SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4nh0'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CMA_B_SAMB105_0
(PROTEIN (MET
REPRESSOR))
4nh0 CELL
DIVISIONFTSK/SPOIIIE

(Thermomonospora
curvata)
5 / 11 GLU A 896
ARG A1069
GLU A 902
PHE A 933
GLY A 930
None
1.37A 1cmaA-4nh0A:
undetectable
1cmaB-4nh0A:
undetectable
1cmaA-4nh0A:
5.75
1cmaB-4nh0A:
5.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EUP_A_ASDA452_1
(CYTOCHROME P450ERYF)
4nh0 CELL
DIVISIONFTSK/SPOIIIE

(Thermomonospora
curvata)
4 / 8 PHE A 686
ILE A 645
LEU A 647
LEU A 659
None
0.85A 1eupA-4nh0A:
undetectable
1eupA-4nh0A:
17.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FOH_A_IPHA802_0
(PHENOL HYDROXYLASE)
4nh0 CELL
DIVISIONFTSK/SPOIIIE

(Thermomonospora
curvata)
5 / 10 ASP A 462
GLY A 469
GLN A 468
ARG A 445
ARG A 447
None
1.24A 1fohA-4nh0A:
undetectable
1fohA-4nh0A:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FOH_B_IPHB802_0
(PHENOL HYDROXYLASE)
4nh0 CELL
DIVISIONFTSK/SPOIIIE

(Thermomonospora
curvata)
5 / 10 ASP A 462
GLY A 469
GLN A 468
ARG A 445
ARG A 447
None
1.20A 1fohB-4nh0A:
undetectable
1fohB-4nh0A:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FOH_C_IPHC802_0
(PHENOL HYDROXYLASE)
4nh0 CELL
DIVISIONFTSK/SPOIIIE

(Thermomonospora
curvata)
5 / 10 ASP A 462
GLY A 469
GLN A 468
ARG A 445
ARG A 447
None
1.22A 1fohC-4nh0A:
undetectable
1fohC-4nh0A:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FOH_D_IPHD802_0
(PHENOL HYDROXYLASE)
4nh0 CELL
DIVISIONFTSK/SPOIIIE

(Thermomonospora
curvata)
5 / 10 ASP A 462
GLY A 469
GLN A 468
ARG A 445
ARG A 447
None
1.23A 1fohD-4nh0A:
undetectable
1fohD-4nh0A:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JFF_B_TA1B601_1
(TUBULIN BETA CHAIN)
4nh0 CELL
DIVISIONFTSK/SPOIIIE

(Thermomonospora
curvata)
5 / 12 VAL A 857
GLU A 856
LEU A 772
LEU A 776
GLY A 786
None
1.01A 1jffB-4nh0A:
undetectable
1jffB-4nh0A:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WG8_B_SAMB3141_1
(PREDICTED
S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)
4nh0 CELL
DIVISIONFTSK/SPOIIIE

(Thermomonospora
curvata)
3 / 3 HIS A1161
ASP A1155
ASN A1124
None
None
ATP  A1404 (-3.5A)
0.86A 1wg8B-4nh0A:
3.3
1wg8B-4nh0A:
13.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WMQ_A_HISA2001_0
(HUT OPERON POSITIVE
REGULATORY PROTEIN)
4nh0 CELL
DIVISIONFTSK/SPOIIIE

(Thermomonospora
curvata)
4 / 6 ARG A 842
ILE A1049
GLY A 871
ALA A 870
None
0.89A 1wmqA-4nh0A:
undetectable
1wmqA-4nh0A:
8.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WMQ_B_HISB1001_0
(HUT OPERON POSITIVE
REGULATORY PROTEIN)
4nh0 CELL
DIVISIONFTSK/SPOIIIE

(Thermomonospora
curvata)
4 / 6 ARG A 842
ILE A1049
GLY A 871
ALA A 870
None
0.90A 1wmqB-4nh0A:
undetectable
1wmqB-4nh0A:
8.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WPU_A_HISA2001_0
(HUT OPERON POSITIVE
REGULATORY PROTEIN)
4nh0 CELL
DIVISIONFTSK/SPOIIIE

(Thermomonospora
curvata)
4 / 6 ARG A 842
ILE A1049
GLY A 871
ALA A 870
None
0.90A 1wpuA-4nh0A:
undetectable
1wpuA-4nh0A:
8.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WPU_B_HISB1001_0
(HUT OPERON POSITIVE
REGULATORY PROTEIN)
4nh0 CELL
DIVISIONFTSK/SPOIIIE

