHOSPHOGLYCERATE
KINASE
(Coxiella
burnetii) 		4 / 7 GLY A 348
GLY A 193
PHE A 377
PHE A 144
 ADP  A 402 ( 3.7A)
None
None
None
 0.80A 3ko0M-4ng4A:
undetectable
3ko0P-4ng4A:
undetectable		 3ko0M-4ng4A:
13.93
3ko0P-4ng4A:
13.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MTE_B_SAMB220_0
(16S RRNA METHYLASE)		 4ng4 PHOSPHOGLYCERATE
KINASE
(Coxiella
burnetii) 		5 / 12 GLY A 194
GLY A 217
ASN A 222
VAL A 191
LEU A 236
 ADP  A 402 (-2.9A)
None
ADP  A 402 (-3.9A)
None
ADP  A 402 ( 4.2A)
 1.04A 3mteB-4ng4A:
3.2		 3mteB-4ng4A:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N23_A_OBNA1_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 4ng4 PHOSPHOGLYCERATE
KINASE
(Coxiella
burnetii) 		5 / 11 PRO A 168
ASP A 142
VAL A  57
ALA A 109
ILE A  59
 None
 1.24A 3n23A-4ng4A:
5.2		 3n23A-4ng4A:
17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O02_B_JN3B1_1
(CELL INVASION
PROTEIN SIPD)		 4ng4 PHOSPHOGLYCERATE
KINASE
(Coxiella
burnetii) 		5 / 10 ILE A 345
ALA A 190
LEU A 378
LEU A 207
VAL A 211
 None
 1.21A 3o02A-4ng4A:
undetectable
3o02B-4ng4A:
undetectable		 3o02A-4ng4A:
22.51
3o02B-4ng4A:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P5N_A_RBFA190_1
(RIBOFLAVIN UPTAKE
PROTEIN)		 4ng4 PHOSPHOGLYCERATE
KINASE
(Coxiella
burnetii) 		5 / 12 THR A 298
ASP A 293
GLY A 329
ALA A 332
ALA A 336
 None
MG  A 401 (-2.9A)
MG  A 401 ( 4.0A)
None
None
 0.88A 3p5nA-4ng4A:
undetectable		 3p5nA-4ng4A:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P5N_B_RBFB190_1
(RIBOFLAVIN UPTAKE
PROTEIN)		 4ng4 PHOSPHOGLYCERATE
KINASE
(Coxiella
burnetii) 		5 / 12 THR A 298
ASP A 293
GLY A 329
ALA A 332
ALA A 336
 None
MG  A 401 (-2.9A)
MG  A 401 ( 4.0A)
None
None
 0.88A 3p5nB-4ng4A:
undetectable		 3p5nB-4ng4A:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PWM_B_017B402_1
(PROTEASE)		 4ng4 PHOSPHOGLYCERATE
KINASE
(Coxiella
burnetii) 		5 / 12 ASP A 293
GLY A 329
ASP A 264
VAL A 279
ILE A 266
 MG  A 401 (-2.9A)
MG  A 401 ( 4.0A)
None
None
None
 1.01A 3pwmA-4ng4A:
undetectable		 3pwmA-4ng4A:
15.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKD_B_CYZB267_1
(GLUTAMATE RECEPTOR 2)		 4ng4 PHOSPHOGLYCERATE
KINASE
(Coxiella
burnetii) 		4 / 5 ILE A 318
PRO A 317
SER A 327
GLY A 319
 None
ADP  A 402 (-4.4A)
None
MG  A 401 (-3.2A)
 1.19A 3tkdA-4ng4A:
undetectable		 3tkdA-4ng4A:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DU2_A_LDPA501_1
(CYTOCHROME P450 BM3
VARIANT B7)		 4ng4 PHOSPHOGLYCERATE
KINASE
(Coxiella
burnetii) 		4 / 7 ALA A 166
ALA A 385
LEU A 389
THR A 390
 None
 0.85A 4du2A-4ng4A:
undetectable		 4du2A-4ng4A:
23.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F84_A_SAMA501_0
(GERANYL DIPHOSPHATE
2-C-METHYLTRANSFERAS
E)		 4ng4 PHOSPHOGLYCERATE
KINASE
(Coxiella
burnetii) 		5 / 12 GLY A 347
GLY A 349
THR A 351
LEU A 355
SER A 368
 None
ADP  A 402 (-4.0A)
ADP  A 402 (-3.5A)
None
None
 1.25A 4f84A-4ng4A:
2.8		 4f84A-4ng4A:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L8F_B_MTXB301_1
(GAMMA-GLUTAMYL
HYDROLASE)		 4ng4 PHOSPHOGLYCERATE
KINASE
(Coxiella
burnetii) 		5 / 11 GLY A 349
GLY A 348
GLY A 347
ALA A 353
LEU A 352
 ADP  A 402 (-4.0A)
ADP  A 402 ( 3.7A)
None
None
None
 0.89A 4l8fB-4ng4A:
undetectable		 4l8fB-4ng4A:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L8F_D_MTXD301_1
(GAMMA-GLUTAMYL
HYDROLASE)		 4ng4 PHOSPHOGLYCERATE
KINASE
(Coxiella
burnetii) 		5 / 11 GLY A 349
GLY A 348
GLY A 347
ALA A 353
LEU A 352
 ADP  A 402 (-4.0A)
ADP  A 402 ( 3.7A)
None
None
None
 0.93A 4l8fD-4ng4A:
3.1		 4l8fD-4ng4A:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJV_A_RITA500_2
(PROTEASE)		 4ng4 PHOSPHOGLYCERATE
KINASE
(Coxiella
burnetii) 		5 / 11 ASP A 293
GLY A 329
ASP A 264
VAL A 279
ILE A 266
 MG  A 401 (-2.9A)
