SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4ngu'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SG9_A_SAMA301_0
(HEMK PROTEIN)		 4ngu TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT
(Desulfovibrio
alaskensis) 		5 / 12 PRO A 221
GLY A 157
ILE A 160
VAL A 154
ASN A 219
 CL  A 401 (-3.8A)
CL  A 401 ( 3.8A)
DAL  A 402 (-4.9A)
None
DAL  A 403 (-2.9A)
 1.14A 1sg9A-4nguA:
undetectable		 1sg9A-4nguA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TMX_B_BEZB882_0
(HYDROXYQUINOL
1,2-DIOXYGENASE)		 4ngu TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT
(Desulfovibrio
alaskensis) 		5 / 12 GLY A 216
TYR A 190
ILE A 200
ARG A 180
VAL A 205
 None
None
None
DAL  A 403 (-3.0A)
None
 1.35A 1tmxB-4nguA:
undetectable		 1tmxB-4nguA:
23.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_B_ACHB1211_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 4ngu TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT
(Desulfovibrio
alaskensis) 		4 / 8 GLN A 246
GLN A 242
ILE A 160
SER A  99
 DAL  A 402 (-4.0A)
None
DAL  A 402 (-4.9A)
DAL  A 402 (-4.5A)
 1.10A 2xz5B-4nguA:
undetectable
2xz5E-4nguA:
undetectable		 2xz5B-4nguA:
20.44
2xz5E-4nguA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y00_B_Y00B601_2
(BETA-1 ADRENERGIC
RECEPTOR)		 4ngu TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT
(Desulfovibrio
alaskensis) 		3 / 3 VAL A 154
ASN A  40
TRP A 202
 None
DAL  A 403 (-4.2A)
DAL  A 403 (-4.1A)
 1.10A 2y00B-4nguA:
undetectable		 2y00B-4nguA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HEC_A_STIA1_2
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 4ngu TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT
(Desulfovibrio
alaskensis) 		4 / 4 LEU A 150
MET A  90
ILE A 326
ASP A 183
 None
 1.44A 3hecA-4nguA:
undetectable		 3hecA-4nguA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3REM_B_SALB301_1
(SALICYLATE
BIOSYNTHESIS PROTEIN
PCHB)		 4ngu TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT
(Desulfovibrio
alaskensis) 		4 / 8 VAL A 232
VAL A 213
TYR A 206
GLN A 233
 None
 1.01A 3remB-4nguA:
undetectable		 3remB-4nguA:
15.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LNX_A_T44A501_1
(THYROID HORMONE
RECEPTOR ALPHA)		 4ngu TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT
(Desulfovibrio
alaskensis) 		4 / 6 SER A  65
GLN A 262
VAL A  35
THR A  34
 None
 1.26A 4lnxA-4nguA:
undetectable		 4lnxA-4nguA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NQA_H_9CRH501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4ngu TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT
(Desulfovibrio
alaskensis) 		5 / 12 ILE A 266
ALA A 270
ALA A 269
LEU A 151
ALA A 152
 None
 1.00A 4nqaH-4nguA:
undetectable		 4nqaH-4nguA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XE5_A_OBNA1104_2
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 4ngu TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT
(Desulfovibrio
alaskensis) 		4 / 6 PRO A 220
ILE A 226
VAL A 205
THR A 163
 None
 0.97A 4xe5A-4nguA:
undetectable		 4xe5A-4nguA:
16.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AYC_A_1YNA502_1
(PROTEIN CYP51)		 4ngu TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT
(Desulfovibrio
alaskensis) 		5 / 12 PHE A  57
ALA A 269
TYR A 243
ALA A 338
ALA A 341
 None
 1.24A 6aycA-4nguA:
undetectable		 6aycA-4nguA:
13.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DRZ_A_H8JA1206_0
(5HT2B RECEPTOR, BRIL
CHIMERA)		 4ngu TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT
(Desulfovibrio
alaskensis) 		5 / 12 VAL A 241
GLY A 314
PHE A 174
PHE A 193
VAL A 168
 None
 1.04A 6drzA-4nguA:
undetectable		 6drzA-4nguA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN5_C_LLLC301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 4ngu TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT
(Desulfovibrio
alaskensis) 		4 / 6 ASP A 173
TYR A 300
GLU A 306
GLU A 312
 None
 1.40A 6mn5C-4nguA:
undetectable		 6mn5C-4nguA:
14.11