(Thermomonospora
curvata)
4 / 6 ARG A 842
ILE A1049
GLY A 871
ALA A 870
None
0.90A 1wpuB-4nh0A:
undetectable
1wpuB-4nh0A:
8.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRQ_A_HISA2001_0
(HUT OPERON POSITIVE
REGULATORY PROTEIN)
4nh0 CELL
DIVISIONFTSK/SPOIIIE

(Thermomonospora
curvata)
4 / 6 ARG A 842
ILE A1049
GLY A 871
ALA A 870
None
0.88A 1wrqA-4nh0A:
undetectable
1wrqA-4nh0A:
8.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRQ_B_HISB1001_0
(HUT OPERON POSITIVE
REGULATORY PROTEIN)
4nh0 CELL
DIVISIONFTSK/SPOIIIE

(Thermomonospora
curvata)
4 / 6 ARG A 842
ILE A1049
GLY A 871
ALA A 870
None
0.90A 1wrqB-4nh0A:
undetectable
1wrqB-4nh0A:
8.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZLQ_A_ACTA1502_0
(NICKEL-BINDING
PERIPLASMIC PROTEIN)
4nh0 CELL
DIVISIONFTSK/SPOIIIE

(Thermomonospora
curvata)
4 / 5 TRP A 437
PRO A 433
GLY A 755
GLY A 753
None
1.13A 1zlqA-4nh0A:
0.3
1zlqA-4nh0A:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BYO_A_LNLA1217_1
(LIPOPROTEIN LPPX)
4nh0 CELL
DIVISIONFTSK/SPOIIIE

(Thermomonospora
curvata)
4 / 4 VAL A 857
LEU A 779
ILE A1036
LEU A 772
None
0.82A 2byoA-4nh0A:
undetectable
2byoA-4nh0A:
11.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2D55_C_DVAC8_0
(ACTINOMYCIN D)
4nh0 CELL
DIVISIONFTSK/SPOIIIE

(Thermomonospora
curvata)
3 / 3 PRO A 854
THR A1064
PRO A1066
None
0.62A 2d55C-4nh0A:
undetectable
2d55C-4nh0A:
2.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIK_P_CHDP1525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)
4nh0 CELL
DIVISIONFTSK/SPOIIIE

(Thermomonospora
curvata)
4 / 7 HIS A 877
ASP A 790
THR A 788
TYR A 787
None
1.42A 2eikN-4nh0A:
undetectable
2eikP-4nh0A:
undetectable
2eikN-4nh0A:
17.50
2eikP-4nh0A:
12.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIM_P_CHDP1525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)
4nh0 CELL
DIVISIONFTSK/SPOIIIE

(Thermomonospora
curvata)
4 / 6 HIS A 877
ASP A 790
THR A 788
TYR A 787
None
1.43A 2eimN-4nh0A:
undetectable
2eimP-4nh0A:
undetectable
2eimN-4nh0A:
17.50
2eimP-4nh0A:
12.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIN_P_CHDP1525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)
4nh0 CELL
DIVISIONFTSK/SPOIIIE

(Thermomonospora
curvata)
4 / 6 HIS A 877
ASP A 790
THR A 788
TYR A 787
None
1.45A 2einN-4nh0A:
undetectable
2einP-4nh0A:
undetectable
2einN-4nh0A:
17.50
2einP-4nh0A:
12.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HXF_B_TA1B601_1
(TUBULIN BETA CHAIN)
4nh0 CELL
DIVISIONFTSK/SPOIIIE

(Thermomonospora
curvata)
5 / 12 VAL A 857
GLU A 856
LEU A 772
LEU A 776
GLY A 786
None
1.01A 2hxfB-4nh0A:
undetectable
2hxfB-4nh0A:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HXH_B_TA1B601_1
(TUBULIN BETA CHAIN)
4nh0 CELL
DIVISIONFTSK/SPOIIIE

(Thermomonospora
curvata)
5 / 12 VAL A 857
GLU A 856
LEU A 772
LEU A 776
GLY A 786
None
1.01A 2hxhB-4nh0A:
undetectable
2hxhB-4nh0A:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2P4N_B_TA1B601_1
(TUBULIN BETA CHAIN)
4nh0 CELL
DIVISIONFTSK/SPOIIIE