MG  A 401 ( 4.0A)
None
None
None
 1.01A 4njvB-4ng4A:
undetectable		 4njvB-4ng4A:
14.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4O33_A_TZNA501_1
(PHOSPHOGLYCERATE
KINASE 1)		 4ng4 PHOSPHOGLYCERATE
KINASE
(Coxiella
burnetii) 		6 / 12 GLY A 194
GLY A 218
GLY A 219
LEU A 236
GLY A 319
VAL A 320
 ADP  A 402 (-2.9A)
ADP  A 402 (-3.2A)
ADP  A 402 ( 4.6A)
ADP  A 402 ( 4.2A)
MG  A 401 (-3.2A)
ADP  A 402 ( 4.2A)
 0.68A 4o33A-4ng4A:
46.0		 4o33A-4ng4A:
42.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4O3F_A_TZNA501_1
(PHOSPHOGLYCERATE
KINASE 1)		 4ng4 PHOSPHOGLYCERATE
KINASE
(Coxiella
burnetii) 		5 / 12 GLY A 194
GLY A 218
GLY A 219
LEU A 236
VAL A 320
 ADP  A 402 (-2.9A)
ADP  A 402 (-3.2A)
ADP  A 402 ( 4.6A)
ADP  A 402 ( 4.2A)
ADP  A 402 ( 4.2A)
 0.72A 4o3fA-4ng4A:
44.1		 4o3fA-4ng4A:
42.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4O3F_A_TZNA501_1
(PHOSPHOGLYCERATE
KINASE 1)		 4ng4 PHOSPHOGLYCERATE
KINASE
(Coxiella
burnetii) 		5 / 12 GLY A 194
GLY A 218
LEU A 236
GLY A 319
VAL A 320
 ADP  A 402 (-2.9A)
ADP  A 402 (-3.2A)
ADP  A 402 ( 4.2A)
MG  A 401 (-3.2A)
ADP  A 402 ( 4.2A)
 0.53A 4o3fA-4ng4A:
44.1		 4o3fA-4ng4A:
42.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OK1_A_198A1001_2
(ANDROGEN RECEPTOR)		 4ng4 PHOSPHOGLYCERATE
KINASE
(Coxiella
burnetii) 		4 / 8 LEU A  94
MET A  29
LEU A  63
HIS A  62
 None
 0.97A 4ok1A-4ng4A:
undetectable		 4ok1A-4ng4A:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PD9_A_ADNA501_2
(NUPC FAMILY PROTEIN)		 4ng4 PHOSPHOGLYCERATE
KINASE
(Coxiella
burnetii) 		3 / 3 THR A 146
ASN A 118
PHE A 117
 None
 0.47A 4pd9A-4ng4A:
undetectable		 4pd9A-4ng4A:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UBE_A_2FAA401_1
(ADENOSINE KINASE)		 4ng4 PHOSPHOGLYCERATE
KINASE
(Coxiella
burnetii) 		5 / 12 SER A 299
GLY A 295
ALA A 332
GLN A 328
ASP A 293
 None
None
None
None
MG  A 401 (-2.9A)
 0.95A 4ubeA-4ng4A:
undetectable		 4ubeA-4ng4A:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGY_A_ERYA403_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 4ng4 PHOSPHOGLYCERATE
KINASE
(Coxiella
burnetii) 		5 / 12 ILE A 318
GLY A 193
PHE A 358
ALA A 354
ILE A 312
 None
 0.95A 5igyA-4ng4A:
undetectable		 5igyA-4ng4A:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IH0_A_ERYA404_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 4ng4 PHOSPHOGLYCERATE
KINASE
(Coxiella
burnetii) 		5 / 12 ILE A 318
GLY A 193
PHE A 358
ALA A 354
ILE A 312
 None
 0.99A 5ih0A-4ng4A:
undetectable		 5ih0A-4ng4A:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KOX_A_RFPA502_1
(PENTACHLOROPHENOL
4-MONOOXYGENASE)		 4ng4 PHOSPHOGLYCERATE
KINASE
(Coxiella
burnetii) 		5 / 12 GLY A 349
ARG A  65
GLY A  64
GLY A 372
GLY A 371
 ADP  A 402 (-4.0A)
None
None
None
None
 0.90A 5koxA-4ng4A:
undetectable		 5koxA-4ng4A:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MUG_A_VIVA301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 4ng4 PHOSPHOGLYCERATE
KINASE
(Coxiella
burnetii) 		5 / 12 VAL A 115
LEU A  63
VAL A  80
LEU A  84
ILE A  47
 None
 0.99A 5mugA-4ng4A:
undetectable		 5mugA-4ng4A:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUI_B_CTCB405_0
(TETRACYCLINE
DESTRUCTASE TET(50))		 4ng4 PHOSPHOGLYCERATE
KINASE
(Coxiella
burnetii) 		5 / 12 LEU A 333
THR A 330
GLY A 319
GLY A 348
PHE A 374
 None
MG  A 401 (-3.3A)
MG  A 401 (-3.2A)
ADP  A 402 ( 3.7A)
None
 1.04A 5tuiB-4ng4A:
undetectable		 5tuiB-4ng4A:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6E5Z_A_CCSA106_0
(PROTEIN/NUCLEIC ACID
DEGLYCASE DJ-1)		 4ng4 PHOSPHOGLYCERATE
KINASE
(Coxiella
burnetii) 		5 / 10 GLY A 217
GLY A 218
ASN A 222
ILE A 215
ALA A 221
 None
ADP  A 402 (-3.2A)
ADP  A 402 (-3.9A)
None
None
 1.12A 6e5zA-4ng4A:
4.7		 6e5zA-4ng4A:
21.34