(Thermomonospora
curvata)
5 / 12 VAL A 857
GLU A 856
LEU A 772
LEU A 776
GLY A 786
None
1.01A 2p4nB-4nh0A:
undetectable
2p4nB-4nh0A:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QX4_B_ML1B233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])
4nh0 CELL
DIVISIONFTSK/SPOIIIE

(Thermomonospora
curvata)
4 / 7 TRP A 978
GLY A 832
THR A 835
PHE A 981
None
None
ATP  A1405 (-4.9A)
None
1.17A 2qx4A-4nh0A:
undetectable
2qx4B-4nh0A:
undetectable
2qx4A-4nh0A:
12.64
2qx4B-4nh0A:
12.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WBE_B_TA1B1439_1
(TUBULIN BETA-2B
CHAIN)
4nh0 CELL
DIVISIONFTSK/SPOIIIE

(Thermomonospora
curvata)
5 / 12 VAL A 857
GLU A 856
LEU A 772
LEU A 776
GLY A 786
None
1.01A 2wbeB-4nh0A:
undetectable
2wbeB-4nh0A:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X91_A_LPRA1615_2
(ANGIOTENSIN
CONVERTING ENZYME)
4nh0 CELL
DIVISIONFTSK/SPOIIIE

(Thermomonospora
curvata)
3 / 3 SER A 975
THR A 835
PHE A1029
None
ATP  A1405 (-4.9A)
None
0.69A 2x91A-4nh0A:
undetectable
2x91A-4nh0A:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGP_A_PCFA1213_0
(WNT INHIBITORY
FACTOR 1)
4nh0 CELL
DIVISIONFTSK/SPOIIIE

(Thermomonospora
curvata)
6 / 12 ILE A 531
LEU A 534
MET A 544
PHE A 604
PHE A 608
VAL A 620
None
1.21A 2ygpA-4nh0A:
undetectable
2ygpA-4nh0A:
8.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_D_2FAD500_2
(ADENOSYLHOMOCYSTEINA
SE)
4nh0 CELL
DIVISIONFTSK/SPOIIIE

(Thermomonospora
curvata)
4 / 4 LEU A1271
GLN A1309
THR A1310
THR A1305
None
ATP  A1404 ( 4.8A)
ATP  A1404 (-4.4A)
None
1.10A 2zj0D-4nh0A:
undetectable
2zj0D-4nh0A:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABM_P_CHDP1525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)
4nh0 CELL
DIVISIONFTSK/SPOIIIE

(Thermomonospora
curvata)
4 / 7 HIS A 877
ASP A 790
THR A 788
TYR A 787
None
1.44A 3abmN-4nh0A:
undetectable
3abmP-4nh0A:
undetectable
3abmN-4nh0A:
17.50
3abmP-4nh0A:
12.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG4_P_CHDP1525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)
4nh0 CELL
DIVISIONFTSK/SPOIIIE

(Thermomonospora
curvata)
4 / 7 HIS A 877
ASP A 790
THR A 788
TYR A 787
None
1.44A 3ag4N-4nh0A:
undetectable
3ag4P-4nh0A:
undetectable
3ag4N-4nh0A:
17.50
3ag4P-4nh0A:
12.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ARU_A_PNXA606_1
(CHITINASE A)
4nh0 CELL
DIVISIONFTSK/SPOIIIE

(Thermomonospora
curvata)
4 / 7 PHE A 908
GLY A 930
TYR A 928
ARG A 921
None
0.87A 3aruA-4nh0A:
undetectable
3aruA-4nh0A:
19.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B0W_A_DGXA1_1
(NUCLEAR RECEPTOR
ROR-GAMMA)
4nh0 CELL
DIVISIONFTSK/SPOIIIE

(Thermomonospora
curvata)
5 / 12 LEU A 776
LEU A 779
PHE A 859
CYH A 861
LEU A 869
None
1.20A 3b0wA-4nh0A:
undetectable
3b0wA-4nh0A:
11.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_G_SVRG506_1
(PHOSPHOLIPASE A2)
4nh0 CELL
DIVISIONFTSK/SPOIIIE

(Thermomonospora
curvata)
4 / 8 VAL A 801
VAL A 802
GLY A 803
PRO A 770
None
0.98A 3bjwA-4nh0A:
undetectable
3bjwA-4nh0A:
7.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DCO_B_TA1B601_1
(BOVINE BETA TUBULIN)
4nh0 CELL
DIVISIONFTSK/SPOIIIE

(Thermomonospora
curvata)
5 / 12 VAL A 857
GLU A 856
LEU A 772
LEU A 776
GLY A 786
None
1.01A 3dcoB-4nh0A:
undetectable
3dcoB-4nh0A:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EDL_B_TA1B601_1
(BETA TUBULIN)
4nh0 CELL
DIVISIONFTSK/SPOIIIE

(Thermomonospora
curvata)
5 / 12 VAL A 857
GLU A 856
LEU A 772
LEU A 776
GLY A 786
None
1.00A 3edlB-4nh0A:
undetectable
3edlB-4nh0A:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FZG_A_SAMA300_0
(16S RRNA METHYLASE)
4nh0 CELL
DIVISIONFTSK/SPOIIIE

(Thermomonospora
curvata)
5 / 12 HIS A 474
GLY A 619
GLY A 615
LEU A 587
GLN A 468
None
1.15A 3fzgA-4nh0A:
1.1
3fzgA-4nh0A:
9.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IZ0_B_TA1B820_1
(BETA TUBULIN, CHAIN
B FROM PDB 1JFF)
4nh0 CELL
DIVISIONFTSK/SPOIIIE

(Thermomonospora
curvata)
5 / 12 VAL A 857
GLU A 856
LEU A 772
LEU A 776
GLY A 786
None
1.00A 3iz0B-4nh0A:
undetectable
3iz0B-4nh0A:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JWQ_A_VIAA901_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
CATALYTIC DOMAIN,
CONE CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
SUBUNIT ALPHA
CHIMERA)
4nh0 CELL
DIVISIONFTSK/SPOIIIE

(Thermomonospora
curvata)
5 / 9 LEU A 798
VAL A 827
LEU A 841
PHE A 937
VAL A 857
None
1.26A 3jwqA-4nh0A:
undetectable
3jwqA-4nh0A:
13.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NK2_X_LDPX433_1
(6-HYDROXY-L-NICOTINE
OXIDASE)
4nh0 CELL
DIVISIONFTSK/SPOIIIE

(Thermomonospora
curvata)
4 / 7 TYR A 545
MET A 552
LEU A 587
LEU A 607
None
1.25A 3nk2X-4nh0A:
undetectable
3nk2X-4nh0A:
18.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A6E_A_SAMA1349_1
(HYDROXYINDOLE
O-METHYLTRANSFERASE)
4nh0 CELL
DIVISIONFTSK/SPOIIIE

(Thermomonospora
curvata)
3 / 3 TYR A 928
ASP A 931
ASP A 935
None
0.77A 4a6eA-4nh0A:
undetectable
4a6eA-4nh0A:
16.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A99_D_MIYD392_1
(TETX2 PROTEIN)
4nh0 CELL
DIVISIONFTSK/SPOIIIE

(Thermomonospora
curvata)
4 / 5 HIS A 759
SER A 528
GLN A 811
VAL A 508
None
1.29A 4a99D-4nh0A:
undetectable
4a99D-4nh0A:
16.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACB_C_DXCC1478_0
(TRANSLATION
ELONGATION FACTOR
SELB)
4nh0 CELL
DIVISIONFTSK/SPOIIIE

(Thermomonospora
curvata)
4 / 6 SER A 626
ASP A 592
ILE A 478
PHE A 594
None
1.01A 4acbC-4nh0A:
undetectable
4acbC-4nh0A:
18.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9N_B_CAMB1420_0
(CYTOCHROME P450)
4nh0 CELL
DIVISIONFTSK/SPOIIIE

(Thermomonospora
curvata)
5 / 10 THR A1310
LEU A1271
GLY A1270
VAL A1102
ASP A1095
ATP  A1404 (-4.4A)
None
None
None
None
1.30A 4c9nB-4nh0A:
undetectable
4c9nB-4nh0A:
17.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9P_B_CAMB423_0
(CYTOCHROME P450)
4nh0 CELL
DIVISIONFTSK/SPOIIIE

(Thermomonospora
curvata)
5 / 10 THR A1310
LEU A1271
GLY A1270
VAL A1102
ASP A1095
ATP  A1404 (-4.4A)
None
None
None
None
1.27A 4c9pB-4nh0A:
undetectable
4c9pB-4nh0A:
17.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F4D_B_CHDB505_0
(FERROCHELATASE,
MITOCHONDRIAL)
4nh0 CELL
DIVISIONFTSK/SPOIIIE

(Thermomonospora
curvata)
5 / 12 LEU A1232
LEU A1240
LEU A1208
ILE A1259
VAL A1212
None
1.25A 4f4dB-4nh0A:
undetectable
4f4dB-4nh0A:
14.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_A_SAMA401_0
(METHYLTRANSFERASE
NSUN4)
4nh0 CELL
DIVISIONFTSK/SPOIIIE

(Thermomonospora
curvata)
5 / 12 GLY A 514
LEU A 598
SER A 599
ASP A 592
LEU A 624
None
1.06A 4fp9A-4nh0A:
undetectable
4fp9A-4nh0A:
15.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_C_SAMC401_0
(METHYLTRANSFERASE
NSUN4)
4nh0 CELL
DIVISIONFTSK/SPOIIIE

(Thermomonospora
curvata)
5 / 12 GLY A 514
LEU A 598
SER A 599
ASP A 592
LEU A 624
None
1.06A 4fp9C-4nh0A:
undetectable
4fp9C-4nh0A:
15.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_F_SAMF401_0
(METHYLTRANSFERASE
NSUN4)
4nh0 CELL
DIVISIONFTSK/SPOIIIE

(Thermomonospora
curvata)
5 / 12 GLY A 514
LEU A 598
SER A 599
ASP A 592
LEU A 624
None
1.06A 4fp9F-4nh0A:
undetectable
4fp9F-4nh0A:
15.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IOM_A_FOLA608_0
(FORMATE--TETRAHYDROF
OLATE LIGASE)
4nh0 CELL
DIVISIONFTSK/SPOIIIE

(Thermomonospora
curvata)
4 / 7 ALA A 800
LEU A 844
LEU A 848
TRP A 794
None
0.98A 4iomA-4nh0A:
undetectable
4iomA-4nh0A:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KOE_F_TR6F101_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B
E-SITE DNA2)
4nh0 CELL
DIVISIONFTSK/SPOIIIE

(Thermomonospora
curvata)
4 / 6 SER A1150
GLY A1116
ASP A1117
GLY A1121
None
None
None
ATP  A1404 (-3.2A)
0.93A 4koeA-4nh0A:
undetectable
4koeB-4nh0A:
undetectable
4koeC-4nh0A:
3.1
4koeA-4nh0A:
18.05
4koeB-4nh0A:
18.05
4koeC-4nh0A:
13.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KOE_H_TR6H101_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B
E-SITE DNA4)
4nh0 CELL
DIVISIONFTSK/SPOIIIE

(Thermomonospora
curvata)
4 / 7 SER A1150
GLY A1116
ASP A1117
GLY A1121
None
None
None
ATP  A1404 (-3.2A)
0.93A 4koeA-4nh0A:
undetectable
4koeB-4nh0A:
undetectable
4koeD-4nh0A:
3.2
4koeA-4nh0A:
18.05
4koeB-4nh0A:
18.05
4koeD-4nh0A:
13.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LA0_B_198B601_1
(SERUM ALBUMIN)
4nh0 CELL
DIVISIONFTSK/SPOIIIE

(Thermomonospora
curvata)
5 / 9 LEU A 587
MET A 544
GLU A 551
PHE A 604
LEU A 591
None
1.48A 4la0B-4nh0A:
undetectable
4la0B-4nh0A:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LVC_B_ADNB501_2
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(SAHASE))
4nh0 CELL
DIVISIONFTSK/SPOIIIE

(Thermomonospora
curvata)
4 / 5 GLN A1309
THR A1310
THR A1305
LEU A1291
ATP  A1404 ( 4.8A)
ATP  A1404 (-4.4A)
None
None
1.00A 4lvcB-4nh0A:
2.4
4lvcB-4nh0A:
18.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LXZ_A_SHHA407_1
(HISTONE DEACETYLASE
2)
4nh0 CELL
DIVISIONFTSK/SPOIIIE

(Thermomonospora
curvata)
5 / 12 HIS A 877
PRO A 876
GLY A 786
HIS A1061
GLY A1062
None
0.98A 4lxzA-4nh0A:
2.8
4lxzA-4nh0A:
15.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2R_A_BZ1A302_2
(CARBONIC ANHYDRASE 2)
4nh0 CELL
DIVISIONFTSK/SPOIIIE

(Thermomonospora
curvata)
4 / 4 HIS A1161
GLU A1207
HIS A1241
LEU A1104
None
1.08A 4m2rA-4nh0A:
undetectable
4m2rA-4nh0A:
12.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MK4_A_CHDA503_0
(FERROCHELATASE,
MITOCHONDRIAL)
4nh0 CELL
DIVISIONFTSK/SPOIIIE

(Thermomonospora
curvata)
5 / 10 LEU A 431
LEU A 751
LEU A 524
ILE A 425
VAL A 691
None
1.18A 4mk4A-4nh0A:
2.6
4mk4A-4nh0A:
14.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OR0_A_NPSA601_1
(SERUM ALBUMIN)
4nh0 CELL
DIVISIONFTSK/SPOIIIE

(Thermomonospora
curvata)
5 / 11 PHE A1029
VAL A 802
GLY A 803
THR A 843
SER A 974
None
0.90A 4or0A-4nh0A:
undetectable
4or0A-4nh0A:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PEV_A_ADNA501_2
(MEMBRANE LIPOPROTEIN
FAMILY PROTEIN)
4nh0 CELL
DIVISIONFTSK/SPOIIIE

(Thermomonospora
curvata)
3 / 3 PRO A 580
LEU A 581
HIS A 561
None
0.71A 4pevA-4nh0A:
3.1
4pevA-4nh0A:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XR4_B_AG2B511_1
(HOMOSPERMIDINE
SYNTHASE)
4nh0 CELL
DIVISIONFTSK/SPOIIIE

(Thermomonospora
curvata)
3 / 3 VAL A 527
PHE A 518
ARG A 490
None
0.88A 4xr4B-4nh0A:
undetectable
4xr4B-4nh0A:
18.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YIA_B_IMNB401_2
(THYROXINE-BINDING
GLOBULIN)
4nh0 CELL
DIVISIONFTSK/SPOIIIE

(Thermomonospora
curvata)
3 / 3 LEU A 436
ARG A 440
ARG A 438
None
0.93A 4yiaB-4nh0A:
undetectable
4yiaB-4nh0A:
2.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z53_F_TR6F101_1
(DNA TOPOISOMERASE 4
SUBUNIT B,DNA
TOPOISOMERASE 4
SUBUNIT A
E-SITE DNA)
4nh0 CELL
DIVISIONFTSK/SPOIIIE

(Thermomonospora
curvata)
4 / 6 GLY A1116
ASP A1117
GLY A1121
SER A1150
None
None
ATP  A1404 (-3.2A)
None
0.94A 4z53A-4nh0A:
undetectable
4z53B-4nh0A:
undetectable
4z53A-4nh0A:
20.75
4z53B-4nh0A:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z53_H_TR6H101_1
(DNA TOPOISOMERASE 4
SUBUNIT B,DNA
TOPOISOMERASE 4
SUBUNIT A
E-SITE DNA)
4nh0 CELL
DIVISIONFTSK/SPOIIIE

(Thermomonospora
curvata)
4 / 7 GLY A1116
ASP A1117
GLY A1121
SER A1150
None
None
ATP  A1404 (-3.2A)
None
0.96A 4z53A-4nh0A:
undetectable
4z53B-4nh0A:
undetectable
4z53A-4nh0A:
20.75
4z53B-4nh0A:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1A_P_CHDP307_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)
4nh0 CELL
DIVISIONFTSK/SPOIIIE

(Thermomonospora
curvata)
4 / 7 HIS A 877
ASP A 790
THR A 788
TYR A 787
None
1.42A 5b1aN-4nh0A:
undetectable
5b1aP-4nh0A:
undetectable
5b1aN-4nh0A:
17.50
5b1aP-4nh0A:
12.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B3S_P_CHDP301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)
4nh0 CELL
DIVISIONFTSK/SPOIIIE

(Thermomonospora
curvata)
4 / 7 HIS A 877
ASP A 790
THR A 788
TYR A 787
None
1.44A 5b3sN-4nh0A:
0.6
5b3sP-4nh0A:
undetectable
5b3sN-4nh0A:
17.50
5b3sP-4nh0A:
12.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D4U_C_SAMC301_0
(UNCHARACTERIZED
PROTEIN MJ0489)
4nh0 CELL
DIVISIONFTSK/SPOIIIE

(Thermomonospora
curvata)
5 / 12 GLY A1294
TYR A1312
LEU A1071
GLY A1093
ILE A1308
ATP  A1404 ( 3.7A)
ATP  A1404 (-4.8A)
None
None
None
0.96A 5d4uC-4nh0A:
undetectable
5d4uC-4nh0A:
12.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D4U_D_SAMD301_0
(UNCHARACTERIZED
PROTEIN MJ0489)
4nh0 CELL
DIVISIONFTSK/SPOIIIE

(Thermomonospora
curvata)
5 / 12 GLY A1294
TYR A1312
LEU A1071
GLY A1093
ILE A1308
ATP  A1404 ( 3.7A)
ATP  A1404 (-4.8A)
None
None
None
0.97A 5d4uD-4nh0A:
undetectable
5d4uD-4nh0A:
12.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GS4_A_ESTA603_2
(ESTROGEN RECEPTOR)
4nh0 CELL
DIVISIONFTSK/SPOIIIE

(Thermomonospora
curvata)
4 / 6 LEU A 494
LEU A 509
PHE A 744
HIS A 526
None
0.78A 5gs4A-4nh0A:
undetectable
5gs4A-4nh0A:
12.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GTR_A_ESTA601_2
(ESTROGEN RECEPTOR)
4nh0 CELL
DIVISIONFTSK/SPOIIIE

(Thermomonospora
curvata)
4 / 5 LEU A 494
LEU A 509
PHE A 744
HIS A 526
None
0.86A 5gtrA-4nh0A:
undetectable
5gtrA-4nh0A:
12.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IAO_C_URFC301_1
(BIFUNCTIONAL PROTEIN
PYRR)
4nh0 CELL
DIVISIONFTSK/SPOIIIE

(Thermomonospora
curvata)
3 / 3 ARG A 555
HIS A 558
ARG A 554
None
0.90A 5iaoC-4nh0A:
2.2
5iaoC-4nh0A:
11.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IAO_F_URFF301_1
(BIFUNCTIONAL PROTEIN
PYRR)
4nh0 CELL
DIVISIONFTSK/SPOIIIE

(Thermomonospora
curvata)
3 / 3 ARG A 555
HIS A 558
ARG A 554
None
0.90A 5iaoF-4nh0A:
undetectable
5iaoF-4nh0A:
11.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JM4_A_BEZA301_0
(14-3-3 PROTEIN
ZETA/DELTA)
4nh0 CELL
DIVISIONFTSK/SPOIIIE

(Thermomonospora
curvata)
4 / 5 PHE A 908
ILE A 913
GLN A 903
ARG A 904
None
1.08A 5jm4A-4nh0A:
undetectable
5jm4A-4nh0A:
11.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JM4_B_BEZB301_0
(14-3-3 PROTEIN
ZETA/DELTA)
4nh0 CELL
DIVISIONFTSK/SPOIIIE

(Thermomonospora
curvata)
4 / 4 PHE A 908
ILE A 913
GLN A 903
ARG A 904
None
1.09A 5jm4B-4nh0A:
1.5
5jm4B-4nh0A:
11.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUI_B_CTCB405_0
(TETRACYCLINE
DESTRUCTASE TET(50))
4nh0 CELL
DIVISIONFTSK/SPOIIIE

(Thermomonospora
curvata)
5 / 12 GLY A 479
THR A 517
GLY A 672
PHE A 686
ILE A 645
None
0.84A 5tuiB-4nh0A:
undetectable
5tuiB-4nh0A:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TWJ_A_SAMA201_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE H)
4nh0 CELL
DIVISIONFTSK/SPOIIIE

(Thermomonospora
curvata)
5 / 12 GLY A 964
SER A 956
LEU A 938
HIS A 970
VAL A 971
None
0.95A 5twjA-4nh0A:
undetectable
5twjA-4nh0A:
10.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X19_P_CHDP306_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)
4nh0 CELL
DIVISIONFTSK/SPOIIIE

(Thermomonospora
curvata)
4 / 6 HIS A 877
ASP A 790
THR A 788
TYR A 787
None
1.43A 5x19N-4nh0A:
undetectable
5x19P-4nh0A:
undetectable
5x19N-4nh0A:
17.50
5x19P-4nh0A:
12.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1B_P_CHDP306_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)
4nh0 CELL
DIVISIONFTSK/SPOIIIE

(Thermomonospora
curvata)
4 / 6 HIS A 877
ASP A 790
THR A 788
TYR A 787
None
1.44A 5x1bN-4nh0A:
undetectable
5x1bP-4nh0A:
undetectable
5x1bN-4nh0A:
17.50
5x1bP-4nh0A:
12.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1F_P_CHDP305_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)
4nh0 CELL
DIVISIONFTSK/SPOIIIE

(Thermomonospora
curvata)
4 / 7 HIS A 877
ASP A 790
THR A 788
TYR A 787
None
1.46A 5x1fN-4nh0A:
undetectable
5x1fP-4nh0A:
undetectable
5x1fN-4nh0A:
17.50
5x1fP-4nh0A:
12.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCQ_P_CHDP301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)
4nh0 CELL
DIVISIONFTSK/SPOIIIE

(Thermomonospora
curvata)
4 / 7 HIS A 877
ASP A 790
THR A 788
TYR A 787
None
1.43A 5zcqN-4nh0A:
undetectable
5zcqP-4nh0A:
undetectable
5zcqN-4nh0A:
17.50
5zcqP-4nh0A:
12.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZWR_A_9KLA402_0
(EST-Y29)
4nh0 CELL
DIVISIONFTSK/SPOIIIE

(Thermomonospora
curvata)
5 / 12 ILE A1244
LEU A1113
GLY A1250
ALA A1251
LEU A1282
None
1.22A 5zwrA-4nh0A:
undetectable
5zwrA-4nh0A:
16.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6APH_A_ADNA501_2
(ADENOSYLHOMOCYSTEINA
SE)
4nh0 CELL
DIVISIONFTSK/SPOIIIE

(Thermomonospora
curvata)
4 / 5 GLN A1309
THR A1310
THR A1305
LEU A1291
ATP  A1404 ( 4.8A)
ATP  A1404 (-4.4A)
None
None
1.02A 6aphA-4nh0A:
2.0
6aphA-4nh0A:
17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BC9_A_ETSA302_2
(CARBONIC ANHYDRASE 2)
4nh0 CELL
DIVISIONFTSK/SPOIIIE

(Thermomonospora
curvata)
4 / 5 HIS A1161
GLU A1207
HIS A1241
LEU A1104
None
1.09A 6bc9A-4nh0A:
undetectable
6bc9A-4nh0A:
6.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DEB_B_MTXB302_1
(BIFUNCTIONAL PROTEIN
FOLD)
4nh0 CELL
DIVISIONFTSK/SPOIIIE

(Thermomonospora
curvata)
5 / 12 LEU A 965
LEU A 798
PHE A 937
SER A 847
THR A 991
None
1.24A 6debB-4nh0A:
undetectable
6debB-4nh0A:
6.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F3M_A_ADNA502_2
(-)
4nh0 CELL
DIVISIONFTSK/SPOIIIE

(Thermomonospora
curvata)
4 / 4 GLN A1309
THR A1310
THR A1305
LEU A1291
ATP  A1404 ( 4.8A)
ATP  A1404 (-4.4A)
None
None
1.02A 6f3mA-4nh0A:
2.1
6f3mA-4nh0A:
17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GBN_B_ADNB501_2
(-)
4nh0 CELL
DIVISIONFTSK/SPOIIIE

(Thermomonospora
curvata)
4 / 5 GLN A1309
THR A1310
THR A1305
LEU A1291
ATP  A1404 ( 4.8A)
ATP  A1404 (-4.4A)
None
None
1.03A 6gbnB-4nh0A:
2.5
6gbnB-4nh0A:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NKN_C_CHDC301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)
4nh0 CELL
DIVISIONFTSK/SPOIIIE

(Thermomonospora
curvata)
4 / 6 HIS A 877
ASP A 790
THR A 788
TYR A 787
None
1.44A 6nknA-4nh0A:
undetectable
6nknC-4nh0A:
undetectable
6nknA-4nh0A:
17.50
6nknC-4nh0A:
12.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMP_C_CHDC303_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)
4nh0 CELL
DIVISIONFTSK/SPOIIIE

(Thermomonospora
curvata)
4 / 6 HIS A 877
ASP A 790
THR A 788
TYR A 787
None
1.43A 6nmpA-4nh0A:
0.5
6nmpC-4nh0A:
undetectable
6nmpA-4nh0A:
17.50
6nmpC-4nh0A:
12.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMP_P_CHDP302_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)
4nh0 CELL
DIVISIONFTSK/SPOIIIE

(Thermomonospora
curvata)
4 / 7 HIS A 877
ASP A 790
THR A 788
TYR A 787
None
1.46A 6nmpN-4nh0A:
undetectable
6nmpP-4nh0A:
undetectable
6nmpN-4nh0A:
17.50
6nmpP-4nh0A:
12.38